Sgk kinases and their role in epithelial transport

Annual Review of Physiology

Volumn 68, Issue , 2006, Pages 461-490

  Loffing, Johannes ^a   Flores, Sandra Y ^b   Staub, Olivier ^b  

^a UNIVERSITY OF FRIBOURG   (Switzerland)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Cell survival; Gene expression; Ion transport; Kidney; Phosphorylation; Ubiquitin

Indexed keywords

ALDOSTERONE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIC GMP DEPENDENT PROTEIN KINASE; ISOENZYME; ISOPROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE C; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; SERUM AND GLUCOCORTICOID REGULATED KINASE 2; SERUM AND GLUCOCORTICOID REGULATED KINASE 3; SODIUM ION; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; CELL LINE; CELL MEMBRANE TRANSPORT; CELL SURVIVAL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INDUCTION; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; ENZYME STRUCTURE; HOMEOSTASIS; HORMONE ACTION; ION TRANSPORT; KIDNEY EPITHELIUM; KIDNEY TUBULE ABSORPTION; KIDNEY TUBULE EXCRETION; NONHUMAN; NULL ALLELE; PARALOGY; PATHOPHYSIOLOGY; PHENOTYPE; PHYSIOLOGY; POTASSIUM EXCRETION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROCESSING; PROTEIN TARGETING; PROTEIN TRANSPORT; REVIEW; SODIUM ABSORPTION; SODIUM TRANSPORT; TRANSCRIPTION REGULATION; UBIQUITINATION;

ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; EPITHELIUM; HUMANS; IMMEDIATE-EARLY PROTEINS; ISOENZYMES; MICE; PROTEIN-SERINE-THREONINE KINASES;

EID: 33646060747     PISSN: 00664278     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.physiol.68.040104.131654     Document Type: Review

References (189)

1. Webster MK, Goya L, Ge Y, Maiyar AC, Firestone GL. 1993. Characterization of sgk, anovel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum. Mol. Cell. Biol. 13:2031-40
2. Webster MK, Goya L, Firestone GL. 1993. Immediate-early transcriptional regulation and rapid mRNA turnover of a putative serine/threonine protein kinase. J. Biol. Chem. 268:11482-85
3. Kumar JM, Brooks DP, Olson BA, Laping NJ. 1999. Sgk, a putative serine/threonine kinase, is differentially expressed in the kidney of diabetic mice and humans. J. Am. Soc. Nephrol. 10:2488-94
4. Golsteyn RM, Schultz SJ, Bartek J, Ziemiecki A, Ried T, Nigg EA. 1994. Cell cycle analysis and chromosomal localization of human Plk1, a putative homologue of the mitotic kinases Drosophila polo and Saccharomyces cerevisiae Cdc5. J. Cell Sci. 107(Pt. 6):1509-17
5. Hamanaka R, Maloid S, Smith MR, O'Connell CD, Longo DL, Ferris DK. 1994. Cloning and characterization of human and murine homologues of the Drosophila polo serine-threonine kinase. Cell Growth Differ. 5:249-57
6. Holtrich U, Wolf G, Brauninger A, Karn T, Bohme B, et al. 1994. Induction and down-regulation of PLK, a human serine/threonine kinase expressed in proliferating cells and tumors. Proc. Natl. Acad. Sci. USA 91:1736-40
7. Simmons DL, Neel BG, Stevens R, Evett G, Erikson RL. 1992. Identification of an early-growth-response gene encoding a novel putative protein kinase. Mol. Cell. Biol. 12:4164-69
8. Donohue PJ, Alberts GF, Guo Y, Winkles JA. 1995. Identification by targeted differential display of an immediate early gene encoding a putative serine/threonine kinase. J. Biol. Chem. 270:10351-57
9. 2+- and integrin-binding protein and are regulated dynamically with synaptic plasticity. EMBO J. 18:5528-39
10. Clay FJ, McEwen SJ, Bertoncello I, Wilks AF, Dunn AR. 1993. Identification and cloning of a protein kinase-encoding mouse gene, Plk, related to the polo gene of Drosophila. Proc. Natl. Acad. Sci. USA 90:4882-86
11. Konietzko U, Kauselmann G, Scafidi J, Staubli U, Mikkers H, et al. 1999. Pim kinase expression is induced by LTP stimulation and required for the consolidation of enduring LTP. EMBO J. 18:3359-69
12. Waldegger S, Erdel M, Nagl UO, Barth P, Raber G, et al. 1998. Genomic organization and chromosomal localization of the human SGK protein kinase gene. Genomics 51:299-302
