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Volumn 6, Issue 8, 2007, Pages 1187-1196

Vector design for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells

Author keywords

Gene therapy; Lentiviral vector; Retroviral vector

Indexed keywords

6 O BENZYLGUANINE; ALKYLATING AGENT; CARMUSTINE; FLUOROURACIL; LENTIVIRUS VECTOR; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; RETROVIRUS VECTOR; TEMOZOLOMIDE;

EID: 34447331660     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dnarep.2007.03.017     Document Type: Article
Times cited : (17)

References (122)
  • 1
    • 33344476395 scopus 로고    scopus 로고
    • Survival of the fittest: in vivo selection and stem cell gene therapy
    • Neff T., Beard B.C., and Kiem H.P. Survival of the fittest: in vivo selection and stem cell gene therapy. Blood 107 5 (2006) 1751-1760
    • (2006) Blood , vol.107 , Issue.5 , pp. 1751-1760
    • Neff, T.1    Beard, B.C.2    Kiem, H.P.3
  • 2
    • 4644232973 scopus 로고    scopus 로고
    • Protection and selection for gene therapy in the hematopoietic system
    • Milsom M.D., and Fairbairn L.J. Protection and selection for gene therapy in the hematopoietic system. J. Gene Med. 6 2 (2004) 133-146
    • (2004) J. Gene Med. , vol.6 , Issue.2 , pp. 133-146
    • Milsom, M.D.1    Fairbairn, L.J.2
  • 3
    • 0036594445 scopus 로고    scopus 로고
    • Gene therapy to protect haematopoietic cells from cytotoxic cancer drugs
    • Sorrentino B.P. Gene therapy to protect haematopoietic cells from cytotoxic cancer drugs. Nat. Rev. Cancer 2 6 (2002) 431-441
    • (2002) Nat. Rev. Cancer , vol.2 , Issue.6 , pp. 431-441
    • Sorrentino, B.P.1
  • 4
    • 30444432097 scopus 로고    scopus 로고
    • Stable gene transfer and expression in human primary T cells by the Sleeping Beauty transposon system
    • Huang X., et al. Stable gene transfer and expression in human primary T cells by the Sleeping Beauty transposon system. Blood 107 2 (2006) 483-491
    • (2006) Blood , vol.107 , Issue.2 , pp. 483-491
    • Huang, X.1
  • 5
    • 0038745599 scopus 로고    scopus 로고
    • Progress and problems with the use of viral vectors for gene therapy
    • Thomas C.E., Ehrhardt A., and Kay M.A. Progress and problems with the use of viral vectors for gene therapy. Nat. Rev. Genet. 4 5 (2003) 346-358
    • (2003) Nat. Rev. Genet. , vol.4 , Issue.5 , pp. 346-358
    • Thomas, C.E.1    Ehrhardt, A.2    Kay, M.A.3
  • 6
    • 33748069163 scopus 로고    scopus 로고
    • In vivo gene transfer into adult stem cells in unconditioned mice by in situ delivery of a lentiviral vector
    • Worsham D.N., et al. In vivo gene transfer into adult stem cells in unconditioned mice by in situ delivery of a lentiviral vector. Mol. Ther. 14 4 (2006) 514-524
    • (2006) Mol. Ther. , vol.14 , Issue.4 , pp. 514-524
    • Worsham, D.N.1
  • 7
    • 0142199654 scopus 로고    scopus 로고
    • Dose finding with retroviral vectors: correlation of retroviral vector copy numbers in single cells with gene transfer efficiency in a cell population
    • Kustikova O.S., et al. Dose finding with retroviral vectors: correlation of retroviral vector copy numbers in single cells with gene transfer efficiency in a cell population. Blood 102 (2003) 3934-3937
    • (2003) Blood , vol.102 , pp. 3934-3937
    • Kustikova, O.S.1
  • 8
    • 3042746907 scopus 로고    scopus 로고
    • Limited lentiviral transgene expression with increasing copy number in an MGMT selection model: lack of copy number selection by drug treatment
    • Zielske S.P., and Gerson S.L. Limited lentiviral transgene expression with increasing copy number in an MGMT selection model: lack of copy number selection by drug treatment. Mol. Ther. 9 6 (2004) 923-931
    • (2004) Mol. Ther. , vol.9 , Issue.6 , pp. 923-931
    • Zielske, S.P.1    Gerson, S.L.2
  • 9
    • 0037772187 scopus 로고    scopus 로고
    • Successful treatment of murine beta-thalassemia using in vivo selection of genetically modified, drug-resistant hematopoietic stem cells
    • Persons D.A., et al. Successful treatment of murine beta-thalassemia using in vivo selection of genetically modified, drug-resistant hematopoietic stem cells. Blood 102 2 (2003) 506-513
    • (2003) Blood , vol.102 , Issue.2 , pp. 506-513
    • Persons, D.A.1
  • 10
    • 33745219190 scopus 로고    scopus 로고
    • Towards hematopoietic stem cell-mediated protection against infection with human immunodeficiency virus
    • Schambach A., et al. Towards hematopoietic stem cell-mediated protection against infection with human immunodeficiency virus. Gene Ther. 13 (2006) 1037-1047
    • (2006) Gene Ther. , vol.13 , pp. 1037-1047
    • Schambach, A.1
  • 11
    • 1342290228 scopus 로고    scopus 로고
    • In vivo selection for human and murine hematopoietic cells transduced with a therapeutic MGMT lentiviral vector that inhibits HIV replication
    • Davis B.M., Humeau L., and Dropulic B. In vivo selection for human and murine hematopoietic cells transduced with a therapeutic MGMT lentiviral vector that inhibits HIV replication. Mol. Ther. 9 2 (2004) 160-172
    • (2004) Mol. Ther. , vol.9 , Issue.2 , pp. 160-172
    • Davis, B.M.1    Humeau, L.2    Dropulic, B.3
  • 12
    • 8844226671 scopus 로고    scopus 로고
    • Hematopoietic stem cell gene therapy of murine protoporphyria by methylguanine-DNA-methyltransferase-mediated in vivo drug selection
    • Richard E., et al. Hematopoietic stem cell gene therapy of murine protoporphyria by methylguanine-DNA-methyltransferase-mediated in vivo drug selection. Gene Ther. 11 22 (2004) 1638-1647
    • (2004) Gene Ther. , vol.11 , Issue.22 , pp. 1638-1647
    • Richard, E.1
  • 13
    • 0037189401 scopus 로고    scopus 로고
    • Correction of ADA-SCID by stem cell gene therapy combined with nonmyeloablative conditioning
    • Aiuti A., et al. Correction of ADA-SCID by stem cell gene therapy combined with nonmyeloablative conditioning. Science 296 5577 (2002) 2410-2413
    • (2002) Science , vol.296 , Issue.5577 , pp. 2410-2413
    • Aiuti, A.1
  • 14
    • 33645734405 scopus 로고    scopus 로고
    • Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1
    • Ott M.G., et al. Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1. Nat. Med. 12 4 (2006) 401-409
    • (2006) Nat. Med. , vol.12 , Issue.4 , pp. 401-409
    • Ott, M.G.1
  • 15
    • 1942469956 scopus 로고    scopus 로고
    • MGMT: its role in cancer aetiology and cancer therapeutics
    • Gerson S.L. MGMT: its role in cancer aetiology and cancer therapeutics. Nat. Rev. Cancer 4 4 (2004) 296-307
    • (2004) Nat. Rev. Cancer , vol.4 , Issue.4 , pp. 296-307
    • Gerson, S.L.1
  • 16
    • 0023250381 scopus 로고
    • Protection of bone marrow transplant recipients from lethal doses of methotrexate by the generation of methotrexate-resistant bone marrow
    • Williams D.A., et al. Protection of bone marrow transplant recipients from lethal doses of methotrexate by the generation of methotrexate-resistant bone marrow. J. Exp. Med. 166 1 (1987) 210-218
    • (1987) J. Exp. Med. , vol.166 , Issue.1 , pp. 210-218
    • Williams, D.A.1
  • 17
    • 10744232285 scopus 로고    scopus 로고
    • In vivo selection of human hematopoietic cells in a xenograft model using combined pharmacologic and genetic manipulations
    • Pollok K.E., et al. In vivo selection of human hematopoietic cells in a xenograft model using combined pharmacologic and genetic manipulations. Hum. Gene Ther. 14 18 (2003) 1703-1714
    • (2003) Hum. Gene Ther. , vol.14 , Issue.18 , pp. 1703-1714
    • Pollok, K.E.1
  • 18
    • 33749041711 scopus 로고    scopus 로고
    • In vivo selection of transduced hematopoietic stem cells and little evidence of their conversion into hepatocytes in vivo
    • Yamaguchi K., et al. In vivo selection of transduced hematopoietic stem cells and little evidence of their conversion into hepatocytes in vivo. J. Hepatol. (2006)
    • (2006) J. Hepatol.
