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Volumn 542, Issue , 2009, Pages 661-704

Chemoprotection by transfer of resistance genes

Author keywords

CD34+ cells; drug resistance gene; hematopoietic stem cells; murine models; myeloprotection; retroviral gene transfer; transduction

Indexed keywords

MURINAE;

EID: 67650314978     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-59745-561-9_34     Document Type: Review
Times cited : (8)

References (276)
  • 1
    • 0025292730 scopus 로고
    • Turning the tables-making normal marrow resistant to chemotherapy
    • Bertino JR . "Turning the tables"-making normal marrow resistant to chemotherapy . J Natl Cancer Inst 1990 ; 82 (15) : 1234-5 .
    • (1990) J. Natl. Cancer Inst. , vol.82 , Issue.15 , pp. 1234-1235
    • Bertino, J.R.1
  • 2
    • 0037772187 scopus 로고    scopus 로고
    • Successful treatment of murine beta-thalassemia using in vivo selection of genetically modified, drug-resistant hematopoietic stem cells
    • Persons DA , Allay ER , Sawai N , et al . Successful treatment of murine beta-thalassemia using in vivo selection of genetically modified, drug-resistant hematopoietic stem cells . Blood 2003 ; 102 (2) : 506-13 .
    • (2003) Blood , vol.102 , Issue.2 , pp. 506-513
    • Persons, D.A.1    Allay, E.R.2    Sawai, N.3
  • 3
    • 0031728131 scopus 로고    scopus 로고
    • Methotrexate selectable retroviral vectors for Gaucher disease
    • Havenga MJ , Werner AB , Valerio D , Van Es HH . Methotrexate selectable retroviral vectors for Gaucher disease . Gene Ther 1998 ; 5 (10) : 1379-88 .
    • (1998) Gene. Ther. , vol.5 , Issue.10 , pp. 1379-1388
    • Havenga, M.J.1    Werner, A.B.2    Valerio, D.3    Van Es, H.H.4
  • 4
    • 0024215897 scopus 로고
    • High-dose chemotherapy with autologous bone marrow transplantation in 50 adVanced resistant Hodgkin's disease patients: An Italian study group report
    • Carella AM , Congiu AM , Gaozza E , et al . High-dose chemotherapy with autologous bone marrow transplantation in 50 adVanced resistant Hodgkin's disease patients: An Italian study group report . J Clin Oncol 1988 ; 6 (9) : 1411-6 .
    • (1988) J. Clin. Oncol. , vol.6 , Issue.9 , pp. 1411-1416
    • Carella, A.M.1    Congiu, A.M.2    Gaozza, E.3
  • 5
    • 0035317310 scopus 로고    scopus 로고
    • Treatment of patients with metastatic germ cell tumors relapsing after high-dose chemotherapy
    • Kollmannsberger C , Mayer F , Kuczyk M , Kanz L , Bokemeyer C . Treatment of patients with metastatic germ cell tumors relapsing after high-dose chemotherapy . World J Urol 2001 ; 19 (2) : 120-5 .
    • (2001) World J. Urol. , vol.19 , Issue.2 , pp. 120-125
    • Kollmannsberger, C.1    Mayer, F.2    Kuczyk, M.3    Kanz, L.4    Bokemeyer, C.5
  • 6
    • 0036327378 scopus 로고    scopus 로고
    • Hematological toxicity of salvage treatment after high-dose chemotherapy and conventional chemotherapy of ovarian cancer
    • Vuento MH , Salmi TA , Remes KJ , Grenman SE . Hematological toxicity of salvage treatment after high-dose chemotherapy and conventional chemotherapy of ovarian cancer . Anticancer Res 2002 ; 22 (2B) : 1151-5 .
    • (2002) Anticancer Res. , vol.22 , Issue.2 , pp. 1151-1155
    • Vuento, M.H.1    Salmi, T.A.2    Remes, K.J.3    Grenman, S.E.4
  • 7
    • 9444271033 scopus 로고    scopus 로고
    • Autologous stem cell transplantation followed by consolidation chemotherapy for relapsed or refractory Hodgkin's lymphoma
    • Rapoport AP , Guo C , Badros A , et al . Autologous stem cell transplantation followed by consolidation chemotherapy for relapsed or refractory Hodgkin's lymphoma . Bone Marrow Transplant 2004 ; 34 (10) : 883-90 .
    • (2004) Bone Marrow Transplant , vol.34 , Issue.10 , pp. 883-890
    • Rapoport, A.P.1    Guo, C.2    Badros, A.3
  • 8
    • 0036124560 scopus 로고    scopus 로고
    • Autotransplantation for adVanced lymphoma and Hodgkin's disease followed by post-transplant rituxan/ GM-CSF or radiotherapy and consolidation chemotherapy
    • Rapoport AP , Meisenberg B , Sarkodee- Adoo C , et al . Autotransplantation for adVanced lymphoma and Hodgkin's disease followed by post-transplant rituxan/ GM-CSF or radiotherapy and consolidation chemotherapy . Bone Marrow Transplant 2002 ; 29 (4) : 303-12 .
    • (2002) Bone Marrow Transplant , vol.29 , Issue.4 , pp. 303-312
    • Rapoport, A.P.1    Meisenberg, B.2    Sarkodee- Adoo, C.3
  • 9
    • 0031972859 scopus 로고    scopus 로고
    • Phase i trial of retroviral-mediated transfer of the human MDR1 gene as marrow chemoprotection in patients undergoing high-dose chemotherapy and autologous stem-cell transplantation
    • Hesdorffer C , Ayello J , Ward M , et al . Phase I trial of retroviral-mediated transfer of the human MDR1 gene as marrow chemoprotection in patients undergoing high-dose chemotherapy and autologous stem-cell transplantation . J Clin Oncol 1998 ; 16 (1) : 165-72 .
    • (1998) J. Clin. Oncol. , vol.16 , Issue.1 , pp. 165-172
    • Hesdorffer, C.1    Ayello, J.2    Ward, M.3
  • 10
    • 0033918766 scopus 로고    scopus 로고
    • Clinical scale production of an improved retroviral vector expressing the human multidrug resistance 1 gene (MDR1)
    • Eckert HG , Kuhlcke K , Schilz AJ , et al . Clinical scale production of an improved retroviral vector expressing the human multidrug resistance 1 gene (MDR1) . Bone Marrow Trans 2000 ; 25 (Suppl 2) : S114 - 7 .
    • (2000) Bone Marrow Trans , vol.25 , Issue.SUPPL. 2
    • Eckert, H.G.1    Kuhlcke, K.2    Schilz, A.J.3
  • 11
    • 0033168346 scopus 로고    scopus 로고
    • Engraftment of MDR1 and NeoR gene-transduced hematopoietic cells after breast cancer chemotherapy
    • Moscow JA , Huang H , Carter C , et al . Engraftment of MDR1 and NeoR gene-transduced hematopoietic cells after breast cancer chemotherapy . Blood 1999 ; 94 (1) : 52-61 .
    • (1999) Blood , vol.94 , Issue.1 , pp. 52-61
    • Moscow, J.A.1    Huang, H.2    Carter, C.3
  • 12
    • 0026637623 scopus 로고
    • Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1
    • Sorrentino BP , Brandt SJ , Bodine D , et al . Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1 . Science 1992 ; 257 (5066) : 99-103 .
    • (1992) Science , vol.257 , Issue.5066 , pp. 99-103
    • Sorrentino, B.P.1    Brandt, S.J.2    Bodine, D.3
  • 13
    • 0034571820 scopus 로고    scopus 로고
    • MDR1 gene expression in NOD/SCID repopulating cells after retroviral gene transfer under clinically releVant conditions
    • Schilz AJ , Schiedlmeier B , Kuhlcke K , et al . MDR1 gene expression in NOD/SCID repopulating cells after retroviral gene transfer under clinically releVant conditions . Mol Ther 2000 ; 2 (6) : 609-18 .
    • (2000) Mol. Ther. , vol.2 , Issue.6 , pp. 609-618
    • Schilz, A.J.1    Schiedlmeier, B.2    Kuhlcke, K.3
  • 14
    • 0030641868 scopus 로고    scopus 로고
    • Coexpression of a multidrug resistance gene (MDR1) and herpes simplex virus thymidine kinase gene in a bicistronic retroviral vector Ha-MDR-IRES-TK allows selective killing of MDR1-transduced human tumors transplanted in nude mice
    • Sugimoto Y , Sato S , Tsukahara S , et al . Coexpression of a multidrug resistance gene (MDR1) and herpes simplex virus thymidine kinase gene in a bicistronic retroviral vector Ha-MDR-IRES-TK allows selective killing of MDR1-transduced human tumors transplanted in nude mice . Cancer Gene Ther 1997 ; 4 (1) : 51-8 .
    • (1997) Cancer Gene. Ther. , vol.4 , Issue.1 , pp. 51-58
    • Sugimoto, Y.1    Sato, S.2    Tsukahara, S.3
  • 15
    • 0034001743 scopus 로고    scopus 로고
    • Drug selection of MDR1-transduced hematopoietic cells ex vivo increases transgene expression and chemoresistance in reconstituted bone marrow in mice
    • Licht T , Goldenberg SK , Vieira WD , Gottesman MM , Pastan I . Drug selection of MDR1-transduced hematopoietic cells ex vivo increases transgene expression and chemoresistance in reconstituted bone marrow in mice . Gene Ther 2000 ; 7 (4) : 348-58 .
    • (2000) Gene. Ther. , vol.7 , Issue.4 , pp. 348-358
    • Licht, T.1    Goldenberg, S.K.2    Vieira, W.D.3    Gottesman, M.M.4    Pastan, I.5
  • 16
    • 0032809319 scopus 로고    scopus 로고
    • Paclitaxel chemotherapy after autologous stem-cell transplantation and engraftment of hematopoietic cells transduced with a retrovirus containing the multidrug resistance complementary DNA (MDR1) in metastatic breast cancer patients
    • Cowan KH , Moscow JA , Huang H , et al . Paclitaxel chemotherapy after autologous stem-cell transplantation and engraftment of hematopoietic cells transduced with a retrovirus containing the multidrug resistance complementary DNA (MDR1) in metastatic breast cancer patients . Clin Cancer Res 1999 ; 5 (7) : 1619-28 .
    • (1999) Clin. Cancer Res. , vol.5 , Issue.7 , pp. 1619-1628
    • Cowan, K.H.1    Moscow, J.A.2    Huang, H.3
  • 17
    • 0034131481 scopus 로고    scopus 로고
    • Efficient retrovirus-mediated transfer of the multidrug resistance 1 gene into autologous human long-term repopulating hematopoietic stem cells
    • Abonour R , Williams DA , Einhorn L , et al . Efficient retrovirus-mediated transfer of the multidrug resistance 1 gene into autologous human long-term repopulating hematopoietic stem cells . Nat Med 2000 ; 6 (6) : 652-8 .
    • (2000) Nat. Med. , vol.6 , Issue.6 , pp. 652-658
    • Abonour, R.1    Williams, D.A.2    Einhorn, L.3
  • 18
    • 0037457015 scopus 로고    scopus 로고
    • Retroviral transduction of a mutant dihydrofolate reductase-thymidylate synthase fusion gene into murine marrow ells confers resistance to both methotrexate and 5-Fluorouracil
    • Capiaux GM , Budak-Alpdogan T , Takebe N , et al . Retroviral transduction of a mutant dihydrofolate reductase-thymidylate synthase fusion gene into murine marrow ells confers resistance to both methotrexate and 5-Fluorouracil . Hum Gene Ther 2003 ; 14 (5) : 435-46 .
    • (2003) Hum. Gene. Ther. , vol.14 , Issue.5 , pp. 435-446
    • Capiaux, G.M.1    Budak-Alpdogan, T.2    Takebe, N.3
  • 19
    • 0033544031 scopus 로고    scopus 로고
    • Expression of a nov el double-mutant dihydrofolate reductasecytidine deaminase fusion gene confers resistance to both methotrexate and cytosine arabinoside
    • Sauerbrey A , McPherson JP , Zhao SC , Banerjee D , Bertino JR . Expression of a nov el double-mutant dihydrofolate reductasecytidine deaminase fusion gene confers resistance to both methotrexate and cytosine arabinoside . Hum Gene Ther 1999 ; 10 (15) : 2495-504 .
    • (1999) Hum. Gene. Ther. , vol.10 , Issue.15 , pp. 2495-2504
    • Sauerbrey, A.1    McPherson, J.P.2    Zhao, S.C.3    Banerjee, D.4    Bertino, J.R.5
  • 20
    • 0030811863 scopus 로고    scopus 로고
    • Co-expression of the herpes simplex virus thymidine kinase gene potentiates methotrexate resistance conferred by transfer of a mutated dihydrofolate reductase gene
    • Mineishi S , Nakahara S , Takebe N , Banerjee D , Zhao SC , Bertino JR . Co-expression of the herpes simplex virus thymidine kinase gene potentiates methotrexate resistance conferred by transfer of a mutated dihydrofolate reductase gene . Gene Ther 1997 ; 4 (6) : 570-6 .
    • (1997) Gene. Ther. , vol.4 , Issue.6 , pp. 570-576
    • Mineishi, S.1    Nakahara, S.2    Takebe, N.3    Banerjee, D.4    Zhao, S.C.5    Bertino, J.R.6
  • 21
    • 0034985885 scopus 로고    scopus 로고
    • Generation of dual resistance to 4-hydroperoxycyclophosphamide and methotrexate by retroviral transfer of the human aldehyde dehydrogenase class 1 gene and a mutated dihydrofolate reductase gene
    • Takebe N , Zhao SC , Adhikari D , et al . Generation of dual resistance to 4-hydroperoxycyclophosphamide and methotrexate by retroviral transfer of the human aldehyde dehydrogenase class 1 gene and a mutated dihydrofolate reductase gene . Mol Ther 2001 ; 3 (1) : 88-96 .
    • (2001) Mol. Ther. , vol.3 , Issue.1 , pp. 88-96
    • Takebe, N.1    Zhao, S.C.2    Adhikari, D.3
  • 22
    • 2442770054 scopus 로고    scopus 로고
    • Coexpression of cytidine deaminase and mutant dihydrofolate reductase by a bicistronic retroviral vector confers resistance to cytosine arabinoside and methotrexate
    • Beausejour CM , Le NL , Letourneau S , Cournoyer D , Momparler RL . Coexpression of cytidine deaminase and mutant dihydrofolate reductase by a bicistronic retroviral vector confers resistance to cytosine arabinoside and methotrexate . Hum Gene Ther 1998 ; 9 (17) : 2537-44 .
    • (1998) Hum. Gene. Ther. , vol.9 , Issue.17 , pp. 2537-2544
    • Beausejour, C.M.1    Le Letourneau, N.L.S.2    Cournoyer, D.3    Momparler, R.L.4
  • 23
    • 0035095233 scopus 로고    scopus 로고
    • A bicistronic retroviral vector to introduce drug resistance genes into human umbilical cord blood CD 34+ cells to improve combination chemotherapy tolerance
    • Wang J , Chen Z , Xia X , Lu D , Xue J , Ruan C . A bicistronic retroviral vector to introduce drug resistance genes into human umbilical cord blood CD 34+ cells to improve combination chemotherapy tolerance . Chin Med J (Engl) 2001 ; 114 (1) : 25-9 .
    • (2001) Chin. Med. J. Engl. , vol.114 , Issue.1 , pp. 25-29
    • Wang, J.1    Chen, Z.2    Xia, X.3    Lu, D.4    Xue, J.5    Ruan, C.6
  • 24
    • 0031007236 scopus 로고    scopus 로고
    • Retroviral coexpression of two different types of drug resistance genes to protect normal cells from combination chemotherapy
    • Suzuki M , Sugimoto Y , Tsukahara S , Okochi E , Gottesman MM , Tsuruo T . Retroviral coexpression of two different types of drug resistance genes to protect normal cells from combination chemotherapy . Clin Cancer Res 1997 ; 3 (6) : 947-54 .
    • (1997) Clin. Cancer Res. , vol.3 , Issue.6 , pp. 947-954
    • Suzuki, M.1    Sugimoto, Y.2    Tsukahara, S.3    Okochi, E.4    Gottesman, M.M.5    Tsuruo, T.6
  • 25
    • 0032486114 scopus 로고    scopus 로고
    • Efficient protection of cells from the genotoxicity of nitrosoureas by the retrovirus-mediated transfer of human O6-methylguanine-DNA methyltransferase using bicistronic vectors with human multidrug resistance gene 1
    • Suzuki M , Sugimoto Y , Tsuruo T . Efficient protection of cells from the genotoxicity of nitrosoureas by the retrovirus-mediated transfer of human O6-methylguanine-DNA methyltransferase using bicistronic vectors with human multidrug resistance gene 1 . Mutat Res 1998 ; 401 (1-2) : 133-41 .
    • (1998) Mutat. Res. , vol.401 , Issue.1-2 , pp. 133-141
    • Suzuki, M.1    Sugimoto, Y.2    Tsuruo, T.3
  • 26
    • 0042733390 scopus 로고    scopus 로고
    • Increased resistance to nitrogen mustards and antifolates following in vitro selection of murine fibroblasts and primary hematopoietic cells transduced with a bicistronic retroviral vector expressing the rat glutathione S-transferase A3 and a mutant dihydrofolate reductase
    • Belzile JP , Karatzas A , Shiu HY , Letourneau S , Palerme JS , Cournoyer D . Increased resistance to nitrogen mustards and antifolates following in vitro selection of murine fibroblasts and primary hematopoietic cells transduced with a bicistronic retroviral vector expressing the rat glutathione S-transferase A3 and a mutant dihydrofolate reductase . Cancer Gene Ther 2003 ; 10 (8) : 637-46 .
    • (2003) Cancer Gene. Ther. , vol.10 , Issue.8 , pp. 637-646
    • Belzile, J.P.1    Karatzas, A.2    Shiu, H.Y.3    Letourneau, S.4    Palerme, J.S.5    Cournoyer, D.6
  • 27
    • 0034803806 scopus 로고    scopus 로고
    • Novel bicistronic retroviral vector expressing gamma-glutamylcysteine synthetase and the multidrug resistance protein 1 (MRP1) protects cells from MRP1-effluxed drugs and alkylating agents
    • Rappa G , Lorico A , Hildinger M , Fodstad O , Baum C . Novel bicistronic retroviral vector expressing gamma-glutamylcysteine synthetase and the multidrug resistance protein 1 (MRP1) protects cells from MRP1-effluxed drugs and alkylating agents . Hum Gene Ther 2001 ; 12 (14) : 1785-96 .
    • (2001) Hum. Gene. Ther. , vol.12 , Issue.14 , pp. 1785-1796
    • Rappa, G.1    Lorico, A.2    Hildinger, M.3    Fodstad, O.4    Baum, C.5
  • 28
    • 2342571081 scopus 로고    scopus 로고
    • A bicistronic SIN-lentiviral vector containing G156A MGMT allows selection and metabolic correction of hematopoietic protoporphyric cell lines
    • Richard E , Geronimi F , Lalanne M , et al . A bicistronic SIN-lentiviral vector containing G156A MGMT allows selection and metabolic correction of hematopoietic protoporphyric cell lines . J Gene Med 2003 ; 5 (9) : 737-47 .
    • (2003) J. Gene. Med. , vol.5 , Issue.9 , pp. 737-747
    • Richard, E.1    Geronimi, F.2    Lalanne, M.3
  • 29
    • 15244351083 scopus 로고    scopus 로고
    • Coordinate dual-gene transgenesis by lentiviral vectors carrying synthetic bidirectional promoters
    • Amendola M , Venneri MA , Biffi A , Vigna E , Naldini L . Coordinate dual-gene transgenesis by lentiviral vectors carrying synthetic bidirectional promoters . Nat Biotechnol 2005 ; 23 (1) : 108-16 .
    • (2005) Nat. Biotechnol. , vol.23 , Issue.1 , pp. 108-116
    • Amendola, M.1    Venneri, M.A.2    Biffi, A.3    Vigna, E.4    Naldini, L.5
  • 30
    • 0041866801 scopus 로고    scopus 로고
    • Bidirectional expression units enable streptogramin-adjustable gene expression in mammalian cells
    • Fux C , Fussenegger M . Bidirectional expression units enable streptogramin-adjustable gene expression in mammalian cells . Biotechnol Bioeng 2003 ; 83 (5) : 618-25 .
