메뉴 건너뛰기




Volumn 103, Issue 2, 2004, Pages 545-552

Lentivector-mediated clonal tracking reveals intrinsic heterogeneity in the human hematopoietic stem cell compartment and culture-induced stem cell impairment

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; LENTIVIRUS VECTOR;

EID: 0942266035     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2003-05-1558     Document Type: Article
Times cited : (131)

References (46)
  • 1
    • 0033649674 scopus 로고    scopus 로고
    • The human sheep xenograft model for the study of the in vivo potential of human HSC and in utero gene transfer [meeting report]
    • Zanjani ED. The human sheep xenograft model for the study of the in vivo potential of human HSC and in utero gene transfer [meeting report]. Stem Cells. 2000;18:151.
    • (2000) Stem Cells , vol.18 , pp. 151
    • Zanjani, E.D.1
  • 2
    • 0012951216 scopus 로고    scopus 로고
    • Normal and leukemic human stem cells assayed in immune-deficient mice
    • Zon LI, ed. New York, NY: Oxford University Press
    • Wang JCY, Dorrell C, Ito CY, et al. Normal and leukemic human stem cells assayed in immune-deficient mice. In: Zon LI, ed. Hematopoiesis: A Developmental Approach. New York, NY: Oxford University Press; 2001:99-118.
    • (2001) Hematopoiesis: A Developmental Approach , pp. 99-118
    • Wang, J.C.Y.1    Dorrell, C.2    Ito, C.Y.3
  • 3
    • 0036754547 scopus 로고    scopus 로고
    • Current understanding of stem cell mobilization: The roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells
    • Lapidot T, Petit I. Current understanding of stem cell mobilization: the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells. Exp Hematol. 2002;30:973-981.
    • (2002) Exp Hematol , vol.30 , pp. 973-981
    • Lapidot, T.1    Petit, I.2
  • 4
    • 0036068925 scopus 로고    scopus 로고
    • Haematopoietic stem cells
    • Bonnet D. Haematopoietic stem cells. J Pathol. 2002;197:430-440.
    • (2002) J Pathol , vol.197 , pp. 430-440
    • Bonnet, D.1
  • 5
    • 0024213526 scopus 로고
    • Engraftment of immune-deficient mice with human hematopoietic stem cells
    • Kamel-Reid S, Dick JE. Engraftment of immune-deficient mice with human hematopoietic stem cells. Science. 1988;242:1706-1709.
    • (1988) Science , vol.242 , pp. 1706-1709
    • Kamel-Reid, S.1    Dick, J.E.2
  • 6
    • 0026581239 scopus 로고
    • Cytokine stimulation of multilineage hematopoiesis from immature human cells engrafted in scid mice
    • Lapidot T, Pflumio F, Doedens M, Murdoch B, Williams DE, Dick JE. Cytokine stimulation of multilineage hematopoiesis from immature human cells engrafted in scid mice. Science. 1992;255:1137-1141.
    • (1992) Science , vol.255 , pp. 1137-1141
    • Lapidot, T.1    Pflumio, F.2    Doedens, M.3    Murdoch, B.4    Williams, D.E.5    Dick, J.E.6
  • 7
    • 16144365969 scopus 로고    scopus 로고
    • Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: Implications for gene therapy
    • Larochelle A, Vormoor J, Hanenberg H, et al. Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: implications for gene therapy. Nat Med. 1996;2:1329-1337.
    • (1996) Nat Med , vol.2 , pp. 1329-1337
    • Larochelle, A.1    Vormoor, J.2    Hanenberg, H.3
  • 8
    • 0035140382 scopus 로고    scopus 로고
    • Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SCID-beta2 microglobulin-null mice
    • Glimm H, Eisterer W, Lee K, et al. Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SCID-beta2 microglobulin-null mice. J Clin Invest. 2001;107:199-206.
