The E3 Ligase TRAF6 regulates akt ubiquitination and activation

Science

Volumn 325, Issue 5944, 2009, Pages 1134-1138

  Yang, Wei Lei ^a,b   Wang, Jing ^a   Chan, Chia Hsin ^a   Lee, Szu Wei ^a,b   Campos, Alejandro D ^a   Lamothe, Betty ^a   Hur, Lana ^a   Grabiner, Brian C ^a,b   Lin, Xin ^a,b   Darnay, Bryant G ^a   Lin, Hui Kuan ^a,b  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR; LYSINE; PROTEIN KINASE B; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UBIQUITIN PROTEIN LIGASE E3;

BIOLOGICAL ANALYSIS; DISEASE INCIDENCE; ENZYME ACTIVITY; GROWTH RATE; MEMBRANE; MOLECULAR ECOLOGY; MUTATION; PLASMA; SIGNALING; TUMOR;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; HUMAN; IN VITRO STUDY; LIGASE CHAIN REACTION; MEMBRANE TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; UBIQUITINATION;

AMINO ACID MOTIFS; ANIMALS; APOPTOSIS; CELL LINE; CELL LINE, TUMOR; CELL MEMBRANE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MICE; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 6; TRANSPLANTATION, HETEROLOGOUS; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 69549116880     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1175065     Document Type: Article

References (23)

1. D. Mukhopadhyay, H. Riezman, Science 315, 201 (2007).
2. C. M. Pickart, Annu. Rev. Biochem. 70, 503 (2001).
3. Single-letter abbreviations for the amino acid residues are as follows: A, Ala; C, Cys; D, Asp; E, Glu; F, Phe; G, Gly; H, His; I, Ile; K, Lys; L, Leu; M, Met; N, Asn; P, Pro; Q, Gln; R, Arg; S, Ser; T, Thr; V, Val; W, Trp; and Y, Tyr.
4. H. K. Lin, L. Wang, Y. C. Hu, S. Altuwaijri, C. Chang, EMBO J. 21, 4037 (2002).
5. L. D. Mayo, D. B. Donner, Proc. Natl. Acad. Sci. U.S.A. 98, 11598 (2001).
6. B. P. Zhou et al., Nat. Cell Biol. 3, 973 (2001).
7. S. Adhikary et al., Cell 123, 409 (2005).
8. Z. J. Chen, Nat. Cell Biol. 7, 758 (2005).
9. B. Lamothe et al., J. Biol. Chem. 282, 4102 (2007).
10. S. R. Datta, A. Brunet, M. E. Greenberg, Genes Dev. 13, 2905 (1999).
11. J. Luo, B. D. Manning, L. C. Cantley, Cancer Cell 4, 257 (2003).
12. L. Bozulic, B. Surucu, D. Hynx, B. A. Hemmings, Mol. Cell 30, 203 (2008).
13. H. G. Yu et al., Int. J. Cancer 122, 433 (2008).
14. Z. Cao, J. Xiong, M. Takeuchi, T. Kurama, D. V. Goeddel, Nature 383, 443 (1996).
15. M. Nishimura, S. Naito, Biol. Pharm. Bull. 28, 886 (2005).
16. D. P. Brazil, J. Park, B. A. Hemmings, Cell 111, 293 (2002).
17. P. Varnai et al., J. Cell Sci. 118, 4879 (2005).
18. A. Bellacosa et al., Oncogene 17, 313 (1998).
19. J. D. Carpten et al., Nature 448, 439 (2007).
20. S. B. Rong et al., J. Med. Chem. 44, 898 (2001).
21. L. C. Cantley, Science 296, 1655 (2002).
22. I. Vivanco, C. L. Sawyers, Nat. Rev. Cancer 2, 489 (2002).
23. We thank M. C. Hung, D. Bohmann, M. Eiliers, A. M. Weissman, S. Lipkowitz, J. L. Wrana, X. Yang, W. C. Yeh, and T. Mak for reagents; M. C. Hung, D. Sarbassov, and M. H. Lee for insightful comments and suggestions; H. Li and S. Zhang for their technical support and sharing reagents; Z. Han for assistance in confocal microscopy; and V. M. Mohlere and T. Locke for their critical reading and editing of our manuscript. This work was supported by the M. D. Anderson Trust Scholar Fund to H.K.L.