13. Firestone GL, Giampaolo JR, O'Keeffe BA. 2003. Stimulus-dependent regulation of serum and glucocorticoid inducible protein kinase (SGK) transcription, subcellular localization and enzymatic activity. Cell Physiol. Biochem. 13:1-12
14. Itani OA, Liu KZ, Cornish KL, Campbell JR, Thomas CP. 2002. Glucocorticoids stimulate human sgk1 gene expression by activation of a GRE in its 5′-flanking region. Am. J. Physiol. Endocrinol. Metab. 283:E971-79
15. Maiyar AC, Phu PT, Huang AJ, Firestone GL. 1997. Repression of glucocorticoid receptor transactivation and DNA binding of a glucocorticoid response element within the serum/glucocorticoid-inducible protein kinase (sgk) gene promoter by the p53 tumor suppressor protein. Mol. Endocrinol. 11:312-29
16. Pearce D, Bhargava A, Cole TJ. 2003. Aldosterone: Its receptor, target genes, and actions. Vitam. Horm. 66:29-76
17. Lang F, Cohen P. 2001. Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms. Sci. STKE 2001:RE17
18. Chen S, Bhargava A, Mastroberardino L, Meijer OC, Wang J, et al. 1999. Epithelial sodium channel regulated by aldosterone-induced protein sgk. Proc. Natl. Acad. Sci. USA 96:2514-19
19. Naray-Fejes-Toth A, Canessa CM, Cleaveland ES, Aldrich G, Fejes-Toth G. 1999. sgk is an aldosterone-induced kinase in the renal collecting duct. J. Biol. Chem. 274:16973-78
20. Waldegger S, Barth P, Raber G, Lang F. 1997. Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume. Proc. Natl. Acad. Sci. USA 94:4440-45
21. Warntges S, Friedrich B, Henke G, Duranton C, Lang PA, et al. 2002. Cerebral localization and regulation of the cell volume-sensitive serum- and glucocorticoid-dependent kinase SGK1. Pflugers Arch. 443:617-24
22. + transport in A6 cells. Am. J. Physiol. Renal Physiol. 283:F105-13
23. Waldegger S, Klingel K, Barth P, Sauter M, Rfer ML, et al. 1999. h-sgk serine-threonine protein kinase gene as transcriptional target of transforming growth factor beta in human intestine. Gastroenterology 116:1081-88
24. Lang F, Klingel K, Wagner CA, Stegen C, Warntges S, et al. 2000. Deranged transcriptional regulation of cell-volume-sensitive kinase hSGK in diabetic nephropathy. Proc. Natl. Acad. Sci. USA 97:8157-62
25. Fillon S, Klingel K, Warntges S, Sauter M, Gabrysch S, et al. 2002. Expression of the serine/threonine kinase hSGK1 in chronic viral hepatitis. Cell Physiol. Biochem. 12:47-54
26. Khan ZA, Barbin YP, Farhangkhoee H, Beier N, Scholz W, Chakrabarti S. 2005. Glucose-induced serum- and glucocorticoid-regulated kinase activation in oncofetal fibronectin expression. Biochem. Biophys. Res. Commun. 329:275-80
27. Imaizumi K, Tsuda M, Wanaka A, Tohyama M, Takagi T. 1994. Differential expression of sgk mRNA, a member of the Ser/Thr protein kinase gene family, in rat brain after CNS injury. Brain Res. Mol. Brain Res. 26:189-96
28. Nishida Y, Nagata T, Takahashi Y, Sugahara-Kobayashi M, Murata A, Asai S. 2004. Alteration of serum/glucocorticoid regulated kinase-1 (sgk-1) gene expression in rat hippocampus after transient global ischemia. Brain Res. Mol. Brain Res. 123:121-25
29. Hollister RD, Page KJ, Hyman BT. 1997. Distribution of the messenger RNA for the extracellularly regulated kinases 1, 2 and 3 in rat brain: Effects of excitotoxic hippocampal lesions. Neuroscience 79:1111-19
30. Tsai KJ, Chen SK, Ma YL, Hsu WL, Lee EH. 2002. sgk, a primary glucocorticoid-induced gene, facilitates memory consolidation of spatial learning in rats. Proc. Natl. Acad. Sci. USA 99:3990-95
31. You H, Jang Y, You-Ten AI, Okada H, Liepa J, et al. 2004. p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1. Proc. Natl. Acad. Sci. USA 101:14057-62
32. Akutsu N, Lin R, Bastien Y, Bestawros A, Enepekides DJ, et al. 2001. Regulation of gene expression by 1α,25-dihydroxyvitamin D3 and its analog EB1089 under growth-inhibitory conditions in squamous carcinoma cells. Mol. Endocrinol. 15:1127-39
33. Murata S, Yoshiara T, Lim CR, Sugino M, Kogure M, et al. 2005. Psychophysiological stress-regulated gene expression in mice. FEBS Lett. 579:2137-42
34. Marzullo L, Tosco A, Capone R, Andersen HS, Capasso A, Leone A. 2004. Identification of dietary copper- and iron-regulated genes in rat intestine. Gene 338:225-33
