Reciprocal DNA topoisomerase II cleavage events at 5′-TATTA-3′ sequences in MLL and AF-9 create homologous single-stranded overhangs that anneal to form der(11) and der(9) genomic breakpoint junctions in treatment-related AML without further processing

Oncogene

Volumn 22, Issue 52, 2003, Pages 8448-8459

  Whitmarsh, Ryan J ^a   Saginario, Charles ^a   Zhuo, Ya ^a,b,h   Hilgenfeld, Eva ^c,i   Rappaport, Eric F ^a   Megonigal, Maureen D ^a,j   Carroll, Martin ^d   Liu, Mingli ^a,k   Osheroff, Neil ^e   Cheung, Nai Kong V ^f   Slater, Diana J ^a   Ried, Thomas ^c   Knutsen, Turid ^c   Blair, Ian A ^g   Felix, Carolyn A ^a,g  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^e VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^g UNIVERSITY OF PENNSYLVANIA   (United States)

^h MERCK RESEARCH LABORATORIES   (United States)

ⁱ UNIVERSITY OF MÜNSTER   (Germany)

^j Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^k THOMAS JEFFERSON UNIVERSITY   (United States)

more..

Author keywords

DNA topoisomerase II; Etoposide; Etoposide catechol; Etoposide quinone; Secondary leukemia; t(9; 11) translocation

Indexed keywords

CYCLOPHOSPHAMIDE; DNA TOPOISOMERASE (ATP HYDROLYSING); DOXORUBICIN; DRUG METABOLITE; ETOPOSIDE; ETOPOSIDE CATECHOL; ETOPOSIDE DERIVATIVE; ETOPOSIDE QUINONE; GRANULOCYTE COLONY STIMULATING FACTOR; GYRASE INHIBITOR; IFOSFAMIDE; MELPHALAN; TOPOTECAN; UNCLASSIFIED DRUG; VINCRISTINE;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ACUTE GRANULOCYTIC LEUKEMIA; ADOLESCENT; ARTICLE; CASE REPORT; CHROMOSOME BREAKAGE; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; DNA DAMAGE; ENZYME ASSAY; ENZYME DEGRADATION; ENZYME INDUCTION; GENE LOSS; GENE SEQUENCE; GENE TRANSLOCATION; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; INTRON; LYMPHADENOPATHY; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; THROMBOCYTOPENIA;

ADOLESCENT; DNA TOPOISOMERASES, TYPE II; DNA-BINDING PROTEINS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, MYELOCYTIC, ACUTE; MALE; MOLECULAR SEQUENCE DATA; MYELOID-LYMPHOID LEUKEMIA PROTEIN; NUCLEAR PROTEINS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENES; RECOMBINATION, GENETIC; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC;

EID: 0346753588     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1207052     Document Type: Article

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