    • Yamaguchi, K.1
  • 19
    • 33747273605 scopus 로고    scopus 로고
    • A pilot study of dose-intensified procarbazine, CCNU, vincristine for poor prognosis brain tumors utilizing fibronectin-assisted, retroviral-mediated modification of CD34+ peripheral blood cells with O6-methylguanine DNA methyltransferase
    • Cornetta K., et al. A pilot study of dose-intensified procarbazine, CCNU, vincristine for poor prognosis brain tumors utilizing fibronectin-assisted, retroviral-mediated modification of CD34+ peripheral blood cells with O6-methylguanine DNA methyltransferase. Cancer Gene. Ther. 13 (2006) 886-895
    • (2006) Cancer Gene. Ther. , Issue.13 , pp. 886-895
    • Cornetta, K.1
  • 20
    • 33644856269 scopus 로고    scopus 로고
    • Differential competitive resistance to methylating versus chloroethylating agents among five O6-alkylguanine DNA alkyltransferases in human hematopoietic cells
    • Fontes A.M., et al. Differential competitive resistance to methylating versus chloroethylating agents among five O6-alkylguanine DNA alkyltransferases in human hematopoietic cells. Mol. Cancer Ther. 5 1 (2006) 121-128
    • (2006) Mol. Cancer Ther. , vol.5 , Issue.1 , pp. 121-128
    • Fontes, A.M.1
  • 21
    • 30344464717 scopus 로고    scopus 로고
    • Equal potency of gammaretroviral and lentiviral SIN vectors for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells
    • Schambach A., et al. Equal potency of gammaretroviral and lentiviral SIN vectors for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells. Mol. Ther. 13 2 (2006) 391-400
    • (2006) Mol. Ther. , vol.13 , Issue.2 , pp. 391-400
    • Schambach, A.1
  • 22
    • 33645878910 scopus 로고    scopus 로고
    • In vivo effects of myeloablative alkylator therapy on survival and differentiation of MGMTP140K-transduced human G-CSF-mobilized peripheral blood cells
    • Cai S., et al. In vivo effects of myeloablative alkylator therapy on survival and differentiation of MGMTP140K-transduced human G-CSF-mobilized peripheral blood cells. Mol. Ther. 13 5 (2006) 1016-1026
    • (2006) Mol. Ther. , vol.13 , Issue.5 , pp. 1016-1026
    • Cai, S.1
  • 23
    • 31544441555 scopus 로고    scopus 로고
    • The P140K mutant of human O(6)-methylguanine-DNA-methyltransferase (MGMT) confers resistance in vitro and in vivo to temozolomide in combination with the novel MGMT inactivator O(6)-(4-bromothenyl)guanine
    • Woolford L.B., et al. The P140K mutant of human O(6)-methylguanine-DNA-methyltransferase (MGMT) confers resistance in vitro and in vivo to temozolomide in combination with the novel MGMT inactivator O(6)-(4-bromothenyl)guanine. J. Gene Med. 8 1 (2006) 29-34
    • (2006) J. Gene Med. , vol.8 , Issue.1 , pp. 29-34
    • Woolford, L.B.1
  • 24
    • 12844249961 scopus 로고    scopus 로고
    • Polyclonal chemoprotection against temozolomide in a large-animal model of drug resistance gene therapy
    • Neff T., et al. Polyclonal chemoprotection against temozolomide in a large-animal model of drug resistance gene therapy. Blood 105 3 (2005) 997-1002
    • (2005) Blood , vol.105 , Issue.3 , pp. 997-1002
    • Neff, T.1
  • 25
    • 7044222540 scopus 로고    scopus 로고
    • Enhanced in vivo selection of bone marrow cells by retroviral-mediated coexpression of mutant O6-methylguanine-DNA-methyltransferase and HOXB4
    • Milsom M.D., et al. Enhanced in vivo selection of bone marrow cells by retroviral-mediated coexpression of mutant O6-methylguanine-DNA-methyltransferase and HOXB4. Mol. Ther. 10 5 (2004) 862-873
    • (2004) Mol. Ther. , vol.10 , Issue.5 , pp. 862-873
    • Milsom, M.D.1
  • 26
    • 4143112450 scopus 로고    scopus 로고
    • Nuclear-localizing O6-benzylguanine-resistant GFP-MGMT fusion protein as a novel in vivo selection marker
    • Choi U., et al. Nuclear-localizing O6-benzylguanine-resistant GFP-MGMT fusion protein as a novel in vivo selection marker. Exp. Hematol. 32 8 (2004) 709-719
    • (2004) Exp. Hematol. , vol.32 , Issue.8 , pp. 709-719
    • Choi, U.1
  • 27
    • 0347086142 scopus 로고    scopus 로고
    • Methylguanine methyltransferase-mediated in vivo selection and chemoprotection of allogeneic stem cells in a large-animal model
    • Neff T., et al. Methylguanine methyltransferase-mediated in vivo selection and chemoprotection of allogeneic stem cells in a large-animal model. J. Clin. Invest. 112 10 (2003) 1581-1588
    • (2003) J. Clin. Invest. , vol.112 , Issue.10 , pp. 1581-1588
    • Neff, T.1
  • 28
    • 0041522307 scopus 로고    scopus 로고
    • Drug selection of mutant methylguanine methyltransferase from different oncoretroviral backbones results in multilineage hematopoietic transgene expression in primary and secondary recipients
    • Davis B.M., et al. Drug selection of mutant methylguanine methyltransferase from different oncoretroviral backbones results in multilineage hematopoietic transgene expression in primary and secondary recipients. J. Hematother. Stem Cell Res. 12 4 (2003) 375-387
    • (2003) J. Hematother. Stem Cell Res. , vol.12 , Issue.4 , pp. 375-387
    • Davis, B.M.1
  • 29
    • 0030613767 scopus 로고    scopus 로고
    • Selection for G156A O6-methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and protection from lethality in mice treated with O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea
    • Davis B.M., et al. Selection for G156A O6-methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and protection from lethality in mice treated with O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea. Cancer Res. 57 22 (1997) 5093-5099
    • (1997) Cancer Res. , vol.57 , Issue.22 , pp. 5093-5099
    • Davis, B.M.1
  • 30
    • 0043201417 scopus 로고    scopus 로고
    • Myeloablation is not required to select and maintain expression of the drug-resistance gene, mutant MGMT, in primary and secondary recipients
    • Bowman J.E., et al. Myeloablation is not required to select and maintain expression of the drug-resistance gene, mutant MGMT, in primary and secondary recipients. Mol. Ther. 8 1 (2003) 42-50
    • (2003) Mol. Ther. , vol.8 , Issue.1 , pp. 42-50
    • Bowman, J.E.1
  • 31
    • 0036140173 scopus 로고    scopus 로고
