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Volumn 44, Issue 1, 2000, Pages 3-21

The delivery of antisense therapeutics

Author keywords

Antisense; Biodegradable polymer; Brain delivery; Delivery; DNAzymes; Liposomes; Microspheres; Oral delivery; Receptor mediated; Ribozymes

Indexed keywords

BIODEGRADATION; BIOPOLYMERS; DISEASES; DNA; DRUG THERAPY;

EID: 0034739601     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(00)00080-6     Document Type: Article
Times cited : (236)

References (105)
  • 1
    • 0031027349 scopus 로고    scopus 로고
    • In vivo studies with antisense oligonucleotides
    • Akhtar S., Agrawal S. In vivo studies with antisense oligonucleotides. Trends Pharmacol. Sci. 18:(1):1997;12-18.
    • (1997) Trends Pharmacol. Sci. , vol.18 , Issue.1 , pp. 12-18
    • Akhtar, S.1    Agrawal, S.2
  • 2
    • 0032960982 scopus 로고    scopus 로고
    • Antisense pharmacodynamics: Critical issues in the transport and delivery of antisense oligonucleotides
    • Juliano R.L., Alahari S., Yoo H., Cho M. Antisense pharmacodynamics: critical issues in the transport and delivery of antisense oligonucleotides. Pharm. Res. 16:1999;494-502.
    • (1999) Pharm. Res. , vol.16 , pp. 494-502
    • Juliano, R.L.1    Alahari, S.2    Yoo, H.3    Cho, M.4
  • 3
    • 0033958635 scopus 로고    scopus 로고
    • Antisense therapeutics: Is it as simple as complementary base recognition?
    • Kandimalla E.R., Agrawal S. Antisense therapeutics: is it as simple as complementary base recognition? Mol. Med. Today. 6:2000;72-81.
    • (2000) Mol. Med. Today , vol.6 , pp. 72-81
    • Kandimalla, E.R.1    Agrawal, S.2
  • 4
    • 0033111032 scopus 로고    scopus 로고
    • Application of preformed hammerhead ribozymes in gene therapy of cancer
    • Sioud M. Application of preformed hammerhead ribozymes in gene therapy of cancer. Int. J. Mol. Med. 3:1999;381-384.
    • (1999) Int. J. Mol. Med. , vol.3 , pp. 381-384
    • Sioud, M.1
  • 6
    • 0033485863 scopus 로고    scopus 로고
    • Nucleic Acid Molecular switches
    • Soukup G.A., Breaker R.R. Nucleic Acid Molecular switches. TIBTECH. 17:1999;469-476.
    • (1999) TIBTECH , vol.17 , pp. 469-476
    • Soukup, G.A.1    Breaker, R.R.2
  • 8
    • 0031694735 scopus 로고    scopus 로고
    • Antisense technology: Selection and delivery of optimally acting antisense oligonucleotides
    • Akhtar S. Antisense technology: Selection and delivery of optimally acting antisense oligonucleotides. J. Drug Targeting. 5:(4):1998;225-234.
    • (1998) J. Drug Targeting , vol.5 , Issue.4 , pp. 225-234
    • Akhtar, S.1
  • 10
    • 12644268252 scopus 로고    scopus 로고
    • Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivo
    • Monia B.P., Sasmor H., Johnston J.F., Freier S.M., Lesnik E.A., Muller M., Geiger T., Altmann K.H., Moser H., Fabbro D. Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivo. Proc. Natl. Acad. Sci. USA. 93:(26):1996;15481-15484.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , Issue.26 , pp. 15481-15484
    • Monia, B.P.1    Sasmor, H.2    Johnston, J.F.3    Freier, S.M.4    Lesnik, E.A.5    Muller, M.6    Geiger, T.7    Altmann, K.H.8    Moser, H.9    Fabbro, D.10
  • 12
    • 0029938209 scopus 로고    scopus 로고
    • Potent antisense oligonucleotides to the human multidrug resistance-1 mRNA are rationally selected by mapping RNA-accessible sites with oligonucleotide libraries
    • Ho S.P., Britton D.H.O., Stone B.A., Behrens D.L., Leffet L.M., Hobbs F.W., Miller J.A., Trainor G.L. Potent antisense oligonucleotides to the human multidrug resistance-1 mRNA are rationally selected by mapping RNA-accessible sites with oligonucleotide libraries. Nucleic Acids Res. 24:(10):1996;1901-1907.
    • (1996) Nucleic Acids Res. , vol.24 , Issue.10 , pp. 1901-1907
    • Ho, S.P.1    Britton, D.H.O.2    Stone, B.A.3    Behrens, D.L.4    Leffet, L.M.5    Hobbs, F.W.6    Miller, J.A.7    Trainor, G.L.8
  • 13
    • 0031032603 scopus 로고    scopus 로고
    • Combinatorial screening and rational optimization for hybridization to-folded hepatitis C virus RNA of oligonucleotides with biological antisense activity
    • W.F. Lima, V. Brown-Drivers, M. Fox, R. Hanecak, T.W. Bruice, Combinatorial screening and rational optimization for hybridization to-folded hepatitis C virus RNA of oligonucleotides with biological antisense activity, J. Biol. Chem. 272(1) (1997) 626-638.
    • (1997) J. Biol. Chem. , vol.272 , Issue.1 , pp. 626-638
    • Lima, W.F.1    Brown-Drivers, V.2    Fox, M.3    Hanecak, R.4    Bruice, T.W.5
  • 14
    • 0032533782 scopus 로고    scopus 로고
    • Rapid determination and quantitation of the accessibility to native RNAs by antisense oligodeoxynucleotides in murine cell extracts
    • Scherr M., Rossi J.J. Rapid determination and quantitation of the accessibility to native RNAs by antisense oligodeoxynucleotides in murine cell extracts. Nucleic Acids Res. 26:(22):1998;5079-5085.
    • (1998) Nucleic Acids Res. , vol.26 , Issue.22 , pp. 5079-5085
    • Scherr, M.1    Rossi, J.J.2
  • 15
    • 0030952735 scopus 로고    scopus 로고
    • Probing accessible sites for ribozymes on human acetylcholinesterase RNA
    • Birikh K.R., Berlin Y.A., Soreq H., Eckstein F. Probing accessible sites for ribozymes on human acetylcholinesterase RNA. RNA. 3:(4):1997;429-437.