    • (2003) Biotechnol Bioeng , vol.83 , Issue.5 , pp. 618-625
    • Fux, C.1    Fussenegger, M.2
  • 31
    • 3142770344 scopus 로고    scopus 로고
    • Novel bidirectional vector strategy for amplification of therapeutic and reporter gene expression
    • Ray S , Paulmurugan R , Hildebrandt I , et al . Novel bidirectional vector strategy for amplification of therapeutic and reporter gene expression . Hum Gene Ther 2004 ; 15 (7) : 681-90 .
    • (2004) Hum. Gene. Ther. , vol.15 , Issue.7 , pp. 681-690
    • Ray, S.1    Paulmurugan, R.2    Hildebrandt, I.3
  • 32
    • 0037320203 scopus 로고    scopus 로고
    • Gene transfer in purified human hematopoietic peripheral-blood stem cells by means of electroporation without prestimulation
    • Weissinger F , Reimer P , Waessa T , et al . Gene transfer in purified human hematopoietic peripheral-blood stem cells by means of electroporation without prestimulation . J Lab Clin Med 2003 ; 141 (2) : 138-49 .
    • (2003) J. Lab Clin Med , vol.141 , Issue.2 , pp. 138-149
    • Weissinger, F.1    Reimer, P.2    Waessa, T.3
  • 33
    • 0035084827 scopus 로고    scopus 로고
    • Efficient expression of foreign genes in human CD34(+) hematopoietic precursor cells using electroporation
    • Wu MH , Liebowitz DN , Smith SL , Williams SF , Dolan ME . Efficient expression of foreign genes in human CD34(+) hematopoietic precursor cells using electroporation . Gene Ther 2001 ; 8 (5) : 384-90 .
    • (2001) Gene. Ther. , vol.8 , Issue.5 , pp. 384-390
    • Wu, M.H.1    Liebowitz, D.N.2    Smith, S.L.3    Williams, S.F.4    Dolan, M.E.5
  • 34
    • 0034948523 scopus 로고    scopus 로고
    • Optimization of culture conditions to enhance transfection of human CD34+ cells by electroporation
    • Wu MH , Smith SL , Danet GH , et al . Optimization of culture conditions to enhance transfection of human CD34+ cells by electroporation . Bone Marrow Trans 2001 ; 27 (11) : 1201-9 .
    • (2001) Bone Marrow Trans , vol.27 , Issue.11 , pp. 1201-1209
    • Wu, M.H.1    Smith, S.L.2    Danet, G.H.3
  • 35
    • 0035182857 scopus 로고    scopus 로고
    • High efficiency electroporation of human umbilical cord blood CD34+ hematopoietic precursor cells
    • Wu MH , Smith SL , Dolan ME . High efficiency electroporation of human umbilical cord blood CD34+ hematopoietic precursor cells . Stem Cells 2001 ; 19 (6) : 492-9 .
    • (2001) Stem. Cells , vol.19 , Issue.6 , pp. 492-499
    • Wu, M.H.1    Smith, S.L.2    Dolan, M.E.3
  • 36
    • 0042700227 scopus 로고    scopus 로고
    • Gene transfer into genomes of human cells by the sleeping beauty transposon system
    • Geurts AM , Yang Y , Clark KJ , et al . Gene transfer into genomes of human cells by the sleeping beauty transposon system . Mol Ther 2003 ; 8 (1) : 108-17 .
    • (2003) Mol. Ther. , vol.8 , Issue.1 , pp. 108-117
    • Geurts, A.M.1    Yang, Y.2    Clark, K.J.3
  • 37
    • 0034623009 scopus 로고    scopus 로고
    • A wide host-range transposon vector for genetic transformation in vertebrates
    • Izsvak Z , Ivics Z , Plasterk RH . Sleeping Beauty, a wide host-range transposon vector for genetic transformation in vertebrates . J Mol Biol 2000 ; 302 (1) : 93-102 .
    • (2000) J. Mol. Biol. , vol.302 , Issue.1 , pp. 93-102
    • Izsvak, Z.1    Ivics, Z.2    Beauty, R.H.3
  • 38
    • 0034103009 scopus 로고    scopus 로고
    • Somatic integration and long-term transgene expression in normal and haemophilic mice using a DNA transposon system
    • Yant SR , Meuse L , Chiu W , Ivics Z , Izsvak Z , Kay MA . Somatic integration and long-term transgene expression in normal and haemophilic mice using a DNA transposon system . Nat Genet 2000 ; 25 (1) : 35-41 .
    • (2000) Nat. Genet. , vol.25 , Issue.1 , pp. 35-41
    • Yant, S.R.1    Meuse, L.2    Chiu, W.3    Ivics, Z.4    Izsvak, Z.5    Kay, M.A.6
  • 39
    • 0142213094 scopus 로고    scopus 로고
    • Helper-Independent Sleeping Beauty transposon-transposase vectors for efficient nonviral gene delivery and persistent gene expression in vivo
    • Mikkelsen JG , Yant SR , Meuse L , Huang Z , Xu H , Kay MA . Helper-Independent Sleeping Beauty transposon-transposase vectors for efficient nonviral gene delivery and persistent gene expression in vivo . Mol Ther 2003 ; 8 (4) : 654-65 .
    • (2003) Mol. Ther. , vol.8 , Issue.4 , pp. 654-665
    • Mikkelsen, J.G.1    Yant, S.R.2    Meuse, L.3    Huang, Z.4    Xu, H.5    Kay, M.A.6
  • 40
    • 19944431736 scopus 로고    scopus 로고
    • Target-site preferences of sleeping beauty transposons
    • Liu G , Geurts AM , Yae K , et al . Target-site preferences of Sleeping Beauty transposons . J Mol Biol 2005 ; 346 (1) : 161-73 .
    • (2005) J. Mol. Biol. , vol.346 , Issue.1 , pp. 161-173
    • Liu, G.1    Geurts, A.M.2    Yae, K.3
  • 41
    • 30444432097 scopus 로고    scopus 로고
    • Stable gene transfer and expression in human primary T cells by the Sleeping Beauty transposon system
    • Huang X , Wilber AC , Bao L , et al . Stable gene transfer and expression in human primary T cells by the Sleeping Beauty transposon system . Blood 2006 ; 107 (2) : 483-91 .
    • (2006) Blood , vol.107 , Issue.2 , pp. 483-491
    • Huang, X.1    Wilber, A.C.2    Bao, L.3
  • 42
    • 33745903117 scopus 로고    scopus 로고
    • Sleeping beauty transposon-mediated nonviral gene therapy
    • Fernando S , Fletcher BS . Sleeping beauty transposon-mediated nonviral gene therapy .BioDrugs 2006 ; 20 (4) : 219-29 .
    • (2006) Bio Drugs , vol.20 , Issue.4 , pp. 219-229
    • Fernando, S.1    Fletcher, B.S.2
  • 43
    • 33748526535 scopus 로고    scopus 로고
    • Stable gene transfer to human CD34(+) hematopoietic cells using the Sleeping Beauty transposon
    • Hollis RP , Nightingale SJ , Wang X , et al . Stable gene transfer to human CD34(+) hematopoietic cells using the Sleeping Beauty transposon . Exp Hematol 2006 ; 34 (10) : 1333-43 .
    • (2006) Exp. Hematol. , vol.34 , Issue.10 , pp. 1333-1343
    • Hollis, R.P.1    Nightingale, S.J.2    Wang, X.3
  • 44
    • 33845981514 scopus 로고    scopus 로고
    • PiggyBac Transposon-mediated Gene Transfer in Human Cells
    • Wilson MH , Coates CJ , George AL , Jr . PiggyBac Transposon-mediated Gene Transfer in Human Cells . Mol Ther 2007 ; 15 (1) : 139-45
    • (2007) Mol. Ther. , vol.15 , Issue.1 , pp. 139-145
    • Wilson, M.H.1    Coates, C.J.2    George Jr., A.L.3
  • 45
  • 46
    • 34248220864 scopus 로고    scopus 로고
    • Standardized reagents and protocols for engineering zinc finger nucleases by modular assembly
    • Wright DA , Thibodeau-Beganny S , Sander JD , et al . Standardized reagents and protocols for engineering zinc finger nucleases by modular assembly . Nat Protoc 2006 ; 1 (3) : 1637-52 .
    • (2006) Nat. Protoc. , vol.1 , Issue.3 , pp. 1637-1652
    • Wright, D.A.1    Thibodeau-Beganny, S.2    Sander, J.D.3
  • 47
    • 33847682924 scopus 로고    scopus 로고
    • Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases
    • Moehle EA , Rock JM , Lee YL , et al . Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases . Proc Natl Acad Sci U S 2007 ; 104 (9) : 3055-60 .
    • (2007) Proc. Natl. Acad. Sci. U S , vol.104 , Issue.9 , pp. 3055-3060
    • Moehle, E.A.1    Rock, J.M.2    Lee, Y.L.3
  • 48
    • 0142084745 scopus 로고    scopus 로고
    • LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1
    • Hacein-Bey-Abina S , Von Kalle C , Schmidt M , et al . LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1 . Science 2003 ; 302 (5644) : 415-9 .
    • (2003) Science , vol.302 , Issue.5644 , pp. 415-419
    • Hacein-Bey-Abina, S.1    Von Kalle, C.2    Schmidt, M.3
  • 49
    • 0037448352 scopus 로고    scopus 로고
    • A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency
    • Hacein-Bey-Abina S , von Kalle C , Schmidt M , et al . A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency . N Engl J Med 2003 ; 348 (3) : 255-6 .
    • (2003) N. Engl. J. Med. , vol.348 , Issue.3 , pp. 255-256
    • Hacein-Bey-Abina, S.1    Von Kalle, C.2    Schmidt, M.3
  • 50
    • 13944278472 scopus 로고    scopus 로고
    • Gene therapy. As Gelsinger case ends, gene therapy suffers another blow
    • Couzin J , Kaiser J . Gene therapy. As Gelsinger case ends, gene therapy suffers another blow . Science 2005 ; 307 (5712) : 1028 .
    • (2005) Science , vol.307 , Issue.5712 , pp. 1028
    • Couzin, J.1    Kaiser, J.2
  • 51
    • 34547118806 scopus 로고    scopus 로고
    • What are the consequences of the fourth case
    • Baum C . What are the consequences of the fourth case? Mol Ther 2007 ; 15 (8) : 1401-2 .
    • (2007) Mol. Ther. , vol.15 , Issue.8 , pp. 1401-1402
    • Baum, C.1
  • 52
    • 33645864066 scopus 로고    scopus 로고
    • Retroviral DNA integration-mechanism and consequences
    • Lewinski MK , Bushman FD . Retroviral DNA integration-mechanism and consequences . Adv Genet 2005 ; 55 : 147-81 .
    • (2005) Adv. Genet. , vol.55 , pp. 147-181
    • Lewinski, M.K.1    Bushman, F.D.2
  • 53
    • 33745684269 scopus 로고    scopus 로고
    • Retroviral DNA integration: Viral and cellular determinants of target-site selection
    • Lewinski MK , Yamashita M , Emerman M , et al . Retroviral DNA integration: Viral and cellular determinants of target-site selection . PLoS Pathog 2006 ; 2 (6) : E60 .
    • (2006) PLoS Pathog , vol.2 , Issue.6
    • Lewinski, M.K.1    Yamashita, M.2    Emerman, M.3
  • 54
    • 21044448037 scopus 로고    scopus 로고
    • Clonal dominance of hematopoietic stem cells triggered by retroviral gene marking
    • Kustikova O , Fehse B , Modlich U , et al . Clonal dominance of hematopoietic stem cells triggered by retroviral gene marking . Science 2005 ; 308 (5725) : 1171-4 .
    • (2005) Science , vol.308 , Issue.5725 , pp. 1171-1174
    • Kustikova, O.1    Fehse, B.2    Modlich, U.3
  • 55
    • 33745108790 scopus 로고    scopus 로고
    • Hematopoietic stem cell gene transfer in tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration
    • Montini E , Cesana D , Schmidt M , et al . Hematopoietic stem cell gene transfer in tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration . Nat Biotechnol 2006 ; 24 (6) : 687-96 .
    • (2006) Nat. Biotechnol. , vol.24 , Issue.6 , pp. 687-696
    • Montini, E.1    Cesana, D.2    Schmidt, M.3
  • 56
    • 34249906359 scopus 로고    scopus 로고
    • Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy
    • Deichmann A , Hacein-Bey-Abina S , Schmidt M , et al . Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy . J Clin Invest 2007 ; 117 (8) : 2225-32 .
    • (2007) J. Clin. Invest. , vol.117 , Issue.8 , pp. 2225-2232
    • Deichmann, A.1    Hacein-Bey-Abina, S.2    Schmidt, M.3
  • 57
    • 34547657665 scopus 로고    scopus 로고
    • Hot spots of retroviral integration in human CD34+ hematopoietic cells
    • Cattoglio C , Facchini G , Sartori D , et al . Hot spots of retroviral integration in human CD34+ hematopoietic cells . Blood 2007 ; 110 (6) : 1770-8 .
    • (2007) Blood , vol.110 , Issue.6 , pp. 1770-1778
    • Cattoglio, C.1    Facchini, G.2    Sartori, D.3
  • 58
    • 34250851635 scopus 로고    scopus 로고
    • Comparison of HIV-derived lentiviral and MLV-based gammaretroviral vector integration sites in primate repopulating cells
    • Beard BC , Dickerson D , Beebe K , et al . Comparison of HIV-derived lentiviral and MLV-based gammaretroviral vector integration sites in primate repopulating cells . Mol Ther 2007 ; 15 (7) : 1356-65 .
    • (2007) Mol. Ther. , vol.15 , Issue.7 , pp. 1356-13565
    • Beard, B.C.1    Dickerson, D.2    Beebe, K.3
  • 59
    • 34547691354 scopus 로고    scopus 로고
    • Retroviral integration and human gene therapy
    • Bushman FD . Retroviral integration and human gene therapy . J Clin Invest 2007 ; 117 (8) : 2083-6 .
    • (2007) J. Clin. Invest. , vol.117 , Issue.8 , pp. 2083-2086
    • Bushman, F.D.1
  • 60
    • 31944444349 scopus 로고    scopus 로고
    • Foamy virus vector integration sites in normal human cells
    • Trobridge GD , Miller DG , Jacobs MA , et al . Foamy virus vector integration sites in normal human cells . Proc Natl Acad Sci U S 2006 ; 103 (5) : 1498-503 .
    • (2006) Proc. Natl. Acad. Sci. U S. , vol.103 , Issue.5 , pp. 1498-1503
    • Trobridge, G.D.1    Miller, D.G.2    Jacobs, M.A.3
  • 61
    • 33645451483 scopus 로고    scopus 로고
    • Mutagenesis and oncogenesis by chromosomal insertion of gene transfer vectors
    • Baum C , Kustikova O , Modlich U , Li Z , Fehse B . Mutagenesis and oncogenesis by chromosomal insertion of gene transfer vectors . Hum Gene Ther 2006 ; 17 (3) : 253-63 .
    • (2006) Hum. Gene. Ther. , vol.17 , Issue.3 , pp. 253-263
    • Baum, C.1    Kustikova, O.2    Modlich, U.3    Li, Z.4    Fehse, B.5
  • 62
    • 21144437399 scopus 로고    scopus 로고
    • Leukemias following retroviral transfer of multidrug resistance 1 (MDR1) are driven by combinatorial insertional mutagenesis
    • Modlich U , Kustikova OS , Schmidt M , et al . Leukemias following retroviral transfer of multidrug resistance 1 (MDR1) are driven by combinatorial insertional mutagenesis . Blood 2005 ; 105 (11) : 4235-46 .
    • (2005) Blood , vol.105 , Issue.11 , pp. 4235-4246
    • Modlich, U.1    Kustikova, O.S.2    Schmidt, M.3
  • 63
    • 0347634456 scopus 로고    scopus 로고
    • Gene therapy insertional mutagenesis insights
    • Dave UP , Jenkins NA , Copeland NG . Gene therapy insertional mutagenesis insights . Science 2004 ; 303 (5656) : 333 .
    • (2004) Science , vol.303 , Issue.5656 , pp. 333
    • Dave, U.P.1    Jenkins, N.A.2    Copeland, N.G.3
  • 64
    • 33847408501 scopus 로고    scopus 로고
    • Retroviral vector insertion sites associated with dominant hematopoietic clones mark stemness" pathways
    • Kustikova OS , Geiger H , Li Z , et al . Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways . Blood 2007 ; 109 (5) : 1897 - 907 .
    • (2007) Blood , vol.109 , Issue.5 , pp. 1897-1907
    • Kustikova, O.S.1    Geiger, H.2    Li, Z.3
  • 65
    • 39849094315 scopus 로고    scopus 로고
    • Globin lentiviral vector insertions can perturb the expression of endogenous genes in beta-thalassemic hematopoietic cells
    • Hargrove PW , Kepes S , Hanawa H , et al . Globin lentiviral vector insertions can perturb the expression of endogenous genes in beta-thalassemic hematopoietic cells . Mol Ther 2008 ; 16 (3) : 525-33 .
    • (2008) Mol. Ther. , vol.16 , Issue.3 , pp. 525-533
    • Hargrove, P.W.1    Kepes, S.2    Hanawa, H.3
  • 66
    • 33646594123 scopus 로고    scopus 로고
    • Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque
    • Seggewiss R , Pittaluga S , Adler RL , et al . Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque . Blood 2006 ; 107 (10) : 3865-7 .
    • (2006) Blood , vol.107 , Issue.10 , pp. 3865-3867
    • Seggewiss, R.1    Pittaluga, S.2    Adler, R.L.3
  • 67
    • 34249727198 scopus 로고    scopus 로고
    • Insertional mutagenesis in gene therapy and stem cell biology
    • Baum C . Insertional mutagenesis in gene therapy and stem cell biology . Curr Opin Hematol 2007 ; 14 (4) : 337-42 .
    • (2007) Curr. Opin. Hematol. , vol.14 , Issue.4 , pp. 337-342
    • Baum, C.1
  • 68
    • 33847636598 scopus 로고    scopus 로고
    • Murine leukemia following irradiation conditioning for transplantation of lentivirally-modified hematopoietic stem cells
    • Siapati EK , Bigger BW , Kashofer K , Themis M , Thrasher AJ , Bonnet D . Murine leukemia following irradiation conditioning for transplantation of lentivirally-modified hematopoietic stem cells . Eur J Haematol 2007 ; 78 (4) : 303-13 .
    • (2007) Eur. J. Haematol. , vol.78 , Issue.4 , pp. 303-313
    • Siapati, E.K.1    Bigger, B.W.2    Kashofer, K.3    Themis, M.4    Thrasher, A.J.5    Bonnet, D.6
  • 69
    • 0037134031 scopus 로고    scopus 로고
    • Murine leukemia induced by retroviral gene marking
    • Li Z , Dullmann J , Schiedlmeier B , et al . Murine leukemia induced by retroviral gene marking . Science 2002 ; 296 (5567) : 497 .
    • (2002) Science , vol.296 , Issue.5567 , pp. 497
    • Li, Z.1    Dullmann, J.2    Schiedlmeier, B.3
  • 70
    • 0037841763 scopus 로고    scopus 로고
    • Transcription start regions in the human genome are favored targets for MLV integration
    • Wu X , Li Y , Crise B , Burgess SM . Transcription start regions in the human genome are favored targets for MLV integration . Science 2003 ; 300 (5626) : 1749-51 .
    • (2003) Science , vol.300 , Issue.5626 , pp. 1749-1751
    • Wu, X.1    Li, Y.2    Crise, B.3    Burgess, S.M.4
  • 71
    • 19344375031 scopus 로고    scopus 로고
    • Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences
    • Mitchell RS , Beitzel BF , Schroder AR , et al . Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences . PLoS Biol 2004 ; 2 (8) : E234 .
    • (2004) PLoS Biol. , vol.2 , Issue.8
    • Mitchell, R.S.1    Beitzel, B.F.2    Schroder, A.R.3
  • 72
    • 0034915569 scopus 로고    scopus 로고
    • Detection and direct genomic sequencing of multiple rare unknown flanking DNA in highly complex samples
    • Schmidt M , Hoffmann G , Wissler M , et al . Detection and direct genomic sequencing of multiple rare unknown flanking DNA in highly complex samples . Hum Gene Ther 2001 ; 12 (7) : 743-9 .