    • Improvement of combination chemotherapy tolerance by introduction of polycistronic retroviral vector drug resistance genes MGMT and MDR1 into human umbilical cord blood CD34+ cells
    • Wang J., et al. Improvement of combination chemotherapy tolerance by introduction of polycistronic retroviral vector drug resistance genes MGMT and MDR1 into human umbilical cord blood CD34+ cells. Leuk. Res. 26 3 (2002) 281-288
    • (2002) Leuk. Res. , vol.26 , Issue.3 , pp. 281-288
    • Wang, J.1
  • 32
    • 0034779672 scopus 로고    scopus 로고
    • G156A MGMT-transduced human mesenchymal stem cells can be selectively enriched by O6-benzylguanine and BCNU
    • Lee K., et al. G156A MGMT-transduced human mesenchymal stem cells can be selectively enriched by O6-benzylguanine and BCNU. J. Hematother. Stem Cell Res. 10 5 (2001) 691-701
    • (2001) J. Hematother. Stem Cell Res. , vol.10 , Issue.5 , pp. 691-701
    • Lee, K.1
  • 33
    • 0034883452 scopus 로고    scopus 로고
    • Protection of hematopoietic cells from O(6)-alkylation damage by O(6)-methylguanine DNA methyltransferase gene transfer: studies with different O(6)-alkylating agents and retroviral backbones
    • Jansen M., et al. Protection of hematopoietic cells from O(6)-alkylation damage by O(6)-methylguanine DNA methyltransferase gene transfer: studies with different O(6)-alkylating agents and retroviral backbones. Eur. J. Haematol. 67 1 (2001) 2-13
    • (2001) Eur. J. Haematol. , vol.67 , Issue.1 , pp. 2-13
    • Jansen, M.1
  • 34
    • 0034990304 scopus 로고    scopus 로고
    • Protection and in vivo selection of hematopoietic stem cells using temozolomide, O6-benzylguanine, and an alkyltransferase-expressing retroviral vector
    • Sawai N., et al. Protection and in vivo selection of hematopoietic stem cells using temozolomide, O6-benzylguanine, and an alkyltransferase-expressing retroviral vector. Mol. Ther. 3 1 (2001) 78-87
    • (2001) Mol. Ther. , vol.3 , Issue.1 , pp. 78-87
    • Sawai, N.1
  • 35
    • 0030061083 scopus 로고    scopus 로고
    • Increasing DNA repair methyltransferase levels via bone marrow stem cell transduction rescues mice from the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic alkylating agent
    • Maze R., et al. Increasing DNA repair methyltransferase levels via bone marrow stem cell transduction rescues mice from the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic alkylating agent. Proc. Natl. Acad. Sci. U.S.A. 93 1 (1996) 206-210
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , Issue.1 , pp. 206-210
    • Maze, R.1
  • 36
    • 33646561281 scopus 로고    scopus 로고
    • Multicistronic lentiviral vectors containing the FMDV 2A cleavage factor demonstrate robust expression of encoded genes at limiting MOI
    • Chinnasamy D., et al. Multicistronic lentiviral vectors containing the FMDV 2A cleavage factor demonstrate robust expression of encoded genes at limiting MOI. Virol. J. 3 (2006) 14
    • (2006) Virol. J. , vol.3 , pp. 14
    • Chinnasamy, D.1
  • 37
    • 0347086143 scopus 로고    scopus 로고
    • In vivo selection of MGMT(P140K) lentivirus-transduced human NOD/SCID repopulating cells without pretransplant irradiation conditioning
    • Zielske S.P., et al. In vivo selection of MGMT(P140K) lentivirus-transduced human NOD/SCID repopulating cells without pretransplant irradiation conditioning. J. Clin. Invest. 112 10 (2003) 1561-1570
    • (2003) J. Clin. Invest. , vol.112 , Issue.10 , pp. 1561-1570
    • Zielske, S.P.1
  • 38
    • 2342571081 scopus 로고    scopus 로고
    • A bicistronic SIN-lentiviral vector containing G156A MGMT allows selection and metabolic correction of hematopoietic protoporphyric cell lines
    • Richard E., et al. A bicistronic SIN-lentiviral vector containing G156A MGMT allows selection and metabolic correction of hematopoietic protoporphyric cell lines. J. Gene Med. 5 9 (2003) 737-747
    • (2003) J. Gene Med. , vol.5 , Issue.9 , pp. 737-747
    • Richard, E.1
  • 39
    • 0033585432 scopus 로고    scopus 로고
    • Recombinant adeno-associated virus-mediated expression of O6-alkylguanine-DNA-alkyltransferase protects human epithelial and hematopoietic cells against chloroethylating agent toxicity
    • Longhurst S.J., et al. Recombinant adeno-associated virus-mediated expression of O6-alkylguanine-DNA-alkyltransferase protects human epithelial and hematopoietic cells against chloroethylating agent toxicity. Hum. Gene Ther. 10 2 (1999) 301-310
    • (1999) Hum. Gene Ther. , vol.10 , Issue.2 , pp. 301-310
    • Longhurst, S.J.1
  • 40
    • 0033589691 scopus 로고    scopus 로고
    • Characterization of the P140K, PVP(138-140)MLK, and G156A O6-methylguanine-DNA methyltransferase mutants: implications for drug resistance gene therapy
    • Davis B.M., et al. Characterization of the P140K, PVP(138-140)MLK, and G156A O6-methylguanine-DNA methyltransferase mutants: implications for drug resistance gene therapy. Hum. Gene Ther. 10 17 (1999) 2769-2778
    • (1999) Hum. Gene Ther. , vol.10 , Issue.17 , pp. 2769-2778
    • Davis, B.M.1
  • 41
    • 0034665336 scopus 로고    scopus 로고
    • Direct reversal of DNA damage by mutant methyltransferase protein protects mice against dose-intensified chemotherapy and leads to in vivo selection of hematopoietic stem cells
    • Ragg S., et al. Direct reversal of DNA damage by mutant methyltransferase protein protects mice against dose-intensified chemotherapy and leads to in vivo selection of hematopoietic stem cells. Cancer Res. 60 18 (2000) 5187-5195
    • (2000) Cancer Res. , vol.60 , Issue.18 , pp. 5187-5195
    • Ragg, S.1
  • 42
    • 29244441185 scopus 로고    scopus 로고
    • Hematopoietic stem cell transduction and amplification in large animal models
    • Trobridge G., Beard B.C., and Kiem H.P. Hematopoietic stem cell transduction and amplification in large animal models. Hum. Gene Ther. 16 12 (2005) 1355-1366
    • (2005) Hum. Gene Ther. , vol.16 , Issue.12 , pp. 1355-1366
    • Trobridge, G.1    Beard, B.C.2    Kiem, H.P.3
  • 43
    • 0020564120 scopus 로고
    • Retrovirus transfer of a bacterial gene into mouse haematopoietic progenitor cells
    • Joyner A., et al. Retrovirus transfer of a bacterial gene into mouse haematopoietic progenitor cells. Nature 305 5934 (1983) 556-558
    • (1983) Nature , vol.305 , Issue.5934 , pp. 556-558