    • (1997) RNA , vol.3 , Issue.4 , pp. 429-437
    • Birikh, K.R.1    Berlin, Y.A.2    Soreq, H.3    Eckstein, F.4
  • 16
    • 0029962816 scopus 로고    scopus 로고
    • DNA chips Analysing sequence by hybridization to oligonucleotides on a large scale
    • Southern E.M. DNA chips Analysing sequence by hybridization to oligonucleotides on a large scale. Trends Genet. 12:(3):1996;110-115.
    • (1996) Trends Genet. , vol.12 , Issue.3 , pp. 110-115
    • Southern, E.M.1
  • 18
    • 0030902471 scopus 로고    scopus 로고
    • Selecting effective antisense reagents on combinatorial oligonucleotide arrays
    • Milner N., Mir K.U., Southern E.M. Selecting effective antisense reagents on combinatorial oligonucleotide arrays. Nature Biotechnol. 15:(6):1997;537-541.
    • (1997) Nature Biotechnol. , vol.15 , Issue.6 , pp. 537-541
    • Milner, N.1    Mir, K.U.2    Southern, E.M.3
  • 19
    • 0022780091 scopus 로고
    • Oligodeoxynucleotide Stability In Subcellular Extracts and Culture Media
    • Wickstrom E. Oligodeoxynucleotide Stability In Subcellular Extracts and Culture Media. J. Biochem. Biophys. Methods. 13:(2):1986;97-102.
    • (1986) J. Biochem. Biophys. Methods , vol.13 , Issue.2 , pp. 97-102
    • Wickstrom, E.1
  • 20
    • 0026002671 scopus 로고
    • Stability Of Antisense DNA Oligodeoxynucleotide. Analogs In Cellular Extracts and Sera
    • Akhtar S., Kole R., Juliano R.L. Stability Of Antisense DNA Oligodeoxynucleotide. Analogs In Cellular Extracts and Sera. Life Sci. 49:(24):1991;1793-1801.
    • (1991) Life Sci. , vol.49 , Issue.24 , pp. 1793-1801
    • Akhtar, S.1    Kole, R.2    Juliano, R.L.3
  • 21
    • 0032945789 scopus 로고    scopus 로고
    • Cellular delivery of hammerhead ribozymes conjugated to a transferrin receptor antibody
    • Hudson A.J., Normand N., Ackroyd J., Akhtar S. Cellular delivery of hammerhead ribozymes conjugated to a transferrin receptor antibody. Int. J. Pharm. 182:(1):1999;49-58.
    • (1999) Int. J. Pharm. , vol.182 , Issue.1 , pp. 49-58
    • Hudson, A.J.1    Normand, N.2    Ackroyd, J.3    Akhtar, S.4
  • 22
    • 0023811885 scopus 로고
    • Oligonucleotide Analogs as potential chemotherapeutic - Agents
    • Ion G. Oligonucleotide Analogs as potential chemotherapeutic - Agents. Pharmaceutical Research. 5:(9):1988;539-549.
    • (1988) Pharmaceutical Research , vol.5 , Issue.9 , pp. 539-549
    • Ion, G.1
  • 24
    • 0033150534 scopus 로고    scopus 로고
    • Cellular delivery of peptide nucleic acids and inhibition of human telomerase
    • Hamilton S.E., Simmons C.G., Kathiriya I.S., Corey D.R. Cellular delivery of peptide nucleic acids and inhibition of human telomerase. Chem. Biol. 6:(6):1999;343-351.
    • (1999) Chem. Biol. , vol.6 , Issue.6 , pp. 343-351
    • Hamilton, S.E.1    Simmons, C.G.2    Kathiriya, I.S.3    Corey, D.R.4
  • 25
    • 0033150534 scopus 로고    scopus 로고
    • Cellular delivery of peptide nucleic acids and inhibition of human telomerase
    • Hamilton S.E., Simmons C.G., Kathiriya I.S., Corey D.R. Cellular delivery of peptide nucleic acids and inhibition of human telomerase. Chem. Biol. 6:(6):1999;343-351.
    • (1999) Chem. Biol. , vol.6 , Issue.6 , pp. 343-351
    • Hamilton, S.E.1    Simmons, C.G.2    Kathiriya, I.S.3    Corey, D.R.4
  • 27
    • 0034003611 scopus 로고    scopus 로고
    • Attenuation of cytomegalovirus-induced endothelial intercellular adhesion molecule-1 mRNA/protein expression and T lymphocyte adhesion by a 2′-O-methoxyethyl antisense oligonucleotide
    • Knight D.A., Briggs B.R., Bennett C.F., Harindranath N., Waldman W.J., Sedmak D.D. Attenuation of cytomegalovirus-induced endothelial intercellular adhesion molecule-1 mRNA/protein expression and T lymphocyte adhesion by a 2′-O-methoxyethyl antisense oligonucleotide. Transplantation. 69:(3):2000;417-426.
    • (2000) Transplantation , vol.69 , Issue.3 , pp. 417-426
    • Knight, D.A.1    Briggs, B.R.2    Bennett, C.F.3    Harindranath, N.4    Waldman, W.J.5    Sedmak, D.D.6
  • 29
    • 0034099359 scopus 로고    scopus 로고
    • In vivo evaluation of a morpholino antisense oligomer directed against tumor necrosis factor-alpha
    • Qin G.Z., Taylor M., Ning Y.Y., Iversen P., Kobzik L. In vivo evaluation of a morpholino antisense oligomer directed against tumor necrosis factor-alpha. Antisense Nucl. Acid Drug Dev. 10:(1):2000;11-16.
    • (2000) Antisense Nucl. Acid Drug Dev. , vol.10 , Issue.1 , pp. 11-16
    • Qin, G.Z.1    Taylor, M.2    Ning, Y.Y.3    Iversen, P.4    Kobzik, L.5
  • 31
    • 0032530117 scopus 로고    scopus 로고
    • Intracellular metabolism of a 2′-O-methyl-stabilized ribozyme after uptake by DOTAP transfection or as free ribozyme. A study by capillary electrophoresis
    • Prasmickaite L., Hogset A., Maelandsmo G., Berg K., Goodchild J., Perkins T., Fodstad O., Hovig E. Intracellular metabolism of a 2′-O-methyl-stabilized ribozyme after uptake by DOTAP transfection or as free ribozyme. A study by capillary electrophoresis. Nucleic Acids Res. 26:(18):1998;4241-4248.
