Site-specific administration of antisense oligonucleotides using biodegradable polymer microspheres provides sustained delivery and improved subcellular biodistribution in the neostriatum of the rat brain

Journal of Drug Targeting

Volumn 8, Issue 5, 2000, Pages 319-334

  Khan, A ^a   Sommer, W ^a   Fuxe, K ^a   Akhtar, S ^a  

^a ASTON UNIVERSITY   (United Kingdom)

Author keywords

Antisense; Biodegradable; Brain delivery; Controlled release; Drug delivery; Oligonucleotides; Poly(lactic acid co glycolic acid)

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; GOSERELIN; HALOTHANE; MICROSPHERE; NUCLEIC ACID; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; PENTOBARBITAL; POLYGLACTIN; POLYMER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIODEGRADATION; BRAIN CELL; CELL NUCLEUS; CELLULAR DISTRIBUTION; CENTRAL NERVOUS SYSTEM; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; CYTOSOL; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EFFECT; DRUG EFFICACY; DRUG ELIMINATION; DRUG FORMULATION; DRUG HALF LIFE; DRUG LABELING; DRUG RELEASE; DRUG SCREENING; DRUG TARGETING; EMULSION; ENCAPSULATION; FLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MALE; MORPHOLOGY; NEOSTRIATUM; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; SURFACE PROPERTY; SUSTAINED DRUG RELEASE; TECHNIQUE;

EID: 0034471699     PISSN: 1061186X     EISSN: None     Source Type: Journal    
DOI: 10.3109/10611860008997909     Document Type: Article

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