Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells

European Journal of Immunology

Volumn 37, Issue 1, 2007, Pages 129-138

  Wang, Jun ^a   Ioan Facsinay, Andreea ^a   van der Voort, Ellen I H ^a   Huizinga, Tom W J ^a   Toes, René E M ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Cell activation; Human T cells; Transcription factors

Indexed keywords

CD3 ANTIBODY; TRANSCRIPTION FACTOR FOXP3;

ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CORRELATION ANALYSIS; HUMAN; HUMAN CELL; IMMUNOMODULATION; IMMUNOREGULATION; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CELLS, CULTURED; COCULTURE TECHNIQUES; CYTOKINES; FORKHEAD TRANSCRIPTION FACTORS; G0 PHASE; HUMANS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LYMPHOCYTE ACTIVATION; SELF TOLERANCE; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; TIME FACTORS;

EID: 33846375082     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200636435     Document Type: Article

References (42)

1. Chatila, T. A., Blaeser, F., Ho, N., Lederman, H. M., Voulgaropoulos, C., Helms, C. and Bowcock, A. M., JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome. J. Clin. Invest. 2000. 106: R75-R81.
2. Wildin, R. S., Ramsdell, F., Peake, J., Faravelli, F., Casanova, J. L., Buist, N., Levy-Lahad, E. et al., X-linked neonatal diabetes mellitus, enteropathy and endocrinopahty syndrome is the human equivalent of mouse scurfy. Nat. Genet. 2001. 27: 18-20.
3. Bennett, C. L., Christie, J., Ramsdell, F., Brunkow, M. E., Ferguson, P. J., Whitesell, L., Kelly, T. E. et al., The immune dysregulation polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat. Genet. 2001. 27: 20-21.
4. Godfrey, V. L., Wilkinson, J. E. and Russell, L. B., X-linked lymphoreticular disease in the scurfy (sf) mutant mouse. Am. J. Pathol. 1991. 138: 1379-1387.
5. - T cells are the effector cells in disease pathogenesis in the scurfy (sf) mouse. J. Immunol. 1994. 153: 3764-3774.
6. Clark, L. B., Appleby, M. W., Brunkow, M. E., Wilkinson, J. E., Ziegler, S. F. and Ramsdell, F., Cellular and molecular characterization of the scurfy mouse mutant. J. Immunol. 1999. 162: 2546-2554.
7. Zahorsky-Reeves, J. L. and Wilkinson, J. E., The murine mutation scurfy (sf) results in an antigen-dependent lymphoproliferative disease with altered T cell sensitivity. Eur. J. Immunol. 2001. 31: 196-204.
8. Brunkow, M. E., Jeffery, E. W., Hjerrild, K. A., Paeper, B., Clark, L. B., Yasayko, S. A., Wilkinson, J. E. et al., Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat. Genet. 2001. 27: 68-73.
9. Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M. and Toda, M., Immunological self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 1995. 155: 1151-1164.
10. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J. Immunol. 1999. 162: 5317-5326.
11. Asano, M., Toda, M., Sakaguchi, N. and Sakaguchi, S., Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med. 1996. 184: 387-396.
12. Hori, S., Nomura, T. and Sakaguchi, S., Control of regulatory T cell development by the transcription factor Foxp3. Science 2003. 299: 1057-1061.
13. + regulatory T cells. Nat. Immunol. 2003. 4: 330-336.
14. Fontenot, J. D., Rasmussen, J. P., Williams, L. M., Dooley, J. L., Farr, A. G. and Rudensky, A. Y., Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 2005. 22: 329-341.
15. + T cells with regulatory properties from human blood. J. Exp. Med. 2001. 193: 1303-1310.
16. + cells: A naturally occurring population of regulatory T cells. Blood 2001. 98: 2736-2744.
