Synthesis and cytotoxic activity of polyamine analogues of camptothecin

Journal of Medicinal Chemistry

Volumn 49, Issue 17, 2006, Pages 5177-5186

  Dallavalle, Sabrina ^a   Giannini, Giuseppe ^b   Alloatti, Domenico ^b   Casati, Andrea ^a   Marastoni, Elena ^b   Musso, Loana ^a   Merlini, Lucio ^a   Morini, Gabriella ^a   Penco, Sergio ^a   Pisano, Claudio ^b   Tinelli, Stella ^c   De Cesare, Michelandrea ^c   Beretta, Giovanni Luca ^c   Zunino, Franco ^c  

^a UNIVERSITY OF MILAN   (Italy)

^b Sigma Tau SpA   (Italy)

^c NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4 [(CAMPTOTHECINYL 7 METHYLIDENE)AMINO]BUTYLCARBAMIC ACID; 7 ETHYL 10 HYDROXYCAMPTOTHECIN; [3 [[4 [[3 (CAMPTOTHECINYL 7 METHYLIDENE)AMINO]PROPYL]TERT BUTOXYCARBONYLAMINO]BUTYL]TERT BUTOXYCARBONYLAMINO]PROPYLCARBAMIC ACID; [3 [[4 [[3 [(CAMPTOTHECINYL 7 METHYL)TERT BUTOXYCARBONYLAMINO]PROPYL]TERT BUTOXYCARBONYLAMINO]BUTYL]TERT BUTOXYCARBONYLAMINO]PROPYL]CARBAMIC ACID; [3 [[4 [[3 [(CAMPTOTHECINYL 7 METHYLIDENE)AMINO]PROPYL]TERT BUTOXYCARBONYLAMINO]BUTYL]TERT BUTOXYCARBONYLAMINO]PROPYL]CARBAMIC ACID; [4 [[3 (CAMPTOTHECINYL 7 METHYLIDENE)AMINO]PROPYL TERT BUTOXYCARBONYLAMINO]BUTYL]CARBAMIC ACID; [4 [[3 [(CAMPTOTHECINYL 7 METHYLIDENE)AMINO]PROPYL]BENZYLOXYCARBONYLAMINO]BUTYL]CARBAMIC ACID; ACRIDINE DERIVATIVE; AZIRIDINE DERIVATIVE; CAMPTOTHECIN DERIVATIVE; CHLORAMBUCIL; DNA TOPOISOMERASE; IRINOTECAN; N (3 AMINOPROPYL) N' [3 (CAMPTOTHECINYL 7 METHYL)AMINOPROPYL]BUTANE 1,4 DIAMINE; NITROIMIDAZOLE DERIVATIVE; POLYAMINE; TOPOTECAN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; CYTOTOXICITY; DNA CLEAVAGE; DRUG DNA INTERACTION; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; LIPOPHILICITY; LOW DRUG DOSE; LUNG CARCINOMA; NONHUMAN; STOMACH CARCINOMA; TUMOR XENOGRAFT;

CAMPTOTHECIN; CELL LINE, TUMOR; CELL PROLIFERATION; DNA; DNA TOPOISOMERASES, TYPE I; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; HYDROLYSIS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; POLYAMINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS;

EID: 33747475241     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060285b     Document Type: Article

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