    • (2001) Hum. Gene. Ther. , vol.12 , Issue.7 , pp. 743-749
    • Schmidt, M.1    Hoffmann, G.2    Wissler, M.3
  • 73
    • 20044396722 scopus 로고    scopus 로고
    • Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells
    • Hematti P , Hong BK , Ferguson C , et al . Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells . PLoS Biol 2004 ; 2 (12) : E423 .
    • (2004) PLoS Biol. , vol.2 , Issue.12
    • Hematti, P.1    Hong, B.K.2    Ferguson, C.3
  • 74
    • 33947210723 scopus 로고    scopus 로고
    • Importance of murine study design for testing toxicity of retroviral vectors in support of phase i trials
    • Will E , Bailey J , Schuesler T , et al . Importance of murine study design for testing toxicity of retroviral vectors in support of phase I trials . Mol Ther 2007 ; 15 (4) : 782-91 .
    • (2007) Mol. Ther. , vol.15 , Issue.4 , pp. 782-791
    • Will, E.1    Bailey, J.2    Schuesler, T.3
  • 75
    • 36749052217 scopus 로고    scopus 로고
    • High-resolution insertion-site analysis by linear amplification-mediated PCR (LAMPCR)
    • Schmidt M , Schwarzwaelder K , Bartholomae C , et al . High-resolution insertion-site analysis by linear amplification-mediated PCR (LAMPCR) . Nat Methods 2007 ; 4 (12) : 1051-7 .
    • (2007) Nat. Methods , vol.4 , Issue.12 , pp. 1051-1057
    • Schmidt, M.1    Schwarzwaelder, K.2    Bartholomae, C.3
  • 76
    • 33645734405 scopus 로고    scopus 로고
    • Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1
    • Ott MG , Schmidt M , Schwarzwaelder K , et al . Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1 . Nat Med 2006 ; 12 (4) : 401-9 .
    • (2006) Nat. Med. , vol.12 , Issue.4 , pp. 401-409
    • Ott, M.G.1    Schmidt, M.2    Schwarzwaelder, K.3
  • 77
    • 0345144017 scopus 로고    scopus 로고
    • Clonality analysis after retroviralmediated gene transfer to CD34+ cells from the cord blood of ADA-deficient SCID neonates
    • Schmidt M , Carbonaro DA , Speckmann C , et al . Clonality analysis after retroviralmediated gene transfer to CD34+ cells from the cord blood of ADA-deficient SCID neonates . Nat Med 2003 ; 9 (4) : 463-8 .
    • (2003) Nat. Med. , vol.9 , Issue.4 , pp. 463-468
    • Schmidt, M.1    Carbonaro, D.A.2    Speckmann, C.3
  • 78
    • 7244231295 scopus 로고    scopus 로고
    • Self-inactivating retroviral vectors with improved RNA processing
    • Kraunus J , Schaumann DH , Meyer J , et al . Self-inactivating retroviral vectors with improved RNA processing . Gene Ther 2004 ; 11 (21) : 1568-78 .
    • (2004) Gene. Ther. , vol.11 , Issue.21 , pp. 1568-1578
    • Kraunus, J.1    Schaumann, D.H.2    Meyer, J.3
  • 79
    • 33750624015 scopus 로고    scopus 로고
    • Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity
    • Modlich U , Bohne J , Schmidt M , et al . Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity . Blood 2006 ; 108 (8) : 2545-53 .
    • (2006) Blood , vol.108 , Issue.8 , pp. 2545-2553
    • Modlich, U.1    Bohne, J.2    Schmidt, M.3
  • 80
    • 33750023988 scopus 로고    scopus 로고
    • Overcoming promoter competition in packaging cells improves production of selfinactivating retroviral vectors
    • Schambach A , Mueller D , Galla M , et al . Overcoming promoter competition in packaging cells improves production of selfinactivating retroviral vectors . Gene Ther 2006 ; 13 (21) : 1524-33 .
    • (2006) Gene. Ther. , vol.13 , Issue.21 , pp. 1524-1533
    • Schambach, A.1    Mueller, D.2    Galla, M.3
  • 81
    • 30344464717 scopus 로고    scopus 로고
    • Equal potency of gammaretroviral and lenti viral SIN vectors for expression of O6-methylguanine- DNA methyltransferase in hematopoietic cells
    • Schambach A , Bohne J , Chandra S , et al . Equal potency of gammaretroviral and lenti viral SIN vectors for expression of O6-methylguanine- DNA methyltransferase in hematopoietic cells . Mol Ther 2006 ; 13 (2) : 391-400 .
    • (2006) Mol. Ther. , vol.13 , Issue.2 , pp. 391-400
    • Schambach, A.1    Bohne, J.2    Chandra, S.3
  • 82
    • 34249298695 scopus 로고    scopus 로고
    • Improving transcriptional termination of self-inactivating gamma-retroviral and lentiviral vectors
    • Schambach A , Galla M , Maetzig T , Loew R , Baum C . Improving transcriptional termination of self-inactivating gamma-retroviral and lentiviral vectors . Mol Ther 2007 ; 15 (6) : 1167-73 .
    • (2007) Mol. Ther. , vol.15 , Issue.6 , pp. 1167-1173
    • Schambach, A.1    Galla, M.2    Maetzig, T.3    Loew, R.4    Baum, C.5
  • 83
    • 39849110286 scopus 로고    scopus 로고
    • Self-inactivating gammaretroviral vectors for gene therapy of X-linked severe combined immunodeficiency
    • Thornhill SI , Schambach A , Howe SJ , et al . Self-inactivating gammaretroviral vectors for gene therapy of X-linked severe combined immunodeficiency . Mol Ther 2008 ; 16 (3) : 590-8 .
    • (2008) Mol. Ther. , vol.16 , Issue.3 , pp. 590-598
    • Thornhill, S.I.1    Schambach, A.2    Howe, S.J.3
  • 84
    • 41149133413 scopus 로고    scopus 로고
    • Physiological promoters reduce the genotoxic risk of integrating gene vectors
    • Zychlinski D, Schambach A, Modlich U, et al. Physiological Promoters Reduce the Genotoxic Risk of Integrating Gene Vectors. Mol Ther 2008.
    • (2008) Mol. Ther.
    • Zychlinski, D.1    Schambach, A.2    Modlich, U.3
  • 85
    • 39549110741 scopus 로고    scopus 로고
    • An experimental system for the evaluation of retroviral vector design to diminish the risk for proto-oncogene activation
    • Ryu BY , EVans-Galea MV , Gray JT , Bodine DM , Persons DA , Nienhuis AW . An experimental system for the evaluation of retroviral vector design to diminish the risk for proto-oncogene activation . Blood 2008 ; 111 (4) : 1866-75 .
    • (2008) Blood , vol.111 , Issue.4 , pp. 1866-1875
    • Ryu, B.Y.1    Evans-Galea, M.V.2    Gray, J.T.3    Bodine, D.M.4    Persons, D.A.5    Nienhuis, A.W.6
  • 86
    • 0344089002 scopus 로고    scopus 로고
    • Comparison of three retroviral vector systems for transduction of nonobese diabetic/severe combined immunodeficiency mice repopulating human CD34+ cord blood cells
    • Leurs C , Jansen M , Pollok KE , et al . Comparison of three retroviral vector systems for transduction of nonobese diabetic/severe combined immunodeficiency mice repopulating human CD34+ cord blood cells . Hum Gene Ther 2003 ; 14 (6) : 509-19 .
    • (2003) Hum. Gene. Ther. , vol.14 , Issue.6 , pp. 509-519
    • Leurs, C.1    Jansen, M.2    Pollok, K.E.3
  • 87
    • 0037062431 scopus 로고    scopus 로고
    • Transduction of human NOD/ SCID-repopulating cells with both lymphoid and myeloid potential by foamy virus vectors
    • Josephson NC , Vassilopoulos G , Trobridge GD , et al . Transduction of human NOD/ SCID-repopulating cells with both lymphoid and myeloid potential by foamy virus vectors . Proc Natl Acad Sci U S A 2002 ; 99 (12) : 8295-300 .
    • (2002) Proc. Natl. Acad. Sci. U S A , vol.99 , Issue.12 , pp. 8295-8300
    • Josephson, N.C.1    Vassilopoulos, G.2    Trobridge, G.D.3
  • 88
    • 0034925596 scopus 로고    scopus 로고
    • Long-term engraftment of nonobese diabetic/severe combined immunodeficient mice with human CD34+ cells transduced by a self-inactivating human immunodeficiency virus type 1 vector
    • Gatlin J , Padgett A , Melkus MW , Kelly PF , Garcia JV . Long-term engraftment of nonobese diabetic/severe combined immunodeficient mice with human CD34+ cells transduced by a self-inactivating human immunodeficiency virus type 1 vector . Hum Gene Ther 2001 ; 12 (9) : 1079-89 .
    • (2001) Hum. Gene. Ther. , vol.12 , Issue.9 , pp. 1079-1089
    • Gatlin, J.1    Padgett, A.2    Melkus, M.W.3    Kelly, P.F.4    Garcia, J.V.5
  • 89
    • 0034222871 scopus 로고    scopus 로고
    • Critical factors influencing stable transduction of human CD34(+) cells with HIV-1-derived lentiviral vectors
    • Haas DL , Case SS , Crooks GM , Kohn DB . Critical factors influencing stable transduction of human CD34(+) cells with HIV-1-derived lentiviral vectors . Mol Ther 2000 ; 2 (1) : 71-80 .
    • (2000) Mol. Ther. , vol.2 , Issue.1 , pp. 71-80
    • Haas, D.L.1    Case, S.S.2    Crooks, G.M.3    Kohn, D.B.4
  • 90
    • 0036588698 scopus 로고    scopus 로고
    • Development of gene therapy for blood disorders by gene transfer into haematopoietic stem cells
    • Karlsson S , Ooka A , Woods NB . Development of gene therapy for blood disorders by gene transfer into haematopoietic stem cells . Haemophilia 2002 ; 8 (3) : 255-60 .
    • (2002) Haemophilia , vol.8 , Issue.3 , pp. 255-260
    • Karlsson, S.1    Ooka, A.2    Woods, N.B.3
  • 91
    • 0037255009 scopus 로고    scopus 로고
    • High cloning capacity of in vitro packaged SV40 vectors with no SV40 virus sequences
    • Kimchi-Sarfaty C , Arora M , Sandalon Z , Oppenheim A , Gottesman MM . High cloning capacity of in vitro packaged SV40 vectors with no SV40 virus sequences . Hum Gene Ther 2003 ; 14 (2) : 167-77 .
    • (2003) Hum. Gene. Ther. , vol.14 , Issue.2 , pp. 167-177
    • Kimchi-Sarfaty, C.1    Arora, M.2    Sandalon, Z.3    Oppenheim, A.4    Gottesman, M.M.5
  • 92
    • 4844220670 scopus 로고    scopus 로고
    • SV40 pseudovirions as highly efficient vectors for gene transfer and their potential application in cancer therapy
    • Kimchi-Sarfaty C , Gottesman MM . SV40 pseudovirions as highly efficient vectors for gene transfer and their potential application in cancer therapy . Curr Pharm Biotechnol 2004 ; 5 (5) : 451-8 .
    • (2004) Curr Pharm Biotechnol , vol.5 , Issue.5 , pp. 451-458
    • Kimchi-Sarfaty, C.1    Gottesman, M.M.2
  • 93
    • 3943068445 scopus 로고    scopus 로고
    • Transduction of multiple cell types using improved conditions for gene delivery and expression of SV40 pseudovirions packaged in vitro
    • Kimchi-Sarfaty C , Alexander NS , Brittain S , Ali S , Gottesman MM . Transduction of multiple cell types using improved conditions for gene delivery and expression of SV40 pseudovirions packaged in vitro . Biotechniques 2004 ; 37 (2) : 270-5 .
    • (2004) Biotechniques , vol.37 , Issue.2 , pp. 270-275
    • Kimchi-Sarfaty, C.1    Alexander, N.S.2    Brittain, S.3    Ali, S.4    Gottesman, M.M.5
  • 94
    • 0035437131 scopus 로고    scopus 로고
    • Gene transfer into murine hematopoietic stem cells with helper-free foamy virus vectors
    • Vassilopoulos G , Trobridge G , Josephson NC , Russell DW . Gene transfer into murine hematopoietic stem cells with helper-free foamy virus vectors . Blood 2001 ; 98 (3) : 604-9 .
    • (2001) Blood , vol.98 , Issue.3 , pp. 604-609
    • Vassilopoulos, G.1    Trobridge, G.2    Josephson, N.C.3    Russell, D.W.4
  • 95
    • 0029655273 scopus 로고    scopus 로고
    • Foamy virus vectors
    • Russell DW , Miller AD . Foamy virus vectors . J Virol 1996 ; 70 (1) : 217-22 .
    • (1996) J. Virol. , vol.70 , Issue.1 , pp. 217-222
    • Russell, D.W.1    Miller, A.D.2
  • 97
    • 35948946526 scopus 로고    scopus 로고
    • Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery
    • Lombardo A , Genovese P , Beausejour CM , et al . Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery . Nat Biotechnol 2007 ; 25 (11) : 1298-306 .
    • (2007) Nat. Biotechnol. , vol.25 , Issue.11 , pp. 1298-1306
    • Lombardo, A.1    Genovese, P.2    Beausejour, C.M.3
  • 98
    • 36849060584 scopus 로고    scopus 로고
    • Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation state
    • Brown BD , Gentner B , Cantore A , et al . Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation state . Nat Biotechnol 2007 ; 25 (12) : 1457-67 .
    • (2007) Nat. Biotechnol. , vol.25 , Issue.12 , pp. 1457-1467
    • Brown, B.D.1    Gentner, B.2    Cantore, A.3
  • 99
    • 36849053006 scopus 로고    scopus 로고
    • A microRNA-regulated lentiviral vector mediates stable correction of hemophilia B mice
    • Brown BD , Cantore A , Annoni A , et al . A microRNA-regulated lentiviral vector mediates stable correction of hemophilia B mice . Blood 2007 ; 110 (13) : 4144-52 .
    • (2007) Blood , vol.110 , Issue.13 , pp. 4144-4152
    • Brown, B.D.1    Cantore, A.2    Annoni, A.3
  • 100
    • 0002613687 scopus 로고    scopus 로고
    • Methods for the construction of etroviral vectors and the generation of high titer producers
    • In: Robbins P , ed. Totowa , Humana Press
    • Riviere I , Sadelain , M.W.J. Methods for the construction of etroviral vectors and the generation of high titer producers . In: Robbins P , ed. Methods in Molecular Medicine . Totowa , Humana Press , 1997 , pp. 59 - 78 .
    • (1997) Methods in Molecular Medicine , pp. 59-78
    • Riviere, I.1    Sadelain, M.W.J.2
  • 101
    • 33644750264 scopus 로고    scopus 로고
    • Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TKmodified donor T cells after allogeneic hematopoietic cell transplantation
    • Berger C , Flowers ME , Warren EH , Riddell SR . Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TKmodified donor T cells after allogeneic hematopoietic cell transplantation . Blood 2006 ; 107 (6) : 2294-302 .
    • (2006) Blood , vol.107 , Issue.6 , pp. 2294-2302
    • Berger, C.1    Flowers, M.E.2    Warren, E.H.3    Riddell, S.R.4
  • 102
    • 17944370860 scopus 로고    scopus 로고
    • Elimination of the truncated message from the herpes simplex virus thymidine kinase suicide gene
    • Chalmers D , Ferrand C , Apperley JF , et al . Elimination of the truncated message from the herpes simplex virus thymidine kinase suicide gene . Mol Ther 2001 ; 4 (2) : 146-8 .
    • (2001) Mol. Ther. , vol.4 , Issue.2 , pp. 146-148
    • Chalmers, D.1    Ferrand, C.2    Apperley, J.F.3
  • 103
    • 0035174929 scopus 로고    scopus 로고
    • Molecular mechanism for ganciclovir resistancein human T lymphocytes transduced with retroviral vectors carrying the herpes simplex virus thymidine kinase gene
    • Garin MI , Garrett E , Tiberghien P , et al . Molecular mechanism for ganciclovir resistancein human T lymphocytes transduced with retroviral vectors carrying the herpes simplex virus thymidine kinase gene . Blood 2001 ; 97 (1) : 122-9 .
    • (2001) Blood , vol.97 , Issue.1 , pp. 122-129
    • Garin, M.I.1    Garrett, E.2    Tiberghien, P.3
  • 104
    • 34247194881 scopus 로고    scopus 로고
    • Engineered human tmpk/AZT as a novel enzyme/prodrug axis for suicide gene therapy
    • Sato T , Neschadim A , Konrad M , Fowler DH , Lavie A , Medin JA . Engineered human tmpk/AZT as a novel enzyme/prodrug axis for suicide gene therapy . Mol Ther 2007 ; 15 (5) : 962-70 .
    • (2007) Mol. Ther. , vol.15 , Issue.5 , pp. 962-970
    • Sato, T.1    Neschadim, A.2    Konrad, M.3    Fowler, D.H.4    Lavie, A.5    Medin, J.A.6
  • 105
    • 33646894965 scopus 로고    scopus 로고
    • In vivo transduction by intravenous injection of a lentiviral vector expressing human ADA into neonatal ADA gene knockout mice: A novel form of enzyme replacement therapy for ADA deficiency
    • Carbonaro DA , Jin X , Petersen D , et al . In vivo transduction by intravenous injection of a lentiviral vector expressing human ADA into neonatal ADA gene knockout mice: A novel form of enzyme replacement therapy for ADA deficiency . Mol Ther 2006 ; 13 (6) : 1110-20 .
    • (2006) Mol. Ther. , vol.13 , Issue.6 , pp. 1110-1120
    • Carbonaro, D.A.1    Jin, X.2    Petersen, D.3
  • 106
    • 39049181300 scopus 로고    scopus 로고
    • Murine and HIV-based retroviral vectors for in vitro and in vivo gene transfer
    • Alfa RW , Blesch A . Murine and HIV-based retroviral vectors for in vitro and in vivo gene transfer . Methods Mol Med 2006 ; 129 : 241-54 .
    • (2006) Methods Mol. Med. , vol.129 , pp. 241-254
    • Alfa, R.W.1    Blesch, A.2
  • 107
    • 33748069163 scopus 로고    scopus 로고
    • In vivo gene transfer into adult stem cells in unconditioned mice by in situ delivery of a lentiviral vector
    • Worsham DN , Schuesler T , von Kalle C , Pan D . In vivo gene transfer into adult stem cells in unconditioned mice by in situ delivery of a lentiviral vector . Mol Ther 2006 ; 14 (4) : 514-24 .
    • (2006) Mol. Ther. , vol.14 , Issue.4 , pp. 514-524
    • Worsham, D.N.1    Schuesler, T.2    Von Kalle, C.3    Pan, D.4
  • 108
    • 14844317327 scopus 로고    scopus 로고
    • Cell type-specific targeting with sindbis pseudotyped lentiviral vectors displaying anti-CCR5 single-chain antibodies
    • Aires da Silva F , Costa MJ , Corte-Real S , Goncalves J . Cell type-specific targeting with sindbis pseudotyped lentiviral vectors displaying anti-CCR5 single-chain antibodies . Hum Gene Ther 2005 ; 16 (2) : 223-34 .
    • (2005) Hum. Gene. Ther. , vol.16 , Issue.2 , pp. 223-234
    • Aires Da Silva, F.1    Costa, M.J.2    Corte-Real, S.3    Goncalves, J.4
  • 109
    • 0027158091 scopus 로고
    • Integration of murine leukemia virus DNA depends on mitosis
    • Roe T , Reynolds TC , Yu G , Brown PO . Integration of murine leukemia virus DNA depends on mitosis . Embo J 1993 ; 12 (5) : 2099-108 .
    • (1993) Embo. J. , vol.12 , Issue.5 , pp. 2099-2108
    • Roe, T.1    Reynolds, T.C.2    Yu, G.3    Brown, P.O.4
  • 110
    • 0032079507 scopus 로고    scopus 로고
    • Identification of human and mouse hematopoietic stem cell populations expressing high levels of mRNA encoding retrovirus receptors
    • Orlic D , Girard LJ , Anderson SM , et al . Identification of human and mouse hematopoietic stem cell populations expressing high levels of mRNA encoding retrovirus receptors . Blood 1998 ; 91 (9) : 3247-54 .