    • Joyner, A.1
  • 44
    • 0021758970 scopus 로고
    • Introduction of new genetic material into pluripotent haematopoietic stem cells of the mouse
    • Williams D.A., et al. Introduction of new genetic material into pluripotent haematopoietic stem cells of the mouse. Nature 310 (1984) 476-480
    • (1984) Nature , vol.310 , pp. 476-480
    • Williams, D.A.1
  • 45
    • 0028962901 scopus 로고
    • The current status of gene therapy using hematopoietic stem cells
    • Kohn D.B. The current status of gene therapy using hematopoietic stem cells. Curr. Opin. Pediatr. 7 1 (1995) 56-63
    • (1995) Curr. Opin. Pediatr. , vol.7 , Issue.1 , pp. 56-63
    • Kohn, D.B.1
  • 46
    • 16644402465 scopus 로고    scopus 로고
    • Gene therapy for hematologic disease: don't throw the baby out with the bathwater!
    • Dunbar C.E. Gene therapy for hematologic disease: don't throw the baby out with the bathwater!. Semin. Hematol. 41 4 (2004) 1-2
    • (2004) Semin. Hematol. , vol.41 , Issue.4 , pp. 1-2
    • Dunbar, C.E.1
  • 47
    • 1942473901 scopus 로고    scopus 로고
    • Gene therapy for inherited disorders of haematopoietic cells
    • Klein C., and Baum C. Gene therapy for inherited disorders of haematopoietic cells. Hematol. J. 5 2 (2004) 103-111
    • (2004) Hematol. J. , vol.5 , Issue.2 , pp. 103-111
    • Klein, C.1    Baum, C.2
  • 48
    • 12144289202 scopus 로고    scopus 로고
    • Long-term clinical and molecular follow-up of large animals receiving retrovirally transduced stem and progenitor cells: no progression to clonal hematopoiesis or leukemia
    • Kiem H.P., et al. Long-term clinical and molecular follow-up of large animals receiving retrovirally transduced stem and progenitor cells: no progression to clonal hematopoiesis or leukemia. Mol. Ther. 9 3 (2004) 389-395
    • (2004) Mol. Ther. , vol.9 , Issue.3 , pp. 389-395
    • Kiem, H.P.1
  • 49
    • 0036892648 scopus 로고    scopus 로고
    • Highly efficient gene transfer into baboon marrow repopulating cells using GALV-pseudotype oncoretroviral vectors produced by human packaging cells
    • Horn P.A., et al. Highly efficient gene transfer into baboon marrow repopulating cells using GALV-pseudotype oncoretroviral vectors produced by human packaging cells. Blood 100 12 (2002) 3960-3967
    • (2002) Blood , vol.100 , Issue.12 , pp. 3960-3967
    • Horn, P.A.1
  • 50
    • 0034131481 scopus 로고    scopus 로고
    • Efficient retrovirus-mediated transfer of the multidrug resistance 1 gene into autologous human long-term repopulating hematopoietic stem cells
    • Abonour R., et al. Efficient retrovirus-mediated transfer of the multidrug resistance 1 gene into autologous human long-term repopulating hematopoietic stem cells. Nat. Med. 6 6 (2000) 652-658
    • (2000) Nat. Med. , vol.6 , Issue.6 , pp. 652-658
    • Abonour, R.1
  • 51
    • 33744496523 scopus 로고    scopus 로고
    • Proteasome activity restricts lentiviral gene transfer into hematopoietic stem cells and is down-regulated by cytokines that enhance transduction
    • Santoni de Sio F.R., et al. Proteasome activity restricts lentiviral gene transfer into hematopoietic stem cells and is down-regulated by cytokines that enhance transduction. Blood 107 11 (2006) 4257-4265
    • (2006) Blood , vol.107 , Issue.11 , pp. 4257-4265
    • Santoni de Sio, F.R.1
  • 53
    • 10944260126 scopus 로고    scopus 로고
    • Retrovirus restriction factors
    • Goff S.P. Retrovirus restriction factors. Mol. Cell 16 6 (2004) 849-859
    • (2004) Mol. Cell , vol.16 , Issue.6 , pp. 849-859
    • Goff, S.P.1
  • 54
    • 2542501560 scopus 로고    scopus 로고
    • Efficient gene transfer into rhesus repopulating hematopoietic stem cells using a simian immunodeficiency virus-based lentiviral vector system
    • Hanawa H., et al. Efficient gene transfer into rhesus repopulating hematopoietic stem cells using a simian immunodeficiency virus-based lentiviral vector system. Blood 103 11 (2004) 4062-4069
    • (2004) Blood , vol.103 , Issue.11 , pp. 4062-4069
    • Hanawa, H.1
  • 55
    • 0036881616 scopus 로고    scopus 로고
    • Vectors derived from simian immunodeficiency virus (SIV)
    • Negre D., and Cosset F.L. Vectors derived from simian immunodeficiency virus (SIV). Biochimie 84 11 (2002) 1161-1171
    • (2002) Biochimie , vol.84 , Issue.11 , pp. 1161-1171
    • Negre, D.1    Cosset, F.L.2
  • 56
    • 8844219667 scopus 로고    scopus 로고
    • Strategies for retargeted gene delivery using vectors derived from lentiviruses
    • Bartosch B., and Cosset F.L. Strategies for retargeted gene delivery using vectors derived from lentiviruses. Curr. Gene Ther. 4 4 (2004) 427-443
    • (2004) Curr. Gene Ther. , vol.4 , Issue.4 , pp. 427-443
    • Bartosch, B.1    Cosset, F.L.2
  • 57
    • 0037441587 scopus 로고    scopus 로고
    • Lentiviral vector transduction of NOD/SCID repopulating cells results in multiple vector integrations per transduced cell: risk of insertional mutagenesis
    • Woods N.B., et al. Lentiviral vector transduction of NOD/SCID repopulating cells results in multiple vector integrations per transduced cell: risk of insertional mutagenesis. Blood 101 4 (2003) 1284-1289
    • (2003) Blood , vol.101 , Issue.4 , pp. 1284-1289
    • Woods, N.B.1
  • 58
    • 19444378586 scopus 로고    scopus 로고
    • Efficiency of transduction of highly purified murine hematopoietic stem cells by lentiviral and oncoretroviral vectors under conditions of minimal in vitro manipulation
    • Mostoslavsky G., et al. Efficiency of transduction of highly purified murine hematopoietic stem cells by lentiviral and oncoretroviral vectors under conditions of minimal in vitro manipulation. Mol. Ther. 11 6 (2005) 932-940
    • (2005) Mol. Ther. , vol.11 , Issue.6 , pp. 932-940
    • Mostoslavsky, G.1
  • 59
    • 34447307815 scopus 로고    scopus 로고
    • Rapid 1-h transduction of whole bone marrow leads to long-term repopulation of murine recipients with lentivirus-modified hematopoietic stem cells
    • Kurre P., Anandakumar P., and Kiem H.P. Rapid 1-h transduction of whole bone marrow leads to long-term repopulation of murine recipients with lentivirus-modified hematopoietic stem cells. Gene Ther. (2005)
    • (2005) Gene Ther.