    • (1998) Nucleic Acids Res. , vol.26 , Issue.18 , pp. 4241-4248
    • Prasmickaite, L.1    Hogset, A.2    Maelandsmo, G.3    Berg, K.4    Goodchild, J.5    Perkins, T.6    Fodstad, O.7    Hovig, E.8
  • 34
    • 0030844046 scopus 로고    scopus 로고
    • Cellular uptake properties of a 2′-amino/2′-O-methyl-modified chimeric hammerhead ribozyme targeted to the epidermal growth factor receptor mRNA
    • Fell P.L., Hudson A.J., Reynolds M.A., Usman N., Akhtar S. Cellular uptake properties of a 2′-amino/2′-O-methyl-modified chimeric hammerhead ribozyme targeted to the epidermal growth factor receptor mRNA. Antisense Nucl. Acid Drug Dev. 7:(4):1997;319-326.
    • (1997) Antisense Nucl. Acid Drug Dev. , vol.7 , Issue.4 , pp. 319-326
    • Fell, P.L.1    Hudson, A.J.2    Reynolds, M.A.3    Usman, N.4    Akhtar, S.5
  • 36
    • 0026550810 scopus 로고
    • Cellular uptake and intracellular fate of antisense oligonucleotides
    • Akhtar S., Juliano R.L. Cellular uptake and intracellular fate of antisense oligonucleotides. TICB. 2:1992;139-144.
    • (1992) TICB , vol.2 , pp. 139-144
    • Akhtar, S.1    Juliano, R.L.2
  • 37
    • 0024199289 scopus 로고
    • Delivery Of C-Myc Antisense Phosphorothioate Oligodeoxynucleotides to Hematopoietic-Cells In Culture By Liposome Fusion - Specific Reduction In C-Myc Protein Expression Correlates With Inhibition Of Cell-Growth and DNA-synthesis
    • Loke S.L., Stein C., Zhang X., Avigan M., Cohen J., Neckers L.M. Delivery Of C-Myc Antisense Phosphorothioate Oligodeoxynucleotides to Hematopoietic-Cells In Culture By Liposome Fusion - Specific Reduction In C-Myc Protein Expression Correlates With Inhibition Of Cell-Growth and DNA-synthesis. Curr. Top. Microbiol. Immunol. 141:1988;282-289.
    • (1988) Curr. Top. Microbiol. Immunol. , vol.141 , pp. 282-289
    • Loke, S.L.1    Stein, C.2    Zhang, X.3    Avigan, M.4    Cohen, J.5    Neckers, L.M.6
  • 38
    • 0034057326 scopus 로고    scopus 로고
    • Studies on uptake, sub-cellular trafficking and efflux of antisense oligodeoxynucleotides in glioma cells using self-assembling cationic lipoplexes as delivery systems
    • Islam A., Handley S.L., Thompson K.S.J., Akhtar S. Studies on uptake, sub-cellular trafficking and efflux of antisense oligodeoxynucleotides in glioma cells using self-assembling cationic lipoplexes as delivery systems. J. Drug Targeting. 7:(5):2000;373-382.
    • (2000) J. Drug Targeting , vol.7 , Issue.5 , pp. 373-382
    • Islam, A.1    Handley, S.L.2    Thompson, K.S.J.3    Akhtar, S.4
  • 42
    • 0033991406 scopus 로고    scopus 로고
    • Preparation and application of liposome-incorporated oligodeoxynucleotides
    • Tari A.M. Preparation and application of liposome-incorporated oligodeoxynucleotides. Methods Enzymol. 313:2000;372-388.
    • (2000) Methods Enzymol. , vol.313 , pp. 372-388
    • Tari, A.M.1
  • 43
    • 0033960559 scopus 로고    scopus 로고
    • Down-regulation of HER2/neu expression induces apoptosis in human cancer cells that overexpress HER2/neu
    • Roh H., Pippin J., Drebin J.A. Down-regulation of HER2/neu expression induces apoptosis in human cancer cells that overexpress HER2/neu. Cancer Res. 60:(3):2000;560-565.
    • (2000) Cancer Res. , vol.60 , Issue.3 , pp. 560-565
    • Roh, H.1    Pippin, J.2    Drebin, J.A.3
  • 44
    • 0031778137 scopus 로고    scopus 로고
    • Specific inhibition of influenza virus RNA polymerase and nucleoprotein gene expression by liposomally encapsulated antisense phosphorothioate oligonucleotides in MDCK cells
    • Abe T., Suzuki S., Hatta T., Takai K., Yokota T., Takaku H. Specific inhibition of influenza virus RNA polymerase and nucleoprotein gene expression by liposomally encapsulated antisense phosphorothioate oligonucleotides in MDCK cells. Antiviral Chem. Chemother. 9:(3):1998;253-262.
    • (1998) Antiviral Chem. Chemother. , vol.9 , Issue.3 , pp. 253-262
    • Abe, T.1    Suzuki, S.2    Hatta, T.3    Takai, K.4    Yokota, T.5    Takaku, H.6
  • 45
    • 0029966767 scopus 로고    scopus 로고
    • Inhibition of expression of the multidrug resistance-associated P-glycoprotein by phosphorothioate and 5′ cholesterol-conjugated phosphorothioate antisense oligonucleotides
    • Alahari S.K., Dean N.M., Fisher M.H., DeLong R., Manoharan M., Tivel K.L., Juliano R.L. Inhibition of expression of the multidrug resistance-associated P-glycoprotein by phosphorothioate and 5′ cholesterol-conjugated phosphorothioate antisense oligonucleotides. Mol. Pharmacol. 50:(4):1996;808-819.
    • (1996) Mol. Pharmacol. , vol.50 , Issue.4 , pp. 808-819
    • Alahari, S.K.1    Dean, N.M.2    Fisher, M.H.3    Delong, R.4    Manoharan, M.5    Tivel, K.L.6    Juliano, R.L.7
  • 46
    • 0033566954 scopus 로고    scopus 로고
    • Specific inhibition of macrophage TNF-alpha expression by in vivo ribozyme treatment
    • Kisich K.O., Malone R.W., Feldstein P.A., Erickson K.L. Specific inhibition of macrophage TNF-alpha expression by in vivo ribozyme treatment. J. Immunol. 163:(4):1999;2008-2016.