    • (1998) Blood , vol.91 , Issue.9 , pp. 3247-3254
    • Orlic, D.1    Girard, L.J.2    Anderson, S.M.3
  • 111
    • 0029767842 scopus 로고    scopus 로고
    • The level of mRNA encoding the amphotropic retrovirus receptor in mouse and human hematopoietic stem cells is low and correlates with the efficiency of retrovirus transduction
    • Orlic D , Girard LJ , Jordan CT , Anderson SM , Cline AP , Bodine DM . The level of mRNA encoding the amphotropic retrovirus receptor in mouse and human hematopoietic stem cells is low and correlates with the efficiency of retrovirus transduction . Proc Natl Acad Sci U S A 1996 ; 93 (20) : 11097-102 .
    • (1996) Proc. Natl. Acad. Sci. U S A , vol.93 , Issue.20 , pp. 11097-1102
    • Orlic, D.1    Girard, L.J.2    Jordan, C.T.3    Anderson, S.M.4    Cline, A.P.5    Bodine, D.M.6
  • 113
    • 0031418294 scopus 로고    scopus 로고
    • Amphotropic or gibbon ape leukemia virus retrovirus binding and transduction correlates with the level of receptor mRNA in human hematopoietic cell lines
    • Sabatino DE , Do BQ , Pyle LC , et al . Amphotropic or gibbon ape leukemia virus retrovirus binding and transduction correlates with the level of receptor mRNA in human hematopoietic cell lines . Blood Cells Mol Dis 1997 ; 23 (3) : 422-33 .
    • (1997) Blood Cells Mol. Dis. , vol.23 , Issue.3 , pp. 422-433
    • Sabatino, D.E.1    Do, B.Q.2    Pyle, L.C.3
  • 114
    • 0034171107 scopus 로고    scopus 로고
    • Superior transduction of mouse hematopoietic stem cells with 10A1 and VSV-G pseudotyped retrovirus vectors
    • Barrette S , Douglas J , Orlic D , et al . Superior transduction of mouse hematopoietic stem cells with 10A1 and VSV-G pseudotyped retrovirus vectors . Mol Ther 2000 ; 1 (4) : 330-8 .
    • (2000) Mol. Ther. , vol.1 , Issue.4 , pp. 330-338
    • Barrette, S.1    Douglas, J.2    Orlic, D.3
  • 115
    • 0037366196 scopus 로고    scopus 로고
    • Cytokines, including stem cell factor alone, enhance lentiviral transduction in nondividing human LTCIC and NOD/SCID repopulating cells
    • Zielske SP , Gerson SL . Cytokines, including stem cell factor alone, enhance lentiviral transduction in nondividing human LTCIC and NOD/SCID repopulating cells . Mol Ther 2003 ; 7 (3) : 325-33 .
    • (2003) Mol. Ther. , vol.7 , Issue.3 , pp. 325-333
    • Zielske, S.P.1    Gerson, S.L.2
  • 116
    • 0942266035 scopus 로고    scopus 로고
    • Lentivector-mediated clonal tracking reveals intrinsic heterogeneity in the human hematopoietic stem cell compartment and culture-induced stem cell impairment
    • Mazurier F , Gan OI , McKenzie JL , Doedens M , Dick JE . Lentivector-mediated clonal tracking reveals intrinsic heterogeneity in the human hematopoietic stem cell compartment and culture-induced stem cell impairment . Blood 2004 ; 103 (2) : 545-52 .
    • (2004) Blood , vol.103 , Issue.2 , pp. 545-552
    • Mazurier, F.1    Gan, O.I.2    McKenzie, J.L.3    Doedens, M.4    Dick, J.E.5
  • 117
    • 0032529523 scopus 로고    scopus 로고
    • Ex vivo expansion of genetically marked rhesus peripheral blood progenitor cells results in diminished long-term repopulating ability
    • Tisdale JF , Hanazono Y , Sellers SE , et al . Ex vivo expansion of genetically marked rhesus peripheral blood progenitor cells results in diminished long-term repopulating ability . Blood 1998 ; 92 (4) : 1131-41 .
    • (1998) Blood , vol.92 , Issue.4 , pp. 1131-1141
    • Tisdale, J.F.1    Hanazono, Y.2    Sellers, S.E.3
  • 118
    • 0033964863 scopus 로고    scopus 로고
    • Expansion of human cord blood CD34(+)CD38(-) cells in ex vivo culture during retroviral transduction without a corresponding increase in SCID repopulating cell (SRC) frequency: Dissociation of SRC phenotype and function
    • Dorrell C , Gan OI , Pereira DS , Hawley RG , Dick JE . Expansion of human cord blood CD34(+)CD38(-) cells in ex vivo culture during retroviral transduction without a corresponding increase in SCID repopulating cell (SRC) frequency: Dissociation of SRC phenotype and function . Blood 2000 ; 95 (1) : 102-10 .
    • (2000) Blood , vol.95 , Issue.1 , pp. 102-110
    • Dorrell, C.1    Gan, O.I.2    Pereira, D.S.3    Hawley, R.G.4    Dick, J.E.5
  • 119
    • 0032532361 scopus 로고    scopus 로고
    • Cell cycle-related changes in repopulating capacity of human mobilized peripheral blood CD34(+) cells in non-obese diabetic/ severe combined immune-deficient mice
    • Gothot A , Van der Loo JC , Clapp DW , Srour EF . Cell cycle-related changes in repopulating capacity of human mobilized peripheral blood CD34(+) cells in non-obese diabetic/ severe combined immune-deficient mice . Blood 1998 ; 92 (8) : 2641-9 .
    • (1998) Blood , vol.92 , Issue.8 , pp. 2641-2649
    • Gothot, A.1    Van Der Loo, J.C.2    Clapp, D.W.3    Srour, E.F.4
  • 120
    • 0036226607 scopus 로고    scopus 로고
    • Lentiviral transduction of P140K MGMT into human CD34(+) hematopoietic progenitors at low multiplicity of infection confers significant resistance to BG/BCNU and allows selection in vitro
    • Zielske SP , Gerson SL . Lentiviral transduction of P140K MGMT into human CD34(+) hematopoietic progenitors at low multiplicity of infection confers significant resistance to BG/BCNU and allows selection in vitro . Mol Ther 2002 ; 5 (4) : 381-7 .
    • (2002) Mol. Ther. , vol.5 , Issue.4 , pp. 381-387
    • Zielske, S.P.1    Gerson, S.L.2
  • 121
    • 0037108187 scopus 로고    scopus 로고
    • Gene therapy of Fanconi anemia: Preclinical efficacy using lentiviral vectors
    • Galimi F , Noll M , Kanazawa Y , et al . Gene therapy of Fanconi anemia: Preclinical efficacy using lentiviral vectors . Blood 2002 ; 100 (8) : 2732-6 .
    • (2002) Blood , vol.100 , Issue.8 , pp. 2732-2736
    • Galimi, F.1    Noll, M.2    Kanazawa, Y.3
  • 122
    • 0036682935 scopus 로고    scopus 로고
    • Lentiviral vectors pseudotyped with a modified RD114 envelope glycoprotein show increased stability in sera and augmented transduction of primary lymphocytes and CD34+ cells derived from human and nonhuman primates
    • Sandrin V , Boson B , Salmon P , et al . Lentiviral vectors pseudotyped with a modified RD114 envelope glycoprotein show increased stability in sera and augmented transduction of primary lymphocytes and CD34+ cells derived from human and nonhuman primates . Blood 2002 ; 100 (3) : 823-32 .
    • (2002) Blood , vol.100 , Issue.3 , pp. 823-832
    • Sandrin, V.1    Boson, B.2    Salmon, P.3
  • 123
    • 1242296984 scopus 로고    scopus 로고
    • Cell cycle requirements for transduction by foamy virus vectors compared to those of oncovirus and lentivirus vectors
    • Trobridge G , Russell DW . Cell cycle requirements for transduction by foamy virus vectors compared to those of oncovirus and lentivirus vectors . J Virol 2004 ; 78 (5) : 2327-35 .
    • (2004) J. Virol. , vol.78 , Issue.5 , pp. 2327-2335
    • Trobridge, G.1    Russell, D.W.2
  • 124
    • 19444378586 scopus 로고    scopus 로고
    • Efficiency of transduction of highly purified murine hematopoietic stem cells by lentiviral and oncoretroviral vectors under conditions of minimal in vitro manipulation
    • Mostoslavsky G , Kotton DN , Fabian AJ , Gray JT , Lee JS , Mulligan RC . Efficiency of transduction of highly purified murine hematopoietic stem cells by lentiviral and oncoretroviral vectors under conditions of minimal in vitro manipulation . Mol Ther 2005 ; 11 (6) : 932-40 .
    • (2005) Mol. Ther. , vol.11 , Issue.6 , pp. 932-940
    • Mostoslavsky, G.1    Kotton, D.N.2    Fabian, A.J.3    Gray, J.T.4    Lee, J.S.5    Mulligan, R.C.6
  • 125
    • 33746239571 scopus 로고    scopus 로고
    • Functional assessment of the engraftment potential of gammaretrovirus-modified CD34+ cells, using a short serum-free transduction protocol
    • Budak-Alpdogan T , Przybylowski M , Gonen M , Sadelain M , Bertino J , Riviere I . Functional assessment of the engraftment potential of gammaretrovirus-modified CD34+ cells, using a short serum-free transduction protocol . Hum Gene Ther 2006 ; 17 (7) : 780-94 .
    • (2006) Hum. Gene. Ther. , vol.17 , Issue.7 , pp. 780-794
    • Budak-Alpdogan, T.1    Przybylowski, M.2    Gonen, M.3    Sadelain, M.4    Bertino, J.5    Riviere, I.6
  • 126
    • 12144291490 scopus 로고    scopus 로고
    • Mobilized blood CD34+ cells transduced and selected with a clinically applicable protocol reconstitute lymphopoiesis in SCID-Hu mice
    • Deola S , Scaramuzza S , Birolo RS , et al . Mobilized blood CD34+ cells transduced and selected with a clinically applicable protocol reconstitute lymphopoiesis in SCID-Hu mice . Hum Gene Ther 2004 ; 15 (3) : 305-11 .
    • (2004) Hum. Gene. Ther. , vol.15 , Issue.3 , pp. 305-311
    • Deola, S.1    Scaramuzza, S.2    Birolo, R.S.3
  • 127
    • 0029784888 scopus 로고    scopus 로고
    • Fibronectin improves transduction of reconstituting hematopoietic stem cells by retroviral vectors: Evidence of direct viral binding to chymotryptic carboxy-terminal fragments
    • Moritz T , Dutt P , Xiao X , et al . Fibronectin improves transduction of reconstituting hematopoietic stem cells by retroviral vectors: Evidence of direct viral binding to chymotryptic carboxy-terminal fragments . Blood 1996 ; 88 (3) : 855-62 .
    • (1996) Blood , vol.88 , Issue.3 , pp. 855-862
    • Moritz, T.1    Dutt, P.2    Xiao, X.3
  • 128
    • 0031564330 scopus 로고    scopus 로고
    • Optimization of fibronectin-assisted retroviral gene transfer into human CD34+ hematopoietic cells
    • Hanenberg H , Hashino K , Konishi H , Hock RA , Kato I , Williams DA . Optimization of fibronectin-assisted retroviral gene transfer into human CD34+ hematopoietic cells . Hum Gene Ther 1997 ; 8 (18) : 2193-206 .
    • (1997) Hum. Gene. Ther. , vol.8 , Issue.18 , pp. 2193-2206
    • Hanenberg, H.1    Hashino, K.2    Konishi, H.3    Hock, R.A.4    Kato, I.5    Williams, D.A.6
  • 129
    • 84858429431 scopus 로고    scopus 로고
    • Bone marrow extracellular matrix molecules improve with sindbis pseudotyped lentiviral vectors displaying anti-CCR5 single-chain antibodies
    • Moritz T , Patel VP , Williams DA . Bone marrow extracellular matrix molecules improve with sindbis pseudotyped lentiviral vectors displaying anti-CCR5 single-chain antibodies . Hum Gene Ther 2005 ; 16 (2) : 223-34
    • (2005) Hum. Gene. Ther. , vol.16 , Issue.2 , pp. 223-234
    • Moritz, T.1    Patel, V.P.2    Williams, D.A.3
  • 130
    • 0027158091 scopus 로고
    • Integration of murine leukemia virus DNA depends on mitosis
    • Roe T , Reynolds TC , Yu G , Brown PO . Integration of murine leukemia virus DNA depends on mitosis . Embo J 1993 ; 12 (5) : 2099-108
    • (1993) Embo. J. , vol.12 , Issue.5 , pp. 2099-2108
    • Roe, T.1    Reynolds, T.C.2    Yu, G.3    Brown, P.O.4
  • 131
    • 0032079507 scopus 로고    scopus 로고
    • Identification of human and mouse hematopoietic stem cell populations expressing high levels of mRNA encoding retrovirus receptors
    • Orlic D , Girard LJ , Anderson SM , et al . Identification of human and mouse hematopoietic stem cell populations expressing high levels of mRNA encoding retrovirus receptors . Blood 1998 ; 91 (9) : 3247-54 .
    • (1998) Blood , vol.91 , Issue.9 , pp. 3247-3254
    • Orlic, D.1    Girard, L.J.2    Anderson, S.M.3
  • 132
    • 0029767842 scopus 로고    scopus 로고
    • The level of mRNA encoding the amphotropic retrovirus receptor in mouse and human hematopoietic stem cells is low and correlates with the efficiency of retrovirus transduction
    • Orlic D , Girard LJ , Jordan CT , Anderson SM , Cline AP , Bodine DM . The level of mRNA encoding the amphotropic retrovirus receptor in mouse and human hematopoietic stem cells is low and correlates with the efficiency of retrovirus transduction . Proc Natl Acad Sci U S A 1996 ; 93 (20) : 11097-102 .
    • (1996) Proc. Natl. Acad. Sci. U S A , vol.93 , Issue.20 , pp. 11097-11102
    • Orlic, D.1    Girard, L.J.2    Jordan, C.T.3    Anderson, S.M.4    Cline, A.P.5    Bodine, D.M.6
  • 134
    • 0031418294 scopus 로고    scopus 로고
    • Amphotropic or gibbon ape leukemia virus retrovirus binding and transduction correlates with the level of receptor mRNA in human hematopoietic cell lines
    • Sabatino DE , Do BQ , Pyle LC , et al . Amphotropic or gibbon ape leukemia virus retrovirus binding and transduction correlates with the level of receptor mRNA in human hematopoietic cell lines . Blood Cells Mol Dis 1997 ; 23 (3) : 422-33 .
    • (1997) Blood Cells Mol. Dis. , vol.23 , Issue.3 , pp. 422-433
    • Sabatino, D.E.1    Do, B.Q.2    Pyle, L.C.3
  • 135
    • 0034171107 scopus 로고    scopus 로고
    • Superior transduction of mouse hematopoietic stem cells with 10A1 and VSV-G pseudotyped retrovirus vectors
    • Barrette S , Douglas J , Orlic D , et al . Superior transduction of mouse hematopoietic stem cells with 10A1 and VSV-G pseudotyped retrovirus vectors . Mol Ther 2000 ; 1 (4) : 330-8 .
    • (2000) Mol. Ther. , vol.1 , Issue.4 , pp. 330-338
    • Barrette, S.1    Douglas, J.2    Orlic, D.3
  • 136
    • 0037366196 scopus 로고    scopus 로고
    • Cytokines, including stem cell factor alone, enhance lentiviral transduction in nondividing human LTCIC and NOD/SCID repopulating cells
    • Zielske SP , Gerson SL . Cytokines, including stem cell factor alone, enhance lentiviral transduction in nondividing human LTCIC and NOD/SCID repopulating cells . Mol Ther 2003 ; 7 (3) : 325-33 .
    • (2003) Mol. Ther. , vol.7 , Issue.3 , pp. 325-333
    • Zielske, S.P.1    Gerson, S.L.2
  • 137
    • 0942266035 scopus 로고    scopus 로고
    • Lentivector-mediated clonal tracking reveals intrinsic heterogeneity in the human hematopoietic stem cell compartment and culture-induced stem cell impairment
    • Mazurier F , Gan OI , McKenzie JL , Doedens M , Dick JE . Lentivector-mediated clonal tracking reveals intrinsic heterogeneity in the human hematopoietic stem cell compartment and culture-induced stem cell impairment . Blood 2004 ; 103 (2) : 545-52 .
    • (2004) Blood , vol.103 , Issue.2 , pp. 545-552
    • Mazurier, F.1    Gan, O.I.2    McKenzie, J.L.3    Doedens, M.4    Dick, J.E.5
  • 138
    • 0032529523 scopus 로고    scopus 로고
    • Ex vivo expansion of genetically marked rhesus peripheral blood progenitor cells results in diminished long-term repopulating ability
    • Tisdale JF , Hanazono Y , Sellers SE , et al . Ex vivo expansion of genetically marked rhesus peripheral blood progenitor cells results in diminished long-term repopulating ability . Blood 1998 ; 92 (4) : 1131-41 .
    • (1998) Blood , vol.92 , Issue.4 , pp. 1131-1141
    • Tisdale, J.F.1    Hanazono, Y.2    Sellers, S.E.3
  • 139
    • 0033964863 scopus 로고    scopus 로고
    • Expansion of human cord blood CD34(+)CD38(-) cells in ex vivo culture during retroviral transduction without a corresponding increase in SCID repopulating cell (SRC) frequency: Dissociation of SRC phenotype and function
    • Dorrell C , Gan OI , Pereira DS , Hawley RG , Dick JE . Expansion of human cord blood CD34(+)CD38(-) cells in ex vivo culture during retroviral transduction without a corresponding increase in SCID repopulating cell (SRC) frequency: Dissociation of SRC phenotype and function . Blood 2000 ; 95 (1) : 102-10 .
    • (2000) Blood , vol.95 , Issue.1 , pp. 102-110
    • Dorrell, C.1    Gan, O.I.2    Pereira, D.S.3    Hawley, R.G.4    Dick, J.E.5
  • 140
    • 0032532361 scopus 로고    scopus 로고
    • Cell cycle-related changes in repopulating capacity of human mobilized peripheral blood CD34(+) cells in non-obese diabetic/ severe combined immune-deficient mice
    • Gothot A , Van der Loo JC , Clapp DW , Srour EF . Cell cycle-related changes in repopulating capacity of human mobilized peripheral blood CD34(+) cells in non-obese diabetic/ severe combined immune-deficient mice . Blood 1998 ; 92 (8) : 2641-9 .
    • (1998) Blood , vol.92 , Issue.8 , pp. 2641-2649
    • Gothot, A.1    Van Der Loo, J.C.2    Clapp, D.W.3    Srour, E.F.4
  • 141
    • 0036226607 scopus 로고    scopus 로고
    • Lentiviral transduction of P140K MGMT into human CD34(+) hematopoietic progenitors at low multiplicity of infection confers significant resistance to BG/BCNU and allows selection in vitro
    • Zielske SP , Gerson SL . Lentiviral transduction of P140K MGMT into human CD34(+) hematopoietic progenitors at low multiplicity of infection confers significant resistance to BG/BCNU and allows selection in vitro . Mol Ther 2002 ; 5 (4) : 381-7 .
    • (2002) Mol. Ther. , vol.5 , Issue.4 , pp. 381-387
    • Zielske, S.P.1    Gerson, S.L.2
  • 142
    • 0037108187 scopus 로고    scopus 로고
    • Gene therapy of Fanconi anemia: Preclinical efficacy using lentiviral vectors
    • Galimi F , Noll M , Kanazawa Y , et al . Gene therapy of Fanconi anemia: Preclinical efficacy using lentiviral vectors . Blood 2002 ; 100 (8) : 2732-6 .
