Cell cycle-related changes in repopulating capacity of human mobilized peripheral blood CD34+ cells in non-obese diabetic/severe combined immune- deficient mice

Blood

Volumn 92, Issue 8, 1998, Pages 2641-2649

  Gothot, André ^b   Van der Loo, Johannes C M ^b   Clapp, D Wade ^b   Srour, Edward F ^a  

^a INDIANA UNIVERSITY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; LIGAND; RECOMBINANT ERYTHROPOIETIN; RECOMBINANT INTERLEUKIN 3; RECOMBINANT STEM CELL FACTOR; THROMBOPOIETIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BURST FORMING UNIT E; CELL CYCLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL POPULATION; CELL TRANSPLANTATION; COLONY FORMING CELL; COLONY FORMING UNIT GM; CONTROLLED STUDY; DIABETES MELLITUS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PERIPHERAL CIRCULATION; PRIORITY JOURNAL; SCID MOUSE;

EID: 0032532361     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v92.8.2641     Document Type: Article

References (40)

1. Emerson SG: Ex vivo expansion of hematopoietic precursors, progenitors, and stem cells: The next generation of cellular therapeutics [Review]. Blood 87:3082, 1996
2. Miller DG, Adam MA, Miller AD: Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection. Mol Cell Biol 10:4239, 1990
3. Hajihosseini M, Iavachev L, Price J: Evidence that retroviruses integrate into post-replication host DNA. EMBO J 12:4969, 1993
4. Leary AG, Zeng HQ, Clark SC, Ogawa M: Growth factor requirements for survival in G0 and entry into the cell cycle of primitive human hemopoietic progenitors. Proc Natl Acad Sci USA 89:4013, 1992
5. Ogawa M: Differentiation and proliferation of hematopoietic stem cells [Review]. Blood 81:2844, 1993
6. Traycoff CM, Kosak ST, Grigsby S, Srour EF: Evaluation of ex vivo expansion potential of cord blood and bone marrow hematopoietic progenitor cells using cell tracking and limiting dilution analysis. Blood 85:2059, 1995
7. Berardi AC, Wang A, Levine JD, Lopez P, Scadden DT: Functional isolation and characterization of human hematopoietic stem cells. Science 267:104, 1995
8. van der Loo JC, Ploemacher RE: Marrow- and spleen-seeding efficiencies of all murine hematopoietic stem cell subsets are decreased by preincubation with hematopoietic growth factors. Blood 85:2598, 1995
9. Peters SO, Kittler EL, Ramshaw HS, Quesenberry PJ: Murine marrow cells expanded in culture with IL-3, IL-6, IL-11, and SCF acquire an engraftment defect in normal hosts. Exp Hematol 23:461, 1995 (erratum 23:568, 1995)
10. Peters SO, Kittler EL, Ramshaw HS, Quesenberry PJ: Ex vivo expansion of murine marrow cells with interleukin-3 (IL-3), IL-6, IL-11, and stem cell factor leads to impaired engraftment in irradiated hosts. Blood 87:30, 1996
11. Traycoff CM, Cornetta K, Yoder MC, Davidson A, Srour EF: Ex vivo expansion of murine hematopoietic progenitor cells generates classes of expanded cells possessing different levels of bone marrow repopulating potential. Exp Hematol 24:299, 1996
12. Ramshaw HS, Rao SS, Crittenden RB, Peters SO, Weier HU, Quesenberry PJ: Engraftment of bone marrow cells into normal unprepared hosts: Effects of 5-fluorouracil and cell cycle status. Blood 86:924, 1995
13. Wang JCY, Doedens M, Dick JE: Primitive human hematopoietic cells are enriched in cord blood compared with adult bone marrow or mobilized peripheral blood as measured by the quantitative in vivo SCID-repopulating cell assay. Blood 89:3319, 1997
14. Cashman JD, Lapidot T, Wang JC, Doedens M, Shultz LD, Lansdorp P, Dick JE, Eaves CJ: Kinetic evidence of the regeneration of multilineage hematopoiesis from primitive cells in normal human bone marrow transplanted into immunodeficient mice. Blood 89:4307, 1997
15. Pflumio F, Izac B, Katz A, Shultz LD, Vainchenker W, Coulombel L: Phenotype and function of human hematopoietic cells engrafting immune-deficient CB17-severe combined immunodeficiency mice and nonobese diabetic-severe combined immunodeficiency mice after transplantation of human cord blood mononuclear cells. Blood 88:3731, 1996
16. + hematopoietic progenitor cells residing in G0. Blood 90:658, 1997
17. + cells isolated in subcompartments of the G0/G1 phase of the cell cycle. Blood 90:4384, 1997
18. Gothot A, Pyatt R, McMahel J, Rice S, Srour EF: Assessment of proliferative and colony-forming capacity after successive in vitro divisions of single human CD34+ cells initially isolated in G0. Exp Hematol 26:562, 1998
19. Shultz LD, Schweitzer PA, Christianson SW, Gott B, Schweitzer IB, Tennent B, McKenna S, Mobraaten L, Rajan TV, Greiner DL, Leiter EH: Multiple defects in innate and adaptive immunologic function in NOD/LTSz-scid mice. J Immunol 154:180, 1995
