ΔMGMT-transduced bone marrow infusion increases tolerance to O6-benzylguanine and 1,3-Bis(2-chloroethyl)-1-nitrosourea and allows intensive therapy of 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant Human colon cancer xenografts

Human Gene Therapy

Volumn 10, Issue 6, 1999, Pages 1021-1030

  Koç, Omer N ^a   Reese, Jane S ^a   Davis, Brian M ^a   Liu, Lili ^a   Majczenko, Karen J ^a   Gerson, Stanton L ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; 6 O BENZYLGUANINE; BETA GALACTOSIDASE; CARMUSTINE; MACROGOL 400; ALKYLATING AGENT; DRUG DERIVATIVE; GUANINE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; O(6) BENZYLGUANINE; O(6)-BENZYLGUANINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD CELL COUNT; BONE MARROW; COLON CANCER; COLONY FORMING UNIT; CONTROLLED STUDY; DRUG SENSITIZATION; DRUG TOLERANCE; ENZYME ACTIVITY; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; NUDE MOUSE; PROVIRUS; RETROVIRUS; TUMOR XENOGRAFT; ANIMAL; BONE MARROW TRANSPLANTATION; CANCER TRANSPLANTATION; CELL DIVISION; COLON TUMOR; DRUG EFFECT; DRUG RESISTANCE; GENE VECTOR; GENETICS; METABOLISM; MULTIMODALITY CANCER THERAPY; PATHOLOGY;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; BONE MARROW TRANSPLANTATION; CARMUSTINE; CELL DIVISION; COLONIC NEOPLASMS; COMBINED MODALITY THERAPY; DRUG RESISTANCE, NEOPLASM; GENETIC VECTORS; GUANINE; HUMANS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; RETROVIRIDAE; TRANSDUCTION, GENETIC;

EID: 0033541165     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430349950018418     Document Type: Article

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