-
1
-
-
0035282789
-
Cellular delivery of antisense oligonucleotides and ribozymes
-
Hughes M.D., Hussain M., Nawaz Q., Sayyed P., Akhtar S. Cellular delivery of antisense oligonucleotides and ribozymes. Drug Discov. Today. 6:2001;303-315.
-
(2001)
Drug Discov. Today
, vol.6
, pp. 303-315
-
-
Hughes, M.D.1
Hussain, M.2
Nawaz, Q.3
Sayyed, P.4
Akhtar, S.5
-
2
-
-
0029977448
-
Antitumor-activity of a phosphorothioate antisense oligodeoxynucleotide targeted against c-raf kinase
-
Monia B.P., Johnston J.F., Geiger T., Muller M., Fabbro D. Antitumor-activity of a phosphorothioate antisense oligodeoxynucleotide targeted against c-raf kinase. Nature Med. 2:1996;668-675.
-
(1996)
Nature Med.
, vol.2
, pp. 668-675
-
-
Monia, B.P.1
Johnston, J.F.2
Geiger, T.3
Muller, M.4
Fabbro, D.5
-
3
-
-
0003038882
-
Mapping of RNA accessible sites for antisense experiments with oligonucleotide libraries
-
Ho S.P., Bao Y., Lesher T., Malhotra R., Ma L.Y., Fluharty S.J., Sakai R.R. Mapping of RNA accessible sites for antisense experiments with oligonucleotide libraries. Nat. Biotechnol. 16:1998;59-63.
-
(1998)
Nat. Biotechnol.
, vol.16
, pp. 59-63
-
-
Ho, S.P.1
Bao, Y.2
Lesher, T.3
Malhotra, R.4
Ma, L.Y.5
Fluharty, S.J.6
Sakai, R.R.7
-
4
-
-
0035873670
-
Antisense oligonucleotides selected by hybridisation to scanning arrays are effective reagents in vivo
-
Sohail M., Hochegger H., Klotzbücher A., Le Guellec R., Hunt T., Southern E. Antisense oligonucleotides selected by hybridisation to scanning arrays are effective reagents in vivo. Nucleic Acids Res. 29:2001;2041-2051.
-
(2001)
Nucleic Acids Res.
, vol.29
, pp. 2041-2051
-
-
Sohail, M.1
Hochegger, H.2
Klotzbücher, A.3
Le Guellec, R.4
Hunt, T.5
Southern, E.6
-
5
-
-
0031694735
-
Antisense technology: Selection and delivery of optimally acting antisense oligonucleotides
-
Akhtar S. Antisense technology: selection and delivery of optimally acting antisense oligonucleotides. J. Drug Target. 5:1998;225-234.
-
(1998)
J. Drug Target.
, vol.5
, pp. 225-234
-
-
Akhtar, S.1
-
6
-
-
12644268252
-
Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivo
-
Monia B.P., Sasmor H., Johnston J.F., Freier S.M., Lesknik E.A., Muller M., Geiger T., Altmann K.H., Moser H., Fabbro D. Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivo. Proc. Natl. Acad. Sci. U.S.A. 93:1997;15481-15484.
-
(1997)
Proc. Natl. Acad. Sci. U.S.A.
, vol.93
, pp. 15481-15484
-
-
Monia, B.P.1
Sasmor, H.2
Johnston, J.F.3
Freier, S.M.4
Lesknik, E.A.5
Muller, M.6
Geiger, T.7
Altmann, K.H.8
Moser, H.9
Fabbro, D.10
-
7
-
-
0031301021
-
Discovering antisense reagents by hybridisation of RNA to oligonucleotide arrays
-
[discussion, 44-6]
-
Southern E.M., Milner N., Ku M. Discovering antisense reagents by hybridisation of RNA to oligonucleotide arrays. Ciba Found Symp. 209:1997;38-44. [discussion, 44-6].
-
(1997)
Ciba Found Symp.