17. + T regulatory cells suppress naive and memory T-cell proliferation and can be expanded in vitro without loss of function. J. Exp. Med. 2001. 193: 1295-1302.
18. - T cells. J. Clin. Invest. 2003. 112: 1437-1443.
19. - cells. Proc. Natl. Acad. Sci. USA 2005. 102: 4103-4108.
20. + T regulatory cells in humans. Hum. Immunol. 2005. 66: 13-20.
21. Allan, S. E., Passerini, L., Bacchetta, R., Crellin, N., Dai, M., Orban, P. C., Ziegler, S. F. et al., The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs. J. Clin. Invest. 2005. 115: 3276-3284.
22. - regulatory T cells. Int. Immunol. 2004. 16: 1643-1656.
23. Mantel, P. Y., Ouaked, N., Ruckert, B., Karagiannidis, C., Welz, R., Blaser, K. and Schmidt-Weber, C. B., Molecular mechanisms underlying FOXP3 induction in human T cells. J. Immunol. 2006. 176: 3593-3602.
24. Gavin, M. A., Torgerson, T. R., Houston, E., Deroos, P., Ho, W. Y., Stray-Pedersen, A., Ocheltree, E. L. et al., Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. Proc. Natl. Acad. Sci. USA 2006. 103: 6659-6664.
25. bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis. J. Immunol. 2004. 172: 6435-6443.
26. + regulatory T cells in inflamed synovia. J. Exp. Med. 2005. 201: 1793-1803.
27. + regulatory T cells in autoimmune polyglandular syndrome type II. J. Exp. Med. 2004. 199: 1285-1291.
28. Prabhala, R. H., Neri, P., Bae, J. E., Tassone, P., Shammas, M. A., Allam C. K., Daley, J. F. et al., Dysfunctional T regulatory cells in multiple myeloma. Blood 2006. 107: 301-304.
29. + regulatory T cells in cancer patients. Blood 2006. 107: 2409-2414.
30. + regulatory T cells correlates with more rapid parasite growth in human malaria infection. Immunity 2005. 23: 287-296.
31. + regulatory T cells at the single-cell level. Eur. J. Immunol. 2005. 35: 1681-1691.
32. - T cells through Foxp3 induction and down-regulation of Smad 7. J. Immunol. 2004. 172: 5149-5153.
33. + T cells prevent the development of organ-specific autoimmune disease by inhibiting the differentiation of autoreactive effector T cells. J. Immunol. 2005. 175: 7135-7142.
34. + regulatory T cells in immunological tolerance to self and non-self. Nat. Immunol. 2005. 6: 345-352.
35. Bettelli, E., Dastrange, M. and Oukka, M., Foxp3 interacts with nuclear factor of activated T cells and NF-κB to repress cytokine gene expression and effector functions of T helper cells. Proc. Natl. Acad. Sci. USA 2005. 102: 5138-5143.
36. Schubert, L. A., Jeffery, E., Zhang, Y., Ramsdell, F. and Ziegler, S. F., Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation. J. Biol. Chem. 2001. 276: 37672-37679.
37. Xiao, S., Matsui, K., Fine, A., Zhu, B., Marshak-Rothstein, A., Widom, R. L. and Ju, S. T., FasL promoter activation by IL-2 through SP1 and NFAT but not Egr-2 and Egr-3. Eur. J. Immunol. 1999. 29: 3456-3465.
38. + regulatory T cells through a STAT dependent mechanism and induces the expansion of these cells in vivo. Blood 2006. 108: 1571-1579.
39. Fontenot, J. D. and Rudensky, A. Y., A well adapted regulatory contrivance: Regulatory T cell development and the forkhead family transcription factor Foxp3. Nat. Immunol. 2005. 6: 331-337.
40. Wu, Y., Borde, M., Heissmeyer, V., Feuerer, M., Lapan, A. D., Stroud, J. C., Bates, D. L. et al., FOXP3 controls regulatory T cell function through cooperation with NFAT Cell 2006. 126: 375-387.
41. + regulatory T cells by peripheral expansion. J. Immunol. 2004. 173: 7259-7268.
42. + T cells expressing foxP3 in IL-2-treated HIV-infected patients. J. Clin. Invest. 2005. 115: 1839-1847.