-
1
-
-
0029560753
-
Genetic analysis of the multidrug transporter
-
Gottesman, M. M., Hrycyna, C., Schoenlein, P. V., Germann, U. A., and Pastan, I. Genetic analysis of the multidrug transporter. Annu. Rev. Genet., 29: 607-649, 1995.
-
(1995)
Annu. Rev. Genet.
, vol.29
, pp. 607-649
-
-
Gottesman, M.M.1
Hrycyna, C.2
Schoenlein, P.V.3
Germann, U.A.4
Pastan, I.5
-
2
-
-
0008632564
-
Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine
-
Ueda, K., Cardarelli, C., Gottesman, M. M., and Pastan, I. Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine. Proc. Natl. Acad. Sci. USA, 84: 3004-3008, 1987.
-
(1987)
Proc. Natl. Acad. Sci. USA
, vol.84
, pp. 3004-3008
-
-
Ueda, K.1
Cardarelli, C.2
Gottesman, M.M.3
Pastan, I.4
-
3
-
-
0013508682
-
A retrovirus carrying a MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells
-
Pastan, I., Gottesman, M. M., Ueda, K., Lovelace, E., Rutherford, A., and Willingham, M. C. A retrovirus carrying a MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells. Proc. Natl. Acad. Sci. USA, 85: 4486-4490, 1988.
-
(1988)
Proc. Natl. Acad. Sci. USA
, vol.85
, pp. 4486-4490
-
-
Pastan, I.1
Gottesman, M.M.2
Ueda, K.3
Lovelace, E.4
Rutherford, A.5
Willingham, M.C.6
-
4
-
-
0026637623
-
Retroviral transfer of the human MDR1 gene permits selection of drug resistant bone marrow cells in vivo
-
Washington DC
-
Sorrentino, B. P., Brandt, S. J., Bodine, D., Gottesman, M. M., Pastan, I., Cline, A., and Nienhuis, A. W. Retroviral transfer of the human MDR1 gene permits selection of drug resistant bone marrow cells in vivo. Science (Washington DC), 257: 99-103, 1992.
-
(1992)
Science
, vol.257
, pp. 99-103
-
-
Sorrentino, B.P.1
Brandt, S.J.2
Bodine, D.3
Gottesman, M.M.4
Pastan, I.5
Cline, A.6
Nienhuis, A.W.7
-
5
-
-
0026705269
-
Transfer and expression of the human multiple drug resistance gene into live mice
-
Podda, S., Ward, M., Himelstein, A., Richardson, C., Flor-Weiss, E., Smith, L., Gottesman, M. M., Pastan, I., and Bank, A. Transfer and expression of the human multiple drug resistance gene into live mice. Proc. Natl. Acad. Sci. USA, 89: 9676-9680, 1992.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 9676-9680
-
-
Podda, S.1
Ward, M.2
Himelstein, A.3
Richardson, C.4
Flor-Weiss, E.5
Smith, L.6
Gottesman, M.M.7
Pastan, I.8
Bank, A.9
-
6
-
-
0029052483
-
Efficient expression of functional human MDR1 gene in murine bone marrow after retroviral transduction of purified hematopoietic stem cells
-
Licht, T., Aksentijevich, I., Gottesman, M. M., and Pastan, I. Efficient expression of functional human MDR1 gene in murine bone marrow after retroviral transduction of purified hematopoietic stem cells. Blood, 86: 111-121, 1995.
-
(1995)
Blood
, vol.86
, pp. 111-121
-
-
Licht, T.1
Aksentijevich, I.2
Gottesman, M.M.3
Pastan, I.4
-
7
-
-
0024427595
-
Expression of a human multidrug resistance cDNA (MDR1) in the bone marrow of transgenic mice: Resistance to daunomycin-induced leukopenia
-
Galski, H., Sullivan, M., Willingham, M. C., Chin, K. V., Gottesman, M. M., Pastan, I., and Merlino, G. T. Expression of a human multidrug resistance cDNA (MDR1) in the bone marrow of transgenic mice: resistance to daunomycin-induced leukopenia. Mol. Cell. Biol., 9: 4357-4363, 1991.
-
(1991)
Mol. Cell. Biol.
