High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site

EMBO Journal

Volumn 21, Issue 16, 2002, Pages 4219-4228

  Biondi, Ricardo M ^a   Komander, David ^a   Thomas, Christine C ^a   Lizcano, Jose M ^a   Deak, Maria ^a   Alessi, Dario R ^a   van Aalten, Daan M F ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

AGC protein kinases; Crystal structure; PDK1 PDK1 interacting fragment; Phosphatidylinositol 3,4,5 trisphosphate

Indexed keywords

3 PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PHOSPHATE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOPEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CATALYST; CRYSTAL STRUCTURE; ENZYME STRUCTURE; HUMAN; HUMAN CELL; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS;

ADENOSINE TRIPHOSPHATE; ALLOSTERIC SITE; AMINO ACID SEQUENCE; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOSPHOPEPTIDES; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; SEQUENCE ALIGNMENT;

EID: 0037102153     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdf437     Document Type: Article

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