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Volumn 171, Issue 11, 2003, Pages 5727-5735

IL-2 Is Not Required for the Initiation of CD8 T Cell Cycling but Sustains Expansion

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2; T LYMPHOCYTE ANTIGEN;

EID: 0345447666     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.11.5727     Document Type: Article
Times cited : (202)

References (63)
  • 1
    • 0017402665 scopus 로고
    • Long term culture of tumour-specific cytotoxic T cells
    • Gillis, S., and K. A. Smith. 1977. Long term culture of tumour-specific cytotoxic T cells. Nature 268:154.
    • (1977) Nature , vol.268 , pp. 154
    • Gillis, S.1    Smith, K.A.2
  • 2
    • 0023907493 scopus 로고
    • Interleukin-2: Inception, impact, and implications
    • Smith, K. A. 1988. Interleukin-2: inception, impact, and implications. Science 240:1169.
    • (1988) Science , vol.240 , pp. 1169
    • Smith, K.A.1
  • 3
    • 0022536230 scopus 로고
    • The structure, function, and expression of interleukin-2 receptors on normal and malignant lymphocytes
    • Waldmann, T. A. 1986. The structure, function, and expression of interleukin-2 receptors on normal and malignant lymphocytes. Science 232:727.
    • (1986) Science , vol.232 , pp. 727
    • Waldmann, T.A.1
  • 4
    • 0026061865 scopus 로고
    • Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28
    • Fraser, J. D., B. A. Irving, G. R. Crabtree, and A. Weiss. 1991. Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28. Science 251:313.
    • (1991) Science , vol.251 , pp. 313
    • Fraser, J.D.1    Irving, B.A.2    Crabtree, G.R.3    Weiss, A.4
  • 5
    • 0025963594 scopus 로고
    • Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation
    • Linsley, P. S., W. Brady, L. Grosmaire, A. Aruffo, N. K. Damle, and J. A. Ledbetter. 1991. Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation. J. Exp. Med. 173:721.
    • (1991) J. Exp. Med. , vol.173 , pp. 721
    • Linsley, P.S.1    Brady, W.2    Grosmaire, L.3    Aruffo, A.4    Damle, N.K.5    Ledbetter, J.A.6
  • 6
    • 0025947895 scopus 로고
    • CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells
    • Jenkins, M. K., P. S. Taylor, S. D. Norton, and K. B. Urdahl. 1991. CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells. J. Immunol. 147:2461.
    • (1991) J. Immunol. , vol.147 , pp. 2461
    • Jenkins, M.K.1    Taylor, P.S.2    Norton, S.D.3    Urdahl, K.B.4
  • 7
    • 0027175221 scopus 로고
    • CD28-B7 interactions allow the induction of CD8+ cytotoxic T lymphocytes in the absence of exogenous help
    • Harding, F. A., and J. P. Allison. 1993. CD28-B7 interactions allow the induction of CD8+ cytotoxic T lymphocytes in the absence of exogenous help. J. Exp. Med. 177:1791.
    • (1993) J. Exp. Med. , vol.177 , pp. 1791
    • Harding, F.A.1    Allison, J.P.2
  • 8
    • 0030056468 scopus 로고    scopus 로고
    • Models of T cell anergy: Is there a common molecular mechanism?
    • Schwartz, R. H. 1996. Models of T cell anergy: is there a common molecular mechanism? J. Exp. Med. 184:1.
    • (1996) J. Exp. Med. , vol.184 , pp. 1
    • Schwartz, R.H.1
  • 9
    • 0031725323 scopus 로고    scopus 로고
    • Molecular regulation of interleukin-2 expression by CD28 co-stimulation and anergy
    • Powell, J. D., J. A. Ragheb, S. Kitagawa-Sakakida, and R. H. Schwartz. 1998. Molecular regulation of interleukin-2 expression by CD28 co-stimulation and anergy. Immunol. Rev. 165:287.