, vol.209
, pp. 38-44
-
-
Southern, E.M.1
Milner, N.2
Ku, M.3
-
8
-
-
0036043328
-
Oligonucleotide scanning arrays: Application to high-throughput screening for effective antisense reagents and the study of nucleic acid interactions
-
Sohail M., Southern E.M. Oligonucleotide scanning arrays: application to high-throughput screening for effective antisense reagents and the study of nucleic acid interactions. Adv. Biochem. Eng. Biotechnol. 77:2002;43-56.
-
(2002)
Adv. Biochem. Eng. Biotechnol.
, vol.77
, pp. 43-56
-
-
Sohail, M.1
Southern, E.M.2
-
10
-
-
0036139884
-
Receptor tyrosine kinases as targets for anticancer drugs
-
Zwick E., Bange J., Ullrich A. Receptor tyrosine kinases as targets for anticancer drugs. Trend Mol. Med. 8:2002;17-23.
-
(2002)
Trend Mol. Med.
, vol.8
, pp. 17-23
-
-
Zwick, E.1
Bange, J.2
Ullrich, A.3
-
11
-
-
0034855942
-
Nuclear localization of EGF receptor and its potential new role as a transcription factor
-
Lin S.Y., Makino K., Xia W., Matin A., Wen Y., Kwong K.Y., Bourguignon L., Hung M.C. Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nat. Cell Biol. 3:2001;802-808.
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 802-808
-
-
Lin, S.Y.1
Makino, K.2
Xia, W.3
Matin, A.4
Wen, Y.5
Kwong, K.Y.6
Bourguignon, L.7
Hung, M.C.8
-
12
-
-
0036362221
-
Epidermal growth factor receptor dependence in human tumors: More than just expression?
-
Arteaga C.L. Epidermal growth factor receptor dependence in human tumors: more than just expression? Oncologist. 7:2002;31-39.
-
(2002)
Oncologist
, vol.7
, pp. 31-39
-
-
Arteaga, C.L.1
-
13
-
-
0036362181
-
Why the epidermal growth factor receptor? The rationale for cancer therapy
-
Baselga J. Why the epidermal growth factor receptor? The rationale for cancer therapy. Oncologist. 7:2002;2-8.
-
(2002)
Oncologist
, vol.7
, pp. 2-8
-
-
Baselga, J.1
-
14
-
-
0029812567
-
A non-antisense sequence-selective effect of a phosphorothioate oligonucleotide targeted to EGFR in A431 cells
-
Coulson J.M., Poyner D.R., Chantry A., Irwin W.J., Akhtar S. A non-antisense sequence-selective effect of a phosphorothioate oligonucleotide targeted to EGFR in A431 cells. Mol. Pharmacol. 50:1996;314-325.
-
(1996)
Mol. Pharmacol.
, vol.50
, pp. 314-325
-
-
Coulson, J.M.1
Poyner, D.R.2
Chantry, A.3
Irwin, W.J.4
Akhtar, S.5
-
15
-
-
0037098261
-
Sequence and chemistry requirements for a novel aptameric oligonucleotide inhibitor of EGF receptor tyrosine kinase activity
-
Akhtar S., Dunnion D., Poyner D., Ackroyd J., Bibby M., Double J. Sequence and chemistry requirements for a novel aptameric oligonucleotide inhibitor of EGF receptor tyrosine kinase activity. Biochem. Pharmacol. 63:2002;2187-2195.
-
(2002)
Biochem. Pharmacol.
, vol.63
, pp. 2187-2195
-
-
Akhtar, S.1
Dunnion, D.2
Poyner, D.3
Ackroyd, J.4
Bibby, M.5
Double, J.6
-
16
-
-
0031686224
-
2′-O-Methyl-modified hammerhead ribozymes targeted to the RNA component of telomerase as sequence-specific inhibitors of telomerase activity
-
Wan M.S.K., Fell P.L., Akhtar S. 2′-O-Methyl-modified hammerhead ribozymes targeted to the RNA component of telomerase as sequence-specific inhibitors of telomerase activity. Antisense Nucleic Acid Drug Dev. 8:1998;309-317.
