Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase

Nature Medicine

Volumn 2, Issue 6, 1996, Pages 668-675

  Monia, Brett P ^a   Johnston, Joseph F ^a   Geiger, Thomas ^b   Muller, Marcel ^b   Fabbro, Doriano ^b  

^a ISIS PHARMACEUTICALS   (United States)

^b CIBA GEIGY LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; PHOSPHOROTHIOIC ACID; PROTEIN KINASE; RAF PROTEIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CELL PROLIFERATION; GENE EXPRESSION REGULATION; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; BASE SEQUENCE; CARCINOMA; CELL DIVISION; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; NEOPLASMS, EXPERIMENTAL; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; OLIGONUCLEOTIDES, ANTISENSE; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-RAF; RNA, MESSENGER; THIONUCLEOTIDES; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0029977448     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0696-668     Document Type: Article

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