Coexpression of a multidrug resistance gene (MDR1) and herpes simplex virus thymidine kinase gene in a bicistronic retroviral vector Ha-MDR-IRES-TK allows selective killing of MDR1-transduced human tumors transplanted in nude mice

Cancer Gene Therapy

Volumn 4, Issue 1, 1997, Pages 51-58

  Sugimoto, Yoshikazu ^a   Sato, Shigeo ^a   Tsukahara, Satomi ^a   Suzuki, Mutsumi ^a   Okochi, Etsuko ^b   Gottesman, Michael M ^c   Pastan, Ira ^c   Tsuruo, Takashi ^a,d  

^a CANCER CHEMOTHERAPY CENTER   (Japan)

^b SANOFI   (France)

^c NATIONAL CANCER INSTITUTE   (United States)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

Bicistronic retrovirus vector; Bone marrow transplantation; Cancer chemotherapy; Ganciclovir; Herpes simplex virus thymidine kinase; Multidrug resistance gene

Indexed keywords

GANCICLOVIR; GLYCOPROTEIN P; THYMIDINE KINASE; VINBLASTINE;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BONE MARROW CELL; CANCER TRANSPLANTATION; CELL CULTURE; ENZYMOLOGY; GENE VECTOR; GENETIC TRANSDUCTION; GENETICS; HERPES SIMPLEX VIRUS 1; HUMAN; METABOLISM; MOUSE; NEOPLASM; NUDE MOUSE; PATHOLOGY; RETROVIRUS;

ANIMALS; BONE MARROW CELLS; GANCICLOVIR; GENETIC VECTORS; HERPESVIRUS 1, HUMAN; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM TRANSPLANTATION; NEOPLASMS; P-GLYCOPROTEIN; RETROVIRIDAE; THYMIDINE KINASE; TRANSDUCTION, GENETIC; TUMOR CELLS, CULTURED; VINBLASTINE;

EID: 0030641868     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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