    • (1999) J. Immunol. , vol.163 , Issue.4 , pp. 2008-2016
    • Kisich, K.O.1    Malone, R.W.2    Feldstein, P.A.3    Erickson, K.L.4
  • 47
    • 0030826783 scopus 로고    scopus 로고
    • Use of a hammerhead ribozyme with cationic liposomes to reduce leukocyte type 12-lipoxygenase expression in vascular smooth muscle
    • Gu J.L., Nadler J., Rossi J. Use of a hammerhead ribozyme with cationic liposomes to reduce leukocyte type 12-lipoxygenase expression in vascular smooth muscle. Mol. Cell. Biochem. 172:(1-2):1997;47-57.
    • (1997) Mol. Cell. Biochem. , vol.172 , Issue.12 , pp. 47-57
    • Gu, J.L.1    Nadler, J.2    Rossi, J.3
  • 48
    • 0026497428 scopus 로고
    • Effect Of Cationic Cholesterol Derivatives On Gene-Transfer and Protein-Kinase-C Activity
    • Farhood H., Bottega R., Epand R.M., Huang L. Effect Of Cationic Cholesterol Derivatives On Gene-Transfer and Protein-Kinase-C Activity. Biochim. Biophys. Acta. 1111:(2):1992;239-246.
    • (1992) Biochim. Biophys. Acta , vol.1111 , Issue.2 , pp. 239-246
    • Farhood, H.1    Bottega, R.2    Epand, R.M.3    Huang, L.4
  • 49
    • 0029856329 scopus 로고    scopus 로고
    • Intracellular distribution and mechanism of delivery of oligonucleotides mediated by cationic lipids
    • Zelphati O., Szoka F.C. Intracellular distribution and mechanism of delivery of oligonucleotides mediated by cationic lipids. Pharm. Res. 13:(9):1996;1367-1372.
    • (1996) Pharm. Res. , vol.13 , Issue.9 , pp. 1367-1372
    • Zelphati, O.1    Szoka, F.C.2
  • 50
    • 0033990409 scopus 로고    scopus 로고
    • Cell-specific optimization of phosphorothioate antisense oligodeoxynucleotide delivery by cationic lipids
    • Williams S.A., Buzby J.S. Cell-specific optimization of phosphorothioate antisense oligodeoxynucleotide delivery by cationic lipids. Methods Enzymol. 313:2000;388-397.
    • (2000) Methods Enzymol. , vol.313 , pp. 388-397
    • Williams, S.A.1    Buzby, J.S.2
  • 51
    • 0034096440 scopus 로고    scopus 로고
    • Effect of cationic liposomes on intracellular trafficking and efficacy of antisense oligonucleotides in mouse peritoneal macrophages
    • Takagi T., Hashiguchi M., Hiramatsu T., Yamashita F., Takakura Y., Hashida M. Effect of cationic liposomes on intracellular trafficking and efficacy of antisense oligonucleotides in mouse peritoneal macrophages. J. Drug Targeting. 7:(5):2000;363-373.
    • (2000) J. Drug Targeting , vol.7 , Issue.5 , pp. 363-373
    • Takagi, T.1    Hashiguchi, M.2    Hiramatsu, T.3    Yamashita, F.4    Takakura, Y.5    Hashida, M.6
  • 53
    • 0031660642 scopus 로고    scopus 로고
    • PH-Sensitive liposomes as a carrier for oligonucleotides a physico-chemical study of the interaction between DOPE and a 15-mer oligonucleotide in quasi-anhydrous samples
    • DeOliveira M.C., Fattal E., Couvreur P., Lesieur P., Bourgaux C., Ollivon M., Dubernet C. pH-Sensitive liposomes as a carrier for oligonucleotides a physico-chemical study of the interaction between DOPE and a 15-mer oligonucleotide in quasi-anhydrous samples. Biochim. Biophys. Acta Biomembr. 1372:(2):1998;301-310.
    • (1998) Biochim. Biophys. Acta Biomembr. , vol.1372 , Issue.2 , pp. 301-310
    • Deoliveira, M.C.1    Fattal, E.2    Couvreur, P.3    Lesieur, P.4    Bourgaux, C.5    Ollivon, M.6    Dubernet, C.7
  • 54
    • 0023280158 scopus 로고
    • Fate and Behavior Of Liposomes Invivo - A Review Of Controlling Factors
    • Senior J.H. Fate and Behavior Of Liposomes Invivo - a Review Of Controlling Factors. CRC Crit. Rev. Ther. Drug Carrier Sys. 3:(2):1987;123-193.
    • (1987) CRC Crit. Rev. Ther. Drug Carrier Sys. , vol.3 , Issue.2 , pp. 123-193
    • Senior, J.H.1
  • 55
    • 0033525573 scopus 로고    scopus 로고
    • Uptake of liposomes containing phosphatidylserine by liver cells in vivo and by sinusoidal liver cells in primary culture: In vivo-in vitro differences
    • Kamps J., Morselt H.W.M., Scherphof G.L. Uptake of liposomes containing phosphatidylserine by liver cells in vivo and by sinusoidal liver cells in primary culture: In vivo-in vitro differences. Biochem. Biophys. Res. Commun. 256:(1):1999;57-62.
    • (1999) Biochem. Biophys. Res. Commun. , vol.256 , Issue.1 , pp. 57-62
    • Kamps, J.1    Morselt, H.W.M.2    Scherphof, G.L.3
  • 56
    • 0032785419 scopus 로고    scopus 로고
    • Lipoplexes and tumours. A review
    • Dass C.R., Burton M.A. Lipoplexes and tumours. A review. J. Pharm. Pharmacol. 51:(7):1999;755-770.
    • (1999) J. Pharm. Pharmacol. , vol.51 , Issue.7 , pp. 755-770
    • Dass, C.R.1    Burton, M.A.2
  • 57
    • 0025341615 scopus 로고
    • Amphipathic Polyethyleneglycols Effectively Prolong the Circulation Time Of Liposomes
    • Klibanov A.L., Maruyama K., Torchilin V.P., Huang L. Amphipathic Polyethyleneglycols Effectively Prolong the Circulation Time Of Liposomes. FEBS Lett. 268:(1):1990;235-237.