-
(1998)
Antisense Nucleic Acid Drug Dev.
, vol.8
, pp. 309-317
-
-
Wan, M.S.K.1
Fell, P.L.2
Akhtar, S.3
-
17
-
-
0028241481
-
Arrays of complementary oligonucleotides for analysing the hybridisation behaviour of nucleic acids
-
Southern E.M., Case-Green S.C., Elder J.K., Johnson M., Mir K.U., Wang L., Williams J.C. Arrays of complementary oligonucleotides for analysing the hybridisation behaviour of nucleic acids. Nucleic Acids Res. 22:1994;1368-1373.
-
(1994)
Nucleic Acids Res.
, vol.22
, pp. 1368-1373
-
-
Southern, E.M.1
Case-Green, S.C.2
Elder, J.K.3
Johnson, M.4
Mir, K.U.5
Wang, L.6
Williams, J.C.7
-
18
-
-
0035230771
-
-
Sohail M, Southern EM. Using oligonucleotide scanning arrays to find effective antisense reagents. In: Pampal JB, editor. Methods in molecular biology - oligonucleotide array methods and protocols. Totowa, NJ: Humana Press; 2001.
-
Sohail M, Southern EM. Using oligonucleotide scanning arrays to find effective antisense reagents. In: Pampal JB, editor. Methods in molecular biology - oligonucleotide array methods and protocols. Totowa, NJ: Humana Press; 2001.
-
-
-
-
19
-
-
0034057326
-
Studies on uptake, sub-cellular trafficking and efflux of antisense oligodeoxynucleotides in glioma cells using self-assembling cationic lipoplexes as delivery systems
-
Islam A., Handley S.L., Thompson K.S.J., Akhtar S. Studies on uptake, sub-cellular trafficking and efflux of antisense oligodeoxynucleotides in glioma cells using self-assembling cationic lipoplexes as delivery systems. J. Drug Target. 7:2000;373-382.
-
(2000)
J. Drug Target.
, vol.7
, pp. 373-382
-
-
Islam, A.1
Handley, S.L.2
Thompson, K.S.J.3
Akhtar, S.4
-
20
-
-
0032890879
-
The folding of large RNAs studied by hybridisation to arrays of complementary oligonucleotides
-
Sohail M., Akhtar S., Southern E.M. The folding of large RNAs studied by hybridisation to arrays of complementary oligonucleotides. RNA. 5:1999;646-655.
-
(1999)
RNA
, vol.5
, pp. 646-655
-
-
Sohail, M.1
Akhtar, S.2
Southern, E.M.3
-
21
-
-
0034600849
-
The ErbB signalling network: Receptor heterodimerization in development and cancer
-
Olayioye M.A., Neve R.M., Lane H.A., Hynes N.E. The ErbB signalling network: receptor heterodimerization in development and cancer. EMBO J. 19:2000;3159-3167.
-
(2000)
EMBO J.
, vol.19
, pp. 3159-3167
-
-
Olayioye, M.A.1
Neve, R.M.2
Lane, H.A.3
Hynes, N.E.4
-
22
-
-
0027268428
-
Eps 15, a novel tyrosine kinase substrate, exhibits transforming activity
-
Fazioli F., Minichiello L., Matoskova B., Wong W.T., Di Fiore P.P. Eps 15, a novel tyrosine kinase substrate, exhibits transforming activity. Mol. Cell. Biol. 13:1993;5814-5828.
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 5814-5828
-
-
Fazioli, F.1
Minichiello, L.2
Matoskova, B.3
Wong, W.T.4
Di Fiore, P.P.5
-
23
-
-
0029917264
-
Coupling of the c-Cbl protooncogene product to ErbB-1/EGF-receptor but not to other ErbB proteins
-
Levkowitz G., Klapper L.N., Tzahar E., Freywald A., Sela M., Yarden Y. Coupling of the c-Cbl protooncogene product to ErbB-1/EGF-receptor but not to other ErbB proteins. Oncogene. 12:1996;117-125.