35. Cowling RT, Birnboim HC. 2000. Expression of serum- and glucocorticoid-regulated kinase (sgk) mRNA is up-regulated by GM-CSF and other proinflammatory mediators in human granulocytes. J. Leukoc. Biol. 67:240-48
36. Mizuno H, Nishida E. 2001. The ERK MAP kinase pathway mediates induction of SGK (serum- and glucocorticoid-inducible kinase) by growth factors. Genes Cells 6:261-68
37. Alliston TN, Maiyar AC, Buse P, Firestone GL, Richards JS. 1997. Follicle stimulating hormone-regulated expression of serum/glucocorticoid-inducible kinase in rat ovarian granulosa cells: A functional role for the Sp1 family in promoter activity. Mol. Endocrinol. 11:1934-49
38. Leong ML, Maiyar AC, Kim B, O'Keeffe BA, Firestone GL. 2003. Expression of the serum- and glucocorticoid-inducible protein kinase, Sgk, is a cell survival response to multipletypes of environmental stress stimuli in mammary epithelial cells. J. Biol.Chem. 278:5871-82
39. Maiyar AC, Huang AJ, Phu PT, Cha HH, Firestone GL. 1996. p53 stimulates promoter activity of the sgk serum/glucocorticoid-inducible serine/threonine protein kinase gene in rodent mammary epithelial cells. J. Biol. Chem. 271:12414-22
40. Kobayashi T, Deak M, Motrice N, Co-hen P. 1999. Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase. Biochem. J. 344:189-97
41. Xu J, Liu D, Gill G, Songyang Z. 2001. Regulation of cytokine-independent survival kinase (CISK) by the Phox homology domain and phosphoinositides. J. Cell Biol. 154:699-705
42. Liu D, Yang X, Songyang Z. 2000. Identification of CISK, a new member of the SGK kinase family that promotes IL-3-dependent survival. Curr. Biol. 10:1233-36
43. Hertweck M, Gobel C, Baumeister R. 2004. C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span. Dev Cell 6:577-88
44. Casamayor A, Torrance PD, Kobayashi T, Thorner J, Alessi DR. 1999. Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Curr. Biol. 9:186-97
45. de Hart AK, Schnell JD, Allen DA, Hicke L. 2002. The conserved Pkh-Ypk kinase cascade is required for endocytosis in yeast. J. Cell Biol. 156:241-48
46. Dai F, Yu L, He H, Zhao Y, Yang J, et al. 1999. Cloning and mapping of a novel human serum/glucocorticoid regulated kinase-like gene, SGKL, to chromosome 8q12.3-q13.1. Genomics 62:95-97
47. Ponting CP. 1996. Novel domains in NADPH oxidase subunits, sorting nexins, and PtdIns 3-kinases: Binding partners of SH3 domains? Protein Sci. 5:2353-57
48. Worby CA, Dixon JE. 2002. Sorting out the cellular functions of sorting nexins. Nat. Rev. Mol. Cell Biol. 3:919-31
49. Xing Y, Liu D, Zhang R, Joachimiak A, Songyang Z, Xu W. 2004. Structural basis of membrane targeting by the Phox homology domain of cytokine-independent survival kinase (CISK-PX). J. Biol. Chem. 279:30662-69
50. Arteaga MF, Canessa CM. 2005. Functional specificity of Sgk1 and Akt1 on ENaC activity. Am. J. Physiol. Renal Physiol. 289:F90-96
51. + channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK. Pflugers Arch. 445:60-66
52. + channel Kv 1.3 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid inducible kinase SGK1. J. Cell. Physiol. 199:194-99
53. +-ATPase by the serum and glucocorticoid-dependent kinase isoforms. Kidney Blood Press. Res. 25:370-74
54. + current by the serum and glucocorticoid-inducible kinase (SGK) isoforms. Pflugers Arch. 445:601-6
55. + channel α,β,γ-ENaC. Pflugers Arch. 445:693-96
56. Bohmer C, Philippin M, Rajamanickam J, Mack A, Broer S, et al. 2004. Stimulation of the EAAT4 glutamate transporter by SGK protein kinase isoforms and PKB. Biochem. Biophys. Res. Commun. 324:1242-48
57. Strutz-Seebohm N, Seebohm G, Shumilina E, Mack AF, Wagner HJ, et al. 2005. Glucocorticoid adrenal steroids and glucocorticoid-inducible kinase isoforms in the regulation of GluR6 expression. J. Physiol. 565:391-401
58. Strutz-Seebohm N, Seebohm G, Mack AF, Wagner HJ, Just L, et al. 2005. Regulation of GluR1 abundance in murine hippocampal neurones by serum- and glucocorticoid-inducible kinase 3. J. Physiol. 565:381-90
59. McCormick JA, Feng Y, Dawson K, Behne MJ, Yu B, et al. 2004. Targeted disruption of the protein kinase SGK3/CISK impairs postnatal hair follicle development. Mol. Biol. Cell 15:4278-88