    • (2002) Blood , vol.100 , Issue.8 , pp. 2732-2736
    • Galimi, F.1    Noll, M.2    Kanazawa, Y.3
  • 143
    • 0036682935 scopus 로고    scopus 로고
    • Lentiviral vectors pseudotyped with a modified RD114 envelope glycoprotein show increased stability in sera and augmented transduction of primary lymphocytes and CD34+ cells derived from human and nonhuman primates
    • Sandrin V , Boson B , Salmon P , et al . Lentiviral vectors pseudotyped with a modified RD114 envelope glycoprotein show increased stability in sera and augmented transduction of primary lymphocytes and CD34+ cells derived from human and nonhuman primates . Blood 2002 ; 100 (3) : 823-32 .
    • (2002) Blood , vol.100 , Issue.3 , pp. 823-832
    • Sandrin, V.1    Boson, B.2    Salmon, P.3
  • 144
    • 1242296984 scopus 로고    scopus 로고
    • Cell cycle requirements for transduction by foamy virus vectors compared to those of oncovirus and lentivirus vectors
    • Trobridge G , Russell DW . Cell cycle requirements for transduction by foamy virus vectors compared to those of oncovirus and lentivirus vectors . J Virol 2004 ; 78 (5) : 2327-35 .
    • (2004) J. Virol. , vol.78 , Issue.5 , pp. 2327-2335
    • Trobridge, G.1    Russell, D.W.2
  • 145
    • 19444378586 scopus 로고    scopus 로고
    • Efficiency of transduction of highly purified murine hematopoietic stem cells by lentiviral and oncoretroviral vectors under conditions of minimal in vitro manipulation
    • Mostoslavsky G , Kotton DN , Fabian AJ , Gray JT , Lee JS , Mulligan RC . Efficiency of transduction of highly purified murine hematopoietic stem cells by lentiviral and oncoretroviral vectors under conditions of minimal in vitro manipulation . Mol Ther 2005 ; 11 (6) : 932-40 .
    • (2005) Mol. Ther. , vol.11 , Issue.6 , pp. 932-940
    • Mostoslavsky, G.1    Kotton, D.N.2    Fabian, A.J.3    Gray, J.T.4    Lee, J.S.5    Mulligan, R.C.6
  • 146
    • 33746239571 scopus 로고    scopus 로고
    • Functional assessment of the engraftment potential of gammaretrovirus-modified CD34+ cells, using a short serum-free transduction protocol
    • Budak-Alpdogan T , Przybylowski M , Gonen M , Sadelain M , Bertino J , Riviere I . Functional assessment of the engraftment potential of gammaretrovirus-modified CD34+ cells, using a short serum-free transduction protocol . Hum Gene Ther 2006 ; 17 (7) : 780-94 .
    • (2006) Hum. Gene. Ther. , vol.17 , Issue.7 , pp. 780-794
    • Budak-Alpdogan, T.1    Przybylowski, M.2    Gonen, M.3    Sadelain, M.4    Bertino, J.5    Riviere, I.6
  • 147
    • 12144291490 scopus 로고    scopus 로고
    • Mobilized blood CD34+ cells transduced and selected with a clinically applicable protocol reconstitute lymphopoiesis in SCID-Hu mice
    • Deola S , Scaramuzza S , Birolo RS , et al . Mobilized blood CD34+ cells transduced and selected with a clinically applicable protocol reconstitute lymphopoiesis in SCID-Hu mice . Hum Gene Ther 2004 ; 15 (3) : 305-11 .
    • (2004) Hum. Gene. Ther. , vol.15 , Issue.3 , pp. 305-311
    • Deola, S.1    Scaramuzza, S.2    Birolo, R.S.3
  • 148
    • 0029784888 scopus 로고    scopus 로고
    • Fibronectin improves transduction of reconstituting hematopoietic stem cells by retroviral vectors: Evidence of direct viral binding to chymotryptic carboxy-terminal fragments
    • Moritz T , Dutt P , Xiao X , et al . Fibronectin improves transduction of reconstituting hematopoietic stem cells by retroviral vectors: Evidence of direct viral binding to chymotryptic carboxy-terminal fragments . Blood 1996 ; 88 (3) : 855-62 .
    • (1996) Blood , vol.88 , Issue.3 , pp. 855-862
    • Moritz, T.1    Dutt, P.2    Xiao, X.3
  • 149
    • 0031564330 scopus 로고    scopus 로고
    • Optimization of fibronectin-assisted retroviral gene transfer into human CD34+ hematopoietic cells
    • Hanenberg H , Hashino K , Konishi H , Hock RA , Kato I , Williams DA . Optimization of fibronectin-assisted retroviral gene transfer into human CD34+ hematopoietic cells . Hum Gene Ther 1997 ; 8 (18) : 2193-206
    • (1997) Hum. Gene. Ther. , vol.8 , Issue.18 , pp. 2193-2206
    • Hanenberg, H.1    Hashino, K.2    Konishi, H.3    Hock, R.A.4    Kato, I.5    Williams, D.A.6
  • 150
    • 0028176884 scopus 로고
    • Bone marrow extracellular matrix molecules improve gene transfer into human hematopoietic cells via retroviral vectors
    • Moritz T , Patel VP , Williams DA . Bone marrow extracellular matrix molecules improve gene transfer into human hematopoietic cells via retroviral vectors . J Clin Invest 1994 ; 93 (4) : 1451-7 .
    • (1994) J. Clin. Invest. , vol.93 , Issue.4 , pp. 1451-1457
    • Moritz, T.1    Patel, V.P.2    Williams, D.A.3
  • 151
    • 0032692396 scopus 로고    scopus 로고
    • Facilitation of retrovirus- mediated gene transfer into hematopoietic stem and progenitor cells and peripheral blood T-lymphocytes utilizing recombinant fibronectin fragments
    • Pollok KE , Williams DA . Facilitation of retrovirus- mediated gene transfer into hematopoietic stem and progenitor cells and peripheral blood T-lymphocytes utilizing recombinant fibronectin fragments . Curr Opin Mol Ther 1999 ; 1 (5) : 595-604 .
    • (1999) Curr. Opin. Mol. Ther. , vol.1 , Issue.5 , pp. 595-604
    • Pollok, K.E.1    Williams, D.A.2
  • 152
    • 0032104669 scopus 로고    scopus 로고
    • An improved method for generating retroviral producer clones for vectors lacking a selectable marker gene
    • Persons DA , Mehaffey MG , Kaleko M , Nienhuis AW , Vanin EF . An improved method for generating retroviral producer clones for vectors lacking a selectable marker gene . Blood Cells Mol Dis 1998 ; 24 (2) : 167-82 .
    • (1998) Blood Cells Mol. Dis. , vol.24 , Issue.2 , pp. 167-182
    • Persons, D.A.1    Mehaffey, M.G.2    Kaleko, M.3    Nienhuis, A.W.4    Vanin, E.F.5
  • 153
    • 0037139748 scopus 로고    scopus 로고
    • Transduction rate constant as more reliable index quantifying efficiency of retroviral gene delivery
    • Kwon YJ , Peng CA . Transduction rate constant as more reliable index quantifying efficiency of retroviral gene delivery . Biotechnol Bioeng 2002 ; 77 (6) : 668-77 .
    • (2002) Biotechnol Bioeng , vol.77 , Issue.6 , pp. 668-677
    • Kwon, Y.J.1    Peng, C.A.2
  • 154
    • 0038709669 scopus 로고    scopus 로고
    • Determination of infectious retro virus concentration from colony-forming assay with quantitative analysis
    • Kwon YJ , Hung G , Anderson WF , Peng CA , Yu H . Determination of infectious retro virus concentration from colony-forming assay with quantitative analysis . J Virol 2003 ; 77 (10) : 5712-20 .
    • (2003) J. Virol. , vol.77 , Issue.10 , pp. 5712-5720
    • Kwon, Y.J.1    Hung, G.2    Anderson, W.F.3    Peng, C.A.4    Yu, H.5
  • 155
    • 0037134792 scopus 로고    scopus 로고
    • Polybrene increases retrovirus gene transfer efficiency by enhancing receptor-independent virus adsorption on target cell membranes
    • Davis HE , Morgan JR , Yarmush ML . Polybrene increases retrovirus gene transfer efficiency by enhancing receptor-independent virus adsorption on target cell membranes . Biophys Chem 2002 ; 97 (2-3) : 159-72 .
    • (2002) Biophys. Chem. , vol.97 , Issue.2-3 , pp. 159-172
    • Davis, H.E.1    Morgan, J.R.2    Yarmush, M.L.3
  • 156
    • 1142286425 scopus 로고    scopus 로고
    • Charged polymers modulate retrovirus transduction via membrane charge neutralization and virus aggregation
    • Davis HE , Rosinski M , Morgan JR , Yarmush ML . Charged polymers modulate retrovirus transduction via membrane charge neutralization and virus aggregation . Biophys J 2004 ; 86 (2) : 1234-42 .
    • (2004) Biophys. J. , vol.86 , Issue.2 , pp. 1234-1242
    • Davis, H.E.1    Rosinski, M.2    Morgan, J.R.3    Yarmush, M.L.4
  • 157
    • 0029156324 scopus 로고
    • Centrifugal enhancement of retroviral mediated gene transfer
    • Bahnson AB , Dunigan JT , Baysal BE , et al . Centrifugal enhancement of retroviral mediated gene transfer . J Virol Methods 1995 ; 54 (2-3) : 131-43 .
    • (1995) J. Virol. Methods , vol.54 , Issue.2-3 , pp. 131-143
    • Bahnson, A.B.1    Dunigan, J.T.2    Baysal, B.E.3
  • 158
    • 0036226792 scopus 로고    scopus 로고
    • Highly efficient retroviral gene transfer based on centrifugation- mediated vector preloading of tissue culture vessels
    • Kuhlcke K , Fehse B , Schilz A , et al . Highly efficient retroviral gene transfer based on centrifugation-mediated vector preloading of tissue culture vessels . Mol Ther 2002 ; 5 (4) : 473-8 .
    • (2002) Mol. Ther. , vol.5 , Issue.4 , pp. 473-478
    • Kuhlcke, K.1    Fehse, B.2    Schilz, A.3
  • 159
    • 0031844578 scopus 로고    scopus 로고
    • Comparison of methods for retroviral mediated transfer of glucocerebrosidase gene to CD34+ hematopoietic progenitor cells
    • Takiyama N , Mohney T , Swaney W , et al . Comparison of methods for retroviral mediated transfer of glucocerebrosidase gene to CD34+ hematopoietic progenitor cells . Eur J Haematol 1998 ; 61 (1) : 1-6 .
    • (1998) Eur. J. Haematol. , vol.61 , Issue.1 , pp. 1-6
    • Takiyama, N.1    Mohney, T.2    Swaney, W.3
  • 160
    • 0033589755 scopus 로고    scopus 로고
    • Increased gene transfer into human cord blood cells by centrifugation-enhanced transduction in fibronectin fragment-coated tubes
    • Sanyal A , Schuening FG . Increased gene transfer into human cord blood cells by centrifugation-enhanced transduction in fibronectin fragment-coated tubes . Hum Gene Ther 1999 ; 10 (17) : 2859-68 .
    • (1999) Hum. Gene. Ther. , vol.10 , Issue.17 , pp. 2859-2868
    • Sanyal, A.1    Schuening, F.G.2
  • 161
    • 0032548402 scopus 로고    scopus 로고
    • High-level gene transfer to cord blood progenitors using gibbon ape leukemia virus pseudotype retroviral vectors and an improved clinically applicable protocol
    • Movassagh M , Desmyter C , Baillou C , et al . High-level gene transfer to cord blood progenitors using gibbon ape leukemia virus pseudotype retroviral vectors and an improved clinically applicable protocol . Hum Gene Ther 1998 ; 9 (2) : 225-34 .
    • (1998) Hum. Gene. Ther. , vol.9 , Issue.2 , pp. 225-234
    • Movassagh, M.1    Desmyter, C.2    Baillou, C.3
  • 162
    • 0031263785 scopus 로고    scopus 로고
    • Comparison of retroviral-mediated gene transfer into cultured human CD34+ hematopoietic progenitor cells derived from peripheral blood, bone marrow, and fetal umbilical cord blood
    • Campain JA , Terrell KL , Tomczak JA , Shpall EJ , Hami LS , Harrison GS . Comparison of retroviral-mediated gene transfer into cultured human CD34+ hematopoietic progenitor cells derived from peripheral blood, bone marrow, and fetal umbilical cord blood . Biol Blood Marrow Transplant 1997 ; 3 (5) : 273-81 .
    • (1997) Biol. Blood Marrow Transplant , vol.3 , Issue.5 , pp. 273-281
    • Campain, J.A.1    Terrell, K.L.2    Tomczak, J.A.3    Shpall, E.J.4    Hami, L.S.5    Harrison, G.S.6
  • 163
    • 0035351273 scopus 로고    scopus 로고
    • Retroviral transduction of human CD34+ cells on fibronectin fragment CH-296 is inhibited by high concentrations of vector containing medium
    • Relander T , Brun A , Hawley RG , Karlsson S , Richter J . Retroviral transduction of human CD34+ cells on fibronectin fragment CH-296 is inhibited by high concentrations of vector containing medium . J Gene Med 2001 ; 3 (3) : 207-18 .
    • (2001) J. Gene. Med. , vol.3 , Issue.3 , pp. 207-218
    • Relander, T.1    Brun, A.2    Hawley, R.G.3    Karlsson, S.4    Richter, J.5
  • 164
    • 0033587581 scopus 로고    scopus 로고
    • Optimization of retroviral gene transduction of mobilized primitive hematopoietic progenitors by using thrombopoietin, Flt3, and Kit ligands and RetroNectin culture
    • Murray L , Luens K , Tushinski R , et al . Optimization of retroviral gene transduction of mobilized primitive hematopoietic progenitors by using thrombopoietin, Flt3, and Kit ligands and RetroNectin culture . Hum Gene Ther 1999 ; 10 (11) : 1743-52 .
    • (1999) Hum. Gene. Ther. , vol.10 , Issue.11 , pp. 1743-1752
    • Murray, L.1    Luens, K.2    Tushinski, R.3
  • 165
    • 0034855958 scopus 로고    scopus 로고
    • Removal of inhibitory substances with recombinant fibronectin-CH-296 plates enhances the retroviral transduction efficiency of CD34(+)CD38(-) bone marrow cells
    • Chono H , Yoshioka H , Ueno M , Kato I . Removal of inhibitory substances with recombinant fibronectin-CH-296 plates enhances the retroviral transduction efficiency of CD34(+)CD38(-) bone marrow cells . J Biochem (Tokyo) 2001 ; 130 (3) : 331-4 .
    • (2001) J. Biochem. (Tokyo) , vol.130 , Issue.3 , pp. 331-334
    • Chono, H.1    Yoshioka, H.2    Ueno, M.3    Kato, I.4
  • 166
    • 0142199654 scopus 로고    scopus 로고
    • Dose finding with retroviral vectors: Correlation of retroviral vector copy numbers in single cells with gene transfer efficiency in a cell population
    • Kustikova OS , Wahlers A , Kuhlcke K , et al . Dose finding with retroviral vectors: Correlation of retroviral vector copy numbers in single cells with gene transfer efficiency in a cell population . Blood 2003 ; 102 (12) : 3934-7 .
    • (2003) Blood , vol.102 , Issue.12 , pp. 3934-3937
    • Kustikova, O.S.1    Wahlers, A.2    Kuhlcke, K.3
  • 167
    • 0033034215 scopus 로고    scopus 로고
    • Thrombopoietin, flt3, and kit ligands together suppress apoptosis of human mobilized CD34+ cells and recruit primitive CD34+ Thy- 1+ cells into rapid division
    • Murray LJ , Young JC , Osborne LJ , Luens KM , Scollay R , Hill BL . Thrombopoietin, flt3, and kit ligands together suppress apoptosis of human mobilized CD34+ cells and recruit primitive CD34+ Thy- 1+ cells into rapid division . Exp Hematol 1999 ; 27 (6) : 1019-28 .
    • (1999) Exp. Hematol. , vol.27 , Issue.6 , pp. 1019-1028
    • Murray, L.J.1    Young, J.C.2    Osborne, L.J.3    Luens, K.M.4    Scollay, R.5    Hill, B.L.6
  • 168
    • 0034791699 scopus 로고    scopus 로고
    • Early-acting cytokine-driven ex vivo expansion of mobilized peripheral blood CD34+ cells generates post-mitotic offspring with preserved engraftment ability in non-obese diabetic/ severe combined immunodeficient mice
    • Herrera C , Sanchez J , Torres A , Bellido C , Rueda A , Alvarez MA . Early-acting cytokine-driven ex vivo expansion of mobilized peripheral blood CD34+ cells generates post-mitotic offspring with preserved engraftment ability in non-obese diabetic/ severe combined immunodeficient mice . Br J Haematol 2001 ; 114 (4) : 920-30 .
    • (2001) Br. J. Haematol. , vol.114 , Issue.4 , pp. 920-930
    • Herrera, C.1    Sanchez, J.2    Torres, A.3    Bellido, C.4    Rueda, A.5    Alvarez, M.A.6
  • 169
    • 0034478163 scopus 로고    scopus 로고
    • Optimized retroviral transduction protocol for human progenitor cells utilizing fibronectin fragments
    • Trarbach T , Greifenberg S , Bardenheuer W , et al . Optimized retroviral transduction protocol for human progenitor cells utilizing fibronectin fragments . Cytotherapy 2000 ; 2 (6) : 429-38 .
    • (2000) Cytotherapy , vol.2 , Issue.6 , pp. 429-438
    • Trarbach, T.1    Greifenberg, S.2    Bardenheuer, W.3
  • 170
    • 0032923391 scopus 로고    scopus 로고
    • Optimization of retroviral-mediated gene transfer to human NOD/SCID mouse repopulating cord blood cells through a systematic analysis of protocol variables
    • Hennemann B , Conneally E , Pawliuk R , et al . Optimization of retroviral-mediated gene transfer to human NOD/SCID mouse repopulating cord blood cells through a systematic analysis of protocol variables . Exp Hematol 1999 ; 27 (5) : 817-25 .
    • (1999) Exp. Hematol. , vol.27 , Issue.5 , pp. 817-825
    • Hennemann, B.1    Conneally, E.2    Pawliuk, R.3
  • 171
    • 0036374931 scopus 로고    scopus 로고
    • Optimization of gene transfer into primitive human hematopoietic cells of granulocyte-colony stimulating factor-mobilized peripheral blood using low-dose cytokines and comparison of a gibbon ape leukemia virus versus an RD114-pseudotyped retroviral vector
    • Van der Loo JC , Liu BL , Goldman AI , Buckley SM , Chrudimsky KS . Optimization of gene transfer into primitive human hematopoietic cells of granulocyte-colony stimulating factor-mobilized peripheral blood using low-dose cytokines and comparison of a gibbon ape leukemia virus versus an RD114-pseudotyped retroviral vector . Hum Gene Ther 2002 ; 13 (11) : 1317-30 .
    • (2002) Hum. Gene. Ther. , vol.13 , Issue.11 , pp. 1317-1330
    • Van Der Loo, J.C.1    Liu, B.L.2    Goldman, A.I.3    Buckley, S.M.4    Chrudimsky, K.S.5
  • 172
    • 0036518338 scopus 로고    scopus 로고
    • Oncoretroviral gene transfer to NOD/SCID repopulating cells using three different viral envelopes
    • Relander T , Karlsson S , Richter J . Oncoretroviral gene transfer to NOD/SCID repopulating cells using three different viral envelopes . J Gene Med 2002 ; 4 (2) : 122-32 .
    • (2002) J. Gene. Med. , vol.4 , Issue.2 , pp. 122-132
    • Relander, T.1    Karlsson, S.2    Richter, J.3
  • 173
    • 0036329306 scopus 로고    scopus 로고
    • Mobilization and transduction of CD34(+) peripheral blood stem cells in patients with X-linked chronic granulomatous disease
    • Ott MG , Merget-Millitzer H , Ottmann OG , et al . Mobilization and transduction of CD34(+) peripheral blood stem cells in patients with X-linked chronic granulomatous disease . J Hematother Stem Cell Res 2002 ; 11 (4) : 683-94 .