    • (1998) Immunol. Rev. , vol.165 , pp. 287
    • Powell, J.D.1    Ragheb, J.A.2    Kitagawa-Sakakida, S.3    Schwartz, R.H.4
  • 10
    • 0020077493 scopus 로고
    • Helper activity is required for the in vivo generation of cytotoxic T lymphocytes
    • Keene, J. A., and J. Forman. 1982. Helper activity is required for the in vivo generation of cytotoxic T lymphocytes. J. Exp. Med. 155:768.
    • (1982) J. Exp. Med. , vol.155 , pp. 768
    • Keene, J.A.1    Forman, J.2
  • 12
    • 0031821875 scopus 로고    scopus 로고
    • + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
    • + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188:287.
    • (1998) J. Exp. Med. , vol.188 , pp. 287
    • Thornton, A.M.1    Shevach, E.M.2
  • 13
    • 0025899598 scopus 로고
    • Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting
    • Schorle, H., T. Holtschke, T. Hunig, A. Schimpl, and I. Horak. 1991. Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature 352:621.
    • (1991) Nature , vol.352 , pp. 621
    • Schorle, H.1    Holtschke, T.2    Hunig, T.3    Schimpl, A.4    Horak, I.5
  • 14
    • 0027369395 scopus 로고
    • Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
    • Sadlack, B., H. Merz, H. Schorle, A. Schimpl, A. C. Feller, and I. Horak. 1993. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75:253.
    • (1993) Cell , vol.75 , pp. 253
    • Sadlack, B.1    Merz, H.2    Schorle, H.3    Schimpl, A.4    Feller, A.C.5    Horak, I.6
  • 15
    • 0028784289 scopus 로고
    • Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment
    • Willerford, D. M., J. Chen, J. A. Ferry, L. Davidson, A. Ma, and F. W. Alt. 1995. Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment. Immunity 3:521.
    • (1995) Immunity , vol.3 , pp. 521
    • Willerford, D.M.1    Chen, J.2    Ferry, J.A.3    Davidson, L.4    Ma, A.5    Alt, F.W.6
  • 17
    • 0025908321 scopus 로고
    • Peripheral selection of the T cell repertoire
    • Rocha, B., and H. von Boehmer. 1991. Peripheral selection of the T cell repertoire. Science 251:1225.
    • (1991) Science , vol.251 , pp. 1225
    • Rocha, B.1    Von Boehmer, H.2
  • 18
    • 0025602793 scopus 로고
    • Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity
    • Webb, S., C. Morris, and J. Sprent. 1990, Extrathymic tolerance of mature T cells: clonal elimination as a consequence of immunity. Cell 63:1249.
    • (1990) Cell , vol.63 , pp. 1249
    • Webb, S.1    Morris, C.2    Sprent, J.3
  • 21
    • 0028142358 scopus 로고
    • Thymic selection and peptide-induced activation of T cell receptor-transgenic CD8 T cells in interleukin-2-deficient mice
    • Kramer, S., C. Mamalaki, I. Horak, A. Schimpl, D. Kioussis, and T. Hunig. 1994. Thymic selection and peptide-induced activation of T cell receptor-transgenic CD8 T cells in interleukin-2-deficient mice. Eur. J. Immunol. 24:2317.
    • (1994) Eur. J. Immunol. , vol.24 , pp. 2317
    • Kramer, S.1    Mamalaki, C.2    Horak, I.3    Schimpl, A.4    Kioussis, D.5    Hunig, T.6
  • 22
    • 0029118133 scopus 로고
    • Normal clonal expansion but impaired Fas-mediated cell death and anergy induction in interleukin-2-deficient mice
    • Kneitz, B., T. Herrmann, S. Yonehara, and A. Schimpl. 1995. Normal clonal expansion but impaired Fas-mediated cell death and anergy induction in interleukin-2-deficient mice. Eur. J. Immunol. 25:2572.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 2572
    • Kneitz, B.1    Herrmann, T.2    Yonehara, S.3    Schimpl, A.4
  • 23
    • 0028843720 scopus 로고
    • Endogenous IL-2 contributes to T cell expansion and IFN-γ production during lymphocytic choriomeningitis virus production
    • Cousens, L. P., J. S. Orange, and C. A. Biron. 1995. Endogenous IL-2 contributes to T cell expansion and IFN-γ production during lymphocytic choriomeningitis virus production. J. Immunol. 155:5690.
