메뉴 건너뛰기




Volumn 107, Issue 6, 2006, Pages 2294-2302

Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TK-modified donor T cells after allogeneic hematopoietic cell transplantation

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CD4 ANTIGEN; CD8 ANTIGEN; CYCLOSPORIN A; CYTOKINE; EPITOPE; HERPES SIMPLEX VIRUS THYMIDINE KINASE; IMATINIB; METHOTREXATE; MONOCLONAL ANTIBODY; PREDNISONE; T LYMPHOCYTE ANTIBODY; THYMIDINE KINASE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

EID: 33644750264     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2005-08-3503     Document Type: Article
Times cited : (292)

References (56)
  • 1
    • 0034606276 scopus 로고    scopus 로고
    • Melanocyte destruction after antigen-specific immunotherapy of melanoma: Direct evidence of T cell-mediated vitiligo
    • Yee C, Thompson JA, Roche P, et al. Melanocyte destruction after antigen-specific immunotherapy of melanoma: direct evidence of T cell-mediated vitiligo. J Exp Med. 2000;192:1637-1643.
    • (2000) J Exp Med , vol.192 , pp. 1637-1643
    • Yee, C.1    Thompson, J.A.2    Roche, P.3
  • 2
    • 0037174674 scopus 로고    scopus 로고
    • Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes
    • Dudley ME, Wunderlich JR, Robbins PF, et al. Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science. 2002;298:850-854.
    • (2002) Science , vol.298 , pp. 850-854
    • Dudley, M.E.1    Wunderlich, J.R.2    Robbins, P.F.3
  • 3
    • 0025100777 scopus 로고
    • Graft-versus-leukemia reactions after bone marrow transplantation
    • Horowitz MM, Gale RP, Sondel PM, et al. Graft-versus-leukemia reactions after bone marrow transplantation. Blood. 1990;75:555-562.
    • (1990) Blood , vol.75 , pp. 555-562
    • Horowitz, M.M.1    Gale, R.P.2    Sondel, P.M.3
  • 4
    • 0030754892 scopus 로고    scopus 로고
    • Human minor histocompatibility antigens: New concepts for marrow transplantation and adoptive immunotherapy
    • Goulmy E. Human minor histocompatibility antigens: new concepts for marrow transplantation and adoptive immunotherapy. Immunol Rev. 1997;157:125-140.
    • (1997) Immunol Rev , vol.157 , pp. 125-140
    • Goulmy, E.1
  • 5
    • 1542267219 scopus 로고    scopus 로고
    • Graft-versus-leukemia reactions in allogeneic chimeras
    • Kolb H-J, Schmid C, Barrett AJ, Schendel DJ. Graft-versus-leukemia reactions in allogeneic chimeras. Blood. 2004;103:767-776.
    • (2004) Blood , vol.103 , pp. 767-776
    • Kolb, H.-J.1    Schmid, C.2    Barrett, A.J.3    Schendel, D.J.4
  • 6
    • 2342484524 scopus 로고    scopus 로고
    • Molecules and mechanisms of the graft-versus-leukemia effect
    • Bleakley M, Riddell SR. Molecules and mechanisms of the graft-versus-leukemia effect. Nat Rev Cancer. 2004;4:371-380.
    • (2004) Nat Rev Cancer , vol.4 , pp. 371-380
    • Bleakley, M.1    Riddell, S.R.2
  • 7
    • 0035575701 scopus 로고    scopus 로고
    • Transduction of an IL-2 gene into human melanoma-reactive lymphocytes results in their continued growth in the absence of exogenous IL-2 and maintenance of specific antitumor activity
    • Liu K, Rosenberg SA. Transduction of an IL-2 gene into human melanoma-reactive lymphocytes results in their continued growth in the absence of exogenous IL-2 and maintenance of specific antitumor activity. J Immunol. 2001;167:6356-6365.
    • (2001) J Immunol , vol.167 , pp. 6356-6365
    • Liu, K.1    Rosenberg, S.A.2
  • 9
    • 0033844706 scopus 로고    scopus 로고
    • Developments in suicide genes for preclinical and clinical applications
    • Spencer DM. Developments in suicide genes for preclinical and clinical applications. Curr Opin Mol Ther. 2000;2:433-440.
    • (2000) Curr Opin Mol Ther , vol.2 , pp. 433-440
    • Spencer, D.M.1
  • 10
    • 1842292373 scopus 로고
    • Thymidine kinase obliteration: Creation of transgenic mice with controlled immune deficiency
    • U S A
    • Heyman RA, Borrelli E, Lesley J, et al. Thymidine kinase obliteration: creation of transgenic mice with controlled immune deficiency. Proc Natl Acad Sci U S A. 1989;86:2698-2702.