    • (2002) J. Hematother Stem. Cell Res. , vol.11 , Issue.4 , pp. 683-694
    • Ott, M.G.1    Merget-Millitzer, H.2    Ottmann, O.G.3
  • 174
    • 0033981566 scopus 로고    scopus 로고
    • A defined window for efficient gene marking of severe combined immunodeficientrepopulating cells using a gibbon ape leu kemia virus-pseudotyped retroviral vector
    • Demaison C , Brouns G , Blundell MP , et al . A defined window for efficient gene marking of severe combined immunodeficientrepopulating cells using a gibbon ape leu kemia virus-pseudotyped retroviral vector . Hum Gene Ther 2000 ; 11 (1) : 91-100 .
    • (2000) Hum. Gene. Ther. , vol.11 , Issue.1 , pp. 91-100
    • Demaison, C.1    Brouns, G.2    Blundell, M.P.3
  • 175
    • 19944421384 scopus 로고    scopus 로고
    • Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector
    • Gaspar HB , Parsley KL , Howe S , et al . Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector . Lancet 2004 ; 364 (9452) : 2181-7 .
    • (2004) Lancet , vol.364 , Issue.9452 , pp. 2181-2187
    • Gaspar, H.B.1    Parsley, K.L.2    Howe, S.3
  • 176
    • 41849142699 scopus 로고    scopus 로고
    • High incidence of leukemia in large animals after stem cell gene therapy with a HOXB4- expressing retroviral vector
    • Zhang XB , Beard BC , Trobridge GD , et al . High incidence of leukemia in large animals after stem cell gene therapy with a HOXB4- expressing retroviral vector . J Clin Invest 2008 ; 118 (4) : 1502-10 .
    • (2008) J. Clin. Invest. , vol.118 , Issue.4 , pp. 1502-1510
    • Zhang, X.B.1    Beard, B.C.2    Trobridge, G.D.3
  • 177
    • 84858431755 scopus 로고    scopus 로고
    • Polyclonal chemoprotection against temozolomide in a large animal model of drug resistance gene therapy
    • Neff T, Beard BC, Peterson LJ, Anandakumar P, Thompson J, Kiem HP. Polyclonal chemoprotection against temozolomide in a large animal model of drug resistance gene therapy. Blood 2004.
    • (2004) Blood
    • Neff, T.1    Beard, B.C.2    Peterson, L.J.3    Anandakumar, P.4    Thompson, J.5    Kiem, H.P.6
  • 178
    • 0942276849 scopus 로고    scopus 로고
    • Induction of cytotoxic T-lymphocyte responses to enhanced green and yellow fluorescent proteins after myeloablative conditioning
    • Morris JC , Conerly M , Thomasson B , Storek J , Riddell SR , Kiem HP . Induction of cytotoxic T-lymphocyte responses to enhanced green and yellow fluorescent proteins after myeloablative conditioning . Blood 2004 ; 103 (2) : 492-9 .
    • (2004) Blood , vol.103 , Issue.2 , pp. 492-499
    • Morris, J.C.1    Conerly, M.2    Thomasson, B.3    Storek, J.4    Riddell, S.R.5    Kiem, H.P.6
  • 179
    • 0345305289 scopus 로고    scopus 로고
    • Direct comparison of steady-state marrow, primed marrow, and mobilized peripheral blood for transduction of hematopoietic stem cells in dogs
    • Thomasson B , Peterson L , Thompson J , Goerner M , Kiem HP . Direct comparison of steady-state marrow, primed marrow, and mobilized peripheral blood for transduction of hematopoietic stem cells in dogs . Hum Gene Ther 2003 ; 14 (17) : 1683-6 .
    • (2003) Hum. Gene. Ther. , vol.14 , Issue.17 , pp. 1683-1686
    • Thomasson, B.1    Peterson, L.2    Thompson, J.3    Goerner, M.4    Kiem, H.P.5
  • 180
    • 0032531012 scopus 로고    scopus 로고
    • Improved gene transfer into baboon marrow repopulating cells using recombinant human fibronectin fragment CH-296 in combination with interleukin-6, stem cell factor, FLT-3 ligand, and megakaryocyte growth and development factor
    • Kiem HP , Andrews RG , Morris J , et al . Improved gene transfer into baboon marrow repopulating cells using recombinant human fibronectin fragment CH-296 in combination with interleukin-6, stem cell factor, FLT-3 ligand, and megakaryocyte growth and development factor . Blood 1998 ; 92 (6) : 1878-86 .
    • (1998) Blood , vol.92 , Issue.6 , pp. 1878-1886
    • Kiem, H.P.1    Andrews, R.G.2    Morris, J.3
  • 181
    • 0030669613 scopus 로고    scopus 로고
    • Gene transfer into marrow repopulating cells: Comparison between amphotropic and gibbon ape leukemia virus pseudotyped retroviral vectors in a competitive repopulation assay in baboons
    • Kiem HP , Heyward S , Winkler A , et al . Gene transfer into marrow repopulating cells: Comparison between amphotropic and gibbon ape leukemia virus pseudotyped retroviral vectors in a competitive repopulation assay in baboons . Blood 1997 ; 90 (11) : 4638-45 .
    • (1997) Blood , vol.90 , Issue.11 , pp. 4638-4645
    • Kiem, H.P.1    Heyward, S.2    Winkler, A.3
  • 182
    • 34249804819 scopus 로고    scopus 로고
    • Unique integration profiles in a canine model of long-term repopulating cells transduced with gammaretrovirus, lentivirus, or foamy virus
    • Beard BC , Keyser KA , Trobridge GD , et al . Unique integration profiles in a canine model of long-term repopulating cells transduced with gammaretrovirus, lentivirus, or foamy virus . Hum Gene Ther 2007 ; 18 (5) : 423-34 .
    • (2007) Hum. Gene. Ther. , vol.18 , Issue.5 , pp. 423-434
    • Beard, B.C.1    Keyser, K.A.2    Trobridge, G.D.3
  • 183
    • 0023925750 scopus 로고
    • Canine model for gene therapy: Inefficient gene expression in dogs reconstituted with autologous marrow infected with retroviral vectors
    • Stead RB , Kwok WW , Storb R , Miller AD . Canine model for gene therapy: Inefficient gene expression in dogs reconstituted with autologous marrow infected with retroviral vectors . Blood 1988 ; 71 (3) : 742-7 .
    • (1988) Blood , vol.71 , Issue.3 , pp. 742-747
    • Stead, R.B.1    Kwok, W.W.2    Storb, R.3    Miller, A.D.4
  • 184
    • 12144289202 scopus 로고    scopus 로고
    • Long-term clinical and molecular follow-up of large animals receiving retrovirally transduced stem and progenitor cells: No progression to clonal hematopoiesis or leukemia
    • Kiem HP , Sellers S , Thomasson B , et al . Long-term clinical and molecular follow-up of large animals receiving retrovirally transduced stem and progenitor cells: no progression to clonal hematopoiesis or leukemia . Mol Ther 2004 ; 9 (3) : 389-95 .
    • (2004) Mol. Ther. , vol.9 , Issue.3 , pp. 389-395
    • Kiem, H.P.1    Sellers, S.2    Thomasson, B.3
  • 185
    • 0034153385 scopus 로고    scopus 로고
    • Prolonged high-level detection of retrovirally marked hematopoietic cells in nonhuman primates after transduction of CD34+ progenitors using clinically feasible methods
    • Wu T , Kim HJ , Sellers SE , et al . Prolonged high-level detection of retrovirally marked hematopoietic cells in nonhuman primates after transduction of CD34+ progenitors using clinically feasible methods . Mol Ther 2000 ; 1 (3) : 285-93 .
    • (2000) Mol. Ther. , vol.1 , Issue.3 , pp. 285-293
    • Wu, T.1    Kim, H.J.2    Sellers, S.E.3
  • 186
    • 0036056412 scopus 로고    scopus 로고
    • In vivo selective expansion of gene-modified hematopoietic cells in a nonhuman primate model
    • Hanazono Y , Nagashima T , Takatoku M , et al . In vivo selective expansion of gene-modified hematopoietic cells in a nonhuman primate model . Gene Ther 2002 ; 9 (16) : 1055-64 .
    • (2002) Gene Ther , vol.9 , Issue.16 , pp. 1055-1064
    • Hanazono, Y.1    Nagashima, T.2    Takatoku, M.3
  • 187
    • 0025832928 scopus 로고
    • Survival and retrovirus infection of murine hematopoietic stem cells in vitro: Effects of 5-FU and method of infection
    • Bodine DM , McDonagh KT , Seidel NE , Nienhuis AW . Survival and retrovirus infection of murine hematopoietic stem cells in vitro: Effects of 5-FU and method of infection . Exp Hematol 1991 ; 19 (3) : 206-12 .
    • (1991) Exp. Hematol. , vol.19 , Issue.3 , pp. 206-212
    • Bodine, D.M.1    McDonagh, K.T.2    Seidel, N.E.3    Nienhuis, A.W.4
  • 188
    • 0032857031 scopus 로고    scopus 로고
    • Reversible expression of CD34 by murine hematopoietic stem cells
    • Sato T , Laver JH , Ogawa M . Reversible expression of CD34 by murine hematopoietic stem cells . Blood 1999 ; 94 (8) : 2548-54 .
    • (1999) Blood , vol.94 , Issue.8 , pp. 2548-2554
    • Sato, T.1    Laver, J.H.2    Ogawa, M.3
  • 189
    • 0034663150 scopus 로고    scopus 로고
    • Mild preconditioning and low-level engraftment confer methotrexate resistance in mice transplanted with marrow expressing drug-resistant dihydrofolate reductase activity
    • James RI , Warlick CA , Diers MD , Gunther R , McIvor RS . Mild preconditioning and low-level engraftment confer methotrexate resistance in mice transplanted with marrow expressing drug-resistant dihydrofolate reductase activity . Blood 2000 ; 96 (4) : 1334-41 .
    • (2000) Blood , vol.96 , Issue.4 , pp. 1334-1341
    • James, R.I.1    Warlick, C.A.2    Diers, M.D.3    Gunther, R.4    McIvor, R.S.5
  • 190
    • 33749256310 scopus 로고    scopus 로고
    • Characterisation of a P140K mutant O6-methylguanine- DNA- methyltransferase (MGMT)-expressing transgenic mouse line with drug-selectable bone marrow
    • Kramer BA , Lemckert FA , Alexander IE , Gunning PW , McCowage GB . Characterisation of a P140K mutant O6-methylguanine- DNA-methyltransferase (MGMT)-expressing transgenic mouse line with drug-selectable bone marrow . J Gene Med 2006 ; 8 (9) : 1071-85 .
    • (2006) J. Gene. Med. , vol.8 , Issue.9 , pp. 1071-1085
    • Kramer, B.A.1    Lemckert, F.A.2    Alexander, I.E.3    Gunning, P.W.4    McCowage, G.B.5
  • 191
    • 40649084281 scopus 로고    scopus 로고
    • Pollok KE repopulation strategy to quantitate engraftment of ex vivo manipulated murine marrow cells in submyeloablated hosts
    • Wyss BK , Meyers JL , Sinn AL , Cai S , Pollok KE repopulation strategy to quantitate engraftment of ex vivo manipulated murine marrow cells in submyeloablated hosts . Exp Hematol 2008 ; 36 (4) : 513-21 .
    • (2008) Exp. Hematol. , vol.36 , Issue.4 , pp. 513-521
    • Wyss, B.K.1    Meyers, J.L.2    Sinn, A.L.3    Cai, S.4
  • 192
    • 0028967307 scopus 로고
    • Ex vivo expansion and selection of human CD34+ peripheral blood progenitor cells after introduction of a mutated dihydrofolate reductase cDNA via retroviral gene transfer
    • Flasshove M , Banerjee D , Mineishi S , Li MX , Bertino JR , Moore MA . Ex vivo expansion and selection of human CD34+ peripheral blood progenitor cells after introduction of a mutated dihydrofolate reductase cDNA via retroviral gene transfer . Blood 1995 ; 85 (2) : 566-74 .
    • (1995) Blood , vol.85 , Issue.2 , pp. 566-574
    • Flasshove, M.1    Banerjee, D.2    Mineishi, S.3    Li, M.X.4    Bertino, J.R.5    Moore, M.A.6
  • 193
    • 0037114698 scopus 로고    scopus 로고
    • Lentiviral gene transfer and ex vivo expansion of human primitive stem cells capable of primary, secondary, and tertiary multilineage repopulation in NOD/SCID mice. Nonobese diabetic/severe combined immunodeficient
    • Piacibello W , Bruno S , Sanavio F , et al . Lentiviral gene transfer and ex vivo expansion of human primitive stem cells capable of primary, secondary, and tertiary multilineage repopulation in NOD/SCID mice. Nonobese diabetic/severe combined immunodeficient . Blood 2002 ; 100 (13) : 4391-400 .
    • (2002) Blood , vol.100 , Issue.13 , pp. 4391-4400
    • Piacibello, W.1    Bruno, S.2    Sanavio, F.3
  • 194
    • 0347986578 scopus 로고    scopus 로고
    • Transduction efficiency of MLV but not of HIV-1 vectors is pseudotype dependent on human primary T lymphocytes
    • Muhlebach MD , Schmitt I , Steidl S , et al . Transduction efficiency of MLV but not of HIV-1 vectors is pseudotype dependent on human primary T lymphocytes . J Mol Med 2003 ; 81 (12) : 801-10 .
    • (2003) J. Mol. Med. , vol.81 , Issue.12 , pp. 801-810
    • Muhlebach, M.D.1    Schmitt, I.2    Steidl, S.3
  • 195
    • 0027389328 scopus 로고
    • Factors affecting the transduction of pluripotent hematopoietic stem cells: Long-term expression of a human adenosine deaminase gene in mice
    • Einerhand MP , Bakx TA , Kukler A , Valerio D . Factors affecting the transduction of pluripotent hematopoietic stem cells: long-term expression of a human adenosine deaminase gene in mice . Blood 1993 ; 81 (1) : 254-63 .
    • (1993) Blood , vol.81 , Issue.1 , pp. 254-263
    • Einerhand, M.P.1    Bakx, T.A.2    Kukler, A.3    Valerio, D.4
  • 196
    • 0026815357 scopus 로고
    • Longterm expression of human argininosuccinate synthetase in mice following bone marrow transplantation with retrovirus-transduced hematopoietic stem cells
    • Demarquoy J , Herman GE , Lorenzo I , Trentin J , Beaudet AL , O'Brien WE . Longterm expression of human argininosuccinate synthetase in mice following bone marrow transplantation with retrovirus-transduced hematopoietic stem cells . Hum Gene Ther 1992 ; 3 (1) : 3-10 .
    • (1992) Hum. Gene. Ther. , vol.3 , Issue.1 , pp. 3-10
    • Demarquoy, J.1    Herman, G.E.2    Lorenzo, I.3    Trentin, J.4    Beaudet, A.L.5    O'brien, W.E.6
  • 197
    • 45149083131 scopus 로고    scopus 로고
    • Rapid production of retroviruses for efficient gene delivery to mammalian cells using 293T cell-based systems
    • Chapter 10:Unit 10 7C.
    • Swift S, Lorens J, Achacoso P, Nolan GP. Rapid production of retroviruses for efficient gene delivery to mammalian cells using 293T cell-based systems. Curr Protoc Immunol 2001;Chapter 10:Unit 10 7C.
    • (2001) Curr. Protoc. Immunol.
    • Swift, S.1    Lorens, J.2    Achacoso, P.3    Nolan, G.P.4
  • 198
    • 34247118420 scopus 로고    scopus 로고
    • Reliable generation of stable high titer producer cell lines for gene therapy
    • Rattmann I , Kleff V , Feldmann A , et al . Reliable generation of stable high titer producer cell lines for gene therapy . Intervirology 2007 ; 50 (3) : 197-203 .
    • (2007) Intervirology , vol.50 , Issue.3 , pp. 197-203
    • Rattmann, I.1    Kleff, V.2    Feldmann, A.3
  • 199
    • 84858407964 scopus 로고    scopus 로고
    • Production scale-up and validation of packaging cell clearance of clinical-grade retroviral vector stocks produced in Cell Factories
    • Przybylowski M, Hakakha A, Stefanski J, Hodges J, Sadelain M, Riviere I. Production scale-up and validation of packaging cell clearance of clinical-grade retroviral vector stocks produced in Cell Factories. Gene Ther 2005.
    • (2005) Gene. Ther.
    • Przybylowski, M.1    Hakakha, A.2    Stefanski, J.3    Hodges, J.4    Sadelain, M.5    Riviere, I.6
  • 200
    • 44049083209 scopus 로고    scopus 로고
    • Immunity to adenoassociated virus vectors in animals and humans: A continued challenge
    • Zaiss AK , Muruve DA . Immunity to adenoassociated virus vectors in animals and humans: A continued challenge . Gene Ther 2008 ; 15 (11) : 808-16 .
    • (2008) Gene. Ther. , vol.15 , Issue.11 , pp. 808-816
    • Zaiss, A.K.1    Muruve, D.A.2
  • 202
    • 0036376741 scopus 로고    scopus 로고
    • Immune response to fetal calf serum by two adenosine deaminasedeficient patients after T cell gene therapy
    • Tuschong L , Soenen SL , Blaese RM , Candotti F , Muul LM . Immune response to fetal calf serum by two adenosine deaminasedeficient patients after T cell gene therapy . Hum Gene Ther 2002 ; 13 (13) : 1605-10 .
    • (2002) Hum. Gene. Ther. , vol.13 , Issue.13 , pp. 1605-1610
    • Tuschong, L.1    Soenen, S.L.2    Blaese, R.M.3    Candotti, F.4    Muul, L.M.5
  • 203
    • 40549111908 scopus 로고    scopus 로고
    • Retroviral integration site analysis in hematopoietic stem cells
    • Kustikova OS , Baum C , Fehse B . Retroviral integration site analysis in hematopoietic stem cells . Methods Mol Biol 2008 ; 430 : 255-67 .
    • (2008) Methods Mol. Biol. , vol.430 , pp. 255-267
    • Kustikova, O.S.1    Baum, C.2    Fehse, B.3
  • 204
    • 0348140861 scopus 로고    scopus 로고
    • Multidrug resistance in hematological malignancy
    • Hirose M , Hosoi E , Hamano S , Jalili A . Multidrug resistance in hematological malignancy . J Med Invest 2003 ; 50 (3-4) : 126-35 .
    • (2003) J. Med. Invest. , vol.50 , Issue.3-4 , pp. 126-135
    • Hirose, M.1    Hosoi, E.2    Hamano, S.3    Jalili, A.4
  • 205
    • 0141888537 scopus 로고    scopus 로고
    • The role of ABC transporters in clinical practice
    • Leonard GD , Fojo T , Bates SE . The role of ABC transporters in clinical practice . Oncologist 2003 ; 8 (5) : 411-24 .
    • (2003) Oncologist , vol.8 , Issue.5 , pp. 411-424
    • Leonard, G.D.1    Fojo, T.2    Bates, S.E.3
  • 206
    • 0033006305 scopus 로고    scopus 로고
    • Multidrug resistance in oncology: Diagnostic and therapeutic approaches
    • Robert J . Multidrug resistance in oncology: Diagnostic and therapeutic approaches . Eur J Clin Invest 1999 ; 29 (6) : 536-45 .
    • (1999) Eur. J. Clin. Invest. , vol.29 , Issue.6 , pp. 536-545
    • Robert, J.1
  • 207
    • 4444255952 scopus 로고    scopus 로고
    • Methotrexate and cytarabine inhibit progression of human lymphoma in NOD/SCID mice carrying a mutant dihydrofolate reductase and cytidine deaminase fusion gene
    • Budak-Alpdogan T , Alpdogan O , Banerjee D , Wang E , Moore MA , Bertino JR . Methotrexate and cytarabine inhibit progression of human lymphoma in NOD/SCID mice carrying a mutant dihydrofolate reductase and cytidine deaminase fusion gene . Mol Ther 2004 ; 10 (3) : 574-84 .
    • (2004) Mol. Ther. , vol.10 , Issue.3 , pp. 574-584
    • Budak-Alpdogan, T.1    Alpdogan, O.2    Banerjee, D.3    Wang, E.4    Moore, M.A.5    Bertino, J.R.6
  • 208
    • 0030999647 scopus 로고    scopus 로고
    • Post-transplant methotrexate administration leads to improved curability of mice bearing a mammary tumor transplanted with marrow transduced with a mutant human dihydrofolate reductase cDNA
    • Zhao SC , Banerjee D , Mineishi S , Bertino JR . Post-transplant methotrexate administration leads to improved curability of mice bearing a mammary tumor transplanted with marrow transduced with a mutant human dihydrofolate reductase cDNA . Hum Gene Ther 1997 ; 8 (8) : 903-9 .
