Guanylyl cyclases and signaling by cyclic GMP

Pharmacological Reviews

Volumn 52, Issue 3, 2000, Pages 375-413

  Lucas, Kimberly A ^a   Pitari, Giovanni M ^a,b   Kazerounian, Shiva ^a   Ruiz Stewart, Inez ^a   Park, Jason ^a   Schulz, Stephanie ^a   Chepenik, Kenneth P ^a   Waldman, Scott A ^a,c  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b UNIVERSITY OF CATANIA   (Italy)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE NUCLEOTIDE; BACTERIAL TOXIN; CALCIUM; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; CYCLIC GMP PHOSPHODIESTERASE; CYSTEINE; DIVALENT CATION; ELECTROLYTE; FREE RADICAL; GASTROINTESTINAL POLYPEPTIDE; GUANYLATE CYCLASE; HORMONE RECEPTOR; ION CHANNEL; ISOENZYME; NATRIURETIC FACTOR; NITRIC OXIDE; PROTOPORPHYRIN; PURINE;

ARTICLE; CELL MOTILITY; CHROMOSOME MAP; DIMERIZATION; ELECTROLYTE BALANCE; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME REGULATION; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; ENZYME SUBUNIT; ENZYMOLOGY; GENETIC DISORDER; GLYCOSYLATION; HUMAN; INTESTINE FLUID; NONHUMAN; OLIGOMERIZATION; PHOTOTRANSDUCTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; VASCULAR SMOOTH MUSCLE;

ANIMALS; CYCLIC GMP; GUANYLATE CYCLASE; HUMANS; SIGNAL TRANSDUCTION;

EID: 0033832073     PISSN: 00316997     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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183. Novel sites for expression of an Escherichia coli heat-stable enterotoxin receptor in the developing rat
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186. 2+ desensitization in vascular smooth muscle by activating the myosin light chain phosphatase
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188. Atrial natriuretic peptide binding, cross-linking, and stimulation of cyclic Gmp accumulation and particulate guanylate cyclase activity in cultured cells
189. Specificity and promiscuity in membrane helix interactions
190. A dimerization motif for transmembrane α-helices
191. 2+ and other divalent cations on enzyme activity
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212. A family of hyperpolarization-activated mammalian cation channels
213. Two pacemaker channels from human heart with profoundly different activation kinetics
214. Cell line-specific transcriptional activation of the promoter of the human guanylyl cyclase C/heat-stable enterotoxin/receptor gene
215. Mice lacking the guanylyl cyclase C receptor are resistant to STa-induced intestinal secretion
216. Localization of the guanylyl cyclase C gene to mouse chromosome 6 and human chromosome 12p12
217. Aberrant adenylyl cyclase/cAMP signal transduction and G protein levels in platelets from hypertensive patients improve with antihypertensive drug therapy
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226. Taste buds have a cyclic nucleotide-activated channel, CNGgust
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228. Mutational analysis of a phosphotransfer motif essential for v-fps tyrosine kinase activity
229. Cyclic 3',5'-guanosine monophosphate synthesis induced by atrial natriuretic peptide, C-type natriuretic peptide, and nitric oxide in the rat retina
230. Interaction of cA-kinase and cG-kinase in mediating relaxation of dispersed smooth muscle cells
231. 2+ signaling in smooth muscle by cAMP- and cGMP-dependent protein kinases. Inhibitory phosphorylation of Pla2 by cyclic nucleotide-dependent protein kinases
232. Identification of the G protein-activating domain of the natriuretic peptide clearance receptor (NPR-C)
233. G protein-dependent activation of smooth muscle eNOS via natriuretic peptide clearance receptor
234. Molecular cloning and expression of cDNAs coding for soluble guanylate cyclase from rat lung
235. Molecular cloning of a cDNA coding for 70 kilodalton subunit of soluble guanylate cyclase from rat lung
236. 2+ modulation of the cGMP-gated channel of bullfrog retinal rod photoreceptors
237. Identification and characterization of a novel β subunit of soluble guanylyl cyclase that is active in the absence of a second subunit and is relatively insensitive to nitric oxide