    • (1990) FEBS Lett. , vol.268 , Issue.1 , pp. 235-237
    • Klibanov, A.L.1    Maruyama, K.2    Torchilin, V.P.3    Huang, L.4
  • 58
    • 0031900833 scopus 로고    scopus 로고
    • The spread and uptake pattern of intracerebrally administered oligonucleotides in nerve and glial cell populations of the rat brain
    • Sommer W., Cui X., Erdmann B., Wiklund L., Bricca G., Heilig M., Fuxe K. The spread and uptake pattern of intracerebrally administered oligonucleotides in nerve and glial cell populations of the rat brain. Antisense Nucl. Acid Drug Dev. 8:(2):1998;75-85.
    • (1998) Antisense Nucl. Acid Drug Dev. , vol.8 , Issue.2 , pp. 75-85
    • Sommer, W.1    Cui, X.2    Erdmann, B.3    Wiklund, L.4    Bricca, G.5    Heilig, M.6    Fuxe, K.7
  • 59
    • 0030926147 scopus 로고    scopus 로고
    • Characterization of complexes of oligonucleotides with polyamidoamine starburst dendrimers and effects on intracellular delivery
    • DeLong R., Stephenson K., Loftus T., Fisher M., Alahari S., Nolting A., Juliano R.L. Characterization of complexes of oligonucleotides with polyamidoamine starburst dendrimers and effects on intracellular delivery. J. Pharm. Sci. 86:(6):1997;762-764.
    • (1997) J. Pharm. Sci. , vol.86 , Issue.6 , pp. 762-764
    • Delong, R.1    Stephenson, K.2    Loftus, T.3    Fisher, M.4    Alahari, S.5    Nolting, A.6    Juliano, R.L.7
  • 60
    • 0029945799 scopus 로고    scopus 로고
    • Regulation of in vitro gene expression using antisense oligonucleotides or antisense expression plasmids transfected using starburst PAMAM dendrimers
    • Bielinska A., KukowskaLatallo J.F., Johnson J., Tomalia D.A., Baker J.R. Regulation of in vitro gene expression using antisense oligonucleotides or antisense expression plasmids transfected using starburst PAMAM dendrimers. Nucleic Acids Res. 24:(11):1996;2176-2182.
    • (1996) Nucleic Acids Res. , vol.24 , Issue.11 , pp. 2176-2182
    • Bielinska, A.1    Kukowskalatallo, J.F.2    Johnson, J.3    Tomalia, D.A.4    Baker, J.R.5
  • 61
    • 0027655718 scopus 로고
    • Polyamidoamine Cascade Polymers Mediate Efficient Transfection Of Cells In Culture
    • Haensler J., Szoka F.C. Polyamidoamine Cascade Polymers Mediate Efficient Transfection Of Cells In Culture. Bioconj. Chem. 4:(5):1993;372-379.
    • (1993) Bioconj. Chem. , vol.4 , Issue.5 , pp. 372-379
    • Haensler, J.1    Szoka, F.C.2
  • 63
    • 0032421644 scopus 로고    scopus 로고
    • PH-sensitive liposomes for receptor-mediated delivery to chicken hepatoma (LMH) cells
    • Skalko N., Peschka R., Altenschmidt U., Lung A., Schubert R. pH-sensitive liposomes for receptor-mediated delivery to chicken hepatoma (LMH) cells. FEBS Lett. 434:(3):1998;351-356.
    • (1998) FEBS Lett. , vol.434 , Issue.3 , pp. 351-356
    • Skalko, N.1    Peschka, R.2    Altenschmidt, U.3    Lung, A.4    Schubert, R.5
  • 65
    • 0032945304 scopus 로고    scopus 로고
    • Gene repair using chimeric RNA DNA oligonucleotides
    • Kren B.T., Metz R., Kumar R., Steer C.J. Gene repair using chimeric RNA DNA oligonucleotides. Semin. Liver Dis. 19:(1):1999;93-104.
    • (1999) Semin. Liver Dis. , vol.19 , Issue.1 , pp. 93-104
    • Kren, B.T.1    Metz, R.2    Kumar, R.3    Steer, C.J.4
  • 66
  • 67
    • 0031041153 scopus 로고    scopus 로고
    • Scavenger receptor-mediated delivery of antisense mini-exon phosphorothioate oligonucleotide to Leishmania-infected macrophages - Selective and efficient elimination of the parasite
    • Chaudhuri G. Scavenger receptor-mediated delivery of antisense mini-exon phosphorothioate oligonucleotide to Leishmania-infected macrophages - Selective and efficient elimination of the parasite. Biochem. Pharmacol. 53:(3):1997;385-391.
    • (1997) Biochem. Pharmacol. , vol.53 , Issue.3 , pp. 385-391
    • Chaudhuri, G.1
  • 68
    • 0034141430 scopus 로고    scopus 로고
    • In vivo protein transduction: Intracellular delivery of biologically active proteins, compounds and DNA
    • Schwarze S.R., Dowdy S.F. In vivo protein transduction: intracellular delivery of biologically active proteins, compounds and DNA. Trends Pharmacol. Sci. 21:(2):2000;45-48.
    • (2000) Trends Pharmacol. Sci. , vol.21 , Issue.2 , pp. 45-48
    • Schwarze, S.R.1    Dowdy, S.F.2
  • 69
    • 0031423050 scopus 로고    scopus 로고
    • Cellular delivery of oligonucleotides by synthetic import peptide carrier
    • Dokka S., Toledo-Velasquez D., Shi X.L., Wang L.Y., Rojanasakul Y. Cellular delivery of oligonucleotides by synthetic import peptide carrier. Pharm. Res. 14:(12):1997;1759-1764.
    • (1997) Pharm. Res. , vol.14 , Issue.12 , pp. 1759-1764
    • Dokka, S.1    Toledo-Velasquez, D.2    Shi, X.L.3    Wang, L.Y.4    Rojanasakul, Y.5
  • 70
    • 0030804766 scopus 로고    scopus 로고
    • A new peptide vector for efficient delivery of oligonucleotides into mammalian cells
    • Morris M.C., Vidal P., Chaloin L., Heitz F., Divita G. A new peptide vector for efficient delivery of oligonucleotides into mammalian cells. Nucleic Acids Res. 25:(14):1997;2730-2736.
    • (1997) Nucleic Acids Res. , vol.25 , Issue.14 , pp. 2730-2736
    • Morris, M.C.1    Vidal, P.2    Chaloin, L.3    Heitz, F.4    Divita, G.5
  • 71
    • 0033520487 scopus 로고    scopus 로고
    • In vivo protein transduction: Delivery of a biologically active protein into the mouse
    • Schwarze S.R., Ho A., VoceroAkbani A., Dowdy S.F. In vivo protein transduction: Delivery of a biologically active protein into the mouse. Science. 285:(5433):1999;1569-1572.