    • Kurre, P.1    Anandakumar, P.2    Kiem, H.P.3
  • 60
    • 33646398840 scopus 로고    scopus 로고
    • AMD3100 mobilizes hematopoietic stem cells with long-term repopulating capacity in nonhuman primates
    • Larochelle A., et al. AMD3100 mobilizes hematopoietic stem cells with long-term repopulating capacity in nonhuman primates. Blood 107 9 (2006) 3772-3778
    • (2006) Blood , vol.107 , Issue.9 , pp. 3772-3778
    • Larochelle, A.1
  • 61
    • 0036682935 scopus 로고    scopus 로고
    • Lentiviral vectors pseudotyped with a modified RD114 envelope glycoprotein show increased stability in sera and augmented transduction of primary lymphocytes and CD34+ cells derived from human and nonhuman primates
    • Sandrin V., et al. Lentiviral vectors pseudotyped with a modified RD114 envelope glycoprotein show increased stability in sera and augmented transduction of primary lymphocytes and CD34+ cells derived from human and nonhuman primates. Blood 100 3 (2002) 823-832
    • (2002) Blood , vol.100 , Issue.3 , pp. 823-832
    • Sandrin, V.1
  • 62
    • 33746239571 scopus 로고    scopus 로고
    • Functional assessment of the engraftment potential of gammaretrovirus-modified CD34(+) cells, using a short serum-free transduction protocol
    • Budak-Alpdogan T., et al. Functional assessment of the engraftment potential of gammaretrovirus-modified CD34(+) cells, using a short serum-free transduction protocol. Hum. Gene Ther. 17 7 (2006) 780-794
    • (2006) Hum. Gene Ther. , vol.17 , Issue.7 , pp. 780-794
    • Budak-Alpdogan, T.1
  • 63
    • 0037129435 scopus 로고    scopus 로고
    • Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy
    • Hacein-Bey-Abina S., et al. Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy. N. Engl. J. Med. 346 16 (2002) 1185-1193
    • (2002) N. Engl. J. Med. , vol.346 , Issue.16 , pp. 1185-1193
    • Hacein-Bey-Abina, S.1
  • 64
    • 19944421384 scopus 로고    scopus 로고
    • Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector
    • Gaspar H.B., et al. Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector. Lancet 364 9452 (2004) 2181-2187
    • (2004) Lancet , vol.364 , Issue.9452 , pp. 2181-2187
    • Gaspar, H.B.1
  • 65
    • 0035070944 scopus 로고    scopus 로고
    • Influence of multiplicity of infection and protein stability on retroviral vector-mediated gene expression in hematopoietic cells
    • Wahlers A., et al. Influence of multiplicity of infection and protein stability on retroviral vector-mediated gene expression in hematopoietic cells. Gene Ther. 8 6 (2001) 477-486
    • (2001) Gene Ther. , vol.8 , Issue.6 , pp. 477-486
    • Wahlers, A.1
  • 66
    • 0037134031 scopus 로고    scopus 로고
    • Murine leukemia induced by retroviral gene marking
    • Li Z., et al. Murine leukemia induced by retroviral gene marking. Science 296 5567 (2002) 497
    • (2002) Science , vol.296 , Issue.5567 , pp. 497
    • Li, Z.1
  • 67
    • 0142084745 scopus 로고    scopus 로고
    • LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1
    • Hacein-Bey-Abina S., et al. LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science 302 5644 (2003) 415-419
    • (2003) Science , vol.302 , Issue.5644 , pp. 415-419
    • Hacein-Bey-Abina, S.1
  • 68
    • 21144437399 scopus 로고    scopus 로고
    • Leukemias following retroviral transfer of multidrug resistance 1 are driven by combinatorial insertional mutagenesis
    • Modlich U., et al. Leukemias following retroviral transfer of multidrug resistance 1 are driven by combinatorial insertional mutagenesis. Blood 105 (2005) 4235-4246
    • (2005) Blood , vol.105 , pp. 4235-4246
    • Modlich, U.1
  • 69
    • 33646594123 scopus 로고    scopus 로고
    • Acute myeloid leukemia associated with retroviral gene transfer to hematopoietic progenitor cells of a rhesus macaque
    • Seggewiss R., et al. Acute myeloid leukemia associated with retroviral gene transfer to hematopoietic progenitor cells of a rhesus macaque. Blood 107 (2006) 3865-3867
    • (2006) Blood , vol.107 , pp. 3865-3867
    • Seggewiss, R.1
  • 70
    • 0037443457 scopus 로고    scopus 로고
    • Side effects of retroviral gene transfer into hematopoietic stem cells
    • Baum C., et al. Side effects of retroviral gene transfer into hematopoietic stem cells. Blood 101 6 (2003) 2099-2114
    • (2003) Blood , vol.101 , Issue.6 , pp. 2099-2114
    • Baum, C.1
  • 71
    • 0028883813 scopus 로고
    • Novel retroviral vectors for efficient expression of the multidrug-resistance (mdr-1) gene in early hemopoietic cells
    • Baum C., et al. Novel retroviral vectors for efficient expression of the multidrug-resistance (mdr-1) gene in early hemopoietic cells. J. Virol. 69 (1995) 7541-7547
    • (1995) J. Virol. , vol.69 , pp. 7541-7547
    • Baum, C.1
  • 72
    • 0028815676 scopus 로고
    • Multiple modifications in cis elements of the long terminal repeat of retroviral vectors lead to increased expression and decreased DNA methylation in embryonic carcinoma cells
    • Challita P.M., et al. Multiple modifications in cis elements of the long terminal repeat of retroviral vectors lead to increased expression and decreased DNA methylation in embryonic carcinoma cells. J. Virol. 69 (1995) 748-755
    • (1995) J. Virol. , vol.69 , pp. 748-755
    • Challita, P.M.1
  • 73
    • 0036811540 scopus 로고    scopus 로고
    • Advances in lentiviral vector design for gene-modification of hematopoietic stem cells
    • Logan A.C., Lutzko C., and Kohn D.B. Advances in lentiviral vector design for gene-modification of hematopoietic stem cells. Curr. Opin. Biotechnol. 13 5 (2002) 429-436
    • (2002) Curr. Opin. Biotechnol. , vol.13 , Issue.5 , pp. 429-436
    • Logan, A.C.1    Lutzko, C.2    Kohn, D.B.3
  • 74
    • 0034322159 scopus 로고    scopus 로고
    • Lentiviral vectors for enhanced gene expression in human hematopoietic cells
    • Ramezani A., Hawley T.S., and Hawley R.G. Lentiviral vectors for enhanced gene expression in human hematopoietic cells. Mol. Ther. 2 (2000) 458-469
    • (2000) Mol. Ther. , vol.2 , pp. 458-469
    • Ramezani, A.1    Hawley, T.S.2    Hawley, R.G.3
  • 75
    • 0038792207 scopus 로고    scopus 로고