60. + retention in the sgk1-knockout mouse. J. Clin. Invest. 110:1263-68
61. Garofalo RS, Orena SJ, Rafidi K, Torchia AJ, Stock JL, et al. 2003. Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta. J. Clin. Invest. 112:197-208
62. Cho H, Mu J, Kim JK, Thorvaldsen JL, Chu Q, et al. 2001. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB β). Science 292:1728-31
63. Boehmer C, Henke G, Schniepp R, Palmada M, Rothstein JD, et al. 2003. Regulation of the glutamate transporter EAAT1 by the ubiquitin ligase Nedd42 and the serum and glucocorticoid-inducible kinase isoforms SGK1/3 and protein kinase B. J. Neurochem. 86:1181-88
64. Boehmer C, Wilhelm V, Palmada M, Wallisch S, Henke G, et al. 2003. Serum and glucocorticoid inducible kinases in the regulation of the cardiac sodium channel SCN5A. Cardiovasc. Res. 57:1079-84
65. + exchanger regulating factor 2, serum and glucocorticoid inducible kinase isoforms, and protein kinase B. Biochem. Biophys. Res. Commun. 313:998-1003
66. Embark HM, Bohmer C, Palmada M, Rajamanickam J. Wyatt AW, et al. 2004. Regulation of CLC-Ka/barttin by the ubiquitin ligase Nedd-4-2 and the serum-and glucocorticoid-dependent kinases. Kidney Int. 66:1918-25
67. l and SGK3 expressed in Xenopus oocytes. Cell Physiol. Biochem. 14:203-12
68. Palmada M, Dieter M, Speil A, Bohmer C, Mack AF, et al. 2004. Regulation of intestinal phosphate cotransporter NaPi IIb by ubiquitin ligase Nedd-4-2 and by serum- and glucocorticoid-dependent kinase 1. Am. J. Physiol. Gastrointest. Liver Physiol. 287:G143-50
69. Palmada M, Speil A, Jeyaraj S, Bohmer C, Lang F. 2005. The serine/threonine kinases SGK1, 3 and PKB stimulate the amino acid transporter ASCT2. Biochem. Biophys. Res. Commun. 331:272-77
70. Alessi DR, Deak M, Casamayor A, Caudwell FB, Motrice N, et al. 1997. 3-phosphoinositide-dependent protein kinase-1 (PDK1): Structural and functional homology with the Drosophila DSTPK61 kinase. Curr. Biol 7:776-89
71. Stokoe D, Stephens LR, Copeland T, Gaffney PR, Reese CB, et al. 1997. Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. Science 277:567-70
72. Vanhaesebroeck B, Alessi DR. 2000. ThePI3K-PDK1 connection: More than just a road to PKB. Biochem. J. 346(Pt. 3):561-76
73. Cheng X, Ma Y, Moore M, Hemmings BA, Taylor SS. 1998. Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase. Proc. Natl. Acad. Sci. USA 95:9849-54
74. Chou MM, Hou W, Johnson J, Graham LK, Lee MH, et al. 1998. Regulation of protein kinase C ξ by PI 3-kinase and PDK-1. Curr. Biol. 8:1069-77
75. Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ. 1998. Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. Science 281:2042-45
76. Alessi DR, Kozlowski MT, Weng QP, Morrice N, Avruch J. 1997. 3-phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro. Curr. Biol. 8:69-81
77. Pullen N, Dennis PB, Andjelkovic M, Dufner A, Kozma SC, et al. 1998. Phosphorylation and activation of p70s6k by PDK1. Science 279:707-10
78. Kobayashi T, Cohen P. 1999. Activation of serum- and glucocorticoid- regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3- phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2. Biochem. J. 339:319-28
79. Park J, Leon MLL, Buse P, Maiyar AC, Firestone GL, Hemmings BA. 1999. Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI3-kinase-stimulated signaling pathway. EMBO J. 18:3024-33
80. Biondi RM, Kieloch A, Currie RA, Deak M, Alessi DR. 2001. The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB. EMBO J. 20:4380-90
81. Perrotti N, He RA, Phillips SA, Haft CR, Taylor SI. 2001. Activation of serum-and glucocorticoid-induced protein kinase (Sgk) by cyclic AMP and insulin. J. Biol. Chem. 276:9406-12
82. Shelly C, Herrera R. 2002. Activation of SGK1 by HGF, Rac1 and integrin-mediated cell adhesion in MDCK cells: PI-3K-dependent and -independent pathways. J. Cell Sci. 115:1985-93
83. Hayashi M, Tapping RI, Chao TH, Lo JF, King CC, et al. 2001. BMK1 mediates growth factor-induced cell proliferation through direct cellular activation of serum and glucocorticoid-inducible kinase. J. Biol. Chem. 276:8631-34