    • (1999) Science , vol.285 , Issue.5433 , pp. 1569-1572
    • Schwarze, S.R.1    Ho, A.2    Voceroakbani, A.3    Dowdy, S.F.4
  • 74
    • 0028500927 scopus 로고
    • Complete Inactivation Of Target Messenger-RNA By Biotinylated Antisense Oligodeoxynucleotide-Avidin
    • Boado R.J., Pardridge W.M. Complete Inactivation Of Target Messenger-RNA By Biotinylated Antisense Oligodeoxynucleotide-Avidin. Conj. Bioconj. Chem. 5:(5):1994;406-410.
    • (1994) Conj. Bioconj. Chem. , vol.5 , Issue.5 , pp. 406-410
    • Boado, R.J.1    Pardridge, W.M.2
  • 75
    • 0028857672 scopus 로고
    • Rapid Plasma-Clearance and Metabolism In-Vivo Of a Phosphorothioate Oligodeoxynucleotide With a Single Internal Phosphodiester Bond
    • Boado R.J., Kang Y.S., Wu D.F., Pardridge W.M. Rapid Plasma-Clearance and Metabolism In-Vivo Of a Phosphorothioate Oligodeoxynucleotide With a Single Internal Phosphodiester Bond. Drug. Metab. Dispos. 23:(11):1995;1297-1300.
    • (1995) Drug. Metab. Dispos. , vol.23 , Issue.11 , pp. 1297-1300
    • Boado, R.J.1    Kang, Y.S.2    Wu, D.F.3    Pardridge, W.M.4
  • 76
    • 0032542782 scopus 로고    scopus 로고
    • Oligonucleotide delivery: Uptake of rat transferrin receptor antibody (OX-26) conjugates into an in vitro immortalised cell line model of the blood-brain barrier
    • N. Normand-Sdiqui, S. Akhtar, Oligonucleotide delivery: Uptake of rat transferrin receptor antibody (OX-26) conjugates into an in vitro immortalised cell line model of the blood-brain barrier, Int. J. Pharm. 163(1-2) (1998) 63-71.
    • (1998) Int. J. Pharm. , vol.163 , Issue.1-2 , pp. 63-71
    • Normand-Sdiqui, N.1    Akhtar, S.2
  • 77
    • 0029925704 scopus 로고    scopus 로고
    • Pharmacokinetics and blood-brain barrier transport of [H-3]-biotinylated phosphorothioate oligodeoxynucleotide conjugated to a vector-mediated drug delivery system
    • Wu D.F., Boado R.J., Pardridge W.M. Pharmacokinetics and blood-brain barrier transport of [H-3]-biotinylated phosphorothioate oligodeoxynucleotide conjugated to a vector-mediated drug delivery system. J. Pharm. Exp. Ther. 276:(1):1996;206-211.
    • (1996) J. Pharm. Exp. Ther. , vol.276 , Issue.1 , pp. 206-211
    • Wu, D.F.1    Boado, R.J.2    Pardridge, W.M.3
  • 78
    • 0032590232 scopus 로고    scopus 로고
    • CB1 receptor density and CB1 receptor-mediated functional effects in rat hippocampus are decreased by an intracerebroventricularly administered antisense oligodeoxynucleotide
    • Kathmann M., Bauer U., Schlicker E. CB1 receptor density and CB1 receptor-mediated functional effects in rat hippocampus are decreased by an intracerebroventricularly administered antisense oligodeoxynucleotide. Naunyn-Schmiedebergs Arch. Pharmacol. 360:(4):1999;421-427.
    • (1999) Naunyn-Schmiedebergs Arch. Pharmacol. , vol.360 , Issue.4 , pp. 421-427
    • Kathmann, M.1    Bauer, U.2    Schlicker, E.3
  • 79
    • 0032587338 scopus 로고    scopus 로고
    • Dopamine D-3 receptor antisense administration reduces basal c-fos and NGFI-B mRNA levels in the rat forebrain
    • Tremblay M., Rouillard C., Levesque D. Dopamine D-3 receptor antisense administration reduces basal c-fos and NGFI-B mRNA levels in the rat forebrain. Synapse. 32:(1):1999;51-57.
    • (1999) Synapse , vol.32 , Issue.1 , pp. 51-57
    • Tremblay, M.1    Rouillard, C.2    Levesque, D.3
  • 80
    • 0030757089 scopus 로고    scopus 로고
    • Critical issues in the antisense inhibition of brain gene expression in vivo: Experiences targeting the 5-HT1A receptor
    • LeCorre S.M., Burnet P.W.J., Meller R., Sharp T., Harrison P.J. Critical issues in the antisense inhibition of brain gene expression in vivo: Experiences targeting the 5-HT1A receptor. Neurochem. Int. 31:(3):1997;349-362.
    • (1997) Neurochem. Int. , vol.31 , Issue.3 , pp. 349-362
    • Lecorre, S.M.1    Burnet, P.W.J.2    Meller, R.3    Sharp, T.4    Harrison, P.J.5
  • 81
    • 0342583091 scopus 로고    scopus 로고
    • Site-specific administration of antisense oligonucleotides using biodegradable polymer microspheres provides sustained delivery and improved subcellular biodistribution in the neostriatum of the rat brain
    • in press
    • A. Khan, W. Sommer, K. Fuxe, S. Akhtar, Site-specific administration of antisense oligonucleotides using biodegradable polymer microspheres provides sustained delivery and improved subcellular biodistribution in the neostriatum of the rat brain, J. Drug Target., in press.
    • J. Drug Target.
    • Khan, A.1    Sommer, W.2    Fuxe, K.3    Akhtar, S.4
  • 83
    • 0031689425 scopus 로고    scopus 로고
    • Development of a sustained-release biodegradable polymer delivery system for site-specific delivery of oligonucleotides: Characterization of P(LA-GA) copolymer microspheres in vitro
    • Lewis K.J., Irwin W.J., Akhtar S. Development of a sustained-release biodegradable polymer delivery system for site-specific delivery of oligonucleotides: Characterization of P(LA-GA) copolymer microspheres in vitro. J. Drug Targeting. 5:(4):1998;291-302.
