Cellular uptake properties of a 2'-amino/2'-O-methyl-modified chimeric hammerhead ribozyme targeted to the epidermal growth factor receptor mRNA

Antisense and Nucleic Acid Drug Development

Volumn 7, Issue 4, 1997, Pages 319-326

  Fell, Patricia L ^a   Hudson, Andrew J ^a   Reynolds, Mark A ^b   Usman, Nassim ^b   Akhtar, Saghir ^a  

^a ASTON UNIVERSITY   (United Kingdom)

^b Sirna Therapeutics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; DEXTRAN SULFATE; EPIDERMAL GROWTH FACTOR RECEPTOR; HEPARIN; MESSENGER RNA; POLYANION; RIBOZYME; RNA DERIVATIVE; SPERMIDINE;

ACTIVE TRANSPORT; ARTICLE; CELL TRANSPORT; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG UPTAKE; ENDOCYTOSIS; ENERGY; FLUORESCENCE; GLIOMA CELL; HUMAN; HUMAN CELL; PH; PRIORITY JOURNAL; RNA STRUCTURE; SALMON; SPERM; TEMPERATURE; TUMOR CELL LINE;

EID: 0030844046     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.1.1997.7.319     Document Type: Article

References (5)

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2. AKHTAR, S. (1995). Delivery Strategies for Antisense Oligonucleotide Therapeutics. (CRC Press, Boca Raton, FL).
3. AKHTAR, S., and AGRAWAL, S. (1997). In vivo studies with antisense oligonucleotides. TIPS 18, 12-18.
4. AKHTAR, S., BECK, G., HAWLEY, P., IRWIN, W.J., and GIBSON, I. (1996). The influence of polarized epithelial (Caco-2) cell differentiation on the cellular binding of phosphodiester and phosphorothioate oligonucleotides. Antisense Nucleic Acids Drug Dev. 6, 197-206.
5. ZELPHATI, O., and SZOKA, F.C. Jr. (1996). Mechanism of oligonucleotide release from cationic liposomes. Proc. Natl. Acad. Sci. USA 93, 11493-11498.