Targeting topoisomerase I cleavage to specific sequences of DNA by triple helix-forming oligonucleotide conjugates. A comparison between a rebeccamycin derivative and camptothecin

Comptes Rendus de l'Academie des Sciences - Serie III

Volumn 322, Issue 9, 1999, Pages 785-790

  Arimondo, Paola B ^a   Bailly, Christian ^b   Boutorine, Alexandre ^a   Sun, Jian Sheng ^a   Garestier, Thérèse ^a   Hélène, Claude ^a  

^a MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

^b INSERM   (France)

Author keywords

Sequence specific DNA cleavage; Topoisomerase I; Topoisomerase I inhibitors; Triple helix forming oligonucleotides

Indexed keywords

CAMPTOTHECIN; CARBAZOLE DERIVATIVE; DNA TOPOISOMERASE; DOUBLE STRANDED RNA; OLIGONUCLEOTIDE; R 6; REBECCAMYCIN;

BIOCHEMISTRY;

ARTICLE; CANCER CHEMOTHERAPY; CONTROLLED STUDY; COVALENT BOND; DNA CLEAVAGE; DNA PROTEIN COMPLEX; DNA SEQUENCE; DRUG BINDING SITE; DRUG DNA BINDING; DRUG EFFICACY; DRUG ISOLATION; DRUG MECHANISM; DRUG POTENCY; DRUG TARGETING; MOLECULAR RECOGNITION; MOLECULAR STABILITY; TRIPLE HELIX;

EID: 0033303826     PISSN: 07644469     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0764-4469(00)80037-2     Document Type: Article

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