Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy

Journal of Clinical Investigation

Volumn 117, Issue 8, 2007, Pages 2225-2232

  Deichmann, Annette ^a,b   Hacein Bey Abina, Salima ^c,d   Schmidt, Manfred ^a,b   Garrigue, Alexandrine ^c   Brugman, Martijn H ^e   Hu, Jingqiong ^a   Glimm, Hanno ^a   Gyapay, Gabor ^f   Prum, Bernard ^g   Fraser, Christopher C ^h   Fischer, Nicolas ⁱ   Schwarzwaelder, Kerstin ^a,b   Siegler, Maria Luise ^a   De Ridder, Dick ^e,j   Pike Overzet, Karin ^e   Howe, Steven J ^k   Thrasher, Adrian J ^k,l   Wagemaker, Gerard ^e   Abel, Ulrich ^b,m   Staal, Frank J T ^e   Delabesse, Eric ⁿ   Villeval, Jean Luc ^o   Aronow, Bruce ^p   Hue, Christophe ^c,d   Prinz, Claudia ^a   Wissler, Manuela ^a   Klanke, Chuck ^q   Weissenbach, Jean ^f   Alexander, Ian ^r   Fischer, Alain ^c,d   Von Kalle, Christof ^a,b,q   Cavazzana Calvo, Marina ^c,d   more..

^a UNIVERSITY OF FREIBURG   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c INSERM   (France)

^d HÔPITAL NECKER ENFANTS MALADES   (France)

^e ERASMUS MEDICAL CENTER   (Netherlands)

^f Genoscope   (France)

^g University of Paris 5   (France)

^h MILLENNIUM PHARMACEUTICALS INC   (United States)

ⁱ LABORATOIRE NATIONAL DE MÉTROLOGIE ET D ESSAIS LNE   (France)

^j Delft University of Technology ^*  (Netherlands)

^k UNIVERSITY COLLEGE LONDON   (United Kingdom)

^l GREAT ORMOND STREET HOSPITAL   (United Kingdom)

^m Tumor Center Heidelberg Mannheim   (Germany)

ⁿ CHU PURPAN   (France)

^o INSTITUT GUSTAVE ROUSSY   (France)

^p CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^q CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

^r CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; RETROVIRUS VECTOR;

ARTICLE; COMBINED IMMUNODEFICIENCY; COMMON INTEGRATION SITE; DNA INTEGRATION; GENE INSERTION; GENE ISOLATION; GENE LOCUS; GENE MAPPING; HUMAN; HUMAN CELL; LYMPHOPOIESIS; PRIORITY JOURNAL; RETROVIRAL INTEGRATION SITE; STEM CELL; T LYMPHOCYTE; VIRAL GENE THERAPY; X CHROMOSOME LINKED DISORDER;

EID: 34249906359     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI31659     Document Type: Article

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