-
(1996)
Oncogene
, vol.12
, pp. 117-125
-
-
Levkowitz, G.1
Klapper, L.N.2
Tzahar, E.3
Freywald, A.4
Sela, M.5
Yarden, Y.6
-
24
-
-
0032893679
-
Eps15 is recruited to the plasma membrane upon epidermal growth factor receptor activation and localizes to components of the endocytic pathway during receptor internalisation
-
Torrisi M.R., Lotti L.V., Belleudi F., Gradini R., Salcini A.E., Confalonieri S., Pelicci P.G., Di Fiore P.P. Eps15 is recruited to the plasma membrane upon epidermal growth factor receptor activation and localizes to components of the endocytic pathway during receptor internalisation. Mol. Biol. Cell. 10:1999;417-434.
-
(1999)
Mol. Biol. Cell
, vol.10
, pp. 417-434
-
-
Torrisi, M.R.1
Lotti, L.V.2
Belleudi, F.3
Gradini, R.4
Salcini, A.E.5
Confalonieri, S.6
Pelicci, P.G.7
Di Fiore, P.P.8
-
25
-
-
0034676451
-
The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5a
-
Lanzetti L., Rybin V., Malabarba M.G., Christoforidis S., Scita G., Zerial M., Di Fiore P.P. The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5a. Nature. 408:2000;374-377.
-
(2000)
Nature
, vol.408
, pp. 374-377
-
-
Lanzetti, L.1
Rybin, V.2
Malabarba, M.G.3
Christoforidis, S.4
Scita, G.5
Zerial, M.6
Di Fiore, P.P.7
-
26
-
-
0032745244
-
Antagonistic effects of protein kinase C α and δ on both transformation and phospholipase D activity mediated by the epidermal growth factor receptor
-
Hornia A., Lu Z., Sukezane T., Zhong M., Joseph T., Frankel P., Foster D.A. Antagonistic effects of protein kinase C α and δ on both transformation and phospholipase D activity mediated by the epidermal growth factor receptor. Mol. Cell. Biol. 19:1999;7672-7680.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 7672-7680
-
-
Hornia, A.1
Lu, Z.2
Sukezane, T.3
Zhong, M.4
Joseph, T.5
Frankel, P.6
Foster, D.A.7
-
27
-
-
0028931859
-
Stimulation of phospholipase D by epidermal growth factor requires protein kinase C activation in Swiss 3T3 cells
-
Yeo E.J., Exton J.H. Stimulation of phospholipase D by epidermal growth factor requires protein kinase C activation in Swiss 3T3 cells. Biol. Chem. 270:1995;3980-3988.
-
(1995)
Biol. Chem.
, vol.270
, pp. 3980-3988
-
-
Yeo, E.J.1
Exton, J.H.2
-
28
-
-
0037010079
-
Epidermal growth factor receptor-targeted therapy in colorectal cancer
-
O'dwyer P.J., Benson A.B. III Epidermal growth factor receptor-targeted therapy in colorectal cancer. Semin. Oncol. 5:2002;10-17.
-
(2002)
Semin. Oncol.
, vol.5
, pp. 10-17
-
-
O'dwyer, P.J.1
Benson A.B. III2
-
29
-
-
0032881288
-
AKT/PKB and other D3 phosphoinositide-regulated kinases: Kinase activation by phosphoinositide-dependent phosphorylation
-
Chan T.O., Rittenhouse S.E., Tsichlis P.N. AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation. Annu. Rev. Biochem. 68:1999;965-1014.
-
(1999)
Annu. Rev. Biochem.
, vol.68
, pp. 965-1014
-
-
Chan, T.O.1
Rittenhouse, S.E.2
Tsichlis, P.N.3
-
30
-
-
0035859872
-
Antisense DNAs as multisite genomic modulators identified by DNA microarray
-
Cho Y.S., Kim M.K., Cheadle C., Neary C., Becker K.G., Cho-Chung Y.S. Antisense DNAs as multisite genomic modulators identified by DNA microarray. Proc. Natl. Acad. Sci. U.S.A. 98:2001;9819-9823.