    • (2001) J Clin Invest , vol.107 , pp. 199-206
    • Glimm, H.1    Eisterer, W.2    Lee, K.3
  • 10
    • 0035478641 scopus 로고    scopus 로고
    • - cells home specifically to the bone marrow of NOD/LtSZ scid/scid mice but show different kinetics in expansion
    • - cells home specifically to the bone marrow of NOD/LtSZ scid/scid mice but show different kinetics in expansion. J Immunol. 2001;167:3692-3698.
    • (2001) J Immunol , vol.167 , pp. 3692-3698
    • Kerre, T.C.1    De Smet, G.2    De Smedt, M.3
  • 11
    • 0038406789 scopus 로고    scopus 로고
    • Biology of hematopoietic stem cells and progenitors: Implications for clinical application
    • Kondo M, Wagers A, Manz M, et al. Biology of hematopoietic stem cells and progenitors: Implications for clinical application. Annu Rev Immunol. 2003;21:759-806.
    • (2003) Annu Rev Immunol , vol.21 , pp. 759-806
    • Kondo, M.1    Wagers, A.2    Manz, M.3
  • 12
    • 0038148364 scopus 로고    scopus 로고
    • Hematopoietic stem cells engraft in mice with absolute efficiency
    • Benveniste P, Cantin C, Hyam D, Iscove NN. Hematopoietic stem cells engraft in mice with absolute efficiency. Nat Immunol. 2003;4:708-713.
    • (2003) Nat Immunol , vol.4 , pp. 708-713
    • Benveniste, P.1    Cantin, C.2    Hyam, D.3    Iscove, N.N.4
  • 13
    • 0035234914 scopus 로고    scopus 로고
    • The return of clonal marking sheds new light on human hematopoietic stem cells
    • Lemischka IR, Jordan CT. The return of clonal marking sheds new light on human hematopoietic stem cells. Nat Immunol. 2001;2:11-12.
    • (2001) Nat Immunol , vol.2 , pp. 11-12
    • Lemischka, I.R.1    Jordan, C.T.2
  • 14
    • 0035228050 scopus 로고    scopus 로고
    • Distinct classes of human stem cells that differ in proliferative and self-renewal potential
    • Guenechea G, Gan OI, Dorrell C, Dick JE. Distinct classes of human stem cells that differ in proliferative and self-renewal potential. Nat Immunol. 2001;2:75-82.
    • (2001) Nat Immunol , vol.2 , pp. 75-82
    • Guenechea, G.1    Gan, O.I.2    Dorrell, C.3    Dick, J.E.4
  • 15
    • 0037296820 scopus 로고    scopus 로고
    • Clinical application of hematopoietic progenitor cell expansion: Current status and future prospects
    • Devine SM, Lazarus HM, Emerson SG. Clinical application of hematopoietic progenitor cell expansion: current status and future prospects. Bone Marrow Transplant. 2003;31:241-252.
    • (2003) Bone Marrow Transplant , vol.31 , pp. 241-252
    • Devine, S.M.1    Lazarus, H.M.2    Emerson, S.G.3
  • 17
    • 0037064543 scopus 로고    scopus 로고
    • Ex vivo expansion of hematopoietic stem cells by cytokines
    • Heike T, Nakahata T. Ex vivo expansion of hematopoietic stem cells by cytokines. Biochim Biophys Acta. 2002;1592:313-321.
    • (2002) Biochim Biophys Acta , vol.1592 , pp. 313-321
    • Heike, T.1    Nakahata, T.2
  • 18
    • 0034045086 scopus 로고    scopus 로고
    • Expansion of human NOD/SCID-repopulating cells by stem cell factor, Flk2/Flt3 ligand, thrombopoietin, IL-6, and soluble IL-6 receptor
    • Ueda T, Tsuji K, Yoshino H, et al. Expansion of human NOD/SCID-repopulating cells by stem cell factor, Flk2/Flt3 ligand, thrombopoietin, IL-6, and soluble IL-6 receptor. J Clin Invest. 2000;105:1013-1021.