, vol.9
, pp. 4357-4363
-
-
Galski, H.1
Sullivan, M.2
Willingham, M.C.3
Chin, K.V.4
Gottesman, M.M.5
Pastan, I.6
Merlino, G.T.7
-
8
-
-
0026089343
-
Transgenic mice that express the human multidrug-resistance gene in bone marrow enable a rapid identification of agents that reverse drug resistance
-
Mickisch, G. H., Merlino, G. T., Galski, H., Gottesman, M. M., and Pastan, I. Transgenic mice that express the human multidrug-resistance gene in bone marrow enable a rapid identification of agents that reverse drug resistance. Proc. Natl. Acad. Sci. USA, 88: 547-551, 1991.
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 547-551
-
-
Mickisch, G.H.1
Merlino, G.T.2
Galski, H.3
Gottesman, M.M.4
Pastan, I.5
-
9
-
-
0025939045
-
Chemotherapy and chemosensitization of transgenic mice which express the human multidrug resistance gene in bone marrow: Efficacy, potency, and toxicity
-
Mickisch, G., Licht, T., Merlino, G. T., Gottesman, M. M., and Pastan, I. Chemotherapy and chemosensitization of transgenic mice which express the human multidrug resistance gene in bone marrow: efficacy, potency, and toxicity. Cancer Res., 51: 5417-5424, 1991.
-
(1991)
Cancer Res.
, vol.51
, pp. 5417-5424
-
-
Mickisch, G.1
Licht, T.2
Merlino, G.T.3
Gottesman, M.M.4
Pastan, I.5
-
13
-
-
0029016285
-
Retrovirus-mediated expression of a DNA repair protein in bone marrow protects hematopoietic cells from nitrosourea-induced toxicity in vitro and in vivo
-
Moritz, T., Mackay, W., Glassner, B. J., Williams, D. A., and Samson, L. Retrovirus-mediated expression of a DNA repair protein in bone marrow protects hematopoietic cells from nitrosourea-induced toxicity in vitro and in vivo. Cancer Res.. 55: 2608-2614, 1995.
-
(1995)
Cancer Res.
, vol.55
, pp. 2608-2614
-
-
Moritz, T.1
Mackay, W.2
Glassner, B.J.3
Williams, D.A.4
Samson, L.5
-
14
-
-
0029056481
-
Retroviral transduction and expression of the human alkyltransferase cDNA provides nitrosourea resistance to hematopoietic cells
-
Allay, J. A., Dumenco, L. L., Koc, O. N., Liu, L., and Gerson, S. L. Retroviral transduction and expression of the human alkyltransferase cDNA provides nitrosourea resistance to hematopoietic cells. Blood, 85: 3342-3351, 1995.
-
(1995)
Blood
, vol.85
, pp. 3342-3351
-
-
Allay, J.A.1
Dumenco, L.L.2
Koc, O.N.3
Liu, L.4
Gerson, S.L.5
-
15
-
-
0028229767
-
Efficient expression of drug-selectable genes in retroviral vectors under control of an internal ribosome entry site
-
Sugimoto, Y., Aksentijevich, I., Gottesman, M. M., and Pastan, I. Efficient expression of drug-selectable genes in retroviral vectors under control of an internal ribosome entry site. Bio/Technology, 12: 694-698, 1994.
-
(1994)
Bio/Technology
, vol.12
, pp. 694-698
-
-
Sugimoto, Y.1
Aksentijevich, I.2
Gottesman, M.M.3
Pastan, I.4
-
16
-
-
0028986284
-
Coexpression of a multidrug-resistance gene (MDR1) and herpes simplex virus thymidine kinase gene as part of a bicistronic messenger RNA in a retrovirus vector allows selective killing of MDR1-transduced cells
-
Sugimoto, Y., Hrycyna, C. A., Aksentijevich, I., Pastan, I., and Gottesman, M. M. Coexpression of a multidrug-resistance gene (MDR1) and herpes simplex virus thymidine kinase gene as part of a bicistronic messenger RNA in a retrovirus vector allows selective killing of MDR1-transduced cells. Clin. Cancer Res., 1: 447-457, 1995.
-
(1995)
Clin. Cancer Res.
, vol.1
, pp. 447-457
-
-
Sugimoto, Y.1
Hrycyna, C.A.2
Aksentijevich, I.3
Pastan, I.4
Gottesman, M.M.5
-
17
-
-
0028821345
-
Retroviral coexpression of a multidrug resistance gene (MDR1) and human α-galactosidase a for gene therapy of Fabry disease
-
Sugimoto, Y., Aksentijevich, I., Murray, G. J., Pastan, I., and Gottesman, M. M. Retroviral coexpression of a multidrug resistance gene (MDR1) and human α-galactosidase A for gene therapy of Fabry disease. Hum. Gene Ther., 6: 905-915, 1995.