84. Meng F, Yamagiwa Y, Taffetani S, Han J, Patel T. 2005. Interleukin-6 activates serum and glucocorticoid kinase via a p38a mitogen activated protein kinase pathway. Am. J. Physiol. Cell Physiol. In press
85. Stokoe D, Campbell DG, Nakielny S, Hidaka H, Leevers SJ, et al. 1992. MAP-KAP kinase-2: A novel protein kinase activated by mitogen-activated protein kinase. EMBO J. 11:3985-94
86. Xu BE, Stippec S, Chu PY, Lazrak A, Li XJ, et al. 2005. WNK1 activates SGK1 to regulate the epithelial sodium channel. Proc. Natl. Acad. Sci. USA 102:10315-20
87. Brickley DR, Mikosz CA, Hagan CR, Conzen SD. 2002. Ubiquitin modification of serum and glucocorticoid-induced protein kinase-1 (SGK-1). J. Biol. Chem. 277:43064-70
88. + transport in mammalian CCD cells requires SGK1 expression. Am. J. Physiol. 284:F480-87
89. Zhou R, Snyder PM. 2005. Nedd4-2 phosphorylation induces serum and glucocorticoid-regulated kinase (SGK) ubiquitination and degradation. J. Biol. Chem. 280:4518-23
90. Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA. 1995. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378:785-89
91. Sakoda H, Gotoh Y, Katagiri H, Kurokawa M, Ono H, et al. 2003. Differing roles of Akt and serum- and glucocorticoid-regulated kinase in glucose metabolism, DNA synthesis, and oncogenic activity. J. Biol. Chem. 278:25802-7
92. Collins BJ, Deak M, Arthur JS, Armit LJ, Alessi DR. 2003. In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation. EMBO J. 22:4202-11
93. Brunet A, Park J, Tran H, Hu LS, Hemmings BA, Greenberg ME. 2001. Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). Mol. Cell. Biol. 21:952-65
94. Zhang BH, Tang ED, Zhu T, Greenberg ME, Vojtek AB, Guan KL. 2001. Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf. J. Biol. Chem. 276:31620-26
95. Chun J, Kwon T, Kim DJ, Park I, Chung G, et al. 2003. Inhibition of mitogen-activated kinase kinase kinase 3 activity through phosphorylation by the serum-and glucocorticoid-induced kinase 1. J. Biochem. 133:103-8
96. Wang D, Sun H, Lang F, Yun CC. 2005. Activation of NHE3 by dexamethasone requires phosphorylation of NHE3 at Ser663 by SGK1. Am. J. Physiol. Cell Physiol. In press
97. Boulkroun S, Fay M, Zennaro MC, Escoubet B, Jaisser F, et al. 2002. Characterization of rat NDRG2 (N-Myc downstream regulated gene 2), a novel early mineralocorticoid-specific induced gene. J. Biol. Chem. 277:31506-15
98. Murray JT, Campbell DG, Morrice N, Auld GC, Shpiro N, et al. 2004. Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3. Biochem. J. 384:477-88
99. + channel cell surface expression. EMBO J. 20:7052-59
100. + channel. J. Biol. Chem. 277:5-8
101. Diakov A, Korbmacher C. 2004. Anovel pathway of epithelial sodium channel activation involves a serum- and glucocorticoid-inducible kinase consensus motif in the C terminus of the channel's alpha;-subunit. J. Biol. Chem. 279:38134-42
102. Stichel CC, Schoenebeck B, Foguet M, Siebertz B, Bader V, et al. 2005. sgk1, a member of an RNA cluster associated with cell death in a model of Parkinson's disease. Eur. J. Neurosci. 21:301-16
103. Gonzalez-Nicolini V, McGinty JF. 2002. Gene expression profile from the striatum of amphetamine-treated rats: A cDNA array and in situ hybridization histochemical study. Brain Res Gene Expr Patterns 1:193-98
104. Rauz S, Walker EA, Hughes SV, Coca-Prados M, Hewison M, et al. 2003. Serum- and glucocorticoid-regulated kinase isoform-1 and epithelial sodium channel subunits in human ocular ciliary epithelium. Invest. Ophthalmol. Vis. Sci. 44:1643-51
105. Rauz S, Walker EA, Murray PI, Stewart PM. 2003. Expression and distribution of the serum and glucocorticoid regulated kinase and the epithelial sodium channel subunits in the human cornea. Exp. Eye Res. 77:101-8
106. Waerntges S, Klingel K, Weigert C, Fillon S, Buck M, et al. 2002. Excessive transcription of the human serum and glucocorticoid dependent kinase hSGK 1 in lung fibrosis. Cell Physiol. Biochem. 12:135-42