-
(2001)
Proc. Natl. Acad. Sci. U.S.A.
, vol.98
, pp. 9819-9823
-
-
Cho, Y.S.1
Kim, M.K.2
Cheadle, C.3
Neary, C.4
Becker, K.G.5
Cho-Chung, Y.S.6
-
31
-
-
0037151062
-
Evaluating the specificity of antisense oligonucleotide conjugates. A DNA array analysis
-
Astriab-Fisher A., Ye D., Sergueev D., Fisher M., Shaw B.R., Juliano R.L. Evaluating the specificity of antisense oligonucleotide conjugates. A DNA array analysis. J. Biol. Chem. 277(25):2002;22980-22984.
-
(2002)
J. Biol. Chem.
, vol.277
, Issue.25
, pp. 22980-22984
-
-
Astriab-Fisher, A.1
Ye, D.2
Sergueev, D.3
Fisher, M.4
Shaw, B.R.5
Juliano, R.L.6
-
32
-
-
0031417757
-
A c-myc phosphorothioate oligonucleotide protects U87-MG glioblastoma cells from toxicity at high concentrations of lipofectin and streptolysin-O
-
Coulson J.M., Akhtar S. A c-myc phosphorothioate oligonucleotide protects U87-MG glioblastoma cells from toxicity at high concentrations of lipofectin and streptolysin-O. Pharm. Sci. 3:1997;197-201.
-
(1997)
Pharm. Sci.
, vol.3
, pp. 197-201
-
-
Coulson, J.M.1
Akhtar, S.2
-
33
-
-
0030987371
-
Cell-surface perturbations of the epidermal growth factor receptors by phosphorothioate oligodeoxynucleotides
-
Rockwell P., O'Connor W.J., King K., Goldstein N.I., Zhang L.M., Stein C.A. Cell-surface perturbations of the epidermal growth factor receptors by phosphorothioate oligodeoxynucleotides. Proc. Natl. Acad. Sci. U.S.A. 94:1997;6523-6524.
-
(1997)
Proc. Natl. Acad. Sci. U.S.A.
, vol.94
, pp. 6523-6524
-
-
Rockwell, P.1
O'Connor, W.J.2
King, K.3
Goldstein, N.I.4
Zhang, L.M.5
Stein, C.A.6
-
34
-
-
0030757686
-
Inhibition of epidermal growth factor receptor gene expression and function decreases proliferation of head and neck squamous carcinoma but not normal mucosal epithelial cells
-
Rubin Grandis J., Chakraborty A., Melhem M.F., Zeng Q., Tweardy D.J. Inhibition of epidermal growth factor receptor gene expression and function decreases proliferation of head and neck squamous carcinoma but not normal mucosal epithelial cells. Oncogene. 15:1997;409-416.
-
(1997)
Oncogene
, vol.15
, pp. 409-416
-
-
Rubin Grandis, J.1
Chakraborty, A.2
Melhem, M.F.3
Zeng, Q.4
Tweardy, D.J.5
-
35
-
-
0033015612
-
Antisense oligonucleotides to the epidermal growth factor receptor
-
Witters L., Kumar R., Mandal M., Bennett C.F., Miraglia L., Lipton A. Antisense oligonucleotides to the epidermal growth factor receptor. Breast Cancer Res. Treat. 53:1999;41-50.
-
(1999)
Breast Cancer Res. Treat.
, vol.53
, pp. 41-50
-
-
Witters, L.1
Kumar, R.2
Mandal, M.3
Bennett, C.F.4
Miraglia, L.5
Lipton, A.6
-
36
-
-
0035879822
-
Antisense oligonucleotides targeting the epidermal growth factor receptor inhibit proliferation, induce apoptosis and cooperate with cytotoxic drugs in human cancer cell lines
-
Ciardiello F., Caputo R., Troiani T., Borriello G., Kandimalla E.R., Agrawal S., Mendelsohn J., Bianco A.R., Tortora G. Antisense oligonucleotides targeting the epidermal growth factor receptor inhibit proliferation, induce apoptosis and cooperate with cytotoxic drugs in human cancer cell lines. Int. J. Cancer. 93:2001;172-178.