    • (1989) Proc Natl Acad Sci , vol.86 , pp. 2698-2702
    • Heyman, R.A.1    Borrelli, E.2    Lesley, J.3
  • 11
    • 13344261952 scopus 로고    scopus 로고
    • T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients
    • Riddell SR, Elliott M, Lewinsohn DA, et al. T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients. Nat Med. 1996;2:216-223.
    • (1996) Nat Med , vol.2 , pp. 216-223
    • Riddell, S.R.1    Elliott, M.2    Lewinsohn, D.A.3
  • 12
    • 0030843493 scopus 로고    scopus 로고
    • HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia
    • Bonini C, Ferrari G, Verzeletti S, et al. HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia. Science. 1997;276:1719-1724.
    • (1997) Science , vol.276 , pp. 1719-1724
    • Bonini, C.1    Ferrari, G.2    Verzeletti, S.3
  • 13
    • 0032505705 scopus 로고    scopus 로고
    • Herpes simplex virus thymidine kinase gene transfer for controlled graft-versus-host disease and graft-versus-leukemia: Clinical follow-up and improved new vectors
    • Verzeletti S, Bonini C, Marktel S, et al. Herpes simplex virus thymidine kinase gene transfer for controlled graft-versus-host disease and graft-versus-leukemia: clinical follow-up and improved new vectors. Hum Gene Ther. 1998;9:2243-2251.
    • (1998) Hum Gene Ther , vol.9 , pp. 2243-2251
    • Verzeletti, S.1    Bonini, C.2    Marktel, S.3
  • 14
    • 0035161228 scopus 로고    scopus 로고
    • Administration of herplex simplex-thymidine kinase-expressing donor T cells with a T-cell-depleted allogeneic marrow graft
    • Tiberghien P, Ferrand C, Lioure B, et al. Administration of herplex simplex-thymidine kinase-expressing donor T cells with a T-cell-depleted allogeneic marrow graft. Blood. 2001;97:63-72.
    • (2001) Blood , vol.97 , pp. 63-72
    • Tiberghien, P.1    Ferrand, C.2    Lioure, B.3
  • 16
    • 0141596016 scopus 로고    scopus 로고
    • Herpes simplex thymidine kinase gene-transduced donor lymphocyte infusions
    • Burt RK, Drobyski WR, Seregina T, et al. Herpes simplex thymidine kinase gene-transduced donor lymphocyte infusions. Exp Hematol. 2003;31:903-910.
    • (2003) Exp Hematol , vol.31 , pp. 903-910
    • Burt, R.K.1    Drobyski, W.R.2    Seregina, T.3
  • 17
    • 0037085323 scopus 로고    scopus 로고
    • Retrovirus-mediated gene transfer in primary T lymphocytes impairs their anti-Epstein-Barr virus potential through both culture-dependent and selection process-dependent mechanisms
    • Sauce D, Bodinier M, Garin M, et al. Retrovirus-mediated gene transfer in primary T lymphocytes impairs their anti-Epstein-Barr virus potential through both culture-dependent and selection process-dependent mechanisms. Blood. 2002;99:1165-1173.
    • (2002) Blood , vol.99 , pp. 1165-1173
    • Sauce, D.1    Bodinier, M.2    Garin, M.3
  • 18
    • 0018973048 scopus 로고
    • Chronic graft-versus-host syndrome in man: A long-term clinicopathologic study of 20 Seattle patients
    • Shulman HM, Sullivan KM, Weiden PL, et al. Chronic graft-versus-host syndrome in man: a long-term clinicopathologic study of 20 Seattle patients. Am J Med. 1980;69:204-217.
    • (1980) Am J Med , vol.69 , pp. 204-217
    • Shulman, H.M.1    Sullivan, K.M.2    Weiden, P.L.3
  • 19
    • 0016187133 scopus 로고
    • Clinical manifestations of graft-versus-host disease in human recipients of marrow from HLA-matched sibling donors
    • Glucksberg H, Storb R, Fefer A, et al. Clinical manifestations of graft-versus-host disease in human recipients of marrow from HLA-matched sibling donors. Transplantation. 1974;18:295-304.