238. Direct regulation of smooth muscle contractile elements by second messengers
239. Cellular mechanisms of the clearance function of type C receptors of atrial natriuretic factor
240. Purification and properties of heme-deficient hepatic solubl guanylate cyclase: Effects of heme and other factors on enzyme activation by NO, NO-heme, and protoporphyrin IX
241. Cloning and characterization of two forms of C-type natriuretic peptide receptor in rat brain
242. A simple structure encodes G protein-activating function of the Igf-II/mannose 6-phosphate receptor
243. Analysis of stimulation-G protein subunit coupling by using active insulin-like growth factor II receptor peptide
244. Human retinal guanylate cyclase (GUC2D) maps to chromosome 17p13.1
245. Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A
246. Dimerization of guanylyl cyclase-activating protein and a mechanism of photoreceptor guanylyl cyclase activation
247. Molecular cloning, cDNA structure, and chromosomal localization of the human type II cGMP-dependent protein kinase
248. Functional reconstitution of photoreceptor guanylate cyclase with native and mutant forms of guanylate cyclase-activating protein 1
249. Localization of guanylate cyclase-activating protein 2 in mammalian retinas
250. Molecular cloning and characterization of retinal photoreceptor guanylyl cyclase-activating protein
251. Intestine-specific activity of the human guanylyl cyclase C promoter is regulated by Cdx 2
252. Interruption of Escherichia coli heat-stable enterotoxin-induced guanylyl cyclase signaling and associated chloride current in human intestinal cells by 2-chloroadenosine
253. Opposing adenine nucleotide-dependent pathways regulate guanylyl cyclase C in rat intestine
254. Regulation of nitric oxide-responsive recombinant soluble guanylyl cyclase by calcium
255. An intracellular adenine nucleotide binding site inhibits guanyly cyclase C by a guanine nucleotide-dependent mechanism
256. Coexistence of guanylate cyclase and atrial natriuretic factor receptor in a 180-kD protein
257. Vasoactive peptides modulate vascular endothelial cell growth factor production and endothelial cell proliferation and invasion
258. Retinal-specific guanylate cyclase gene mutations in Leber's congenital amaurosis
259. Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II
260. Defective smooth muscle regulation in cGMP kinase I-deficient mice
261. Structure and function of cGMP-dependent protein kinases
262. Dephosphorylation of the guanylyl cyclase-A receptor causes desensitization
263. Protein kinase C-dependent desensitization of the atrial natriuretic peptide receptor is mediated by dephosphorylation
264. Identification and characterization of the major phosphorylation sites of the B-type natriuretic peptide receptor
265. Phosphorylation of the kinase homology domain is essential for activation of the A-type natriuretic peptide receptor
266. Atrial natriuretic peptide inhibits mitogen-activated protein kinase through the clearance receptor. Potential role in the inhibition of astrocyte proliferation
267. Cyclic guanosine monophosphate-dependent protein kinase is targeted to intermediate filaments and phosphory-lates vimentin in A23187-stimulated human neutrophils
268. Molecular mechanisms of vertebrate photoreceptor light adaptation
269. cGMP-dependent protein kinase in dorsal root ganglion: Relationship with nitric oxide synthase and nociceptive neurons
270. Cystic fibrosis: A disease in electrolyte transport
271. 2+ pump of bovine pulmonary artery
272. Receptor-mediated regulation of guanylate cyclase activity in spermatozoa
273. Role of heterotrimeric G-proteins in epidermal growth factor signalling
274. Effects of heat-stable enterotoxin of Yersinia enterocolitica on ion transport and cyclic guanosine 3',5'-monophosphate metabolism in rabbit ileum
275. Mode of action of heat-stable Escherichia coli enterotoxin. Tissue and subcellular specificities and role of cyclic Gmp
276. Atrial natriuretic peptide inhibits growth of hepatoblastoma (HEP G2) cells by means of activation of clearance receptors