    • (1998) J. Drug Targeting , vol.5 , Issue.4 , pp. 291-302
    • Lewis, K.J.1    Irwin, W.J.2    Akhtar, S.3
  • 85
    • 0030867627 scopus 로고    scopus 로고
    • Microparticles of poly(DL-lactic-co-glycolic acid)/poly(ethylene glycol) blends for controlled drug delivery
    • Cleek R.L., Ting K.C., Eskin S.G., Mikos A.G. Microparticles of poly(DL-lactic-co-glycolic acid)/poly(ethylene glycol) blends for controlled drug delivery. J. Control. Rel. 48:(2-3):1997;259-268.
    • (1997) J. Control. Rel. , vol.48 , Issue.23 , pp. 259-268
    • Cleek, R.L.1    Ting, K.C.2    Eskin, S.G.3    Mikos, A.G.4
  • 86
    • 0029938916 scopus 로고    scopus 로고
    • Biodegradable polymer matrices for the sustained exogenous delivery of a biologically active c-myc hammerhead ribozyme
    • Hudson A.J., Lewis K.J., Rao M.V., Akhtar S. Biodegradable polymer matrices for the sustained exogenous delivery of a biologically active c-myc hammerhead ribozyme. Int. J. Pharm. 136:(1-2):1996;23-29.
    • (1996) Int. J. Pharm. , vol.136 , Issue.12 , pp. 23-29
    • Hudson, A.J.1    Lewis, K.J.2    Rao, M.V.3    Akhtar, S.4
  • 87
    • 0028811665 scopus 로고
    • Biodegradable Poly(L-Lactic Acid) Matrices For the Sustained Delivery Of Antisense Oligonucleotides
    • Lewis K.J., Irwin W.J., Akhtar S. Biodegradable Poly(L-Lactic Acid) Matrices For the Sustained Delivery Of Antisense Oligonucleotides. J. Control. Rel. 37:(1-2):1995;173-183.
    • (1995) J. Control. Rel. , vol.37 , Issue.12 , pp. 173-183
    • Lewis, K.J.1    Irwin, W.J.2    Akhtar, S.3
  • 88
    • 0030919006 scopus 로고    scopus 로고
    • Antisense oligonucleotide delivery to cultured macrophages is improved by incorporation into sustained-release biodegradable polymer microspheres
    • Akhtar S., Lewis K.J. Antisense oligonucleotide delivery to cultured macrophages is improved by incorporation into sustained-release biodegradable polymer microspheres. Int. J. Pharm. 151:(1):1997;57-67.
    • (1997) Int. J. Pharm. , vol.151 , Issue.1 , pp. 57-67
    • Akhtar, S.1    Lewis, K.J.2
  • 89
    • 0026536219 scopus 로고
    • Polyalkylcyanoacrylate Nanoparticles As Polymeric Carriers For Antisense Oligonucleotides
    • Chavany C., Ledoan T., Couvreur P., Puisieux F., Helene C. Polyalkylcyanoacrylate Nanoparticles As Polymeric Carriers For Antisense Oligonucleotides. Pharm. Res. 9:(4):1992;441-449.
    • (1992) Pharm. Res. , vol.9 , Issue.4 , pp. 441-449
    • Chavany, C.1    Ledoan, T.2    Couvreur, P.3    Puisieux, F.4    Helene, C.5
  • 90
    • 0027935614 scopus 로고
    • Adsorption Of Oligonucleotides Onto Polyisohexylcyanoacrylate Nanoparticles Protects Them Against Nucleases and Increases Their Cellular Uptake
    • Chavany C., Saisonbehmoaras T., Ledoan T., Puisieux F., Couvreur P., Helene C. Adsorption Of Oligonucleotides Onto Polyisohexylcyanoacrylate Nanoparticles Protects Them Against Nucleases and Increases Their Cellular Uptake. Pharm. Res. 11:(9):1994;1370-1378.
    • (1994) Pharm. Res. , vol.11 , Issue.9 , pp. 1370-1378
    • Chavany, C.1    Saisonbehmoaras, T.2    Ledoan, T.3    Puisieux, F.4    Couvreur, P.5    Helene, C.6
  • 91
  • 92
    • 0028037219 scopus 로고
    • Antisense Oligonucleotides Adsorbed to Polyalkylcyanoacrylate Nanoparticles Specifically Inhibit Mutated Ha-Ras-Mediated Cell-Proliferation and Tumorigenicity In Nude-Mice
    • Schwab G., Chavany C., Duroux I., Goubin G., Lebeau J., Helene C., Saisonbehmoaras T. Antisense Oligonucleotides Adsorbed to Polyalkylcyanoacrylate Nanoparticles Specifically Inhibit Mutated Ha-Ras-Mediated Cell-Proliferation and Tumorigenicity In Nude-Mice. Proc. Natl. Acad. Sci. USA. 91:(22):1994;10460-10464.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , Issue.22 , pp. 10460-10464
    • Schwab, G.1    Chavany, C.2    Duroux, I.3    Goubin, G.4    Lebeau, J.5    Helene, C.6    Saisonbehmoaras, T.7
  • 93
    • 0027220386 scopus 로고
    • Penetration Of Oligonucleotides Into Mouse Organism Through Mucosa and Skin
    • Vlassov V.V., Karamyshev V.N., Yakubov L.A. Penetration Of Oligonucleotides Into Mouse Organism Through Mucosa and Skin. FEBS Lett. 327:(3):1993;271-274.
    • (1993) FEBS Lett. , vol.327 , Issue.3 , pp. 271-274
    • Vlassov, V.V.1    Karamyshev, V.N.2    Yakubov, L.A.3
  • 95
    • 0033598705 scopus 로고    scopus 로고
    • Antitumor activity and pharmacokinetics of a mixed-backbone antisense oligonucleotide targeted to the RI alpha subunit of protein kinase A after oral administration
    • Wang H., Cai Q.Y., Zeng X.F., Yu D., Agrawal S., Zhang R.W. Antitumor activity and pharmacokinetics of a mixed-backbone antisense oligonucleotide targeted to the RI alpha subunit of protein kinase A after oral administration. Proc. Natl. Acad. Sci. USA. 96:(24):1999;13989-13994.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , Issue.24 , pp. 13989-13994
    • Wang, H.1    Cai, Q.Y.2    Zeng, X.F.3    Yu, D.4    Agrawal, S.5    Zhang, R.W.6
  • 96
    • 0031950147 scopus 로고    scopus 로고
    • Pulmonary bioavailability of a phosphorothioate oligonucleotide (CGP 64128A): Comparison with other delivery routes
    • Nicklin P.L., Bayley D., Giddings J., Craig S.J., Cummins L.L., Hastewell J.G., Phillips J.A. Pulmonary bioavailability of a phosphorothioate oligonucleotide (CGP 64128A): Comparison with other delivery routes. Pharm. Res. 15:(4):1998;583-591.
