A new approach to the inhibition of gene expression

Trends in Biotechnology

Volumn 20, Issue 2, 2002, Pages 49-51

  Caplen, Natasha J ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; PHYSIOLOGICAL MODELS; RNA;

DOWN-REGULATION;

GENES;

RNA;

GENE;

DOWN REGULATION; GENE EXPRESSION; GENE FUNCTION; GENE SILENCING; HUMAN; MAMMAL CELL; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; RESEARCH; SHORT SURVEY;

MAMMALIA;

EID: 0036467758     PISSN: 01677799     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-7799(01)01900-X     Document Type: Review

References (24)

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3. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
4. A species of small antisense RNA in posttranscriptional gene silencing in plants
5. RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals
6. Role for a bidentate ribonuclease in the initiation step of RNA interference
7. A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in C. elegans
8. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing
9. A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA
10. Argonaute2, a link between genetic and biochemical analyses of RNAi
11. Domains in gene silencing and cell differentiation proteins: The novel PAZ domain and redefinition of the Piwi domain
12. Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase
13. EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans
14. DNA methylation and chromatin structure affect transcriptional and post-transcriptional transgene silencing in Arabidopsis
15. dsRNA-mediated gene silencing in cultured Drosophila cells: A tissue culture model for the analysis of RNA interference
16. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
17. Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems
18. Functional genomic analysis of C. elegans chromosome I by systematic RNA interference
19. Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III
20. Heritable gene silencing in Drosophila using double-stranded RNA
21. Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase
22. Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding
23. Double-stranded RNA induces mRNA degradation in Trypanosoma brucei
24. Rescue of polyglutamine mediated cytotoxicity by double-stranded RNA-mediated RNA interference