Increasing DNA repair methyltransferase levels via bone marrow stem cell transduction rescues mice from the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic alkylating agent

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 1, 1996, Pages 206-210

  Maze, Rodney ^a,b   Carney, James P ^b   Kelley, Mark R ^a,b   Glassner, Brian J ^c   Williams, David A ^a,b   Samson, Leona ^c  

^a RILEY HOSPITAL FOR CHILDREN   (United States)

^b INDIANA UNIVERSITY   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Chloroethylnitrosourea; DNA repair; O6 methylguanine DNA methyltransferase; Retroviral vector

Indexed keywords

CARMUSTINE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PHOSPHOGLYCERATE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOLOGOUS BONE MARROW TRANSPLANTATION; BONE MARROW HYPOPLASIA; BONE MARROW SUPPRESSION; BONE MARROW TOXICITY; CONTROLLED STUDY; CYTOTOXICITY; DNA ADDUCT; DNA ALKYLATION; DNA DAMAGE; DNA REPAIR; FEMALE; GENE EXPRESSION; GENETIC TRANSDUCTION; HEMATOPOIETIC STEM CELL; MOUSE; NONHUMAN; PANCYTOPENIA; PRIORITY JOURNAL;

ANIMALS; BONE MARROW; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; CARMUSTINE; DNA REPAIR; DRUG RESISTANCE; FEMALE; GENE TRANSFER TECHNIQUES; HUMANS; METHYLTRANSFERASES; MICE; MICE, INBRED C57BL; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; SURVIVAL ANALYSIS;

ANIMALIA; MURINAE;

EID: 0030061083     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.1.206     Document Type: Article

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