    • Performance- and safety-enhanced lentiviral vectors containing the human interferon-beta scaffold attachment region and the chicken beta-globin insulator
    • Ramezani A., Hawley T.S., and Hawley R.G. Performance- and safety-enhanced lentiviral vectors containing the human interferon-beta scaffold attachment region and the chicken beta-globin insulator. Blood 101 (2003) 4717-4724
    • (2003) Blood , vol.101 , pp. 4717-4724
    • Ramezani, A.1    Hawley, T.S.2    Hawley, R.G.3
  • 76
    • 0032125682 scopus 로고    scopus 로고
    • Sustained gene expression in retrovirally transduced, engrafting human hematopoietic stem cells and their lympho-myeloid progeny
    • Cheng L., et al. Sustained gene expression in retrovirally transduced, engrafting human hematopoietic stem cells and their lympho-myeloid progeny. Blood 92 1 (1998) 83-92
    • (1998) Blood , vol.92 , Issue.1 , pp. 83-92
    • Cheng, L.1
  • 77
    • 33745108790 scopus 로고    scopus 로고
    • Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration
    • Montini E., et al. Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration. Nat. Biotechnol. 24 6 (2006) 687-696
    • (2006) Nat. Biotechnol. , vol.24 , Issue.6 , pp. 687-696
    • Montini, E.1
  • 78
    • 33750624015 scopus 로고    scopus 로고
    • Novel cell culture assays reveal the importance of retroviral vector design for insertional genotoxicity
    • Modlich U., et al. Novel cell culture assays reveal the importance of retroviral vector design for insertional genotoxicity. Blood 108 (2006) 2545-2553
    • (2006) Blood , vol.108 , pp. 2545-2553
    • Modlich, U.1
  • 79
    • 0346132122 scopus 로고
    • Self-inactivating retroviral vectors designed for transfer of whole genes into mammalian cells
    • Yu S.F., et al. Self-inactivating retroviral vectors designed for transfer of whole genes into mammalian cells. Proc. Natl. Acad. Sci. U.S.A. 83 (1986) 3194-3198
    • (1986) Proc. Natl. Acad. Sci. U.S.A. , vol.83 , pp. 3194-3198
    • Yu, S.F.1
  • 80
    • 0031710033 scopus 로고    scopus 로고
    • A third-generation lentivirus vector with a conditional packaging system
    • Dull T., et al. A third-generation lentivirus vector with a conditional packaging system. J. Virol. 72 11 (1998) 8463-8471
    • (1998) J. Virol. , vol.72 , Issue.11 , pp. 8463-8471
    • Dull, T.1
  • 81
    • 33750023988 scopus 로고    scopus 로고
    • Overcoming promoter interference in packaging cells improves production of self-inactivating retroviral vectors
    • Schambach A., et al. Overcoming promoter interference in packaging cells improves production of self-inactivating retroviral vectors. Gene Ther. 13 (2006) 1524-1533
    • (2006) Gene Ther. , vol.13 , pp. 1524-1533
    • Schambach, A.1
  • 82
    • 33745668475 scopus 로고    scopus 로고
    • A new generation of retroviral producer cells: predictable and stable virus production by Flp mediated site-specific integration of retroviral vectors
    • Schucht R., et al. A new generation of retroviral producer cells: predictable and stable virus production by Flp mediated site-specific integration of retroviral vectors. Mol. Ther. 14 2 (2006) 285-292
    • (2006) Mol. Ther. , vol.14 , Issue.2 , pp. 285-292
    • Schucht, R.1
  • 83
    • 0038333587 scopus 로고    scopus 로고
    • Continuous high-titer HIV-1 vector production
    • Ikeda Y., et al. Continuous high-titer HIV-1 vector production. Nat. Biotechnol. 21 5 (2003) 569-572
    • (2003) Nat. Biotechnol. , vol.21 , Issue.5 , pp. 569-572
    • Ikeda, Y.1
  • 84
    • 33745664380 scopus 로고    scopus 로고
    • A trans-lentiviral packaging cell line for high-titer conditional self-inactivating HIV-1 vectors
    • Cockrell A.S., et al. A trans-lentiviral packaging cell line for high-titer conditional self-inactivating HIV-1 vectors. Mol. Ther. 14 2 (2006) 276-284
    • (2006) Mol. Ther. , vol.14 , Issue.2 , pp. 276-284
    • Cockrell, A.S.1
  • 85
    • 22444431606 scopus 로고    scopus 로고
    • Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system
    • Dupuy A.J., et al. Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system. Nature 436 7048 (2005) 221-226
    • (2005) Nature , vol.436 , Issue.7048 , pp. 221-226
    • Dupuy, A.J.1
  • 86
    • 0037841763 scopus 로고    scopus 로고
    • Transcription start regions in the human genome are favored targets for MLV integration
    • Wu X., et al. Transcription start regions in the human genome are favored targets for MLV integration. Science 300 5626 (2003) 1749-1751
    • (2003) Science , vol.300 , Issue.5626 , pp. 1749-1751
    • Wu, X.1
  • 87
    • 23844507993 scopus 로고    scopus 로고
    • Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice
    • Themis M., et al. Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice. Mol. Ther. 12 4 (2005) 763-771
    • (2005) Mol. Ther. , vol.12 , Issue.4 , pp. 763-771
    • Themis, M.1
  • 88
    • 33646361846 scopus 로고    scopus 로고
    • Gene therapy: therapeutic gene causing lymphoma
    • Woods N.B., et al. Gene therapy: therapeutic gene causing lymphoma. Nature 440 7088 (2006) 1123
    • (2006) Nature , vol.440 , Issue.7088 , pp. 1123
    • Woods, N.B.1
  • 89
    • 0034255145 scopus 로고    scopus 로고
    • A chromatin insulator protects retrovirus vectors from chromosomal position effects
    • Emery D.W., et al. A chromatin insulator protects retrovirus vectors from chromosomal position effects. Proc. Natl. Acad. Sci. U.S.A. 97 16 (2000) 9150-9155
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , Issue.16 , pp. 9150-9155
    • Emery, D.W.1
  • 90
    • 27744489220 scopus 로고    scopus 로고
    • Silencing and variegation of gammaretrovirus and lentivirus vectors
    • Ellis J. Silencing and variegation of gammaretrovirus and lentivirus vectors. Hum. Gene Ther. 16 11 (2005) 1241-1246
    • (2005) Hum. Gene Ther. , vol.16 , Issue.11 , pp. 1241-1246
    • Ellis, J.1
  • 91
    • 33646887376 scopus 로고    scopus 로고
    • Genotoxicity of retroviral integration in hematopoietic cells
    • Nienhuis A.W., Dunbar C.E., and Sorrentino B.P. Genotoxicity of retroviral integration in hematopoietic cells. Mol. Ther. 13 6 (2006) 1031-1049