107. Alliston TN, Gonzalez-Robayna IJ, Buse P, Firestone GL, Richards JS. 2000. Expression and localization of serum/glucocorticoid-induced kinase in the rat ovary: Relation to follicular growth and differentiation. Endocrinology 141:385-95
108. Klingel K, Warntges S, Bock J, Wagner CA, Sauter M, et al. 2000. Expression of cell volume-regulated kinase h-sgk in pancreatic tissue. Am. J. Physiol. Gastrointest. Liver Physiol. 279:G998-1002
109. Friedrich B, Warntges S, Klingel K, Sauter M, Kandolf R, et al. 2002. Up-regulation of the human serum and glucocorticoid-dependent kinase 1 in glomerulonephritis. Kidney Blood Press. Res. 25:303-7
110. Huber SM, Friedrich B, Klingel K, Lenka N, Hescheler J, Lang F. 2001. Protein and mRNA expression of serum and glucocorticoid-dependent kinase 1 in metanephrogenesis. Dev. Dyn. 221:464-69
111. Lee E, Lein ES, Firestone GL. 2001. Tissue-specific expression of the transcriptionally regulated serum and glucocorticoid-inducible protein kinase (Sgk) during mouse embryogenesis. Mech. Dev. 103:177-81
112. Naray-Fejes-Toth A, Helms MN, Stokes JB, Fejes-Toth G. 2004. Regulation of sodium transport in mammalian collecting duct cells by aldosterone-induced kinase, SGK1: Structure/function studies. Mol. Cell Endocrinol. 217:197-202
113. Coric T, Hernandez N, Alvarez de la Rosa D, Shao D, Wang T, Canessa CM. 2004. Expression of ENaC and serum- and glucocorticoid-induced kinase 1 in the rat intestinal epithelium. Am. J. Physiol. Gastrointest. Liver Physiol. 286:G663-70
114. Alvarez de la Rosa D, Coric T, Todorovic N, Shao D, Wang T, Canessa CM. 2003. Distribution and regulation of expression of serum- and glucocorticoid-induced kinase-1 in the rat kidney. J. Physiol. 551:455-66
115. Buse P, Tran SH, Luther E, Phu PT, Aponte GW, Firestone GL. 1999. Cell cycle and hormonal control of nuclear-cytoplasmic localization of the serum-and glucocorticoid-inducible protein kinase, Sgk, in mammary tumor cells. A novel convergence point of anti-proliferative and proliferative cell signaling pathways. J. Biol. Chem. 274:7253-63
116. Loffing J, Pietri L, Aregger F, Bloch-Faure M, Ziegler U, et al. 2000. Differential subcellular localization of ENaC subunits in mouse kidney in response to high- and low-Na diets. Am. J. Physiol. 279:F252-58
117. Chen WS, Xu PZ, Gottlob K, Chen ML, Sokol K, et al. 2001. Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev. 15:2203-8
118. Pearce D. 2001. The role of SGK1 in hormone-regulated sodium transport. Trends Endocrinol. Metab. 12:341-47
119. Maiyar AC, Leong ML, Firestone GL. 2003. Importin-alpha; mediates the regulated nuclear targeting of serum- and glucocorticoid-inducible protein kinase (Sgk) by recognition of a nuclear localization signal in the kinase central domain. Mol. Biol. Cell 14:1221-39
120. Loffing J, Zecevic M, Féraille E, Kaissling B, Asher C, et al. 2001. Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system: Possible role of SGK. Am. J. Physiol. 280:F675-82
121. Kellenberger S, Schild L. 2002. Epithelial sodium channel/degenerin family of ion channels: A variety of functions for a shared structure. Physiol. Rev. 82:735-67
122. Canessa CM, Schild L, Buell G, Thorens B, Gautschi I, et al. 1994. Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits. Nature 367:463-67
123. Canessa CM, Horisberger J-D, Rossier BC. 1993. Epithelial sodium channel related to proteins involved in neurodegeneration. Nature 361:467-70
124. + channel. A new channel type with homologies to Caenorhabditis elegans degenerins. FEBS Lett. 318:95-99
125. + channel are differently regulated by aldosterone. J. Biol. Chem. 269:13736-39
126. Firsov D, Gautschi I, Mérillat A-M, Rossier BC, Schild L. 1998. The heterotetrameric architecture of the epithelial sodium channel (ENaC). EMBO J. 17:344-52
127. Eskandari S, Snyder PM, Kreman M, Zampighi GA, Welsh MJ, Wright EM. 1999. Number of subunits comprising the epithelial sodium channel. J. Biol. Chem. 274:27281-86
128. Snyder PM, Cheng C, Prince LS, Rogers JC, Welsh MJ. 1998. Electrophysilogical and biochemical evidence that DEG/ENaC cation channels are composed of nine subunits. J. Biol. Chem. 273:681-84
129. + channel. J. Biol. Chem. 269:12981-86