277. Structure of the type B human natriuretic peptide receptor gene and association of a novel microsatellite polymorphism with essential hypertension
278. Phosphorylation of tyrosine hydroxylase by cGMP-dependent protein kinase in intact bovine chromaffin cells
279. Stoichiometry of the atrial natriuretic factor-R1 receptor complex in the bovine zona glomerulosa
280. Regulation of cell signaling by the cytoplasmic domains of the heat-stable enterotoxin receptor: Identification of autoinhibitory and activating motifs
281. Downregulation of soluble guanylyl cyclase in young and aging spontaneously hypertensive rats
282. 2+ channels by cyclic nucleotide cross activation of opposing protein kinases in rabbit portal vein
283. Functional properties of a naturally occurring isoform of soluble guanylyl cyclase
284. Transfected cGMP-dependent protein kinase suppresses calcium transients by inhibition of inositol 1,4,5-trisphosphate production
285. Cyclic Gmp-mediated phospholamban phosphorylation in intact cardiomyocytes
286. Guanylyl cyclase C is up-regulated by nonparenchymal cells and hepatocytes in regenerating rat liver
287. Guanyl cyclase. Determination of enzyme activity
288. Carboxy-terminal extension stabilizes the topological stereoisomers of guanylin
289. Guanylyl cyclase is a heat-stable enterotoxin receptor
290. Disruption of the guanylyl cyclase-C gene leads to a paradoxical phenotype of viable but heat-stable enterotoxin-resistant mice
291. The primary structure of a plasma membrane guanylate cyclase demonstrates diversity within this new receptor family
292. The cloning and expression of a new guanylyl cyclase orphan receptor
293. The stereochemical course of the reaction catalyzed by soluble bovine lung guanylate cyclase
294. 'Tension' on heme by the proximal base and ligand reactivity: Conclusions drawn from model compounds for the reaction of hemoglobin
295. Covalent coupling of a resact analogue to guanylate cyclase
296. Purification of atrial natriuretic peptide receptor from bovine lung. Evidence for a disulfide-linked subunit structure
297. Molecular cloning of a retina-specific membrane guanylyl cyclase
298. Identification of a novel guanylyl cyclase that is related to receptor guanylyl cyclases, but lacks extracellular and transmembrane domains
299. Membrane guanylate cyclase is a cell-surface receptor with homology to protein kinases
300. Location of cAMP-dependent protein kinase type I with the Tcr-CD3 complex
301. The α1 subunit of soluble guanylyl cyclase is expressed prenatally in the rat brain
302. Smooth muscle cell expression of type I cyclic Gmp-dependent protein kinase is suppressed by continuous exposure to nitrovasodilators, theophylline, cyclic Gmp, and cyclic Amp
303. Identification of a guanylyl cyclase-activating protein-binding site within the catalytic domain of retinal guanylyl cyclase 1
304. Purification and characterization of heat-stable enterotoxin produced by a strain of E. coli pathogenic for man
305. Soluble guanylate cyclase from bovine lung: Activation with nitric oxide and carbon monoxide and spectral characterization of the ferrous and ferric states
306. Spectral and kinetic studies on the activation of soluble guanylate cyclase by nitric oxide
307. Electron paramagnetic resonance spectral evidence for the formation of a pentacoordinate nitrosyl-heme complex on soluble guanylate cyclase
308. The disulfide linkages and glycosylation sites of the human natriuretic peptide recepter-C homodimer
309. Molecular characterization of human and mouse photoreceptor guanylate cyclase-activating protein (GCAP) and chromosomal localization of the human gene
310. A new natriuretic peptide in porcine brain
311. C-type natriuretic peptide (CNP): A new member of natriuretic peptide family identified in porcine brain
312. Exchange of substrate and inhibitor specificities between adenylyl and guanylyl cyclases
313. Regulation of myosin phosphatase by a specific interaction with cGMP-dependent protein kinase Iα
314. A peptide associated with eggs causes a mobility shift in a major plasma membrane protein of spermatozoa