    • (1995) J. Immunol. , vol.155 , pp. 5690
    • Cousens, L.P.1    Orange, J.S.2    Biron, C.A.3
  • 24
    • 0028568313 scopus 로고
    • T lymphocyte-mediated antiviral immune responses in mice are diminished by treatment with monoclonal antibody directed against the interleukin-2 receptor
    • Utermohlen, O., A. Tarnok, L, Bonig, and F. Lehmann-Grube. 1994. T lymphocyte-mediated antiviral immune responses in mice are diminished by treatment with monoclonal antibody directed against the interleukin-2 receptor. Eur. J. Immunol. 24:3093.
    • (1994) Eur. J. Immunol. , vol.24 , pp. 3093
    • Utermohlen, O.1    Tarnok, A.2    Bonig, L.3    Lehmann-Grube, F.4
  • 25
    • 0036604208 scopus 로고    scopus 로고
    • Essential role for IL-2 in the regulation of antiviral extralymphoid CD8 T cell responses
    • D'Souza, W. N., K. S. Schluns, D. Masopust, and L. Lefrançois. 2002. Essential role for IL-2 in the regulation of antiviral extralymphoid CD8 T cell responses. J. Immunool. 168:5566.
    • (2002) J. Immunool. , vol.168 , pp. 5566
    • D'Souza, W.N.1    Schluns, K.S.2    Masopust, D.3    Lefrançois, L.4
  • 27
    • 0033711689 scopus 로고    scopus 로고
    • Expression of intestine-specific antigen reveals novel pathways of CD8 T cell tolerance induction
    • Vezys, V., S. Olson, and L. Lefrançois. 2000. Expression of intestine-specific antigen reveals novel pathways of CD8 T cell tolerance induction. Immunity 12:505.
    • (2000) Immunity , vol.12 , pp. 505
    • Vezys, V.1    Olson, S.2    Lefrançois, L.3
  • 29
    • 0031065209 scopus 로고    scopus 로고
    • Age-dependent intestinal lymphoproliferative disorder due to stem cell factor receptor deficiency: Parameters in small and large intestine
    • Laky, K., L. Lefrançois, and L. Puddington. 1997. Age-dependent intestinal lymphoproliferative disorder due to stem cell factor receptor deficiency: parameters in small and large intestine. J. Immunol. 158:1417.
    • (1997) J. Immunol. , vol.158 , pp. 1417
    • Laky, K.1    Lefrançois, L.2    Puddington, L.3
  • 30
    • 0035937587 scopus 로고    scopus 로고
    • Preferential localization of effector memory cells in nonlymphoid tissue
    • Masopust, D., V. Vezys, A. L. Marzo, and L. Lefrançois. 2001. Preferential localization of effector memory cells in nonlymphoid tissue. Science 291:2413.
    • (2001) Science , vol.291 , pp. 2413
    • Masopust, D.1    Vezys, V.2    Marzo, A.L.3    Lefrançois, L.4
  • 31
    • 0019218668 scopus 로고
    • IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt-2 antigen block T cell-mediated cytolysis in the absence of complement
    • Sarmiento, M., A. L. Glasebrook, and F. W. Fitch. 1980. IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt-2 antigen block T cell-mediated cytolysis in the absence of complement. J. Immunol. 125:2665.