    • (1974) Transplantation , vol.18 , pp. 295-304
    • Glucksberg, H.1    Storb, R.2    Fefer, A.3
  • 20
    • 0025853454 scopus 로고
    • Dominant positive and negative selection using a hygromycin phosphotransferase-thymidine kinase fusion gene
    • Lupton SD, Brunton LL, Kalberg VA, Overall RA. Dominant positive and negative selection using a hygromycin phosphotransferase-thymidine kinase fusion gene. Mol Cell Biol. 1991;11:3374-3378.
    • (1991) Mol Cell Biol , vol.11 , pp. 3374-3378
    • Lupton, S.D.1    Brunton, L.L.2    Kalberg, V.A.3    Overall, R.A.4
  • 21
    • 0032950813 scopus 로고    scopus 로고
    • Production and culture of HSVtk-transduced suicidal lymphocytes induces variable changes in the lymphocyte subset composition
    • Marini FC III, Kornblau SM. Production and culture of HSVtk-transduced suicidal lymphocytes induces variable changes in the lymphocyte subset composition. Bone Marrow Transplant. 1999;23:907-915.
    • (1999) Bone Marrow Transplant , vol.23 , pp. 907-915
    • Marini III, F.C.1    Kornblau, S.M.2
  • 22
    • 0025361125 scopus 로고
    • The use of anti-CD3 and anti-CD28 monoclonal antibodies to clone and expand human antigen-specific T cells
    • Riddell SR, Greenberg PD. The use of anti-CD3 and anti-CD28 monoclonal antibodies to clone and expand human antigen-specific T cells. J Immunol Methods. 1990;128:189-201.
    • (1990) J Immunol Methods , vol.128 , pp. 189-201
    • Riddell, S.R.1    Greenberg, P.D.2
  • 23
    • 9044251206 scopus 로고    scopus 로고
    • A novel murine retrovirus identified during testing for helper virus in human gene transfer trials
    • Miller AD, Bonham L, Alfano J, et al. A novel murine retrovirus identified during testing for helper virus in human gene transfer trials. J Virol. 1996;70:1804-1809.
    • (1996) J Virol , vol.70 , pp. 1804-1809
    • Miller, A.D.1    Bonham, L.2    Alfano, J.3
  • 24
    • 0035171689 scopus 로고    scopus 로고
    • Nonmyeloablative immunosuppressive regimen prolongs in vivo persistence of gene-modified autologous T cells in a nonhuman primate model
    • Berger C, Huang M-L, Gough M, et al. Nonmyeloablative immunosuppressive regimen prolongs in vivo persistence of gene-modified autologous T cells in a nonhuman primate model. J Virol. 2001;75:799-808.
    • (2001) J Virol , vol.75 , pp. 799-808
    • Berger, C.1    Huang, M.-L.2    Gough, M.3
  • 25
    • 0030757710 scopus 로고    scopus 로고
    • Use of α-2a-interferon to treat cytogenetic relapse of chronic myeloid leukemia after marrow transplantation
    • Higano CS, Chielens D, Raskind W, et al. Use of α-2a-interferon to treat cytogenetic relapse of chronic myeloid leukemia after marrow transplantation. Blood. 1997;90:2549-2554.
    • (1997) Blood , vol.90 , pp. 2549-2554
    • Higano, C.S.1    Chielens, D.2    Raskind, W.3
  • 26
    • 0026686761 scopus 로고
    • Use of α interferon for the treatment of relapse of chronic myelogenous leukemia in chronic phase after allogeneic bone marrow transplantation
    • Higano CS, Raskind WH, Singer JW. Use of α interferon for the treatment of relapse of chronic myelogenous leukemia in chronic phase after allogeneic bone marrow transplantation. Blood. 1992;80:1437-1442.
    • (1992) Blood , vol.80 , pp. 1437-1442
    • Higano, C.S.1    Raskind, W.H.2    Singer, J.W.3
  • 27
    • 0029100438 scopus 로고
    • Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients
    • Kolb H-J, Schattenberg A, Goldman JM, et al. Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. Blood. 1995;86:2041-2050.
    • (1995) Blood , vol.86 , pp. 2041-2050
    • Kolb, H.-J.1    Schattenberg, A.2    Goldman, J.M.3
  • 28
    • 2942712161 scopus 로고    scopus 로고
    • Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation
    • Collins RH Jr, Shpilberg O, Drobyski WR, et al. Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation. J Clin Oncol. 1997;15:433-444.