    • (2000) J Clin Invest , vol.105 , pp. 1013-1021
    • Ueda, T.1    Tsuji, K.2    Yoshino, H.3
  • 19
    • 0030788152 scopus 로고    scopus 로고
    • Quantitative analysis reveals expansion of human hematopoietic repopulating cells after short-term ex vivo culture
    • Bhatia M, Bonnet D, Kapp U, Wang JCY, Murdoch B, Dick JE. Quantitative analysis reveals expansion of human hematopoietic repopulating cells after short-term ex vivo culture. J Exp Med. 1997;186:619-624.
    • (1997) J Exp Med , vol.186 , pp. 619-624
    • Bhatia, M.1    Bonnet, D.2    Kapp, U.3    Wang, J.C.Y.4    Murdoch, B.5    Dick, J.E.6
  • 20
    • 0030886656 scopus 로고    scopus 로고
    • Expansion in vitro of transplantable human cord blood stem cells demonstrated using a quantitative assay of their lympho-myeloid repopulating activity in nonobese diabetic-scid/scid mice
    • Conneally E, Cashman J, Petzer A, Eaves C. Expansion in vitro of transplantable human cord blood stem cells demonstrated using a quantitative assay of their lympho-myeloid repopulating activity in nonobese diabetic-scid/scid mice. Proc Natl Acad Sci U S A. 1997;94:9836-9841.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 9836-9841
    • Conneally, E.1    Cashman, J.2    Petzer, A.3    Eaves, C.4
  • 21
    • 0037114698 scopus 로고    scopus 로고
    • Lentiviral gene transfer and ex vivo expansion of human primitive stem cells capable of primary, secondary, and tertiary multilineage repopulation in NOD/SCID mice
    • Piacibello W, Bruno S, Sanavio F, et al. Lentiviral gene transfer and ex vivo expansion of human primitive stem cells capable of primary, secondary, and tertiary multilineage repopulation in NOD/SCID mice. Blood. 2002;100:4391-4400.
    • (2002) Blood , vol.100 , pp. 4391-4400
    • Piacibello, W.1    Bruno, S.2    Sanavio, F.3
  • 22
    • 0033152360 scopus 로고    scopus 로고
    • Engraftment in nonobese diabetic severe combined immunodeficient mice of human CD34(+) cord blood cells after ex vivo expansion: Evidence for the amplification and self-renewal of repopulating stem cells
    • Piacibello W, Sanavio F, Severino A, et al. Engraftment in nonobese diabetic severe combined immunodeficient mice of human CD34(+) cord blood cells after ex vivo expansion: evidence for the amplification and self-renewal of repopulating stem cells. Blood. 1999;93:3736-3749.
    • (1999) Blood , vol.93 , pp. 3736-3749
    • Piacibello, W.1    Sanavio, F.2    Severino, A.3
  • 23
    • 0032532361 scopus 로고    scopus 로고
    • Cell cycle-related changes in repopulating capacity of human mobilized peripheral blood CD34(+) cells in non-obese diabetic/severe combined immune-deficient mice
    • Gothot A, van der Loo JC, Clapp DW, Srour EF. Cell cycle-related changes in repopulating capacity of human mobilized peripheral blood CD34(+) cells in non-obese diabetic/severe combined immune-deficient mice. Blood. 1998;92:2641-2649.
    • (1998) Blood , vol.92 , pp. 2641-2649
    • Gothot, A.1    Van Der Loo, J.C.2    Clapp, D.W.3    Srour, E.F.4
  • 24
    • 0345196594 scopus 로고    scopus 로고
    • Delayed engraftment of nonobese diabetic/severe combined immunodeficient mice transplanted with ex vivo-expanded human CD34(+) cord blood cells
    • Guenechea G, Segovia JC, Albella B, et al. Delayed engraftment of nonobese diabetic/severe combined immunodeficient mice transplanted with ex vivo-expanded human CD34(+) cord blood cells. Blood. 1999;93:1097-1105.