    • (1980) J. Immunol. , vol.125 , pp. 2665
    • Sarmiento, M.1    Glasebrook, A.L.2    Fitch, F.W.3
  • 32
    • 0002382284 scopus 로고
    • Monoclonal antibodies to mouse lymphocyte differentiation alloantigens
    • G. J. Hammerling, U. Hammerling, and J. F. Kearney, eds. Elsevier/North-Holland, Amsterdam
    • Shen, F. W. 1981. Monoclonal antibodies to mouse lymphocyte differentiation alloantigens. In Monoclonal Antibodies and T-Cell Hybridomas: Perspectives and Technical Advances. G. J. Hammerling, U. Hammerling, and J. F. Kearney, eds. Elsevier/North-Holland, Amsterdam, pp. 25-31.
    • (1981) Monoclonal Antibodies and T-Cell Hybridomas: Perspectives and Technical Advances , pp. 25-31
    • Shen, F.W.1
  • 33
    • 0032167855 scopus 로고    scopus 로고
    • Generation of mucosal cytotoxic T cells against soluble protein by tissue-specific environmental and costimulatory signals
    • Kim, S. K., D. S. Reed, S. Olson, M. J. Schnell, J. K. Rose, P. A. Morton, and L. Lefrançois. 1998. Generation of mucosal cytotoxic T cells against soluble protein by tissue-specific environmental and costimulatory signals. Proc. Natl. Acad. Sci. USA 95:10814.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 10814
    • Kim, S.K.1    Reed, D.S.2    Olson, S.3    Schnell, M.J.4    Rose, J.K.5    Morton, P.A.6    Lefrançois, L.7
  • 34
    • 0023821578 scopus 로고
    • Introduction of soluble protein into the class I pathway of antigen processing and presentation
    • Moore, M. W., F. R. Carbone, and M. J. Bevan. 1988. Introduction of soluble protein into the class I pathway of antigen processing and presentation. Cell 54:777.
    • (1988) Cell , vol.54 , pp. 777
    • Moore, M.W.1    Carbone, F.R.2    Bevan, M.J.3
  • 36
    • 0028863215 scopus 로고
    • Differences in the interleukin-2 (IL-2) receptor system in human and mouse: A chain is required for formation of the functional mouse IL-2 receptor
    • Nemoto, T., T. Takeshita, N. Ishii, M. Kondo, M. Higuchi, S. Satomi, M. Nakamura, S. Mori, and K. Sugamura. 1995. Differences in the interleukin-2 (IL-2) receptor system in human and mouse: a chain is required for formation of the functional mouse IL-2 receptor. Eur. J. Immunol. 25:3001.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 3001
    • Nemoto, T.1    Takeshita, T.2    Ishii, N.3    Kondo, M.4    Higuchi, M.5    Satomi, S.6    Nakamura, M.7    Mori, S.8    Sugamura, K.9
  • 37
    • 0030033393 scopus 로고    scopus 로고
    • Lack of intermediate-affinity interleukin-2 receptor in mice leads to dependence on interleukin-2 receptor α, β and γ chain expression for T cell growth
    • Chastagner, P., J. L, Moreau, Y. Jacques, T. Tanaka, M. Miyasaka, M. Kondo, K. Sugamura, and J. Theze. 1996. Lack of intermediate-affinity interleukin-2 receptor in mice leads to dependence on interleukin-2 receptor α, β and γ chain expression for T cell growth. Eur. J. Immunol. 26:201.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 201
    • Chastagner, P.1    Moreau, J.L.2    Jacques, Y.3    Tanaka, T.4    Miyasaka, M.5    Kondo, M.6    Sugamura, K.7    Theze, J.8
  • 38
  • 40
    • 0037340215 scopus 로고    scopus 로고
    • Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process
    • Bruniquel, D., and R. H. Schwartz. 2003. Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process. Nat. Immunol. 4:235.