-
(1995)
Hum. Gene Ther.
, vol.6
, pp. 905-915
-
-
Sugimoto, Y.1
Aksentijevich, I.2
Murray, G.J.3
Pastan, I.4
Gottesman, M.M.5
-
18
-
-
0030045657
-
A bicistronic retrovirus vector containing a picornavirus internal ribosome entry site allows for correction of X-linked CGD by selection for MDR1 expression
-
Sokolic., R. A., Sekhsaria, S., Sugimoto, Y., Whiting-Theobald, N., Linton, G. F., Li, F., Gottesman, M. M., and Malech, H. L. A bicistronic retrovirus vector containing a picornavirus internal ribosome entry site allows for correction of X-linked CGD by selection for MDR1 expression. Blood. 87: 42-50, 1996.
-
(1996)
Blood
, vol.87
, pp. 42-50
-
-
Sokolic, R.A.1
Sekhsaria, S.2
Sugimoto, Y.3
Whiting-Theobald, N.4
Linton, G.F.5
Li, F.6
Gottesman, M.M.7
Malech, H.L.8
-
19
-
-
0022767368
-
Redesign of retrovirus packaging cell line to avoid recombination leading to helper virus production
-
Miller, A. D., and Buttimore, C. Redesign of retrovirus packaging cell line to avoid recombination leading to helper virus production. Mol. Cell. Biol., 6: 2895-2902, 1986.
-
(1986)
Mol. Cell. Biol.
, vol.6
, pp. 2895-2902
-
-
Miller, A.D.1
Buttimore, C.2
-
20
-
-
0022994130
-
6-methylguanine methyltransferase gene into repair-deficient human cells and restoration of cellular resistance to N-methyl-N′-nitro-N-nitrosoguanidine
-
6-methylguanine methyltransferase gene into repair-deficient human cells and restoration of cellular resistance to N-methyl-N′-nitro-N-nitrosoguanidine. Mutat. Res., 166: 135-141, 1986.
-
(1986)
Mutat. Res.
, vol.166
, pp. 135-141
-
-
Ishizaki, K.1
Tsujimura, T.2
Yawata, H.3
Fujio, C.4
Nakabeppu, Y.5
Sekiguchi, M.6
Ikenaga, M.7
-
21
-
-
0023392945
-
High efficiency transformation of mammalian cells by plasmid DNA
-
Chen, C., and Okayama, H. High efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol., 7: 2745-2752, 1987.
-
(1987)
Mol. Cell. Biol.
, vol.7
, pp. 2745-2752
-
-
Chen, C.1
Okayama, H.2
-
22
-
-
0345139075
-
Functional role for the 170-to 180-kDa glycoprotein specific to drug-resistant tumor cells as revealed by monoclonal antibodies
-
Hamada, H., and Tsuruo, T. Functional role for the 170-to 180-kDa glycoprotein specific to drug-resistant tumor cells as revealed by monoclonal antibodies. Proc. Natl. Acad. Sci. USA. 83: 7785-7789, 1986.
-
(1986)
Proc. Natl. Acad. Sci. USA
, vol.83
, pp. 7785-7789
-
-
Hamada, H.1
Tsuruo, T.2
-
23
-
-
0028880358
-
Establishment and evaluation of MRK16-magnetic cell sorting assays for detecting low expression of multidrug resistance P-glycoprotein using human leukemia cell lines and peripheral blood cells from healthy donors
-
Okochi, E., Iwahashi, T., Ariyoshi, K., Watabe, H., Tsuruo, T., and Ono, K. Establishment and evaluation of MRK16-magnetic cell sorting assays for detecting low expression of multidrug resistance P-glycoprotein using human leukemia cell lines and peripheral blood cells from healthy donors. J. Immunol. Methods. 187: 127-137, 1995.
-
(1995)
J. Immunol. Methods
, vol.187
, pp. 127-137
-
-
Okochi, E.1
Iwahashi, T.2
Ariyoshi, K.3
Watabe, H.4
Tsuruo, T.5
Ono, K.6
-
24
-
-
0014949207
-
Cleavage of structural proteins during the assembly of the head of bacteriophage T4
-
Laemmli, U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.), 227: 680-685, 1970.
-
(1970)
Nature (Lond.)