    • (1999) Blood , vol.93 , pp. 1097-1105
    • Guenechea, G.1    Segovia, J.C.2    Albella, B.3
  • 25
    • 0033964863 scopus 로고    scopus 로고
    • Expansion of human cord blood CD34(+)CD38(-) cells in ex vivo culture during retroviral transduction without a corresponding increase in SCID repopulating cell (SRC) frequency: Dissociation of SRC phenotype and function
    • Dorrell C, Gan OI, Pereira DS, Hawley RG, Dick JE. Expansion of human cord blood CD34(+)CD38(-) cells in ex vivo culture during retroviral transduction without a corresponding increase in SCID repopulating cell (SRC) frequency: dissociation of SRC phenotype and function. Blood. 2000;95:102-110.
    • (2000) Blood , vol.95 , pp. 102-110
    • Dorrell, C.1    Gan, O.I.2    Pereira, D.S.3    Hawley, R.G.4    Dick, J.E.5
  • 26
    • 0034199171 scopus 로고    scopus 로고
    • - bone marrow and cord blood-derived SCID-repopulating cells with third-generation lentiviral vectors
    • - bone marrow and cord blood-derived SCID-repopulating cells with third-generation lentiviral vectors. Mol Ther. 2000;1:452-459.
    • (2000) Mol Ther , vol.1 , pp. 452-459
    • Guenechea, G.1    Gan, O.I.2    Inamitsu, T.3
  • 27
    • 0033120735 scopus 로고    scopus 로고
    • One-day ex vivo culture allows effective gene transfer into human nonobese diabetic/severe combined immune-deficient repopulating cells using high-titer vesicular stomatitis virus G protein pseudotyped retrovirus
    • Rebel VI, Tanaka M, Lee JS, et al. One-day ex vivo culture allows effective gene transfer into human nonobese diabetic/severe combined immune-deficient repopulating cells using high-titer vesicular stomatitis virus G protein pseudotyped retrovirus. Blood. 1999;93:2217-2224.
    • (1999) Blood , vol.93 , pp. 2217-2224
    • Rebel, V.I.1    Tanaka, M.2    Lee, J.S.3
  • 28
    • 0033731126 scopus 로고    scopus 로고
    • Ex vivo expansion of transplantable human hematopoietic stem cells: Where do we stand in the year 2000?
    • Shih CC, DiGiusto D, Forman SJ. Ex vivo expansion of transplantable human hematopoietic stem cells: where do we stand in the year 2000? J Hematother Stem Cell Res. 2000;9:621-628.
    • (2000) J Hematother Stem Cell Res , vol.9 , pp. 621-628
    • Shih, C.C.1    DiGiusto, D.2    Forman, S.J.3
  • 29
    • 0030920565 scopus 로고    scopus 로고
    • CD34 positive PBPC expanded ex vivo may not provide durable engraftment following myeloablative chemoradiotherapy regimens
    • Holyoake TL, Alcorn MJ, Richmond L, et al. CD34 positive PBPC expanded ex vivo may not provide durable engraftment following myeloablative chemoradiotherapy regimens. Bone Marrow Transplant. 1997;19:1095-1101.
    • (1997) Bone Marrow Transplant , vol.19 , pp. 1095-1101
    • Holyoake, T.L.1    Alcorn, M.J.2    Richmond, L.3
  • 30
    • 0034759948 scopus 로고    scopus 로고
    • The molecular basis for the cytokine-induced defect in homing and engraftment of hematopoietic stem cells
    • Berrios VM, Dooner GJ, Nowakowski G, et al. The molecular basis for the cytokine-induced defect in homing and engraftment of hematopoietic stem cells. Exp Hematol. 2001;29:1326-1335.