    • (2003) Nat. Immunol. , vol.4 , pp. 235
    • Bruniquel, D.1    Schwartz, R.H.2
  • 41
    • 0031965469 scopus 로고    scopus 로고
    • A natural immunological adjuvant enhances T cell clonal expansion through a CD28-dependent, interleukin (IL)-2-independent mechanism
    • Khoruts, A., A. Mondino, K. A. Pape, S. L. Reiner, and M. K. Jenkins. 1998. A natural immunological adjuvant enhances T cell clonal expansion through a CD28-dependent, interleukin (IL)-2-independent mechanism. J. Exp. Med. 187: 225.
    • (1998) J. Exp. Med. , vol.187 , pp. 225
    • Khoruts, A.1    Mondino, A.2    Pape, K.A.3    Reiner, S.L.4    Jenkins, M.K.5
  • 42
    • 0034177560 scopus 로고    scopus 로고
    • Regulation of lymphoid homeostasis by IL-2 receptor signals in vivo
    • Leung, D. T., S. Morefield, and D. M. Willerford. 2000. Regulation of lymphoid homeostasis by IL-2 receptor signals in vivo. J. Immunol. 164:3527.
    • (2000) J. Immunol. , vol.164 , pp. 3527
    • Leung, D.T.1    Morefield, S.2    Willerford, D.M.3
  • 43
    • 0037103249 scopus 로고    scopus 로고
    • Opposing effects of IL-2 in tumor immunotherapy: Promoting CD8 T cell growth and inducing apoptosis
    • Shrikant, P., and M. F. Mescher. 2002. Opposing effects of IL-2 in tumor immunotherapy: promoting CD8 T cell growth and inducing apoptosis. J. Immunol. 169:1753.
    • (2002) J. Immunol. , vol.169 , pp. 1753
    • Shrikant, P.1    Mescher, M.F.2
  • 44
    • 0036839499 scopus 로고    scopus 로고
    • + T cells increases the size of the acute antiviral response and of the resulting memory T cell pool
    • + T cells increases the size of the acute antiviral response and of the resulting memory T cell pool. J. Immunol. 169:4990.
    • (2002) J. Immunol. , vol.169 , pp. 4990
    • Cheng, L.E.1    Greenberg, P.D.2
  • 48
    • 0021230355 scopus 로고
    • Interleukin 2 regulates expression of its receptor and synthesis of γ interferon by human T lymphocytes
    • Reem, G. H., and N. H. Yeh. 1984. Interleukin 2 regulates expression of its receptor and synthesis of γ interferon by human T lymphocytes. Science 225:429.
    • (1984) Science , vol.225 , pp. 429
    • Reem, G.H.1    Yeh, N.H.2
  • 49
    • 0035282433 scopus 로고    scopus 로고
    • Visualizing the generation of memory CD4 T cells in the whole body
    • Reinhardt, R. L., A. Khoruts, R. Merica, T. Zell, and M. K. Jenkins. 2001. Visualizing the generation of memory CD4 T cells in the whole body. Nature 410:101.
    • (2001) Nature , vol.410 , pp. 101
    • Reinhardt, R.L.1    Khoruts, A.2    Merica, R.3    Zell, T.4    Jenkins, M.K.5
  • 50
    • 0033215132 scopus 로고    scopus 로고
    • Regulation of T cell homeostasis by heparan sulfate-bound IL-2
    • Wrenshall, L. E., and J. L. Platt. 1999. Regulation of T cell homeostasis by heparan sulfate-bound IL-2. J. Immunol. 163:3793.
    • (1999) J. Immunol. , vol.163 , pp. 3793
    • Wrenshall, L.E.1    Platt, J.L.2
  • 51
    • 0035873191 scopus 로고    scopus 로고
    • Cutting edge: Antigen-independent CD8 T cell proliferation
    • Wong, P., and E. G. Pamer. 2001. Cutting edge: antigen-independent CD8 T cell proliferation. J. Immunol. 166:5864.
    • (2001) J. Immunol. , vol.166 , pp. 5864
    • Wong, P.1    Pamer, E.G.2
  • 52
    • 0035348175 scopus 로고    scopus 로고
    • + T cell differentiation: Initial antigen encounter triggers a developmental program in naive cells
    • + T cell differentiation: initial antigen encounter triggers a developmental program in naive cells. Nat. Immunol. 2:415.