    • (1997) J Clin Oncol , vol.15 , pp. 433-444
    • Collins Jr., R.H.1    Shpilberg, O.2    Drobyski, W.R.3
  • 29
    • 0033649353 scopus 로고    scopus 로고
    • Granulocyte colony-stimulating factor given to donors before apheresis does not prevent aplasia in patients treated with donor leucocyte infusion for recurrent chronic myeloid leukemia after bone marrow transplantation
    • Flowers MED, Leisenring W, Beach K, et al. Granulocyte colony-stimulating factor given to donors before apheresis does not prevent aplasia in patients treated with donor leucocyte infusion for recurrent chronic myeloid leukemia after bone marrow transplantation. Biol Blood Marrow Transplant. 2000;6:321-326.
    • (2000) Biol Blood Marrow Transplant , vol.6 , pp. 321-326
    • Flowers, M.E.D.1    Leisenring, W.2    Beach, K.3
  • 30
    • 0034651931 scopus 로고    scopus 로고
    • Treatment of relapsed leukemia after unrelated donor marrow transplantation with unrelated donor leukocyte infusions
    • Porter DL, Collins RH Jr, Hardy C, et al. Treatment of relapsed leukemia after unrelated donor marrow transplantation with unrelated donor leukocyte infusions. Blood. 2000;95:1214-1221.
    • (2000) Blood , vol.95 , pp. 1214-1221
    • Porter, D.L.1    Collins Jr., R.H.2    Hardy, C.3
  • 31
    • 0344511772 scopus 로고    scopus 로고
    • Safety of retroviral gene marking with a truncated NGF receptor
    • Bonini C, Grez M, Traversari C, et al. Safety of retroviral gene marking with a truncated NGF receptor. Nat Med. 2003;9:367-369.
    • (2003) Nat Med , vol.9 , pp. 367-369
    • Bonini, C.1    Grez, M.2    Traversari, C.3
  • 32
    • 0034054579 scopus 로고    scopus 로고
    • Genetic modification of human T cells with CD20: A strategy to purify and lyse transduced cells with anti-CD20 antibodies
    • Introna M, Barbui AM, Bambacioni F, et al. Genetic modification of human T cells with CD20: a strategy to purify and lyse transduced cells with anti-CD20 antibodies. Hum Gene Ther. 2000;11:611-620.
    • (2000) Hum Gene Ther , vol.11 , pp. 611-620
    • Introna, M.1    Barbui, A.M.2    Bambacioni, F.3
  • 33
    • 0042199069 scopus 로고    scopus 로고
    • Transduction and selection of human T cells with novel CD34/thymidine kinase chimeric suicide genes for the treatment of graft-versus-host disease
    • Rettig MP, Ritchey JK, Meyerrose TE, Haug JS, Dipersio JF. Transduction and selection of human T cells with novel CD34/thymidine kinase chimeric suicide genes for the treatment of graft-versus-host disease. Mol Ther. 2003;8:29-41.
    • (2003) Mol Ther , vol.8 , pp. 29-41
    • Rettig, M.P.1    Ritchey, J.K.2    Meyerrose, T.E.3    Haug, J.S.4    Dipersio, J.F.5
  • 34
    • 0034182866 scopus 로고    scopus 로고
    • CD34 splice variants: An attractive marker for selection of gene-modified cells
    • Fehse B, Richters A, Putimtseva-Scharf K, et al. CD34 splice variants: an attractive marker for selection of gene-modified cells. Mol Ther. 2000;1:448-456.
    • (2000) Mol Ther , vol.1 , pp. 448-456
    • Fehse, B.1    Richters, A.2    Putimtseva-Scharf, K.3
  • 35
    • 0028297316 scopus 로고
    • Tumors expressing the cytosine deaminase suicide gene can be eliminated in vivo with 5-fluorocytosine and induce protective immunity to wild type tumor
    • Mullen CA, Coale MM, Lowe R, Blaese RM. Tumors expressing the cytosine deaminase suicide gene can be eliminated in vivo with 5-fluorocytosine and induce protective immunity to wild type tumor. Cancer Res. 1994;54:1503-1506.
    • (1994) Cancer Res , vol.54 , pp. 1503-1506
    • Mullen, C.A.1    Coale, M.M.2    Lowe, R.3    Blaese, R.M.4
  • 36
    • 0034690616 scopus 로고    scopus 로고
    • Retrovirus-mediated gene transfer in primary T lymphocytes: Influence of the transduction/selection process and of ex vivo expansion on the T cell receptor β chain hypervariable region repertoire
    • Ferrand C, Robinet E, Contassot E, et al. Retrovirus-mediated gene transfer in primary T lymphocytes: influence of the transduction/selection process and of ex vivo expansion on the T cell receptor β chain hypervariable region repertoire. Hum Gene Ther. 2000;11:1151-1164.