-
(2001)
Int. J. Cancer
, vol.93
, pp. 172-178
-
-
Ciardiello, F.1
Caputo, R.2
Troiani, T.3
Borriello, G.4
Kandimalla, E.R.5
Agrawal, S.6
Mendelsohn, J.7
Bianco, A.R.8
Tortora, G.9
-
37
-
-
0034815717
-
Treatment of the T98G glioblastoma cell line with antisense oligonucleotides directed toward mRNA encoding transforming growth factor-alpha and the epidermal growth factor receptor
-
Rubenstein M., Glick R., Lichtor T., Mirochnik Y., Chou P., Guinan P. Treatment of the T98G glioblastoma cell line with antisense oligonucleotides directed toward mRNA encoding transforming growth factor-alpha and the epidermal growth factor receptor. Med. Oncol. 18:2001;121-130.
-
(2001)
Med. Oncol.
, vol.18
, pp. 121-130
-
-
Rubenstein, M.1
Glick, R.2
Lichtor, T.3
Mirochnik, Y.4
Chou, P.5
Guinan, P.6
-
38
-
-
0034739601
-
The delivery of antisense therapeutics
-
Akhtar S., Hughes M.D., Khan A., Bibby M., Hussain M., Nawaz Q., Double J., Sayyed P. The delivery of antisense therapeutics. Adv. Drug Deliv. 44:2000;3-21.
-
(2000)
Adv. Drug Deliv.
, vol.44
, pp. 3-21
-
-
Akhtar, S.1
Hughes, M.D.2
Khan, A.3
Bibby, M.4
Hussain, M.5
Nawaz, Q.6
Double, J.7
Sayyed, P.8
-
40
-
-
0030902471
-
Selecting effective antisense reagents on combinatorial oligonucleotide arrays
-
Milner N., Mir K.U., Southern E.M. Selecting effective antisense reagents on combinatorial oligonucleotide arrays. Nat. Biotechnol. 15:1997;537-541.
-
(1997)
Nat. Biotechnol.
, vol.15
, pp. 537-541
-
-
Milner, N.1
Mir, K.U.2
Southern, E.M.3
-
41
-
-
0032857575
-
Determining the influence of structure on hybridisation using oligonucleotide arrays
-
Mir K.U., Southern E.M. Determining the influence of structure on hybridisation using oligonucleotide arrays. Nat. Biotechnol. 17:1999;788-792.
-
(1999)
Nat. Biotechnol.
, vol.17
, pp. 788-792
-
-
Mir, K.U.1
Southern, E.M.2
-
42
-
-
0034773184
-
New B-type cyclin synthesis is required between meiosis I and II during Xenopus oocyte maturation
-
Hochegger H., Klotzbucher A., Kirk J., Howell M., Le Guellec K., Fletcher K., Duncan T., Sohail M., Hunt T. New B-type cyclin synthesis is required between meiosis I and II during Xenopus oocyte maturation. Development. 128:2001;3795-3807.
-
(2001)
Development
, vol.128
, pp. 3795-3807
-
-
Hochegger, H.1
Klotzbucher, A.2
Kirk, J.3
Howell, M.4
Le Guellec, K.5
Fletcher, K.6
Duncan, T.7
Sohail, M.8
Hunt, T.9
-
43
-
-
0028008469
-
The receptor for EGF and its ligands: Expression, prognostic value and target for therapy in cancer [review]
-
Modjtahedi H., Dean C. The receptor for EGF and its ligands: expression, prognostic value and target for therapy in cancer [review]. Int. J. Oncol. 4:1994;277-296.
-
(1994)
Int. J. Oncol.
, vol.4
, pp. 277-296
-
-
Modjtahedi, H.1
Dean, C.2
|