130. Canessa CM, Mérillat A-M, Rossier BC. 1994. Membrane topology of the epithelial sodium channel in intact cells. Am. J. Physiol. 267:C1682-90
131. Snyder PM, McDonald FJ, Stokes JB, Welsh MJ. 1994. Membrane topology of the amiloride-sensitive epithelial sodium channel. J. Biol. Chem. 269:24379-83
132. Chen HI, Sudol M. 1995. The WW domain of Yes-associated protein binds a novel proline-rich ligand that differs from the consensus established for SH3-binding modules. Proc. Natl. Acad. Sci. USA 92:7819-23
133. Staub O, Rotin D. 1996. WW domains. Structure 4:495-99
134. Liddle GW, Bledsoe T, Coppage WS Jr. 1963. A familial renal disorder simulating primary aldosteronism but with negligible aldosterone secretion. Trans. Assoc. Am. Physicians 76:199-213
135. Hansson JH, Nelson-Williams C, Suzuki H, Schild L, Shimkets RA, et al. 1995. Hypertension caused by a truncated epithelial sodium channel γ subunit: Genetic heterogeneity of Liddle syndrome. Nat. Genet. 11:76-82
136. Shimkets RA, Warnock DG, Bositis CM, Nelson-Williams C, Hansson JH, et al. 1994. Liddle's syndrome: Heritable human hypertension caused by mutations in the β subunit of the epithelial sodium channel. Cell 79:407-14
137. + channel and a mutant causi ng Liddle syndrome: A quantitative approach. Proc. Natl. Acad. Sci. USA 93:15370-75
138. + channel. Cell 83:969-78
139. Schild L, Canessa CM, Shimkets RA, Warnock DG, Lifton RP, Rossier BC. 1995. A mutation in the epithelial sodium channel causing Liddle's disease increases channel activity in the Xenopus laevis oocyte expression system. Proc. Natl. Acad. Sci. USA 92:5699-703
140. + channel subunits as a target sequence for mutations causing channel activation found in Liddle syndrome. EMBO J. 15:2381-87
141. + channel deleted in Liddle's syndrome. EMBO J. 15:2371-80
142. + channel by interaction of Nedd4 with a PY motif deleted in Liddle's syndrome. J. Biol. Chem. 273:30012-17
143. +. Proc. Natl. Acad. Sci. USA 95:7169-73
144. Kanelis V, Rotin D, Forman-Kay JD. 2001. Solution structure of a Nedd4 WW domain-ENaC peptide complex. Nat. Struct. Biol. 8:1-6
145. + channel (ENaC) by Nedd4 in Liddle's syndrome. J. Clin. Invest. 103:667-73
146. + channel. FASEB J. 15:204-14
147. + channel regulation. Am. J. Physiol. 281:F469-77
148. Snyder PM, Steines JC, Olson DR. 2004. Relative contribution of Nedd4 and Nedd-4-2 to ENaC regulation in epithelia determined by RNA interference. J. Biol. Chem. 279:5042-46
149. Harvey KF, Dinudom A, Cook DI, Kumar S. 2001. The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel. J. Biol. Chem. 276:8597-601
150. + channel (ENaC) by ubiquitination. EMBO J. 16:6325-36
151. + transport. Am. J. Physiol 283:F377-87
152. + homeostasis and hypertension. Endocr. Rev. 23:258-75
153. Vallon V, Wulff P, Huang DY, Loffing J, Volkl H, et al. 2005. Role of Sgk1 in salt and potassium homeostasis. Am. J. Physiol. Regul. Integr. Camp. Physiol. 288:R4-10
154. Bhargava A, Wang J, Pearce D. 2004. Regulation of epithelial ion transport by aldosterone through changes in gene expression. Mol. Cell. Endocrinol. 217:189-96
155. Verrey F, Loffing J, Zecevic M, Heitzmann D, Staub O. 2003. SGK1: Aldosterone-induced relay of Na+ transport regulation in distal kidney nephron cells. Cell Physiol. Biochem. 13:21-28
156. Zecevic M, Heitzmann D, Camargo SM, Verrey F. 2004. SGK1 increases Na, K-ATP cell-surface expression and function in Xenopus laevis oocytes. Pflugers Arch. 448:29-35
157. +ATPase by the serum and glucocorticoid-dependent kinase sgkl. Pflugers Arch. 444:426-31
158. Alvarez de la Rosa D, Zhang P, Naray-Fejes-Toth A, Fejes-Toth G, Canessa CM. 1999. The serum andglucocorticoid kinase sgk increases the abundance of epithelial sodium channels in the plasma membrane of Xenopus oocytes. J. Biol. Chem. 274:37834-39
159. Vuagniaux G, Vallet V, Jaeger NF, Hummler E, Rossier BC. 2002. Synergistic activation of ENaC by three membrane-bound channel-activating serine proteases (raCAP1, mCAP2, and mCAP3) and serum- and glucocorticoid-regulated kinase (Sgk1) in Xenopus oocytes. J. Gen. Physiol. 120:191-201