    • (2006) Mol. Ther. , vol.13 , Issue.6 , pp. 1031-1049
    • Nienhuis, A.W.1    Dunbar, C.E.2    Sorrentino, B.P.3
  • 92
    • 33746801652 scopus 로고    scopus 로고
    • Unique risk factors for insertional mutagenesis in a mouse model of XSCID gene therapy
    • Shou Y., et al. Unique risk factors for insertional mutagenesis in a mouse model of XSCID gene therapy. Proc. Natl. Acad. Sci. U.S.A. 103 31 (2006) 11730-11735
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , Issue.31 , pp. 11730-11735
    • Shou, Y.1
  • 93
    • 0024991898 scopus 로고
    • pEF-BOS, a powerful mammalian expression vector
    • Mizushima S., and Nagata S. pEF-BOS, a powerful mammalian expression vector. Nucleic Acids Res. 18 17 (1990) 5322
    • (1990) Nucleic Acids Res. , vol.18 , Issue.17 , pp. 5322
    • Mizushima, S.1    Nagata, S.2
  • 94
    • 0034548823 scopus 로고    scopus 로고
    • Lentiviral gene transfer into primary and secondary NOD/SCID repopulating cells
    • Woods N.B., et al. Lentiviral gene transfer into primary and secondary NOD/SCID repopulating cells. Blood 96 12 (2000) 3725-3733
    • (2000) Blood , vol.96 , Issue.12 , pp. 3725-3733
    • Woods, N.B.1
  • 95
    • 0034669932 scopus 로고    scopus 로고
    • High-level transgene expression in human hematopoietic progenitors and differentiated blood lineages after transduction with improved lentiviral vectors
    • Salmon P., et al. High-level transgene expression in human hematopoietic progenitors and differentiated blood lineages after transduction with improved lentiviral vectors. Blood 96 10 (2000) 3392-3398
    • (2000) Blood , vol.96 , Issue.10 , pp. 3392-3398
    • Salmon, P.1
  • 96
    • 4143145142 scopus 로고    scopus 로고
    • Lentivirus-mediated expression of mutant MGMTP140K protects human CD34+ cells against the combined toxicity of O6-benzylguanine and 1,3-bis(2-chloroethyl)-nitrosourea or temozolomide
    • Chinnasamy D., et al. Lentivirus-mediated expression of mutant MGMTP140K protects human CD34+ cells against the combined toxicity of O6-benzylguanine and 1,3-bis(2-chloroethyl)-nitrosourea or temozolomide. Hum. Gene Ther. 15 8 (2004) 758-769
    • (2004) Hum. Gene Ther. , vol.15 , Issue.8 , pp. 758-769
    • Chinnasamy, D.1
  • 97
    • 0029965285 scopus 로고    scopus 로고
    • Increased levels of spliced RNA account for augmented expression from the MFG retroviral vector in hematopoietic cells
    • Krall W.J., et al. Increased levels of spliced RNA account for augmented expression from the MFG retroviral vector in hematopoietic cells. Gene Ther. 3 1 (1996) 37-48
    • (1996) Gene Ther. , vol.3 , Issue.1 , pp. 37-48
    • Krall, W.J.1
  • 98
    • 0032978712 scopus 로고    scopus 로고
    • Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors
    • Zufferey R., et al. Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors. J. Virol. 73 (1999) 2886-2892
    • (1999) J. Virol. , vol.73 , pp. 2886-2892
    • Zufferey, R.1
  • 99
    • 0034322479 scopus 로고    scopus 로고
    • Context dependence of different modules for posttranscriptional enhancement of gene expression from retroviral vectors
    • Schambach A., et al. Context dependence of different modules for posttranscriptional enhancement of gene expression from retroviral vectors. Mol. Ther. 2 5 (2000) 435-445
    • (2000) Mol. Ther. , vol.2 , Issue.5 , pp. 435-445
    • Schambach, A.1
  • 100
    • 0043254420 scopus 로고    scopus 로고
    • Construction of retroviral vectors with improved safety, gene expression, and versatility
    • Kim S.H., et al. Construction of retroviral vectors with improved safety, gene expression, and versatility. J. Virol. 72 (1998) 994-1004
    • (1998) J. Virol. , vol.72 , pp. 994-1004
    • Kim, S.H.1
  • 101
    • 0032899919 scopus 로고    scopus 로고
    • Design of 5′ untranslated sequences in retroviral vectors developed for medical use
    • Hildinger M., et al. Design of 5′ untranslated sequences in retroviral vectors developed for medical use. J. Virol. 73 5 (1999) 4083-4089
    • (1999) J. Virol. , vol.73 , Issue.5 , pp. 4083-4089
    • Hildinger, M.1
  • 102
    • 33645103149 scopus 로고    scopus 로고
    • Woodchuck hepatitis virus post-transcriptional regulatory element deleted from X protein and promoter sequences enhances retroviral vector titer and expression
    • Schambach A., et al. Woodchuck hepatitis virus post-transcriptional regulatory element deleted from X protein and promoter sequences enhances retroviral vector titer and expression. Gene Ther. 13 7 (2006) 641-645
    • (2006) Gene Ther. , vol.13 , Issue.7 , pp. 641-645
    • Schambach, A.1
  • 103
    • 0036207464 scopus 로고    scopus 로고
    • Improving the post-transcriptional aspects of lentiviral vectors
    • Hope T. Improving the post-transcriptional aspects of lentiviral vectors. Curr. Top. Microbiol. Immunol. 261 (2002) 179-189
    • (2002) Curr. Top. Microbiol. Immunol. , vol.261 , pp. 179-189
    • Hope, T.1
  • 104
    • 7244231295 scopus 로고    scopus 로고
    • Self-inactivating retroviral vectors with improved RNA processing
    • Kraunus J., et al. Self-inactivating retroviral vectors with improved RNA processing. Gene Ther. 11 (2004) 1568-1578
    • (2004) Gene Ther. , vol.11 , pp. 1568-1578
    • Kraunus, J.1
  • 105
    • 1642555634 scopus 로고    scopus 로고
    • Engineering the splice acceptor for improved gene expression and viral titer in an MLV-based retroviral vector
    • Lee J.T., et al. Engineering the splice acceptor for improved gene expression and viral titer in an MLV-based retroviral vector. Gene Ther. 11 1 (2004) 94-99
    • (2004) Gene Ther. , vol.11 , Issue.1 , pp. 94-99
    • Lee, J.T.1
  • 106
    • 0033962412 scopus 로고    scopus 로고
    • Split-intron retroviral vectors: enhanced expression with improved safety
    • Ismail S.I., et al. Split-intron retroviral vectors: enhanced expression with improved safety. J. Virol. 74 5 (2000) 2365-2371
    • (2000) J. Virol. , vol.74 , Issue.5 , pp. 2365-2371
    • Ismail, S.I.1
  • 107
    • 0032584225 scopus 로고    scopus 로고
    • Packaging of intron-containing genes into retrovirus vectors by alphavirus vectors