    • (2001) Nat. Immunol. , vol.2 , pp. 415
    • Kaech, S.M.1    Ahmed, R.2
  • 53
    • 0035348246 scopus 로고    scopus 로고
    • Naive CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation
    • Van Stipdonk, M. J., E. E. Lemmens, and S. P. Schoenberger. 2001. Naive CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation. Nat. Immunol. 2:423.
    • (2001) Nat. Immunol. , vol.2 , pp. 423
    • Van Stipdonk, M.J.1    Lemmens, E.E.2    Schoenberger, S.P.3
  • 54
    • 0035102242 scopus 로고    scopus 로고
    • Contrasting roles of IL-2 and IL-15 in the life and death of lymphocytes: Implications for immunotherapy
    • Waldmann, T. A., S. Dubois, and Y. Tagaya. 2001. Contrasting roles of IL-2 and IL-15 in the life and death of lymphocytes: implications for immunotherapy. Immunity 14:105.
    • (2001) Immunity , vol.14 , pp. 105
    • Waldmann, T.A.1    Dubois, S.2    Tagaya, Y.3
  • 55
    • 0035169507 scopus 로고    scopus 로고
    • Interleukin 15: Biology and relevance to human disease
    • Fehniger, T. A., and M. A. Caligiuri. 2001. Interleukin 15: biology and relevance to human disease. Blood 97:14.
    • (2001) Blood , vol.97 , pp. 14
    • Fehniger, T.A.1    Caligiuri, M.A.2
  • 56
    • 0037093844 scopus 로고    scopus 로고
    • Cutting edge: Requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells
    • Schluns, K. S., K. Williams, A. Ma, X. X. Zheng, and L. Lefrançois. 2002. Cutting edge: requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells. J. Immunol. 168:4827.
    • (2002) J. Immunol. , vol.168 , pp. 4827
    • Schluns, K.S.1    Williams, K.2    Ma, A.3    Zheng, X.X.4    Lefrançois, L.5
  • 57
  • 58
    • 0034332403 scopus 로고    scopus 로고
    • Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo
    • Schluns, K. S., W. C. Kieper, S. C. Jameson, and L. Lefrançois. 2000. Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo. Nat. Immunol. 1:426.
    • (2000) Nat. Immunol. , vol.1 , pp. 426
    • Schluns, K.S.1    Kieper, W.C.2    Jameson, S.C.3    Lefrançois, L.4
  • 60
    • 0037222183 scopus 로고    scopus 로고
    • Efficient induction of primary and secondary T cell-dependent immune responses in vivo in the absence of functional IL-2 and IL-15 receptors
    • Yu, A., J. Zhou, N. Marten, C. C. Bergmann, M. Mammolenti, R. B. Levy, and T. R. Malek. 2003. Efficient induction of primary and secondary T cell-dependent immune responses in vivo in the absence of functional IL-2 and IL-15 receptors. J. Immunol. 170:236.
    • (2003) J. Immunol. , vol.170 , pp. 236
    • Yu, A.1    Zhou, J.2    Marten, N.3    Bergmann, C.C.4    Mammolenti, M.5    Levy, R.B.6    Malek, T.R.7
  • 61
    • 0031041301 scopus 로고    scopus 로고
    • The common cytokine receptor γ chain plays an essential role in regulating lymphoid homeostasis
    • Nakajima, H., E. W. Shores, M. Noguchi, and W. J. Leonard. 1997. The common cytokine receptor γ chain plays an essential role in regulating lymphoid homeostasis. J. Exp. Med. 185:189.
    • (1997) J. Exp. Med. , vol.185 , pp. 189
    • Nakajima, H.1    Shores, E.W.2    Noguchi, M.3    Leonard, W.J.4


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