    • (1998) Pharm. Res. , vol.15 , Issue.4 , pp. 583-591
    • Nicklin, P.L.1    Bayley, D.2    Giddings, J.3    Craig, S.J.4    Cummins, L.L.5    Hastewell, J.G.6    Phillips, J.A.7
  • 97
    • 0029077765 scopus 로고
    • Radiolabeling Of Methylphosphonate and Phosphorothioate Oligonucleotides and Evaluation Of Their Transport In Everted Rat Jejunum Sacs
    • Hughes J.A., Avrutskaya A.V., Brouwer K.L.R., Wickstrom E., Juliano R.L. Radiolabeling Of Methylphosphonate and Phosphorothioate Oligonucleotides and Evaluation Of Their Transport In Everted Rat Jejunum Sacs. Pharm. Res. 12:(6):1995;817-824.
    • (1995) Pharm. Res. , vol.12 , Issue.6 , pp. 817-824
    • Hughes, J.A.1    Avrutskaya, A.V.2    Brouwer, K.L.R.3    Wickstrom, E.4    Juliano, R.L.5
  • 98
    • 0029781792 scopus 로고    scopus 로고
    • Interactions of phosphodiester and phosphorothioate oligonucleotides with intestinal epithelial Caco-2 cells
    • Beck G.F., Irwin W.J., Nicklin P.L., Akhtar S. Interactions of phosphodiester and phosphorothioate oligonucleotides with intestinal epithelial Caco-2 cells. Pharm. Res. 13:(7):1996;1028-1037.
    • (1996) Pharm. Res. , vol.13 , Issue.7 , pp. 1028-1037
    • Beck, G.F.1    Irwin, W.J.2    Nicklin, P.L.3    Akhtar, S.4
  • 99
    • 0029806868 scopus 로고    scopus 로고
    • The influence of polarized epithelial (Caco-2) cell differentiation on the cellular binding of phosphodiester and phosphorothioate oligonucleotides
    • Akhtar S., Beck G.F., Hawley P., Irwin W.J., Gibson I. The influence of polarized epithelial (Caco-2) cell differentiation on the cellular binding of phosphodiester and phosphorothioate oligonucleotides. Antisense Nucl. Acid Drug Dev. 6:(3):1996;197-206.
    • (1996) Antisense Nucl. Acid Drug Dev. , vol.6 , Issue.3 , pp. 197-206
    • Akhtar, S.1    Beck, G.F.2    Hawley, P.3    Irwin, W.J.4    Gibson, I.5
  • 100
    • 0030802140 scopus 로고    scopus 로고
    • Interaction of oligonucleotide-conjugates with the dipeptide transporter system in caco-2 cells
    • Moore V.A., Dunnion D.J., Brown T., Irwin W.J., Akhtar S. Interaction of oligonucleotide-conjugates with the dipeptide transporter system in caco-2 cells. Biochem. Pharmacol. 53:(9):1997;1223-1228.
    • (1997) Biochem. Pharmacol. , vol.53 , Issue.9 , pp. 1223-1228
    • Moore, V.A.1    Dunnion, D.J.2    Brown, T.3    Irwin, W.J.4    Akhtar, S.5
  • 102
    • 0028846708 scopus 로고
    • A synthetic, chemically modified ribozyme eliminates amelogenin, the major translation product in developing mouse enamel in vivo
    • Lyngstadaas S.P., Risnes S., Sproat B.S., Thrane P.S., Prydz H.P. A synthetic, chemically modified ribozyme eliminates amelogenin, the major translation product in developing mouse enamel in vivo. EMBO J. 14:1995;5224-5229.
    • (1995) EMBO J. , vol.14 , pp. 5224-5229
    • Lyngstadaas, S.P.1    Risnes, S.2    Sproat, B.S.3    Thrane, P.S.4    Prydz, H.P.5
  • 103
    • 0029977448 scopus 로고    scopus 로고
    • Antitumor-activity of a phosphorothioate antisense oligodeoxynucleotide targeted against c-raf kinase
    • Monia B.P., Johnston J.F., Geiger T., Muller M., Fabbro D. Antitumor-activity of a phosphorothioate antisense oligodeoxynucleotide targeted against c-raf kinase. Nature Med. 2:1996;668-675.
    • (1996) Nature Med. , vol.2 , pp. 668-675
    • Monia, B.P.1    Johnston, J.F.2    Geiger, T.3    Muller, M.4    Fabbro, D.5
  • 104
    • 0029833019 scopus 로고    scopus 로고
    • Treatment Of Glioblastoma U-87 By Systemic Administration Of An Antisense Protein-Kinase C-Alpha Phosphorothioate Oligodeoxynucleotide
    • Yazaki T., Ahmad S., Chahlavi A., Zylberkatz E., Dean N.M., Rabkin S.D., Martuza R.L., Glazer R.I. Treatment Of Glioblastoma U-87 By Systemic Administration Of An Antisense Protein-Kinase C-Alpha Phosphorothioate Oligodeoxynucleotide. Mol. Pharmacol. 50:1996;236-242.
    • (1996) Mol. Pharmacol. , vol.50 , pp. 236-242
    • Yazaki, T.1    Ahmad, S.2    Chahlavi, A.3    Zylberkatz, E.4    Dean, N.M.5    Rabkin, S.D.6    Martuza, R.L.7    Glazer, R.I.8
  • 105
    • 0030239828 scopus 로고    scopus 로고
    • Induction Of Nk Activity In Murine And Human-Cells By CPG Motifs In Oligodeoxynucleotides And Bacterial-DNA
    • Ballas Z.K., Rasmussen W.L., Krieg A.M. Induction Of Nk Activity In Murine And Human-Cells By CPG Motifs In Oligodeoxynucleotides And Bacterial-DNA. J. Immunol. 157:1996;1840-1845.
    • (1996) J. Immunol. , vol.157 , pp. 1840-1845
    • Ballas, Z.K.1    Rasmussen, W.L.2    Krieg, A.M.3


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