Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation

Journal of Biological Chemistry

Volumn 285, Issue 7, 2010, Pages 4587-4594

  Sunami, Tomoko ^a   Byrne, Noel ^b   Diehl, Ronald E ^b   Funabashi, Kaoru ^a   Hall, Dawn L ^b   Ikuta, Mari ^a   Patel, Sangita B ^b   Shipman, Jennifer M ^b   Smith, Robert F ^b   Takahashi, Ikuko ^a   Zugay Murphy, Joan ^b   Iwasawa, Yoshikazu ^a   Lumb, Kevin J ^b   Munshi, Sanjeev K ^b   Sharma, Sujata ^b  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION LOOPS; CELL-CYCLE PROGRESSION; CRYSTAL FORMS; GLUCOSE HOMEOSTASIS; HYDROPHOBIC MOTIFS; IN-CELL; KINASE DOMAINS; MTOR SIGNALING; PHOSPHOINOSITIDES; S6 KINASE; STAUROSPORINES; STRUCTURAL BASIS;

CELL PROLIFERATION; GLUCOSE; GROWTH KINETICS; PHOSPHORYLATION;

CRYSTAL STRUCTURE;

PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; S6 KINASE; STAUROSPORINE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME CONFORMATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; GEL PERMEATION CHROMATOGRAPHY; HUMAN; INSECT CELL; LIGHT SCATTERING; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; ULTRACENTRIFUGATION;

CHROMATOGRAPHY, GEL; CRYSTALLOGRAPHY, X-RAY; HUMANS; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; STAUROSPORINE; ULTRACENTRIFUGATION;

EID: 77951184638     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.040667     Document Type: Article

References (33)

1. Gout, I., Minami, T., Hara, K., Tsujishita, Y., Filonenko, V., Waterfield, M. D., and Yonezawa, K. (1998) J. Biol. Chem. 273, 30061-30064
2. Grove, J. R., Banerjee, P., Balasubramanyam, A., Coffer, P. J., Price, D. J., Avruch, J., and Woodgett, J. R. (1991) Mol. Cell. Biol. 11, 5541-5550
3. Ruvinsky, I., and Meyuhas, O. (2006) Trends Biochem. Sci. 31, 342-348
4. Dann, S. G., Selvaraj, A., and Thomas, G. (2007) Trends Mol. Med. 13, 252-259
5. Manning, B. D. (2004) J. Cell Biol. 167, 399-403
6. Le, X. F., Hittelman, W. N., Liu, J., McWatters, A., Li, C., Mills, G. B., and Bast, R. C., Jr. (2003) Oncogene 22, 484-497
7. Mukhopadhyay, N. K., Price, D. J., Kyriakis, J. M., Pelech, S., Sanghera, J., and Avruch, J. (1992) J. Biol. Chem. 267, 3325-3335
8. Ali, S. M., and Sabatini, D. M. (2005) J. Biol. Chem. 280, 19445-19448
9. Pullen, N., Dennis, P. B., Andjelkovic, M., Dufner, A., Kozma, S. C., Hemmings, B. A., and Thomas, G. (1998) Science 279, 707-710
10. Dennis, P. B., Pullen, N., Pearson, R. B., Kozma, S. C., and Thomas, G. (1998) J. Biol. Chem. 273, 14845-14852
11. Kornienko, M., Montalvo, A., Carpenter, B. E., Lenard, M., Abeywickrema, P., Hall, D. L., Darke, P. L., and Kuo, L. C. (2005) Assay Drug Dev. Technol. 3, 661-674
12. Laue, T. M., Shah, B. D., Ridgeway, T. M., and Pelletier, S. L. (1992) in Analytical Ultracentrifugation in Biochemistry and Polymer Science (Harding, S. E., Rowe, A. J., and Horton, J. C., eds), The Royal Society of Chemistry, Cambridge, UK
13. Otwinowski, Z., and Minor, W. (1997) Methods Enzymol. 276, 307-326
14. Navaza, J. (1994) Acta Crystallogr. Sect. A 50, 157-163
15. Brünger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. D Biol. Crystallogr. 54, 905-921
16. Emsley, P., and Cowtan, K. (2004) Acta Crystallogr. D Biol. Crystallogr. 60, 2126-2132
17. McCoy, A. J., Grosse-Kunstleve, R. W., Adams, P. D., Winn, M. D., Storoni, L. C., and Read, R. J. (2007) J. Appl. Crystallogr. 40, 658-674
18. Ericsson, U. B., Hallberg, B. M., Detitta, G. T., Dekker, N., and Nordlund, P. (2006) Anal. Biochem. 357, 289-298
19. Zhang, W. G., Shor, B., and Yu, K. (2006) Protein Expr. Purif. 46, 414-420
20. Zhao, B., Lehr, R., Smallwood, A. M., Ho, T. F., Maley, K., Randall, T., Head, M. S., Koretke, K. K., and Schnackenberg, C. G. (2007) Protein Sci. 16, 2761-2769
21. Ikuta, M., Kornienko, M., Byrne, N., Reid, J. C., Mizuarai, S., Kotani, H., and Munshi, S. K. (2007) Protein Sci. 16, 2626-2635
22. Gold, M. G., Barford, D., and Komander, D. (2006) Curr. Opin. Struct. Biol. 16, 693-701
23. Nolen, B., Taylor, S., and Ghosh, G. (2004) Mol. Cell 15, 661-675
24. De Bondt, H. L., Rosenblatt, J., Jancarik, J., Jones, H. D., Morgan, D. O., and Kim, S. H. (1993) Nature 363, 595-602
25. Pike, A. C., Rellos, P., Niesen, F. H., Turnbull, A., Oliver, A. W., Parker, S. A., Turk, B. E., Pearl, L. H., and Knapp, S. (2008) EMBO J. 27, 704-714
26. Oliver, A. W., Paul, A., Boxall, K. J., Barrie, S. E., Aherne, G. W., Garrett, M. D., Mittnacht, S., and Pearl, L. H. (2006) EMBO J. 25, 3179-3190
27. Lee, S. J., Cobb, M. H., and Goldsmith, E. J. (2009) Protein Sci. 18, 304-313
28. Liu, Y., and Eisenberg, D. (2002) Protein Sci. 11, 1285-1299
29. Yang, J., Cron, P., Thompson, V., Good, V. M., Hess, D., Hemmings, B. A., and Barford, D. (2002) Mol. Cell 9, 1227-1240
30. Mol, C. D., Fabbro, D., and Hosfield, D. J. (2004) Curr. Opin. Drug Discov. Devel. 7, 639-648
31. Hauge, C., and Frödin, M. (2006) J. Cell Sci. 119, 3021-3023
32. Breitenlechner, C. B., Friebe, W. G., Brunet, E., Werner, G., Graul, K., Thomas, U., Künkele, K. P., Schäfer, W., Gassel, M., Bossemeyer, D., Huber, R., Engh, R. A., and Masjost, B. (2005) J. Med. Chem. 48, 163-170
33. Jacobs, M., Hayakawa, K., Swenson, L., Bellon, S., Fleming, M., Taslimi, P., and Doran, J. (2006) J. Biol. Chem. 281, 260-268