160. Flores SY, Loffing-Cueni D, Kamynina E, Daidie D, Gerbex C, et al. 2005.
161. + channels by phosphorylation-dependent interaction with Nedd4-2 ubiquitin ligase. J. Biol. Chem. 280:13187-94
162. 161a. Bhalla V, Daidie D, Li H, Pao AC, Lagrange LP, et al. 2005. SGK1 regulates ubiquitin ligase Nedd4-2 by inducing interaction with 14-3-3. Mol. Endocrinol. In press
163. Wang J, Barbry P, Maiyar AC, Rozansky DJ, Bhargava A, et al. 2001. SGK integrates insulin and mineralocorticoid regulation of epithelial sodium transport. Am. J. Physiol. 280:F303-13
164. Alvarez de la Rosa D, Paunescu TG, Els WJ, Helraan SI, Canessa CM. 2004. Mechanisms of regulation of epithelial sodium channel by SGK1 in A6 cells. J. Gen. Physiol. 124:395-407
165. Gumz ML, Popp MP, Wingo CS, Cain BD. 2003. Early transcriptional effects of aldosterone in a mouse inner medullary collecting duct cell line. Am. J. Physiol. Renal Physiol. 285:F664-73
166. Bhargava A, Fullerton MJ, Myles K, Purdy TM, Funder JW, et al. 2001. The serum- and glucocorticoid-induced kinase is a physiological mediator of aldosterone action. Endocrinology 142:1587-94
167. Brennan FE, Fuller PJ. 2000, Rapid up-regulation of serum and glucocorticoid-regulated kinase (sgk) gene expression by corticosteroids in vivo. Mol. Cell. Endocrinol. 166:129-36
168. Hou J, Speirs HJ, Seckl JR, Brown RW. 2002. Sgk1 gene expression in kidney and its regulation by aldosterone: Spatio-temporal heterogeneity and quantitative analysis. J. Am. Soc. Nephrol. 13:1190-98
169. +. J. Am. Soc. Nephrol. 14:1107-15
170. + channel. Am. J. Physiol. 278:F613-19
171. Farjah M, Roxas BP, Geenen DL, Danziger RS. 2003. Dietary salt regulates renal SGK1 abundance: Relevance to salt sensitivity in the Dahl rat. Hypertension 41:874-78
172. Bell LM, Leong ML, Kim B, Wang E, Park J, et al. 2000. Hyperosmotic stress stimulates promoter activity and regulates cellular utilization of the serum-and glucocorticoid-inducible protein kinase (Sgk) by a p38 MAPK-dependent pathway. J. Biol. Chem. 275:25262-72
173. Chen S, McCormick JA, Prabaker K, Wang J, Pearce D, Gardner DG. 2004. Sgk1 mediates osmotic induction of NPR-A gene in rat inner medullary collecting duct cells. Hypertension 43:866-71
174. Due C, Farman N, Canessa CM, Bonvalet J-P, Rossier BC. 1994. Cell-specific expression of epithelial sodium channel α, β, and γ subunits in aldosterone-responsive epithelia from the rat: Localization by in situ hybridization and immunocytochemistry. J. Cell Biol. 127:1907-21
175. Alvarez De La Rosa D, Canessa CM. 2003. Role of SGK in hormonal regulation of epithelial sodium channel in Aocells. Am. J. Physiol. 284:C404-14
176. + transport. Am. J. Physiol. 282:C494-500
177. Vallon V, Huang DY, Grahammer F, Wyatt AW, Osswald H, et al. 2005. SGK1 as a determinant of kidney function and salt intake in response to mineralocorticoid excess. Am. J. Physiol. Regul. Integr. Comp. Physiol. 289:R395-401
178. Palmer LG, Antonian L, Frindt G. 1994. Regulation of apical K and Na channels and Na/K pumps in rat cortical collecting tubule by dietary K. J. Gen. Physiol. 104:693-710
179. Palmer LG, Frindt G. 1999. Regulation of apical K channels in rat cortical collecting tubule during changes in dietary K intake. Am. J. Physiol. 277:F805-12
180. + channel ROMK1 by the serum- and glucocorticoid-inducible kinase SGK1. Biochem. Biophys. Res. Commun. 311:629-34
181. + channel, ROMK1. Biochem. Biophys. Res. Commun. 307:967-72
182. + channel ROMK1. J. Am. Soc. Nephrol. 13:2823-30
183. Yoo D, Kim BY, Campo C, Nance L, King A, et al. 2003. Cell surface expression of the ROMK (Kir 1.1) channel is regulated by the aldosterone-induced kinase, SGK-1, and protein kinase A. J. Biol. Chem. 278:23066-75
184. + elimination in the sgk1-knockout mouse. J. Am. Soc. Nephrol. 15:885-91
185. Hong G, Lockhart A, Davis B, Rahmoune H, Baker S, et al. 2003. PPARγ activation enhances cell surface ENαCα via up-regulation of SGK1 in human collecting duct cells. FASEB J. 17:1966-68
186. Bistrup C, Thiesson HC, Jensen BL, Skott O. 2005. Reduced activity of 11β-hydroxysteroid dehydrogenase type 2 is not responsible for sodium retention in nephrotic rats. Acta Physiol. Scand. 184:161-69
187. Yu Z, Serra A, Sauter D, Loffing J, Ackermann D, et al. 2005. Sodium retention in rats with liver cirrhosis is associated with increased renal abundance of NaCl cotransporter (NCC). Nephrol. Dial. Transplant. 20:1833-41
188. Busjahn A, Aydin A, Uhlmann R, Krasko C, Bahring S, et al. 2002. Serum- and glucocorticoid-regulated kinase (SGK1) gene and blood pressure. Hypertension 40:256-60
189. Trochen N, Ganapathipillai S, Ferrari P, Frey BM, Frey FJ. 2004. Low prevalence of nonconservative mutations of serum and glucocorticoid-regulated kinase (SGK1) gene in hypertensive and renal patients. Nephrol. Dial. Transplant. 19:2499-504