315. Hepatocyte nuclear factor-4 regulates intestinal expression of the guanylin/heat-stable toxin receptor
316. The guanylin/STa receptor is expressed in crypts and apical epithelium throughout the mouse intestine
317. C-type natriuretic peptide attenuates evoked dopamine efflux by influencing Goα
318. Role of Na(+)-K+ Atpase in cyclic Gmp-mediated relaxation of canine pulmonary artery smooth muscle cells
319. cDNA cloning and gene expression of human type Iα cGMP-dependent protein kinase
320. Two cardiac natriuretic peptide genes (atrial natriuretic peptide and brain natriuretic peptide) are organized in tandem in the mouse and human genomes
321. The dominant W42 spotting phenotype results from a missense mutation in the c-kit receptor kinase
322. Biological effects of C-type natriuretic peptide in human myofibroblastic hepatic stellate cells
323. Structural framework for the protein kinase family
324. Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsα. GtpγS
325. The basolateral targeting signal in the cytoplasmic domain of glycoprotein G from vesicular stomatitis virus resembles a variety of intracellular targeting motifs related by primary sequence but having diverse targeting activities
326. Dominant negative mutations of the guanylyl cyclase-A receptor. Extracellular domain deletion and catalytic domain point mutations
327. Different crosslinking agents identify distinctly different putative Escherichia coli heat-stable enterotoxin rat intestinal cell receptor proteins
328. Hemagglutination and adhesiveness of toxigenic Escherichia coli isolated from humans
329. The membrane form of guanylate cyclase. Homology with a subunit of the cytoplasmic form of the enzyme
330. The carboxyl region contains the catalytic domain of the membrane form of guanylate cyclase
331. Intestine-specific gene transcription
332. Purification of guanylate cyclase from rat liver supernatant
333. 31P Nmr spectroscopy
334. Two amino acid substitutions convert a guanylyl cyclase, RetGC-1, into an adenylyl cyclase
335. Domain-specific stabilization of photoreceptor membrane guanylyl cyclase by adenine nucleotides and guanylyl cyclase activating proteins (GCAPs)
336. Biochemical analysis of a dimerization domain mutation in RetGC-1 associated with dominant cone-red dystrophy
337. Cloning and expression of a novel cyclic Gmp-dependent protein kinase from mouse brain
338. Differential expression of mRNA for guanylyl cyclase-linked endothelium-derived relaxing factor receptor subunits in rat kidney
339. Internalization of E. coli ST mediated by guanylyl cyclase C in T84 human colon carcinoma cells
340. Guanosine 3',5'-cyclic monophos-phate-dependent protein kinase II mediates heat-stable, enterotoxin-provoked chloride secretion in rat intestine
341. Differential role of cyclic Gmp-dependent protein kinase II in ion transport in murine small intestine and colon
342. Effect of cyclic Gmp on intestinal transport
343. Guanylyl cyclase C is an N-linked glycoprotein receptor that accounts for multiple heat-stable enterotoxin-binding proteins in the intestine
344. Membrane targeting of cGMP-dependent protein kinase is required for cystic fibrosis transmembrane conductance regulator Cl- channel activation
345. Heat-stable enterotoxin activation of immunopurified guanylyl cyclase C. Modulation by adenine nucleotides
346. Heat-stable enterotoxin receptor/guanylyl cyclase C is an oligomer consisting of functionally distinct subunits, which are non-covalently linked in the intestine
347. Guanylin-, heat-stable enterotoxin of Escherichia coli- and vasoactive intestinal peptide-induced water and ion secretion in the rat intestine in vivo
348. Natriuretic peptide receptors on rat thymocytes: Inhibition of proliferation by atrial natriuretic peptide
349. The significance of Ser1029 of the heat-stable enterotoxin receptor (STaR): Relation of STa-mediated guanylyl cyclase activation and signaling by phorbol myristate acetate
350. Role of cGMP-kinase II in the control of renin secretion and renin expression