    • (1997) Hum. Gene. Ther. , vol.8 , Issue.8 , pp. 903-909
    • Zhao, S.C.1    Banerjee, D.2    Mineishi, S.3    Bertino, J.R.4
  • 209
    • 7044286411 scopus 로고    scopus 로고
    • Competitive repopulation assay of two gene-marked cord blood units in NOD/ SCID/gammac(null) mice
    • Yahata T , Ando K , Miyatake H , et al . Competitive repopulation assay of two gene-marked cord blood units in NOD/ SCID/gammac(null) mice . Mol Ther 2004 ; 10 (5) : 882-91 .
    • (2004) Mol. Ther. , vol.10 , Issue.5 , pp. 882-891
    • Yahata, T.1    Ando, K.2    Miyatake, H.3
  • 210
    • 44449120863 scopus 로고    scopus 로고
    • NOD/Shiscid IL2rgamma(null) (NOG) mice more appropriate for humanized mouse models
    • Ito M , Kobayashi K , Nakahata T . NOD/Shiscid IL2rgamma(null) (NOG) mice more appropriate for humanized mouse models . Curr Top Microbiol Immunol 2008 ; 324 : 53-76 .
    • (2008) Curr Top Microbiol Immunol , vol.324 , pp. 53-76
    • Ito, M.1    Kobayashi, K.2    Nakahata, T.3
  • 211
    • 18344410760 scopus 로고    scopus 로고
    • NOD/SCID/gamma(null) mouse: An excellent recipient mouse model for engraft - Ment of human cells
    • Ito M , Hiramatsu H , Kobayashi K , et al . NOD/SCID/gamma(null) mouse: An excellent recipient mouse model for engraft - ment of human cells . Blood 2002 ; 100 (9) : 3175-82 .
    • (2002) Blood , vol.100 , Issue.9 , pp. 3175-3182
    • Ito, M.1    Hiramatsu, H.2    Kobayashi, K.3
  • 212
    • 17744372078 scopus 로고    scopus 로고
    • Improved post-transcriptional processing of an MDR1 retrovirus elevates expression of multidrug resistance in primary human hematopoietic cells
    • Knipper R , Kuehlcke K , Schiedlmeier B , et al . Improved post-transcriptional processing of an MDR1 retrovirus elevates expression of multidrug resistance in primary human hematopoietic cells . Gene Ther 2001 ; 8 (3) : 239-46 .
    • (2001) Gene. Ther. , vol.8 , Issue.3 , pp. 239-246
    • Knipper, R.1    Kuehlcke, K.2    Schiedlmeier, B.3
  • 213
    • 0033199281 scopus 로고    scopus 로고
    • Retroviral transfer of human MDR1 gene to hematopoietic cells: Effects of drug selection and of transcript splicing on expression of encoded P-glycoprotein
    • Licht T , Aran JM , Goldenberg SK , Vieira WD , Gottesman MM , Pastan I . Retroviral transfer of human MDR1 gene to hematopoietic cells: Effects of drug selection and of transcript splicing on expression of encoded P-glycoprotein . Hum Gene Ther 1999 ; 10 (13) : 2173-85 .
    • (1999) Hum. Gene. Ther. , vol.10 , Issue.13 , pp. 2173-2185
    • Licht, T.1    Aran, J.M.2    Goldenberg, S.K.3    Vieira, W.D.4    Gottesman, M.M.5    Pastan, I.6
  • 214
    • 0032505749 scopus 로고    scopus 로고
    • Poor expression of MDR1 transgene in HeLa cells by bicistronic Moloney murine leukemia virus-based vector
    • Zaboikin MM , Schuening FG . Poor expression of MDR1 transgene in HeLa cells by bicistronic Moloney murine leukemia virus-based vector . Hum Gene Ther 1998 ; 9 (15) : 2263-75 .
    • (1998) Hum. Gene. Ther. , vol.9 , Issue.15 , pp. 2263-2275
    • Zaboikin, M.M.1    Schuening, F.G.2
  • 215
    • 0038346086 scopus 로고    scopus 로고
    • Impact of splice-site mutations of the human MDR1 cDNA on its stability and expression following retroviral gene transfer
    • Cmejlova J , Hildinger M , Cmejla R , et al . Impact of splice-site mutations of the human MDR1 cDNA on its stability and expression following retroviral gene transfer . Gene Ther 2003 ; 10 (12) : 1061-5 .
    • (2003) Gene. Ther. , vol.10 , Issue.12 , pp. 1061-1065
    • Cmejlova, J.1    Hildinger, M.2    Cmejla, R.3
  • 216
    • 0029058758 scopus 로고
    • Expression of retroviral vectors containing the human multidrug resistance 1 cDNA in hematopoietic cells of transplanted mice
    • Sorrentino BP , McDonagh KT , Woods D , Orlic D . Expression of retroviral vectors containing the human multidrug resistance 1 cDNA in hematopoietic cells of transplanted mice . Blood 1995 ; 86 (2) : 491-501 .
    • (1995) Blood , vol.86 , Issue.2 , pp. 491-501
    • Sorrentino, B.P.1    McDonagh, K.T.2    Woods, D.3    Orlic, D.4
  • 217
    • 0031963925 scopus 로고    scopus 로고
    • Dominant selection of hematopoietic progenitor cells with retroviral MDR1 co-expression vectors
    • Hildinger M , Fehse B , Hegewisch-Becker S , et al . Dominant selection of hematopoietic progenitor cells with retroviral MDR1 co-expression vectors . Hum Gene Ther 1998 ; 9 (1) : 33-42 .
    • (1998) Hum. Gene. Ther. , vol.9 , Issue.1 , pp. 33-42
    • Hildinger, M.1    Fehse, B.2    Hegewisch-Becker, S.3
  • 218
    • 0032188998 scopus 로고    scopus 로고
    • Transduction of murine bone marrow cells with an MDR1 vector enables ex vivo stem cell expansion, but these expanded grafts cause a myeloproliferative syndrome in transplanted mice
    • Bunting KD , Galipeau J , Topham D , Benaim E , Sorrentino BP . Transduction of murine bone marrow cells with an MDR1 vector enables ex vivo stem cell expansion, but these expanded grafts cause a myeloproliferative syndrome in transplanted mice . Blood 1998 ; 92 (7) : 2269-79 .
    • (1998) Blood , vol.92 , Issue.7 , pp. 2269-2279
    • Bunting, K.D.1    Galipeau, J.2    Topham, D.3    Benaim, E.4    Sorrentino, B.P.5
  • 219
    • 0034254733 scopus 로고    scopus 로고
    • Enforced P-glycoprotein pump function in murine bone marrow cells results in expansion of side population stem cells in vitro and repopulating cells in vivo
    • Bunting KD , Zhou S , Lu T , Sorrentino BP . Enforced P-glycoprotein pump function in murine bone marrow cells results in expansion of side population stem cells in vitro and repopulating cells in vivo . Blood 2000 ; 96 (3) : 902-9 .
    • (2000) Blood , vol.96 , Issue.3 , pp. 902-909
    • Bunting, K.D.1    Zhou, S.2    Lu, T.3    Sorrentino, B.P.4
  • 220
    • 0031909353 scopus 로고    scopus 로고
    • Feasibility of multidrug resistance (MDR-1) gene transfer in patients undergoing highdose therapy and peripheral blood stem cell transplantation for lymphoma
    • Devereux S , Corney C , Macdonald C , et al . Feasibility of multidrug resistance (MDR-1) gene transfer in patients undergoing highdose therapy and peripheral blood stem cell transplantation for lymphoma . Gene Ther 1998 ; 5 (3) : 403-8 .
    • (1998) Gene. Ther. , vol.5 , Issue.3 , pp. 403-408
    • Devereux, S.1    Corney, C.2    MacDonald, C.3
  • 221
    • 0035869398 scopus 로고    scopus 로고
    • The effect of multidrug-resistance 1 gene versus neo transduction on ex vivo and in vivo expansion of rhesus macaque hematopoietic repopulating cells
    • Sellers SE , Tisdale JF , Agricola BA , et al . The effect of multidrug-resistance 1 gene versus neo transduction on ex vivo and in vivo expansion of rhesus macaque hematopoietic repopulating cells . Blood 2001 ; 97 (6) : 1888-91 .
    • (2001) Blood , vol.97 , Issue.6 , pp. 1888-1891
    • Sellers, S.E.1    Tisdale, J.F.2    Agricola, B.A.3
  • 222
    • 0036570062 scopus 로고    scopus 로고
    • Clinical releVance of MGMT in the treatment of cancer
    • Gerson SL . Clinical releVance of MGMT in the treatment of cancer . J Clin Oncol 2002 ; 20 (9) : 2388-99 .
    • (2002) J. Clin. Oncol. , vol.20 , Issue.9 , pp. 2388-2399
    • Gerson, S.L.1
  • 223
    • 0038192240 scopus 로고    scopus 로고
    • A bicistronic retroviral vector containing MGMT and MDR1 drug resistance genes transfer into human umbilical cord blood CD34+ cells to improve combination chemotherapy tolerance]
    • Wang JS , Sun DJ , Lin GW , Fei J . [A bicistronic retroviral vector containing MGMT and MDR1 drug resistance genes transfer into human umbilical cord blood CD34+ cells to improve combination chemotherapy tolerance] . Shi Yan Sheng Wu Xue Bao 2001 ; 34 (3) : 227-33 .
    • (2001) Shi. Yan. Sheng Wu. Xue. Bao. , vol.34 , Issue.3 , pp. 227-233
    • Wang, J.S.1    Sun, D.J.2    Lin, G.W.3    Fei, J.4
  • 224
    • 0030061083 scopus 로고    scopus 로고
    • Increasing DNA repair methyltransferase levels via bone marrow stem cell transduction rescues mice from the toxic effects of 1,3-bis (2-chloroethyl)-1- nitrosourea, a chemotherapeutic alkylating agent
    • Maze R , Carney JP , Kelley MR , Glassner BJ , Williams DA , Samson L . Increasing DNA repair methyltransferase levels via bone marrow stem cell transduction rescues mice from the toxic effects of 1,3-bis (2-chloroethyl)-1- nitrosourea, a chemotherapeutic alkylating agent . Proc Natl Acad Sci U S A 1996 ; 93 (1) : 206-10 .
    • (1996) Proc. Natl. Acad. Sci. U S A , vol.93 , Issue.1 , pp. 206-210
    • Maze, R.1    Carney, J.P.2    Kelley, M.R.3    Glassner, B.J.4    Williams, D.A.5    Samson, L.6
  • 225
    • 0033541165 scopus 로고    scopus 로고
    • DeltaMGMT- transduced bone marrow infusion increases tolerance to O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea and allows intensive therapy of 1,3-bis (2-chloroethyl)-1-nitrosourea-resistant human colon cancer xenografts
    • Koc ON , Reese JS , Davis BM , Liu L , Majczenko KJ , Gerson SL . DeltaMGMT- transduced bone marrow infusion increases tolerance to O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea and allows intensive therapy of 1,3-bis (2-chloroethyl)-1-nitrosourea-resistant human colon cancer xenografts . Hum Gene Ther 1999 ; 10 (6) : 1021-30 .
    • (1999) Hum. Gene. Ther. , vol.10 , Issue.6 , pp. 1021-1030
    • Koc, O.N.1    Reese, J.S.2    Davis, B.M.3    Liu, L.4    Majczenko, K.J.5    Gerson, S.L.6
  • 226
    • 0347086143 scopus 로고    scopus 로고
    • In vivo selection of MGMT (P140K) lentivirus-transduced human NOD/ SCID repopulating cells without pretransplant irradiation conditioning
    • Zielske SP , Reese JS , Lingas KT , Donze JR , Gerson SL . In vivo selection of MGMT (P140K) lentivirus-transduced human NOD/ SCID repopulating cells without pretransplant irradiation conditioning . J Clin Invest 2003 ; 112 (10) : 1561-70 .
    • (2003) J. Clin. Invest. , vol.112 , Issue.10 , pp. 1561-1570
    • Zielske, S.P.1    Reese, J.S.2    Lingas, K.T.3    Donze, J.R.4    Gerson, S.L.5
  • 227
    • 3042746907 scopus 로고    scopus 로고
    • Limited lentiviral transgene expression with increasing copy number in an MGMT selection model: Lack of copy number selection by drug treatment
    • Zielske SP , Lingas KT , Li Y , Gerson SL . Limited lentiviral transgene expression with increasing copy number in an MGMT selection model: lack of copy number selection by drug treatment . Mol Ther 2004 ; 9 (6) : 923-31 .
    • (2004) Mol. Ther. , vol.9 , Issue.6 , pp. 923-931
    • Zielske, S.P.1    Lingas, K.T.2    Li, Y.3    Gerson, S.L.4
  • 228
    • 0033589691 scopus 로고    scopus 로고
    • Characterization of the P140K, PVP(138- 140)MLK, and G156A O6-methylguanine-DNA methyltransferase mutants: Implications for drug resistance gene therapy
    • Davis BM , Roth JC , Liu L , Xu-Welliver M , Pegg AE , Gerson SL . Characterization of the P140K, PVP(138-140)MLK, and G156A O6-methylguanine-DNA methyltransferase mutants: Implications for drug resistance gene therapy . Hum Gene Ther 1999 ; 10 (17) : 2769-78 .
    • (1999) Hum. Gene. Ther. , vol.10 , Issue.17 , pp. 2769-2778
    • Davis, B.M.1    Roth, J.C.2    Liu, L.3    Xu-Welliver, M.4    Pegg, A.E.5    Gerson, S.L.6
  • 229
    • 0034657950 scopus 로고    scopus 로고
    • Limiting numbers of G156A O(6)-methylguanine- DNA methyltransferase- transduced marrow progenitors repopulate nonmyeloablated mice after drug selection
    • Davis BM , Koc ON , Gerson SL . Limiting numbers of G156A O(6)-methylguanine- DNA methyltransferase-transduced marrow progenitors repopulate nonmyeloablated mice after drug selection . Blood 2000 ; 95 (10) : 3078-84 .
    • (2000) Blood , vol.95 , Issue.10 , pp. 3078-3084
    • Davis, B.M.1    Koc, O.N.2    Gerson, S.L.3
  • 230
    • 0030613767 scopus 로고    scopus 로고
    • Selection for G156A O6-methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and protection from lethality in mice treated with O6-benzylguanine and 1,3-bis(2- chloroethyl)-1-nitrosourea
    • Davis BM , Reese JS , Koc ON , Lee K , Schupp JE , Gerson SL . Selection for G156A O6-methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and protection from lethality in mice treated with O6-benzylguanine and 1,3-bis(2- chloroethyl)-1-nitrosourea . Cancer Res 1997 ; 57 (22) : 5093-9 .
    • (1997) Cancer Res. , vol.57 , Issue.22 , pp. 5093-5099
    • Davis, B.M.1    Reese, J.S.2    Koc, O.N.3    Lee, K.4    Schupp, J.E.5    Gerson, S.L.6
  • 231
    • 0041522307 scopus 로고    scopus 로고
    • Drug selection of mutant methylguanine methyltransferase from different oncoretroviral backbones results in multilineage hematopoietic transgene expression in primary and secondary recipients
    • Davis BM , Reese JS , Lingas K , Gerson SL . Drug selection of mutant methylguanine methyltransferase from different oncoretroviral backbones results in multilineage hematopoietic transgene expression in primary and secondary recipients . J Hematother Stem Cell Res 2003 ; 12 (4) : 375-87 .
    • (2003) J. Hematother Stem. Cell Res. , vol.12 , Issue.4 , pp. 375-387
    • Davis, B.M.1    Reese, J.S.2    Lingas, K.3    Gerson, S.L.4
  • 232
    • 34447331660 scopus 로고    scopus 로고
    • Vector design for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells
    • Schambach A , Baum C . Vector design for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells . DNA Repair (Amst) 2007 ; 6 (8) : 1187-96 .
    • (2007) DNA Repair Amst , vol.6 , Issue.8 , pp. 1187-1196
    • Schambach, A.1    Baum, C.2
  • 233
    • 0033919655 scopus 로고    scopus 로고
    • Protection of hematopoietic cells against combined O6-benzylguanine and chloroethylnitrosourea treatment by mutant forms of O6-methylguanine DNA methyltransferase
    • Williams DA , Maze R , Kurpad C , Pegg A , Erickson LC . Protection of hematopoietic cells against combined O6-benzylguanine and chloroethylnitrosourea treatment by mutant forms of O6-methylguanine DNA methyltransferase . Bone Marrow Transplant 2000 ; 25 (Suppl 2) : S105 - 9 .
    • (2000) Bone Marrow Transplant , vol.25 , Issue.SUPPL. 2
    • Williams, D.A.1    Maze, R.2    Kurpad, C.3    Pegg, A.4    Erickson, L.C.5
  • 234
    • 0032813030 scopus 로고    scopus 로고
    • Retroviral-mediated expression of the P140A, but not P140A/G156A, mutant form of O6-methylguanine DNA methyltransferase protects hematopoietic cells against O6-benzylguanine sensitization to chloroethylnitrosourea treatment
    • Maze R , Kurpad C , Pegg AE , Erickson LC , Williams DA . Retroviral-mediated expression of the P140A, but not P140A/G156A, mutant form of O6-methylguanine DNA methyltransferase protects hematopoietic cells against O6-benzylguanine sensitization to chloroethylnitrosourea treatment . J Pharmacol Exp Ther 1999 ; 290 (3) : 1467-74 .
    • (1999) J. Pharmacol. Exp. Ther. , vol.290 , Issue.3 , pp. 1467-1474
    • Maze, R.1    Kurpad, C.2    Pegg, A.E.3    Erickson, L.C.4    Williams, D.A.5
  • 235
    • 0022904675 scopus 로고
    • Carcinogenesis in F-344 rats induced by nitrosohydroxyalkyl- chloroethylureas
    • Lijinsky W , Kovatch RM , Singer SS . Carcinogenesis in F-344 rats induced by nitrosohydroxyalkyl- chloroethylureas . J Cancer Res Clin Oncol 1986 ; 112 (3) : 221-8 .
    • (1986) J. Cancer Res. Clin. Oncol. , vol.112 , Issue.3 , pp. 221-228
    • Lijinsky, W.1    Kovatch, R.M.2    Singer, S.S.3
  • 236
    • 0021799376 scopus 로고
    • Carmustine as a cause of acute nonlymphocytic leukemia
    • Greene MH , Boice JD , Jr. , Strike TA . Carmustine as a cause of acute nonlymphocytic leukemia . N Engl J Med 1985 ; 313 (9) : 579 .
    • (1985) N. Engl. J. Med. , vol.313 , Issue.9 , pp. 579
    • Greene, M.H.1    Boice Jr., J.D.2    Strike, T.A.3
  • 237
    • 0028797769 scopus 로고
    • Effect of clinically modeled regimens on the growth response and development of resistance in human colon carcinoma cell lines
    • Pizzorno G , Handschumacher RE . Effect of clinically modeled regimens on the growth response and development of resistance in human colon carcinoma cell lines . Biochem Pharmacol 1995 ; 49 (4) : 559-65 .
    • (1995) Biochem. Pharmacol. , vol.49 , Issue.4 , pp. 559-565
    • Pizzorno, G.1    Handschumacher, R.E.2
  • 238
    • 0031015454 scopus 로고    scopus 로고
    • Fluorouracil in colorectal cancer-A tale of two drugs: Implications for biochemical modulation
    • Sobrero AF , Aschele C , Bertino JR . Fluorouracil in colorectal cancer-a tale of two drugs: Implications for biochemical modulation . J Clin Oncol 1997 ; 15 (1) : 368-81 .
    • (1997) J. Clin. Oncol. , vol.15 , Issue.1 , pp. 368-381
    • Sobrero, A.F.1    Aschele, C.2    Bertino, J.R.3
  • 239
    • 0018886366 scopus 로고
    • Mechanisms of sensitivity and resistance of murine tumors to 5-fluorouracil
    • Ardalan B , Cooney DA , Jayaram HN , et al . Mechanisms of sensitivity and resistance of murine tumors to 5-fluorouracil . Cancer Res 1980 ; 40 (5) : 1431-7 .
