Synthesis and activity of a folate peptide camptothecin prodrug

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 20, 2006, Pages 5350-5355

  Henne, Walter A ^a   Doorneweerd, Derek D ^a   Hilgenbrink, Andrew R ^a   Kularatne, Sumith A ^a   Low, Philip S ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

Camptothecin; Carbonate; Disulfide; Endocytosis; Folate; Folic acid; Peptide; Prodrug; Releasable linker; Targeted drug delivery

Indexed keywords

CAMPTOTHECIN DERIVATIVE; CARBONIC ACID; DISULFIDE; FOLIC ACID DERIVATIVE; PEPTIDE DERIVATIVE; PRODRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL PROLIFERATION; CELL STRAIN KB; CONJUGATE; CONTROLLED STUDY; CYTOTOXICITY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; RECEPTOR AFFINITY;

BINDING, COMPETITIVE; CAMPTOTHECIN; CARRIER PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; FOLATE RECEPTORS, GPI-ANCHORED; FOLIC ACID; HUMANS; MOLECULAR STRUCTURE; PRODRUGS; RECEPTORS, CELL SURFACE; STEREOISOMERISM; TIME FACTORS;

EID: 33748294199     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.07.076     Document Type: Article

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