, vol.227
, pp. 680-685
-
-
Laemmli, U.K.1
-
25
-
-
0027992876
-
Intracellular localization and function of DNA repair methyltransferase in human cells
-
Ishibashi, T., Nakabeppu, Y., Kawate, H., Sachem, K., Hayakawa, H., and Sekiguchi, M. Intracellular localization and function of DNA repair methyltransferase in human cells. Mutat. Res., 315: 199-212, 1994.
-
(1994)
Mutat. Res.
, vol.315
, pp. 199-212
-
-
Ishibashi, T.1
Nakabeppu, Y.2
Kawate, H.3
Sachem, K.4
Hayakawa, H.5
Sekiguchi, M.6
-
26
-
-
0025362703
-
Expression of a human complementary DNA for the multidrug resistance gene in murine hematopoietic precursor cells with the use of retroviral gene transfer
-
Bethesda
-
McLachlin, J. R., Eglitis, M. A., Ueda, K., Kantoff, P. W., Pastan, I. H., Anderson, W. F., and Gottesman, M. M. Expression of a human complementary DNA for the multidrug resistance gene in murine hematopoietic precursor cells with the use of retroviral gene transfer. J. Natl. Cancer Inst. (Bethesda), 82: 1260-1263, 1990.
-
(1990)
J. Natl. Cancer Inst.
, vol.82
, pp. 1260-1263
-
-
McLachlin, J.R.1
Eglitis, M.A.2
Ueda, K.3
Kantoff, P.W.4
Pastan, I.H.5
Anderson, W.F.6
Gottesman, M.M.7
-
27
-
-
0028255868
-
Drug-selected coexpression of human glucocerebrosidase and P-glycoprotein using a bicistronic vector
-
Aran, J. M., Gottesman, M. M., and Pastan, I. Drug-selected coexpression of human glucocerebrosidase and P-glycoprotein using a bicistronic vector. Proc. Natl. Acad. Sci. USA, 91: 3176-3180, 1994.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 3176-3180
-
-
Aran, J.M.1
Gottesman, M.M.2
Pastan, I.3
-
28
-
-
0027984922
-
Retroviral mediated Transfer of the human multidrug resistance gene (MDR-1) into hematopoietic stem cells during autologous transplantation after intensive chemotherapy for metastatic breast cancer
-
O'Shaughnessy, J. A., Cowan, K. H., Nienhuis, A. W., McDonagh, K. T., Sorrentino, B. P., Dunbar, C. E., Chiang, Y., Wilson, W., Goldspiel, B., Kohler, D., Cottler-Fox, M., Leitman, S., Gottesman, M. M., Pastan, I., Denicoff, R. N., Noone, M., and Gress, R. Retroviral mediated Transfer of the human multidrug resistance gene (MDR-1) into hematopoietic stem cells during autologous transplantation after intensive chemotherapy for metastatic breast cancer. Hum. Gene Ther., 5: 891-911, 1994.
-
(1994)
Hum. Gene Ther.
, vol.5
, pp. 891-911
-
-
O'Shaughnessy, J.A.1
Cowan, K.H.2
Nienhuis, A.W.3
McDonagh, K.T.4
Sorrentino, B.P.5
Dunbar, C.E.6
Chiang, Y.7
Wilson, W.8
Goldspiel, B.9
Kohler, D.10
Cottler-Fox, M.11
Leitman, S.12
Gottesman, M.M.13
Pastan, I.14
Denicoff, R.N.15
Noone, M.16
Gress, R.17
-
29
-
-
0028608124
-
Human MDR gene transfer in patients with advanced cancer
-
Hesdorfer, C., Antman, K., Bank, A., Fetell, M., Mears, G., and Begg, M. Human MDR gene transfer in patients with advanced cancer. Hum. Gene Ther., 5: 1151-1160, 1994.
-
(1994)
Hum. Gene Ther.
, vol.5
, pp. 1151-1160
-
-
Hesdorfer, C.1
Antman, K.2
Bank, A.3
Fetell, M.4
Mears, G.5
Begg, M.6
-
30
-
-
0030021116
-
Use of safety-modified retroviruses to introduce chemotherapy resistance sequences into normal hematopoietic cells for chemoprotection during the therapy of ovarian cancer: A pilot trial
-
Deisseroth, A. B., Kavanagh, J., and Champlin, R. Use of safety-modified retroviruses to introduce chemotherapy resistance sequences into normal hematopoietic cells for chemoprotection during the therapy of ovarian cancer: a pilot trial. Hum. Gene Ther., 7: 401-416, 1996.
-
(1996)
Hum. Gene Ther.