    • (2001) Exp Hematol , vol.29 , pp. 1326-1335
    • Berrios, V.M.1    Dooner, G.J.2    Nowakowski, G.3
  • 31
    • 0035731827 scopus 로고    scopus 로고
    • Gene therapy for genetic haematological disorders and immunodeficiencies
    • Kohn DB. Gene therapy for genetic haematological disorders and immunodeficiencies. J Intern Med. 2001;249:379-390.
    • (2001) J Intern Med , vol.249 , pp. 379-390
    • Kohn, D.B.1
  • 33
    • 0036811540 scopus 로고    scopus 로고
    • Advances in lentiviral vector design for gene-modification of hematopoietic stem cells
    • Logan AC, Lutzko C, Kohn DB. Advances in lentiviral vector design for gene-modification of hematopoietic stem cells. Curr Opin Biotechnol. 2002;13:429-436.
    • (2002) Curr Opin Biotechnol , vol.13 , pp. 429-436
    • Logan, A.C.1    Lutzko, C.2    Kohn, D.B.3
  • 34
    • 0037424875 scopus 로고    scopus 로고
    • Current developments in the design of onco-retrovirus and lentivirus vector systems for hematopoietic cell gene therapy
    • Brenner S, Malech HL. Current developments in the design of onco-retrovirus and lentivirus vector systems for hematopoietic cell gene therapy. Biochim Biophys Acta. 2003;1640:1-24.
    • (2003) Biochim Biophys Acta , vol.1640 , pp. 1-24
    • Brenner, S.1    Malech, H.L.2
  • 35
    • 0034040751 scopus 로고    scopus 로고
    • Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences
    • Follenzi A, Ailles LE, Bakovic S, Geuna M, Naldini L. Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences. Nat Genet. 2000;25:217-222.
    • (2000) Nat Genet , vol.25 , pp. 217-222
    • Follenzi, A.1    Ailles, L.E.2    Bakovic, S.3    Geuna, M.4    Naldini, L.5
  • 36
    • 0028281703 scopus 로고
    • Immature human cord blood progenitors engraft and proliferate to high levels in immune-deficient SCID mice
    • Vormoor J, Lapidot T, Pflumio F, et al. Immature human cord blood progenitors engraft and proliferate to high levels in immune-deficient SCID mice. Blood. 1994;83:2489-2497.
    • (1994) Blood , vol.83 , pp. 2489-2497
    • Vormoor, J.1    Lapidot, T.2    Pflumio, F.3
  • 37
    • 0029909095 scopus 로고    scopus 로고
    • Local clonal analysis of the hematopoietic system shows that multiple small short-living clones maintain life-long hematopoiesis in reconstituted mice
    • Drize NJ, Keller JR, Chertkov JL. Local clonal analysis of the hematopoietic system shows that multiple small short-living clones maintain life-long hematopoiesis in reconstituted mice. Blood. 1996;88:2927-2938.
    • (1996) Blood , vol.88 , pp. 2927-2938
    • Drize, N.J.1    Keller, J.R.2    Chertkov, J.L.3
  • 38
    • 0037783434 scopus 로고    scopus 로고
    • A highly sensitive strategy for SCID-Repopulating cell assay by direct injection of primitive human hematopoietic cells into NOD/SCID mice bone marrow
    • Yahata T, Ando K, Sato T, et al. A highly sensitive strategy for SCID-Repopulating cell assay by direct injection of primitive human hematopoietic cells into NOD/SCID mice bone marrow. Blood. 2003;101:2905-2913.
    • (2003) Blood , vol.101 , pp. 2905-2913
    • Yahata, T.1    Ando, K.2    Sato, T.3
  • 39
    • 0038281385 scopus 로고    scopus 로고
    • SCID-repopulating cell activity of human cord blood-derived CD34-negative cells assured by intra-bone marrow injection
    • Wang J, Kimura T, Asada R, et al. SCID-repopulating cell activity of human cord blood-derived CD34-negative cells assured by intra-bone marrow injection. Blood. 2003;101:2924-2931.