    • (2000) Hum Gene Ther , vol.11 , pp. 1151-1164
    • Ferrand, C.1    Robinet, E.2    Contassot, E.3
  • 37
    • 0035870253 scopus 로고    scopus 로고
    • Preemptive control of graft-versus-host disease in a murine allogeneic transplant model using retrovirally transduced murine suicidal lymphocytes
    • Kornblau SM, Stiouf I, Snell V, et al. Preemptive control of graft-versus-host disease in a murine allogeneic transplant model using retrovirally transduced murine suicidal lymphocytes. Cancer Res. 2001;61:3355-3360.
    • (2001) Cancer Res , vol.61 , pp. 3355-3360
    • Kornblau, S.M.1    Stiouf, I.2    Snell, V.3
  • 38
    • 0037441766 scopus 로고    scopus 로고
    • Immunologic potential of donor lymphocytes expressing a suicide gene for early immune reconstitution after hematopoietic T-cell-depleted stem cell transplantation
    • Marktel S, Magnani Z, Ciceri F, et al. Immunologic potential of donor lymphocytes expressing a suicide gene for early immune reconstitution after hematopoietic T-cell-depleted stem cell transplantation. Blood. 2003;101:1290-1298.
    • (2003) Blood , vol.101 , pp. 1290-1298
    • Marktel, S.1    Magnani, Z.2    Ciceri, F.3
  • 39
    • 0037438666 scopus 로고    scopus 로고
    • CD28 costimulation and immunoaffinity-based selection efficiently generate primary gene-modified T cells for adoptive immunotherapy
    • Berger C, Blau CA, Clackson T, Riddell SR, Heimfeld S. CD28 costimulation and immunoaffinity-based selection efficiently generate primary gene-modified T cells for adoptive immunotherapy. Blood. 2003;101:476-484.
    • (2003) Blood , vol.101 , pp. 476-484
    • Berger, C.1    Blau, C.A.2    Clackson, T.3    Riddell, S.R.4    Heimfeld, S.5
  • 40
    • 21044431642 scopus 로고    scopus 로고
    • Improving the ex vivo retroviral-mediated suicide-gene transfer process in T lymphocytes to preserve immune function
    • Robinet E, Fehse B, Ebeling S, et al. Improving the ex vivo retroviral-mediated suicide-gene transfer process in T lymphocytes to preserve immune function. Cytotherapy. 2005;7:150-157.
    • (2005) Cytotherapy , vol.7 , pp. 150-157
    • Robinet, E.1    Fehse, B.2    Ebeling, S.3
  • 41
    • 0037481021 scopus 로고    scopus 로고
    • Human T lymphocytes transduced by lentiviral vectors in the absence of TCR-activation maintain an intact immune competence
    • Cavalieri S, Cazzaniga S, Geuna M, et al. Human T lymphocytes transduced by lentiviral vectors in the absence of TCR-activation maintain an intact immune competence. Blood. 2003;102:497-505.
    • (2003) Blood , vol.102 , pp. 497-505
    • Cavalieri, S.1    Cazzaniga, S.2    Geuna, M.3
  • 43
    • 0035452585 scopus 로고    scopus 로고
    • Use of overlapping peptide mixtures as antigens for cytokine flow cytometry
    • Maecker HT, Dunn HS, Suni MA, et al. Use of overlapping peptide mixtures as antigens for cytokine flow cytometry. J Immunol Methods. 2001;255:27-40.
    • (2001) J Immunol Methods , vol.255 , pp. 27-40
    • Maecker, H.T.1    Dunn, H.S.2    Suni, M.A.3
  • 44
    • 2542454549 scopus 로고    scopus 로고
    • Analyzing T-cell responses to cytomegalovirus by cytokine flow cytometry
    • Maecker HT, Maino VC. Analyzing T-cell responses to cytomegalovirus by cytokine flow cytometry. Hum Immunol. 2004;65:493-499.
    • (2004) Hum Immunol , vol.65 , pp. 493-499
    • Maecker, H.T.1    Maino, V.C.2
  • 45
    • 0024598645 scopus 로고
    • Demonstration by class I gene transfer that reduced susceptibility of human cells to natural killer cell-mediated lysis is inversely correlated with HLA class I antigen expression
    • Shimizu Y, DeMars R. Demonstration by class I gene transfer that reduced susceptibility of human cells to natural killer cell-mediated lysis is inversely correlated with HLA class I antigen expression. Eur J Immunol. 1989;19:447-451.
