Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells

Nature

Volumn 441, Issue 7095, 2006, Pages 890-893

  Williams, Matthew A ^a   Tyznik, Aaron J ^a   Bevan, Michael J ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; CELLS; IMMUNOLOGY; VACCINES;

INFECTIONS; INTERLEUKIN-2 SIGNALS; MEMORY T CELLS;

CELL CULTURE;

INTERLEUKIN 2;

CHIMERA; GROWTH RESPONSE; IMMUNE RESPONSE; MEMORY; PROTEIN; RODENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CD8+ T LYMPHOCYTE; CELL COUNT; CELL FUNCTION; CHIMERA; IMMUNOTHERAPY; IN VITRO STUDY; MEMORY CELL; MOUSE; NONHUMAN; PRIMARY INFECTION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VACCINATION;

EID: 33745224089     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature04790     Document Type: Article

References (30)

1. Smith, K. A. Interleukin-2: inception, impact, and implications. Science 240, 1169-1176 (1988).
2. Sadlack, B. et al. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75, 253-261 (1993).
3. Schorle, H., Holtschke, T., Hunig, T., Schimpl, A. & Horak, I. Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature 352, 621-624 (1991).
4. Suzuki, H. et al. Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor β. Science 268, 1472-1476 (1995).
5. Willerford, D. M. et al. Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment. Immunity 3, 521-530 (1995).
6. + regulatory T cells in the absence of interleukin 2 signaling. Nature Immunol. 6, 1152-1159 (2005).
7. Fontenot, J. D., Rasmussen, J. P., Gavin, M. A. & Rudensky, A. Y. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nature Immunol. 6, 1142-1151 (2005).
8. Malek, T. R. & Bayer, A. L. Tolerance, not immunity, crucially depends on IL-2. Nature Rev. Immunol. 4, 665-674 (2004).
9. Setoguchi, R., Hori, S., Takahashi, T. & Sakaguchi, S. Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J. Exp. Med. 201, 723-735 (2005).
10. Jameson, S. C. T cell homeostasis: keeping useful T cells alive and live T cells useful. Semin. Immunol. 17, 231-237 (2005).
11. Kaech, S. M. et al. Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nature Immunol. 4, 1191-1198 (2003).
12. Kaech, S. M., Wherry, E. J. & Ahmed, R. Effector and memory T-cell differentiation: implications for vaccine development. Nature Rev. Immunol. 2, 251-262 (2002).
13. Surh, C. D. & Sprent, J. Regulation of mature T cell homeostasis. Semin. Immunol. 17, 183-191 (2005).
14. + T cell memory. Science 297, 2060-2063 (2002).
15. + T lymphocytes. Nature 421, 852-856 (2003).
16. Shedlock, D. J. & Shen, H. Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science 300, 337-339 (2003).
17. Sun, J. C. & Bevan, M. J. Defective CD8 T cell memory following acute infection without CD4 T cell help. Science 300, 339-342 (2003).
18. + T cells after acute infection. Nature Immunol. 5, 927-933 (2004).
19. Cousens, L. P., Orange, J. S. & Biron, C. A. Endogenous IL-2 contributes to T cell expansion and IFN-γ production during lymphocytic choriomeningitis virus infection. J. Immunol. 155, 5690-5699 (1995).
20. Kundig, T. M. et al. Immune responses in interleukin-2-deficient mice. Science 262, 1059-1061 (1993).
21. D'Souza, W. N. & Lefrancois, L. IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion. J. Immunol. 171, 5727-5735 (2003).
22. D'Souza, W. N., Schluns, K. S., Masopust, D. & Lefrancois, L. Essential role for IL-2 in the regulation of antiviral extralymphoid CD8 T cell responses. J. Immunol. 168, 5566-5572 (2002).
23. Yu, A. et al. Efficient induction of primary and secondary T cell-dependent immune responses in vivo in the absence of functional IL-2 and IL-15 receptors. J. Immunol. 170, 236-242 (2003).
24. Wherry, E. J. et al. Lineage relationship and protective immunity of memory CD8 T cell subsets. Nature Immunol. 4, 225-234 (2003).
25. Manjunath, N. et al. Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes. J. Clin. Invest. 108, 871-878 (2001).
26. + T cell lineage commitment. Nature Immunol. 6, 793-799 (2005).
27. Boyman, O., Kovar, M., Rubinstein, M., Surh, C. D. & Sprent, J. Selective stimulation of T cell subsets with antibody-cytokine immune complexes. Science 311, 1924-1927 (2006).
28. Granucci, F. et al. Inducible IL-2 production by dendritic cells revealed by global gene expression analysis. Nature Immunol. 2, 882-888 (2001).
29. Ahmed, R., Salmi, A., Butler, L. D., Chiller, J. M. & Oldstone, M. B. Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence. J. Exp. Med. 160, 521-540 (1984).
30. Murali-Krishna, K. et al. Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity 8, 177-187 (1998).