    • (2003) Blood , vol.101 , pp. 2924-2931
    • Wang, J.1    Kimura, T.2    Asada, R.3
  • 40
    • 0038379165 scopus 로고    scopus 로고
    • Rapid myeloerythroid repopulation after intrafemoral transplantation of NOD-SCID mice reveals a new class of human stem cells
    • Mazurier F, Doedens M, Gan OI, Dick JE. Rapid myeloerythroid repopulation after intrafemoral transplantation of NOD-SCID mice reveals a new class of human stem cells. Nat Med. 2003;9:959-963.
    • (2003) Nat Med , vol.9 , pp. 959-963
    • Mazurier, F.1    Doedens, M.2    Gan, O.I.3    Dick, J.E.4
  • 41
    • 0032493377 scopus 로고    scopus 로고
    • Retroviral transduction of TLS-ERG initiates a leukemogenic program in normal human hematopoietic cells
    • Pereira DS, Dorrell C, Ito CY, et al. Retroviral transduction of TLS-ERG initiates a leukemogenic program in normal human hematopoietic cells. Proc Natl Acad Sci U S A. 1998;95:8239-8244.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 8239-8244
    • Pereira, D.S.1    Dorrell, C.2    Ito, C.Y.3
  • 42
    • 0036852308 scopus 로고    scopus 로고
    • Molecular evidence of lentiviral vector-mediated gene transfer into human self-renewing, multipotent, long-term NOD/SCID repopulating hematopoietic cells
    • Ailles L, Schmidt M, Santoni de Sio FR, et al. Molecular evidence of lentiviral vector-mediated gene transfer into human self-renewing, multipotent, long-term NOD/SCID repopulating hematopoietic cells. Mol Ther. 2002;6:615-626.
    • (2002) Mol Ther , vol.6 , pp. 615-626
    • Ailles, L.1    Schmidt, M.2    Santoni De Sio, F.R.3
  • 43
    • 0030925298 scopus 로고    scopus 로고
    • Kinetic evidence of the regeneration of multilineage hematopoiesis from primitive cells in normal human bone marrow transplanted into immunodeficient mice
    • Cashman JD, Lapidot T, Wang JCY, et al. Kinetic evidence of the regeneration of multilineage hematopoiesis from primitive cells in normal human bone marrow transplanted into immunodeficient mice. Blood. 1997;89:4307-4316.
    • (1997) Blood , vol.89 , pp. 4307-4316
    • Cashman, J.D.1    Lapidot, T.2    Wang, J.C.Y.3
  • 44
    • 0025398116 scopus 로고
    • Retrovirus packaging cells
    • Miller AD. Retrovirus packaging cells. Hum Gene Ther. 1990;1:5-14.
    • (1990) Hum Gene Ther , vol.1 , pp. 5-14
    • Miller, A.D.1
  • 45
    • 0037441587 scopus 로고    scopus 로고
    • Lentiviral vector transduction of NOD/SCID repopulating cells results in multiple vector integrations per transduced cell: Risk of insertional mutagenesis
    • Woods NB, Muessig A, Schmidt M, et al. Lentiviral vector transduction of NOD/SCID repopulating cells results in multiple vector integrations per transduced cell: risk of insertional mutagenesis. Blood. 2003;101:1284-1289.
    • (2003) Blood , vol.101 , pp. 1284-1289
    • Woods, N.B.1    Muessig, A.2    Schmidt, M.3
  • 46
    • 0034724857 scopus 로고    scopus 로고
    • Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease
    • Cavazzana-Calvo M, Hacein-Bey S, de Saint Basile G, et al. Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease. Science. 2000;288:669-672.
    • (2000) Science , vol.288 , pp. 669-672
    • Cavazzana-Calvo, M.1    Hacein-Bey, S.2    De Saint Basile, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.