Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 18, 2008, Pages 6584-6589

  Zhu, Jidong ^a   Blenis, John ^a   Yuan, Junying ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Phosphorylation; Proliferation; RSK; S6K1; Ubiquitination

Indexed keywords

INSULIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MUTANT PROTEIN; MYC PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN MAD1; PROTEIN P90; S6 KINASE; SERINE; CELL CYCLE PROTEIN; MAD1L1 PROTEIN, HUMAN; MITOGENIC AGENT; NUCLEAR PROTEIN; PHOSPHOSERINE;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; FLUORESCENCE ACTIVATED CELL SORTING; GENE CONTROL; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CHEMISTRY; DRUG EFFECT; ENZYME SPECIFICITY; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION; PROTEIN PROCESSING; SERUM; THERMODYNAMICS; TUMOR CELL LINE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; ENZYME ACTIVATION; HUMANS; INSULIN; MITOGENS; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PHOSPHORYLATION; PHOSPHOSERINE; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-MYC; RIBOSOMAL PROTEIN S6 KINASES; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; SERUM; SUBSTRATE SPECIFICITY; THERMODYNAMICS; TRANSCRIPTION, GENETIC;

EID: 44349134920     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0802785105     Document Type: Article

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