Gene silencing nucleic acids designed by scanning arrays: Anti-EGFR activity of siRNA, ribozyme and DNA enzymes targeting a single hybridization-accessible region using the same delivery system

Journal of Drug Targeting

Volumn 11, Issue 7, 2003, Pages 449-456

  Beale, Gary ^a,e   Hollins, Andrew J ^a   Benboubetra, Mustapha ^a   Sohail, Muhammad ^c   Fox, Stephen P ^a   Benter, Ibrahim ^d   Akhtar, Saghir ^a,b  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b FERHAT ABBAS UNIVERSITY   (Algeria)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d KUWAIT UNIVERSITY   (Kuwait)

^e UNIVERSITY OF YORK   (United Kingdom)

Author keywords

Antisense; DNA enzyme; Ribozyme; siRNA

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; DNA ENZYME; ENZYME; EPIDERMAL GROWTH FACTOR RECEPTOR; LIPOFECTIN; MESSENGER RNA; RIBOZYME; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; CELL GROWTH; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA MICROARRAY; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG TARGETING; DRUG UPTAKE; ENZYME MECHANISM; FLUORESCENCE ANALYSIS; GENE SILENCING; HUMAN; HUMAN CELL; IC 50; NONVIRAL GENE DELIVERY SYSTEM; NUCLEIC ACID HYBRIDIZATION; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

BLOTTING, WESTERN; CELL LINE, TUMOR; DNA; DNA, CATALYTIC; DRUG DELIVERY SYSTEMS; FLOW CYTOMETRY; GENE SILENCING; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; ISOTOPE LABELING; LIPOSOMES; NUCLEIC ACID HYBRIDIZATION; NUCLEIC ACIDS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OLIGONUCLEOTIDES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA, CATALYTIC; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 1842588051     PISSN: 1061186X     EISSN: None     Source Type: Journal    
DOI: 10.1080/1061186042000207039     Document Type: Article

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