, vol.7
, pp. 401-416
-
-
Deisseroth, A.B.1
Kavanagh, J.2
Champlin, R.3
-
31
-
-
0028661063
-
Use of safety-modified retroviruses to introduce chemotherapy resistance sequences into normal hematopoietic cells for chemoprotection during the therapy of breast cancer: A pilot trial
-
Deisseroth, A. B., Holmea, F., Hortobagyi, G., and Champlin, R. Use of safety-modified retroviruses to introduce chemotherapy resistance sequences into normal hematopoietic cells for chemoprotection during the therapy of breast cancer: a pilot trial. Hum. Gene Ther., 5: 1507-1522, 1994.
-
(1994)
Hum. Gene Ther.
, vol.5
, pp. 1507-1522
-
-
Deisseroth, A.B.1
Holmea, F.2
Hortobagyi, G.3
Champlin, R.4
-
32
-
-
0022548054
-
Retrovirus-mediated transfer and expression of drug resistance genes in human haematopoietic progenitor cells
-
Hock, R. A., and Miller, A. D. Retrovirus-mediated transfer and expression of drug resistance genes in human haematopoietic progenitor cells. Nature (Lond.), 320: 275-277, 1986.
-
(1986)
Nature (Lond.)
, vol.320
, pp. 275-277
-
-
Hock, R.A.1
Miller, A.D.2
-
33
-
-
0023250381
-
Protection of bone marrow transplant recipients from lethal doses of methotrexate by the generation of methotrexate-resistant bone marrow
-
Williams, D. A., Hsieh, K., DeSilva, A., and Mulligan, R. C. Protection of bone marrow transplant recipients from lethal doses of methotrexate by the generation of methotrexate-resistant bone marrow. J. Exp. Med., 166: 210-218, 1987.
-
(1987)
J. Exp. Med.
, vol.166
, pp. 210-218
-
-
Williams, D.A.1
Hsieh, K.2
DeSilva, A.3
Mulligan, R.C.4
-
34
-
-
0025089990
-
Serial transplantation of methotrexate-resistant bone marrow: Protection of murine recipients from drug toxicity by progeny of transduced stem cells
-
Corey, C. A., DeSilva, A. D., Holland, C. A., and Williams, D. A. Serial transplantation of methotrexate-resistant bone marrow: protection of murine recipients from drug toxicity by progeny of transduced stem cells. Blood, 75: 337-343, 1990.
-
(1990)
Blood
, vol.75
, pp. 337-343
-
-
Corey, C.A.1
DeSilva, A.D.2
Holland, C.A.3
Williams, D.A.4
-
35
-
-
0027435476
-
Expression of a rat glutathione S-transferase complementary DNA in rat mammary carcinoma cells: Impact upon alkylater-induced toxicity
-
Schecter, R. L., Alaoui-Jamali, M. A., Woo, A., Fahl, W. E., and Batist, G. Expression of a rat glutathione S-transferase complementary DNA in rat mammary carcinoma cells: impact upon alkylater-induced toxicity. Cancer Res., 53: 4900-4906, 1993.
-
(1993)
Cancer Res.
, vol.53
, pp. 4900-4906
-
-
Schecter, R.L.1
Alaoui-Jamali, M.A.2
Woo, A.3
Fahl, W.E.4
Batist, G.5
-
36
-
-
0027956024
-
Retrovirus-mediated gene transfer of rat glutathione S-transferase Yc confers alkylating drug resistance in NIH 3T3 mouse fibroblasts
-
Greenbaum, M., Letourneau, S., Assar, H., Schecter, R. L., Batist, G., and Cournoyer, D. Retrovirus-mediated gene transfer of rat glutathione S-transferase Yc confers alkylating drug resistance in NIH 3T3 mouse fibroblasts. Cancer Res., 54: 4442-4447, 1994.
-
(1994)
Cancer Res.
, vol.54
, pp. 4442-4447
-
-
Greenbaum, M.1
Letourneau, S.2
Assar, H.3
Schecter, R.L.4
Batist, G.5
Cournoyer, D.6
-
38
-
-
0025941670
-
6-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: The role of MGMT in protection against the genotoxic effects of alkylating agents
-
Lond.
-
6-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: the role of MGMT in protection against the genotoxic effects of alkylating agents. Carcinogenesis (Lond.), 12: 1857-1867, 1992.
-
(1992)
Carcinogenesis
, vol.12
, pp. 1857-1867
-
-
Kaina, B.1
Fritz, G.2
Mitra, S.3
Coquerelle, T.4
|