20. Jordan CT, Yamasaki G, Minamoto D: High-resolution cell cycle analysis of defined phenotypic subsets within primitive human hematopoietic cell populations. Exp Hematol 24:1347, 1996
21. Lapidot T, Pflumio F, Doedens M, Murdoch B, Williams DE, Dick JE: Cytokine stimulation of multilineage hematopoiesis from immature human cells engrafted in SCID mice. Science 255:1137, 1992
22. Sutherland HJ, Eaves CJ, Lansdorp PM, Thacker JD, Hogge DE: Differential regulation of primitive human hematopoietic cells in long-term cultures maintained on genetically engineered murine stromal cells. Blood 78:666, 1991
23. Taswell C: Limiting dilution assays for the determination of immunocompetent cell frequencies. J Immunol 126:1614, 1981
24. Conneally E, Cashman J, Petzer A, Eaves C: Expansion in vitro of transplantable human cord blood stem cells demonstrated using a quantitative assay of their lympho-myeloid repopulating activity in nonobese diabetic-scid/scid mice. Proc Natl Acad Sci USA 94:9836, 1997
25. Srour E, Bregni M, Traycoff C, Aguero B, Kosak S, Hoffman R, Siena S, Gianni A: Long-term hematopoietic culture-initiating cells are more abundant in mobilized peripheral blood grafts than in bone marrow but have a more limited ex vivo expansion potential. Blood Cells Mol Dis 22:68, 1996
26. Uchida N, He D, Friera A, Reitsma M, Sasaki D, Chen B, Tsukamoto A: The unexpected G0/G1 cell cycle status of mobilized hematopoietic stem cells from the peripheral blood. Blood 89:465, 1997
27. Roberts AW, Metcalf D: Noncycling state of peripheral blood progenitor cells mobilized by granulocyte colony-stimulating factor and other cytokines. Blood 86:1600, 1995
28. Petzer AL, Zandstra PW, Piret JM, Eaves CJ: Differential cytokine effects on primitive (CD34+CD38-) human hematopoietic cells: Novel responses to Flt3-ligand and thrombopoietin. J Exp Med 183:2551, 1996
29. Yonemura Y, Hsun K, Hirayama F, Souza LM, Ogawa M: Interleukin 3 or interleukin 1 abrogates the reconstituting ability of hematopoietic stem cells. Proc Natl Acad Sci USA 93:4040, 1996
30. Zandstra PW, Conneally E, Petzer AL, Piret JM, Eaves CJ: Cytokine manipulation of primitive human hematopoietic cell self-renewal. Proc Natl Acad Sci USA 94:4698, 1997
31. Kobayashi M, Laver JH, Kato T, Miyazaki H, Ogawa M: Thrombopoietin supports proliferation of human primitive hematopoietic cells in synergy with Steel factor and/or interleukin-3. Blood 88:429, 1996
32. Gan OI, Murdoch B, Larochelle A, Dick JE: Differential maintenance of primitive human SCID-repopuIating cells, clonogenic progenitors, and long term culture-initiating cells after incubation on human bone marrow stromal cells. Blood 90:641, 1997
33. Laroehelle A, Vormoor J, Hanenberg H, Wang JC, Bhatia M, Lapidot T, Moritz T, Murdoch B, Xiao XL, Kato I, Williams DA, Dick JE: Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: Implications for gene therapy. Nat Med 2:1329, 1996
34. Bhatia M, Bonnet D, Kapp U, Wang JC, Murdoch B, Dick JE: Quantitative analysis reveals expansion of human hematopoietic repopulating cells after short-term ex vivo culture. J Exp Med 186:619, 1997
35. Levesque JP, Leavesley DI, Niutta S, Vadas M, Simmons PJ: Cytokines increase human hematopoietic cell adhesiveness by activation of very late antigen (VLA)-4 and VLA-5 integrins. J Exp Med 181:1805, 1995
36. Levesque JP, Haylock DN, Simmons PJ: Cytokine regulation of proliferation and cell adhesion are correlated events in human CD34+ hemopoietic progenitors. Blood 88:1168, 1996
37. Legras S, Levesque JP, Charrad R, Moromoto K, Le Bousse C, Clay D, Jasmin C, Smadja-Joffe F: mediated adhesiveness of Clay D, Jasmin C, Smadia-Joffe F: CD44-mediated adhesiveness of human hematopoieitc progenitors to hyaluronan is modulated by human hematopoieitc progenitors to hyaluronan is modulated by cytokines. Blood 89:1905, 1997
38. Prosper F, Stroncek D, McCarthy JB, Verfaillie CM: Mobilization and homing of peripheral blood progenitors is related to reversible downregulation of alpha4beta 1 integrin expression and function. J Clin Invest 101:2456, 1998
39. Traycoff CM, Yoder M, Hiatt K, Srour EF: Functional associa tion between expression of adhesion molecules and marrow repopulating potential of primitive murine hematopoietic progenitor cells. Exp Hematol 25:736a, 1997 (abstr)
40. Verfaillie CM, Mc Carthy JB, Mc Glave PB: Differentiation of primitive human multipotent hematopoietic progenitors into single lineage clonogemc progenitors is accompanied by alterations in their interaction with fibronectin. J Exp Med 174:693, 1991