    • (1980) Cancer Res. , vol.40 , Issue.5 , pp. 1431-1437
    • Ardalan, B.1    Cooney, D.A.2    Jayaram, H.N.3
  • 240
    • 0030927503 scopus 로고    scopus 로고
    • Phenotypic and functional changes induced at the clonal level in hematopoietic stem cells after 5-fluorouracil treatment
    • Randall TD , Weissman IL . Phenotypic and functional changes induced at the clonal level in hematopoietic stem cells after 5-fluorouracil treatment . Blood 1997 ; 89 (10) : 3596-606 .
    • (1997) Blood , vol.89 , Issue.10 , pp. 3596-3606
    • Randall, T.D.1    Weissman, I.L.2
  • 241
    • 0034254827 scopus 로고    scopus 로고
    • Inactivation of a GFP retrovirus occurs at multiple levels in long-term repopulating stem cells and their differentiated progeny
    • Klug CA , Cheshier S , Weissman IL . Inactivation of a GFP retrovirus occurs at multiple levels in long-term repopulating stem cells and their differentiated progeny . Blood 2000 ; 96 (3) : 894-901 .
    • (2000) Blood , vol.96 , Issue.3 , pp. 894-901
    • Klug, C.A.1    Cheshier, S.2    Weissman, I.L.3
  • 242
    • 0036840102 scopus 로고    scopus 로고
    • Donor chimerism and stem cell function in a murine congenic transplantation model after low-dose radiation conditioning: Effects of a retroviral-mediated gene transfer protocol and implications for gene therapy
    • Goebel WS , Yoder MC , Pech NK , Dinauer MC . Donor chimerism and stem cell function in a murine congenic transplantation model after low-dose radiation conditioning: Effects of a retroviral-mediated gene transfer protocol and implications for gene therapy . Exp Hematol 2002 ; 30 (11) : 1324-32 .
    • (2002) Exp. Hematol. , vol.30 , Issue.11 , pp. 1324-1332
    • Goebel, W.S.1    Yoder, M.C.2    Pech, N.K.3    Dinauer, M.C.4
  • 243
    • 20844434966 scopus 로고    scopus 로고
    • Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells
    • Shultz LD , Lyons BL , Burzenski LM , et al . Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells . J Immunol 2005 ; 174 (10) : 6477-89 .
    • (2005) J. Immunol. , vol.174 , Issue.10 , pp. 6477-6489
    • Shultz, L.D.1    Lyons, B.L.2    Burzenski, L.M.3
  • 244
    • 0035684026 scopus 로고    scopus 로고
    • Differential transduction efficiency of SCIDrepopulating cells derived from umbilical cord blood and granulocyte colony-stimulating factor-mobilized peripheral blood
    • Pollok KE , Van Der Loo JC , Cooper RJ , et al . Differential transduction efficiency of SCIDrepopulating cells derived from umbilical cord blood and granulocyte colony-stimulating factor-mobilized peripheral blood . Hum Gene Ther 2001 ; 12 (17) : 2095-108 .
    • (2001) Hum. Gene. Ther. , vol.12 , Issue.17 , pp. 2095-2108
    • Pollok, K.E.1    Van Der Loo, J.C.2    Cooper, R.J.3
  • 245
    • 0030765960 scopus 로고    scopus 로고
    • Transduction of retrovirus-mediated NeoR gene into CD34+ cells purified from granulocyte colony-stimulating factor (G-CSF)-mobilized infant and cord blood
    • Abe T , Ito M , Okamoto Y , et al . Transduction of retrovirus-mediated NeoR gene into CD34+ cells purified from granulocyte colony-stimulating factor (G-CSF)-mobilized infant and cord blood . Exp Hematol 1997 ; 25 (9) : 966-71 .
    • (1997) Exp. Hematol. , vol.25 , Issue.9 , pp. 966-971
    • Abe, T.1    Ito, M.2    Okamoto, Y.3
  • 246
    • 0027362741 scopus 로고
    • High efficiency retroviral mediated gene transduction into single isolated immature and replatable CD34(3+) hematopoietic stem/progenitor cells from human umbilical cord blood
    • Lu L , Xiao M , Clapp DW , Li ZH , Broxmeyer HE . High efficiency retroviral mediated gene transduction into single isolated immature and replatable CD34(3+) hematopoietic stem/progenitor cells from human umbilical cord blood . J Exp Med 1993 ; 178 (6) : 2089-96 .
    • (1993) J. Exp. Med. , vol.178 , Issue.6 , pp. 2089-2096
    • Lu, L.1    Xiao, M.2    Clapp, D.W.3    Li, Z.H.4    Broxmeyer, H.E.5
  • 247
    • 0032525157 scopus 로고    scopus 로고
    • Delayed targeting of cytokine-nonresponsive human bone marrow CD34(+) cells with retrovirus-mediated gene transfer enhances transduction efficiency and longterm expression of transduced genes
    • Veena P , Traycoff CM , Williams DA , et al .Delayed targeting of cytokine-nonresponsive human bone marrow CD34(+) cells with retrovirus-mediated gene transfer enhances transduction efficiency and longterm expression of transduced genes . Blood 1998 ; 91 (10) : 3693-701 .
    • (1998) Blood , vol.91 , Issue.10 , pp. 3693-3701
    • Veena, P.1    Traycoff, C.M.2    Williams, D.A.3
  • 248
    • 0033764617 scopus 로고    scopus 로고
    • Large scale purification of human blood CD34+ cells from cryopreserved peripheral blood stem cells, using a nylon-fiber syringe system and immunomagnetic microspheres
    • Koizumi K , Nishio M , Endo T , et al . Large scale purification of human blood CD34+ cells from cryopreserved peripheral blood stem cells, using a nylon-fiber syringe system and immunomagnetic microspheres . Bone Marrow Transplant 2000 ; 26 (7) : 787-93 .
    • (2000) Bone Marrow Transplant , vol.26 , Issue.7 , pp. 787-793
    • Koizumi, K.1    Nishio, M.2    Endo, T.3
  • 249
    • 0031739576 scopus 로고    scopus 로고
    • CD34+ cell selection from frozen cord blood products using the Isolex 300i and CliniMACS CD34 selection devices
    • McNiece IK , Stoney GB , Kern BP , Briddell RA . CD34+ cell selection from frozen cord blood products using the Isolex 300i and CliniMACS CD34 selection devices . J Hematother 1998 ; 7 (5) : 457-61 .
    • (1998) J. Hematother , vol.7 , Issue.5 , pp. 457-461
    • McNiece, I.K.1    Stoney, G.B.2    Kern, B.P.3    Briddell, R.A.4
  • 250
    • 0028785797 scopus 로고
    • Processing and cryopreservation of placental/umbilical cord blood for unrelated bone marrow reconstitution
    • Rubinstein P , Dobrila L , Rosenfield RE , et al . Processing and cryopreservation of placental/umbilical cord blood for unrelated bone marrow reconstitution . Proc Natl Acad Sci U S A 1995 ; 92 (22) : 10119-22 .
    • (1995) Proc. Natl. Acad. Sci. U S A , vol.92 , Issue.22 , pp. 10119-10122
    • Rubinstein, P.1    Dobrila, L.2    Rosenfield, R.E.3
  • 251
    • 0030907823 scopus 로고    scopus 로고
    • Ex vivo expansion of frozen/thawed CD34+ cells isolated from frozen human apheresis products
    • Martinson JA , Loudovaris M , Smith SL , et al . Ex vivo expansion of frozen/thawed CD34+ cells isolated from frozen human apheresis products . J Hematother 1997 ; 6 (1) : 69-75 .
    • (1997) J. Hematother , vol.6 , Issue.1 , pp. 69-75
    • Martinson, J.A.1    Loudovaris, M.2    Smith, S.L.3
  • 252
    • 0031569609 scopus 로고    scopus 로고
    • Enhanced human CD4+ T cell engraftment in beta2-microglobulin- deficient NOD-scid mice
    • Christianson SW , Greiner DL , Hesselton RA , et al . Enhanced human CD4+ T cell engraftment in beta2-microglobulin- deficient NOD-scid mice . J Immunol 1997 ; 158 (8) : 3578-86 .
    • (1997) J. Immunol. , vol.158 , Issue.8 , pp. 3578-3586
    • Christianson, S.W.1    Greiner, D.L.2    Hesselton, R.A.3
  • 253
    • 0034656421 scopus 로고    scopus 로고
    • Beta2 microglobulin- deficient (B2m(null)) NOD/SCID mice are excellent recipients for studying human stem cell function
    • Kollet O , Peled A , Byk T , et al . beta2 microglobulin- deficient (B2m(null)) NOD/SCID mice are excellent recipients for studying human stem cell function . Blood 2000 ; 95 (10) : 3102-5 .
    • (2000) Blood , vol.95 , Issue.10 , pp. 3102-3105
    • Kollet, O.1    Peled, A.2    Byk, T.3
  • 254
    • 0042243661 scopus 로고    scopus 로고
    • Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/gammacnull mice model
    • Hiramatsu H , Nishikomori R , Heike T , et al . Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/gammacnull mice model . Blood 2003 ; 102 (3) : 873-80 .
    • (2003) Blood , vol.102 , Issue.3 , pp. 873-880
    • Hiramatsu, H.1    Nishikomori, R.2    Heike, T.3
  • 255
    • 0034488186 scopus 로고    scopus 로고
    • Negative influence of IL3 on the expansion of human cord blood in vivo long-term repopulating stem cells
    • Piacibello W , Gammaitoni L , Bruno S , et al . Negative influence of IL3 on the expansion of human cord blood in vivo long-term repopulating stem cells . J Hematother Stem Cell Res 2000 ; 9 (6) : 945-56 .
    • (2000) J. Hematother Stem. Cell Res. , vol.9 , Issue.6 , pp. 945-956
    • Piacibello, W.1    Gammaitoni, L.2    Bruno, S.3
  • 256
    • 3242711055 scopus 로고    scopus 로고
    • Thrombopoietin, flt3-ligand and c-kit-ligand modulate HOX gene expression in expanding cord blood CD133 cells
    • McGuckin CP , Forraz N , Pettengell R , Thompson A . Thrombopoietin, flt3-ligand and c-kit-ligand modulate HOX gene expression in expanding cord blood CD133 cells . Cell Prolif 2004 ; 37 (4) : 295-306 .
    • (2004) Cell Prolif. , vol.37 , Issue.4 , pp. 295-306
    • McGuckin, C.P.1    Forraz, N.2    Pettengell, R.3    Thompson, A.4
  • 257
    • 0035004524 scopus 로고    scopus 로고
    • Envelope fusion protein binding studies in an inducible model of retrovirus receptor expression and in CD34(+) cells emphasize limited transduction at low receptor levels
    • Kurre P , Morris J , Miller AD , Kiem HP . Envelope fusion protein binding studies in an inducible model of retrovirus receptor expression and in CD34(+) cells emphasize limited transduction at low receptor levels . Gene Ther 2001 ; 8 (8) : 593-9 .
    • (2001) Gene. Ther. , vol.8 , Issue.8 , pp. 593-599
    • Kurre, P.1    Morris, J.2    Miller, A.D.3    Kiem, H.P.4
  • 258
    • 0033857834 scopus 로고    scopus 로고
    • The 17 nucleotides downstream from the env gene stop codon are important for murine leukemia virus packaging
    • Yu SS , Kim JM , Kim S . The 17 nucleotides downstream from the env gene stop codon are important for murine leukemia virus packaging . J Virol 2000 ; 74 (18) : 8775-80 .
    • (2000) J. Virol. , vol.74 , Issue.18 , pp. 8775-8780
    • Yu, S.S.1    Kim, J.M.2    Kim, S.3
  • 259
    • 0029862497 scopus 로고    scopus 로고
    • Rfaut stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes
    • Ory DS , Neugeboren BA , Mulligan RC .stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes . Proc Natl Acad Sci U S A 1996 ; 93 (21) : 11400-6 .
    • (1996) Proc. Natl. Acad. Sci. U S A , vol.93 , Issue.21 , pp. 11400-6
    • Ory, D.S.1    Neugeboren, B.A.2    Mulligan, R.C.3
  • 260
    • 0034142253 scopus 로고    scopus 로고
    • Retrovirally transduced mouse dendritic cells require CD4+ T cell help to elicit antitumor immunity: Implications for the clinical use of dendritic cells
    • Schnell S , Young JW , Houghton AN , Sadelain M . Retrovirally transduced mouse dendritic cells require CD4+ T cell help to elicit antitumor immunity: Implications for the clinical use of dendritic cells . J Immunol 2000 ; 164 (3) : 1243-50 .
    • (2000) J. Immunol. , vol.164 , Issue.3 , pp. 1243-1250
    • Schnell, S.1    Young, J.W.2    Houghton, A.N.3    Sadelain, M.4
  • 261
    • 0029976140 scopus 로고    scopus 로고
    • Self-renewal of primitive human hematopoietic cells (long-termculture- initiating cells) in vitro and their expansion in defined medium
    • Petzer AL , Hogge DE , Landsdorp PM , Reid DS , Eaves CJ . Self-renewal of primitive human hematopoietic cells (long-termculture- initiating cells) in vitro and their expansion in defined medium . Proc Natl Acad Sci U S A 1996 ; 93 (4) : 1470-4 .
    • (1996) Proc. Natl. Acad. Sci. U S A , vol.93 , Issue.4 , pp. 1470-1474
    • Petzer, A.L.1    Hogge, D.E.2    Landsdorp, P.M.3    Reid, D.S.4    Eaves, C.J.5
  • 262
    • 0030723296 scopus 로고    scopus 로고
    • Serum-free production, concentration and purification of recombinant retroviruses
    • Seppen J , Kimmel RJ , Osborne WR . Serum-free production, concentration and purification of recombinant retroviruses . Biotechniques 1997 ; 23 (5) : 788-90 .
    • (1997) Biotechniques , vol.23 , Issue.5 , pp. 788-790
    • Seppen, J.1    Kimmel, R.J.2    Osborne, W.R.3
  • 263
    • 0034633617 scopus 로고    scopus 로고
    • Packaging cell line characteristics and optimizing retroviral vector titer: The National Gene Vector Laboratory experience
    • Reeves L , Smucker P , Cornetta K . Packaging cell line characteristics and optimizing retroviral vector titer: The National Gene Vector Laboratory experience . Hum Gene Ther 2000 ; 11 (15) : 2093-103 .
    • (2000) Hum. Gene. Ther. , vol.11 , Issue.15 , pp. 2093-2103
    • Reeves, L.1    Smucker, P.2    Cornetta, K.3
  • 264
    • 0034515324 scopus 로고    scopus 로고
    • Clinical retroviral vector production: Step filtration using clinically approved filters improves titers
    • Reeves L , Cornetta K . Clinical retroviral vector production: Step filtration using clinically approved filters improves titers . Gene Ther 2000 ; 7 (23) : 1993 - 8 .
    • (2000) Gene. Ther. , vol.7 , Issue.23 , pp. 1993-1998
    • Reeves, L.1    Cornetta, K.2
  • 265
    • 33646479480 scopus 로고    scopus 로고
    • Lentiviral vectors pseudotyped with murine ecotropic envelope: Increased biosafety and convenience in preclinical research
    • Schambach A , Galla M , Modlich U , et al . Lentiviral vectors pseudotyped with murine ecotropic envelope: Increased biosafety and convenience in preclinical research . Exp Hematol 2006 ; 34 (5) : 588-92 .
    • (2006) Exp. Hematol. , vol.34 , Issue.5 , pp. 588-592
    • Schambach, A.1    Galla, M.2    Modlich, U.3
  • 266
    • 0035464294 scopus 로고    scopus 로고
    • Optimization of retroviral vector generation for clinical application
    • Schilz AJ , Kuhlcke K , Fauser AA , Eckert HG . Optimization of retroviral vector generation for clinical application . J Gene Med 2001 ; 3 (5) : 427-36 .
    • (2001) J. Gene. Med. , vol.3 , Issue.5 , pp. 427-36
    • Schilz, A.J.1    Kuhlcke, K.2    Fauser, A.A.3    Eckert, H.G.4
  • 267
    • 0028076782 scopus 로고
    • Improved methods of retroviral vector transduction and production for gene therapy
    • Kotani H , Newton PB , 3 rd , Zhang S , et al . Improved methods of retroviral vector transduction and production for gene therapy . Hum Gene Ther 1994 ; 5 (1) : 19-28 .
    • (1994) Hum. Gene. Ther. , vol.5 , Issue.1 , pp. 19-28
    • Kotani, H.1    Newton Iii, P.B.2    Zhang, S.3
  • 268
    • 33646148048 scopus 로고    scopus 로고
    • Relationship between retroviral vector membrane and vector stability
    • Carmo M , Faria TQ , Falk H , et al . Relationship between retroviral vector membrane and vector stability . J Gen Virol 2006 ; 87 (Pt 5) : 1349-56 .
    • (2006) J. Gen. Virol. , vol.87 , Issue.PART 5 , pp. 1349-1356
    • Carmo, M.1    Faria, T.Q.2    Falk, H.3
  • 269
    • 4043123892 scopus 로고    scopus 로고
    • Clinical grade vector production: Analysis of yield, stability, and storage of gmp-produced retroviral vectors for gene therapy
    • Wikstrom K , Blomberg P , Islam KB . Clinical grade vector production: Analysis of yield, stability, and storage of gmp-produced retroviral vectors for gene therapy . Biotechnol Prog 2004 ; 20 (4) : 1198-203 .
    • (2004) Biotechnol. Prog. , vol.20 , Issue.4 , pp. 1198-1203
    • Wikstrom, K.1    Blomberg, P.2    Islam, K.B.3
  • 271
    • 0032784630 scopus 로고    scopus 로고
    • Rapid titer determination using quantitative real-time PCR
    • Sanburn N , Cornetta K . Rapid titer determination using quantitative real-time PCR . Gene Ther 1999 ; 6 (7) : 1340-5 .
    • (1999) Gene. Ther. , vol.6 , Issue.7 , pp. 1340-1345
    • Sanburn, N.1    Cornetta, K.2
  • 272
    • 0031804093 scopus 로고    scopus 로고
    • Adenovirus facilitated infection of human cells with ecotropic retrovirus
    • Scott-Taylor TH , Gallardo HF , Gansbacher B , Sadelain M . Adenovirus facilitated infection of human cells with ecotropic retrovirus . Gene Ther 1998 ; 5 (5) : 621-9 .
    • (1998) Gene. Ther. , vol.5 , Issue.5 , pp. 621-629
    • Scott-Taylor, T.H.1    Gallardo, H.F.2    Gansbacher, B.3    Sadelain, M.4
  • 273
    • 0035261902 scopus 로고    scopus 로고
    • Kinetic analyses of stability of simple and complex retroviral vectors
    • Higashikawa F , Chang L . Kinetic analyses of stability of simple and complex retroviral vectors . Virology 2001 ; 280 (1) : 124-31 .
    • (2001) Virology , vol.280 , Issue.1 , pp. 124-131
    • Higashikawa, F.1    Chang, L.2
  • 274
    • 0030865201 scopus 로고    scopus 로고
    • Moloney murine leukemia virus-derived retroviral vectors decay intracellularly with a half-life in the range of 5.5 to 7.5 hours
    • Andreadis ST , Brott D , Fuller AO , Palsson BO . Moloney murine leukemia virus-derived retroviral vectors decay intracellularly with a half-life in the range of 5.5 to 7.5 hours . J Virol 1997 ; 71 (10) : 7541-8 .
    • (1997) J. Virol , vol.71 , Issue.10 , pp. 7541-7548
    • Andreadis, S.T.1    Brott, D.2    Fuller, A.O.3    Palsson, B.O.4
  • 275
    • 0034281468 scopus 로고    scopus 로고
    • Effects of culture parameters on the production of retroviral vectors by a human packaging cell line
    • McTaggart S , Al-Rubeai M . Effects of culture parameters on the production of retroviral vectors by a human packaging cell line . Biotechnol Prog 2000 ; 16 (5) : 859-65 .
    • (2000) Biotechnol. Prog. , vol.16 , Issue.5 , pp. 859-865
    • McTaggart, S.1    Al-Rubeai, M.2


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