351. Use of guanylyl cyclase C for detecting micrometastases in lymph nodes of patients with colon cancer
352. Intestinal receptor for heat-stable enterotoxin of Escherichia coli is tightly coupled to a novel form of particulate guanylate cyclase
353. Copurification of atrial natriuretic peptide receptor and particulate guanylyl cyclase
354. Cyclic Gmp synthesis and function
355. Atrial natriuretic factor selectively activates particulate guanylate cyclase and elevates cyclic Gmp in rat tissues
356. The fate of 180 in guanosine monophosphate during enzymic transformations leading to guanosine 3',5'-monophosphate generation
357. Mechanism of platelet inhibition by nitric oxide: In vivo phosphorylation of thromboxane receptor by cyclic Gmp-dependent protein kinase
358. Possible obligatory functions of cyclic nucleotides in hypercapnia-induced cerebral vasodilation in adult rats
359. Functional domains of soluble guanylyl cyclase
360. Mutation of His-105 in the β1 subunit yields a nitric oxide-insensitive form of soluble guanylyl cyclase
361. A mutation of the atrial natriuretic peptide (guanylyl cyclase-A) receptor results in a constitutively hyper-active enzyme
362. Phorbol esters enhance the cyclic Gmp response of T84 cells to the heat-stable enterotoxin of Escherichia coli (STa)
363. A functional chimera of mammalian guanylyl and adenylyl cyclases
364. The uroguanylin gene (Guca1b) is linked to guanylin (Guca2) on mouse chromosome 4
365. Detection of guanyl cyclase in mammalian tissues
366. Opossum kidney contains a functional receptor for the Escherichia coli heat-stable enterotoxin
367. Mechanosensory transduction in sensory and motile cilia
368. Differential regional expression of three natriuretic peptide receptor genes within primate tissues
369. Identification of sequences mediating guanylyl cyclase dimerization
370. Atrial natriuretic factor elicits an endothelium-independent relaxation and activates particulate guanylate cyclase in vascular smooth muscle
371. Guanylate cyclase from bovine lung. A kinetic analysis of the regulation of the purified soluble enzyme by protoporphyrin IX, heme, and nitrosyl-heme
372. The guanylyl cyclase-A receptor transduces an atrial natriuretic peptide/ATP activation signal in the absence of other proteins
373. Vimentin is transiently colocalized with and phosphorylated by cyclic Gmp-dependent protein kinase in formyl-peptide-stimulated neutrophils
374. The primary structure of the rat guanylyl cyclase A/atrial natriuretic peptide receptor gene
375. Two cytoplasmic domains of mammalian adenylyl cyclase form a Gs α- and forskolin-activated enzyme in vitro
376. Two membrane forms of guanylyl cyclase found in the eye
377. Chromosomal localization and genomic organization of genes encoding guanylyl cyclase receptors expressed in olfactory sensory neurons and retina
378. Disruption of a retinal guanylyl cyclase gene leads to cone-specific dystrophy and paradoxical rod behavior
379. Transduction mechanisms of vertebrate and invertebrate photoreceptors
380. Involvement of cGMP-dependent protein kinase in adrenergic potentiation of transmitter release from the calyx-type presynaptic terminal
381. Plasma membrane Ca(2+)-pump Atpase is not a substrate for cGMP-dependent protein kinase
382. Assignment of GuciA2, the gene coding for the α2 subunit of soluble guanylyl cyclase, to position 11q21-q22 on human chromosome 11
383. 2+-binding proteins involves its dimerization
384. Guanylyl cyclase expression in specific sensory neurons: A new family of chemosensory receptors
385. A new form of guanylyl cyclase is preferentially expressed in rat kidney
386. Homodimerization of soluble guanylyl cyclase subunits. Dimerization analysis using a glutathione s-transferase affinity tag
387. Interruption of transmembrane signaling as a novel antisecretory strategy to treat enterotoxigenic diarrhea
388. A pivotal role for the transmembrane domain in transforming growth factor-β receptor activation
389. Cyclic nucleotide gated channels
390. Rat brain guanylate cyclase. Purification, amphiphilic properties and immunological characterization