BN 80927: A novel homocamptothecin with inhibitory activities on both topoisomerase I and topoisomerase II

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 17, 1999, Pages 2599-2602

  Lavergne, Olivier ^a   Harnett, Jeremiah ^a   Rolland, Alain ^a   Lanco, Christophe ^a   Lesueur Ginot, Laurence ^a   Demarquay, Danièle ^a   Huchet, Marion ^a   Coulomb, Hélène ^a   Bigg, Dennis C H ^a  

^a Institut Henri Beaufour   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BN 80927; CAMPTOTHECIN DERIVATIVE; DNA; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); DRUG ANALOG; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CATTLE; DROSOPHILA; DRUG CYTOTOXICITY; DRUG DNA INTERACTION; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; NONHUMAN; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CAMPTOTHECIN; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HUMANS; TUMOR CELLS, CULTURED;

EID: 0033530146     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00428-X     Document Type: Article

References (24)

1. Rothenberg, M.L. Ann. Oncol. 1997, 8, 837-855.
2. Lavergne, O.; Lesueur-Ginot, L.; Pla Rodas, F.; Bigg, D.C.H. Bioorg. Med. Chem. Lett. 1997, 7, 2235-2238.
3. Lesueur-Ginot, L.; Demarquay, D.; Kiss, R.; Kasprzyk, P.G.; Dassonneville, L.; Bailly, C.; Camara, J.; Lavergne, O.; Bigg, D.C.H. Cancer Res. 1999, 59, 2939-2943.
4. Lavergne, O.; Lesueur-Ginot, L.; Pla Rodas, F.; Kasprzyk, P.G.; Pommier, J.; Demarquay, D.; Prévost, G.; Ulibarri, G.; Rolland, A.; Schiano-Liberatore, A.M.; Harnett, J.; Pons, D.; Camara, J.; Bigg, D.C.H. J. Med. Chem. 1998, 41, 5410-5419.
5. Kasprzyk, P.G.; Demarquay, D.; Lesueur-Ginot, L.; Carlson, M.; Lauer, J.; Huchet, M.; Coulomb, H.; Camara, J.; Lavergne, O.; Bigg, D.C.H. Proc. Am. Assoc. Cancer Res. 1999, 40, [abstract 739]
6. Spicer, J.A.; Gamage, S.A.; Atwell, G.J.; Finlay, G.J.; Baguley, B.C.; Denny, W.A. J. Med. Chem. 1997, 40, 1919-1929.
7. Riou, J.F.; Fosse, P.; Nguyen, C.H.; Larsen, A.K.; Bissery, M.C.; Grondard, L.; Saucier, J.M.; Bisagni, E.; Lavelle, F. Cancer Res 1993, 53, 5987-5993.
8. Gatto, B.; Capranico, G.; Palumbo, M. Curr. Pharm. Design 1999, 5, 195-215.
9. Except for a CPT/VP-16 "hybrid" molecule: Bastow, K.F.; Wang, H.K.; Cheng, Y.C.; Lee, K.H. Bioorg. Med. Chem. 1997, 5, 1481-1488.
10. All new compounds gave satisfactory analysis and spectroscopic data consistent with the proposed structure.
11. Sugasawa, T.; Adachi, M.; Sasakura, K.; Kitagawa, A. J Org. Chem. 1979, 44, 578-586.
12. Comins, D.L.; Jianhua, G. Tetrahedron Lett. 1994, 35, 2819-2822.
13. Comins, D.L.; Baevsky, M.F.; Hong, H. J. Am. Chem. Soc. 1992, 114, 10971-10972.
14. Bjornsti, M.A.; Osheroff, N. DNA Topoisomerase Protocols, Vol. I: DNA Topology and Enzymes; Humana Press: Totowa (NJ), 1999.
15. Ishiyama, M.; Tominaga, H.; Shiga, M.; Sasamoto, K.; Ohkura, Y.; Ueno, K. Biol. Pharm. Bull. 1996, 19, 1518-1520.
16. van Gijn, R.; ten Bokkel, H.; Rodenhuis, S.; Vermorken, J.B.; van Tellingen, O.; Rosing, H.; van Warmerdam, L.J.; Beijnen, J.H. Anticancer Drugs 1999, 10, 17-23.
17. Wall, M.E.; Wani, M.C. In Camptothecins: New Anticancer Agents; Potmesil, M., Pinedo, H.M., Eds.; CRC Press: Boca Raton (Fl), 1995; pp 21-41.
18. Lavergne, O.; Bigg, D.C.H. Bull. Cancer 1998, Spec No 1, 51-58.
19. Cao, Z.; Harris, N.; Kozielski, A.; Vardeman, D.; Stehlin, J.S.; Giovanella, B. J. Med. Chem. 1998, 41, 31-37.
20. Greenwald, R.B.; Pendri, A.; Conover, C.D.; Lee, C.; Choe, Y.H.; Gilbert, C.; Martinez, A.; Xia, J.; Wu, D.; Hsue, M. Bioorg. Med. Chem. 1998, 6, 551-562.
21. Colbern, G.T.; Dykes, D.J.; Engbers, C.; Musterer, R.; Hiller, A.; Pegg, E.; Saville, R.; Weng, S.; Luzzio, M.; Uster, P.; Amantea, M.; Working, P.K. Clin. Cancer Res. 1998, 4, 3077-3082.
22. Pommier, Y.; Kohlhagen, G.; Kohn, K.W.; Leteurtre, F.; Wani, M.C.; Wall, M.E. Proc. Natl. Acad. Sci. U. S. A. 1995, 92, 8861-8865.
23. Zhao, R.; al-Said, N.H.; Sternbach, D.L.; Lown, J.W. J. Med. Chem. 1997, 40, 216-225.
24. Bailly, C. (Centre Oscar Lambret, Lille, France) unpublished results.