    • (1989) Eur J Immunol , vol.19 , pp. 447-451
    • Shimizu, Y.1    DeMars, R.2
  • 47
    • 0032584149 scopus 로고    scopus 로고
    • Synthetic activation of caspases: Artificial death switches
    • U S A
    • MacCorkle RA, Freeman KW, Spencer DM. Synthetic activation of caspases: artificial death switches. Proc Natl Acad Sci U S A. 1998;95:3655-3660.
    • (1998) Proc Natl Acad Sci , vol.95 , pp. 3655-3660
    • MacCorkle, R.A.1    Freeman, K.W.2    Spencer, D.M.3
  • 48
    • 0035282726 scopus 로고    scopus 로고
    • A Fasbased suicide switch in human T cells for the treatment of graft-versus-host disease
    • Thomis DC, Marktel S, Bonini C, et al. A Fasbased suicide switch in human T cells for the treatment of graft-versus-host disease. Blood. 2001;97:1249-1257.
    • (2001) Blood , vol.97 , pp. 1249-1257
    • Thomis, D.C.1    Marktel, S.2    Bonini, C.3
  • 49
    • 0842264038 scopus 로고    scopus 로고
    • Pharmacologically regulated Fas-mediated death of adoptively transferred T cells in a nonhuman primate model
    • Berger C, Blau CA, Huang ML, et al. Pharmacologically regulated Fas-mediated death of adoptively transferred T cells in a nonhuman primate model. Blood. 2004;103:1261-1269.
    • (2004) Blood , vol.103 , pp. 1261-1269
    • Berger, C.1    Blau, C.A.2    Huang, M.L.3
  • 50
    • 19344365874 scopus 로고    scopus 로고
    • An inducible caspase 9 safety switch for T-cell therapy
    • Straathof KC, Pulè MA, Yotnda P, et al. An inducible caspase 9 safety switch for T-cell therapy. Blood. 2005;105:4247-4254.
    • (2005) Blood , vol.105 , pp. 4247-4254
    • Straathof, K.C.1    Pulè, M.A.2    Yotnda, P.3
  • 51
    • 0033588876 scopus 로고    scopus 로고
    • Improved artificial death switches based on caspases and FADD
    • Fan L, Freeman KW, Khan T, Pham E, Spencer DM. Improved artificial death switches based on caspases and FADD. Hum Gene Ther. 1999;10:2273-2285.
    • (1999) Hum Gene Ther , vol.10 , pp. 2273-2285
    • Fan, L.1    Freeman, K.W.2    Khan, T.3    Pham, E.4    Spencer, D.M.5
  • 52
    • 85047697543 scopus 로고    scopus 로고
    • Ablation of microvessels in vivo upon dimerization of iCaspase-9
    • Nör JE, Hu Y, Song W, Spencer DM, Núñez G. Ablation of microvessels in vivo upon dimerization of iCaspase-9. Gene Ther. 2002;9:444-451.
    • (2002) Gene Ther , vol.9 , pp. 444-451
    • Nör, J.E.1    Hu, Y.2    Song, W.3    Spencer, D.M.4    Núñez, G.5
  • 53
    • 0030800070 scopus 로고    scopus 로고
    • Inhibition of death receptor signals by cellular FLIP
    • Irmler M, Thome M, Hahne M, et al. Inhibition of death receptor signals by cellular FLIP. Nature. 1997;388:190-195.
    • (1997) Nature , vol.388 , pp. 190-195
    • Irmler, M.1    Thome, M.2    Hahne, M.3
  • 54
    • 0030810926 scopus 로고    scopus 로고
    • X-linked IAP is a direct inhibitor of cell-death proteases
    • Deveraux QL, Takahashi R, Salvesen GS, Reed JC. X-linked IAP is a direct inhibitor of cell-death proteases. Nature. 1997;388:300-304.
    • (1997) Nature , vol.388 , pp. 300-304
    • Deveraux, Q.L.1    Takahashi, R.2    Salvesen, G.S.3    Reed, J.C.4
  • 56
    • 4644324025 scopus 로고    scopus 로고
    • Cancer immunotherapy: Moving beyond current vaccines
    • Rosenberg SA, Yang JC, Restifo NP. Cancer immunotherapy: moving beyond current vaccines. Nat Med. 2004;10:909-915.
    • (2004) Nat Med , vol.10 , pp. 909-915
    • Rosenberg, S.A.1    Yang, J.C.2    Restifo, N.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.