    • Li K.J., and Garoff H. Packaging of intron-containing genes into retrovirus vectors by alphavirus vectors. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 3650-3654
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 3650-3654
    • Li, K.J.1    Garoff, H.2
  • 108
    • 0024853361 scopus 로고
    • Regulation by HIV Rev depends upon recognition of splice sites
    • Chang D.D., and Sharp P.A. Regulation by HIV Rev depends upon recognition of splice sites. Cell 59 5 (1989) 789-795
    • (1989) Cell , vol.59 , Issue.5 , pp. 789-795
    • Chang, D.D.1    Sharp, P.A.2
  • 109
    • 0036632178 scopus 로고    scopus 로고
    • RNA 3′ readthrough of oncoretrovirus and lentivirus: implications for vector safety and efficacy
    • Zaiss A.K., Son S., and Chang L.J. RNA 3′ readthrough of oncoretrovirus and lentivirus: implications for vector safety and efficacy. J. Virol. 76 14 (2002) 7209-7219
    • (2002) J. Virol. , vol.76 , Issue.14 , pp. 7209-7219
    • Zaiss, A.K.1    Son, S.2    Chang, L.J.3
  • 110
    • 11844288284 scopus 로고    scopus 로고
    • Potential oncogene activity of the woodchuck hepatitis post-transcriptional regulatory element (WPRE)
    • Kingsman S.M., Mitrophanous K., and Olsen J.C. Potential oncogene activity of the woodchuck hepatitis post-transcriptional regulatory element (WPRE). Gene Ther. 12 1 (2005) 3-4
    • (2005) Gene Ther. , vol.12 , Issue.1 , pp. 3-4
    • Kingsman, S.M.1    Mitrophanous, K.2    Olsen, J.C.3
  • 111
    • 15244351083 scopus 로고    scopus 로고
    • Coordinate dual-gene transgenesis by lentiviral vectors carrying synthetic bidirectional promoters
    • Amendola M., et al. Coordinate dual-gene transgenesis by lentiviral vectors carrying synthetic bidirectional promoters. Nat. Biotechnol. 23 1 (2005) 108-116
    • (2005) Nat. Biotechnol. , vol.23 , Issue.1 , pp. 108-116
    • Amendola, M.1
  • 112
    • 0020538097 scopus 로고
    • Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell lines
    • Greenberger J.S., et al. Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell lines. Proc. Natl. Acad. Sci. U.S.A. 80 10 (1983) 2931-2935
    • (1983) Proc. Natl. Acad. Sci. U.S.A. , vol.80 , Issue.10 , pp. 2931-2935
    • Greenberger, J.S.1
  • 113
    • 0029164598 scopus 로고
    • Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase
    • Metzger D., et al. Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase. Proc. Natl. Acad. Sci. U.S.A. 92 15 (1995) 6991-6995
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , Issue.15 , pp. 6991-6995
    • Metzger, D.1
  • 114
    • 30344473326 scopus 로고    scopus 로고
    • Efficient control of gene expression in the hematopoietic system using a single Tet-on inducible lentiviral vector
    • 3
    • Barde I., et al. Efficient control of gene expression in the hematopoietic system using a single Tet-on inducible lentiviral vector. Mol. Ther. 13 2 (2006) 82-90 3
    • (2006) Mol. Ther. , vol.13 , Issue.2 , pp. 82-90
    • Barde, I.1
  • 115
    • 0034202721 scopus 로고    scopus 로고
    • Lentiviral vectors: regulated gene expression
    • Kafri T., et al. Lentiviral vectors: regulated gene expression. Mol. Ther. 1 6 (2000) 516-521
    • (2000) Mol. Ther. , vol.1 , Issue.6 , pp. 516-521
    • Kafri, T.1
  • 116
    • 0036193248 scopus 로고    scopus 로고
    • Robust and efficient regulation of transgene expression in vivo by improved tetracycline-dependent lentiviral vectors
    • Vigna E., et al. Robust and efficient regulation of transgene expression in vivo by improved tetracycline-dependent lentiviral vectors. Mol. Ther. 5 3 (2002) 252-261
    • (2002) Mol. Ther. , vol.5 , Issue.3 , pp. 252-261
    • Vigna, E.1
  • 117
    • 0032549686 scopus 로고    scopus 로고
    • Efficient transduction of human hematopoietic cells with the human multidrug resistance gene 1 via SV40 pseudovirions
    • Rund D., et al. Efficient transduction of human hematopoietic cells with the human multidrug resistance gene 1 via SV40 pseudovirions. Hum. Gene Ther. 9 5 (1998) 649-657
    • (1998) Hum. Gene Ther. , vol.9 , Issue.5 , pp. 649-657
    • Rund, D.1
  • 118
    • 33644822908 scopus 로고    scopus 로고
    • Effective gene therapy with nonintegrating lentiviral vectors
    • Yanez-Munoz R.J., et al. Effective gene therapy with nonintegrating lentiviral vectors. Nat. Med. 12 3 (2006) 348-353
    • (2006) Nat. Med. , vol.12 , Issue.3 , pp. 348-353
    • Yanez-Munoz, R.J.1
  • 119
    • 33744468295 scopus 로고    scopus 로고
    • Transient gene expression by nonintegrating lentiviral vectors
    • Nightingale S.J., et al. Transient gene expression by nonintegrating lentiviral vectors. Mol. Ther. 13 6 (2006) 1121-1132
    • (2006) Mol. Ther. , vol.13 , Issue.6 , pp. 1121-1132
    • Nightingale, S.J.1
  • 120
    • 0023792796 scopus 로고
    • Chromatin domain surrounding the human interferon-beta gene as defined by scaffold-attached regions
    • Bode J., and Maass K. Chromatin domain surrounding the human interferon-beta gene as defined by scaffold-attached regions. Biochemistry 27 13 (1988) 4706-4711
    • (1988) Biochemistry , vol.27 , Issue.13 , pp. 4706-4711
    • Bode, J.1    Maass, K.2
  • 121
    • 0033780721 scopus 로고    scopus 로고
    • Mitotic stability of S/MAR containing episomal vectors is provided by nuclear matrix association
    • Baiker A., et al. Mitotic stability of S/MAR containing episomal vectors is provided by nuclear matrix association. Nat. Cell Biol. 2 (2000) 182-184
    • (2000) Nat. Cell Biol. , vol.2 , pp. 182-184
    • Baiker, A.1
  • 122
    • 3843139313 scopus 로고    scopus 로고
    • Nuclear scaffold/matrix attached region modules linked to a transcription unit are sufficient for replication and maintenance of a mammalian episome
    • Jenke A.W., et al. Nuclear scaffold/matrix attached region modules linked to a transcription unit are sufficient for replication and maintenance of a mammalian episome. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 11322-11327
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 11322-11327
    • Jenke, A.W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.