메뉴 건너뛰기




Volumn 196, Issue 6, 2002, Pages 851-857

Interleukin 2 signaling is required for CD4+ regulatory T cell function

Author keywords

Autoimmunity; CD4+ T lymphocytes; Encephalomyelitis; Hypersensitivity; Immune tolerance

Indexed keywords

CD4 ANTIGEN; IMMUNOGLOBULIN E; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; OVALBUMIN;

EID: 0037120053     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20020190     Document Type: Article
Times cited : (529)

References (35)
  • 1
    • 0027369395 scopus 로고
    • Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
    • Sadlack, B., H. Merz, H. Schorle, A. Schimpl, A.C. Feller, and I. Horak. 1993. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell. 75:253-261.
    • (1993) Cell , vol.75 , pp. 253-261
    • Sadlack, B.1    Merz, H.2    Schorle, H.3    Schimpl, A.4    Feller, A.C.5    Horak, I.6
  • 2
    • 0028783963 scopus 로고
    • Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells
    • Sadlack, B., J. Lohler, H. Schorle, G. Klebb, H. Haber, E. Sickel, R.J. Noelle, and I. Horak. 1995. Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells. Eur. J. Immunol. 25:3053-3059.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 3053-3059
    • Sadlack, B.1    Lohler, J.2    Schorle, H.3    Klebb, G.4    Haber, H.5    Sickel, E.6    Noelle, R.J.7    Horak, I.8
  • 3
    • 0028784289 scopus 로고
    • Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment
    • Willerford, D.M., J. Chen, J.A. Ferry, L. Davidson, A. Ma, and F.W. Alt. 1995. Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity. 3:521-530.
    • (1995) Immunity , vol.3 , pp. 521-530
    • Willerford, D.M.1    Chen, J.2    Ferry, J.A.3    Davidson, L.4    Ma, A.5    Alt, F.W.6
  • 5
    • 0026017971 scopus 로고
    • Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis
    • Lenardo, M.J. 1991. Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis. Nature. 353:858-861.
    • (1991) Nature , vol.353 , pp. 858-861
    • Lenardo, M.J.1
  • 6
    • 0029118133 scopus 로고
    • Normal clonal expansion but impaired Fas-mediated cell death and anergy induction in interleukin-2-deficient mice
    • Kneitz, B., T. Herrmann, S. Yonehara, and A. Schimpl. 1995. Normal clonal expansion but impaired Fas-mediated cell death and anergy induction in interleukin-2-deficient mice. Eur. J. Immunol. 25:2572-2577.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 2572-2577
    • Kneitz, B.1    Herrmann, T.2    Yonehara, S.3    Schimpl, A.4
  • 8
    • 17544398702 scopus 로고    scopus 로고
    • Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis
    • Refaeli, Y., L. Van Parijs, C.A. London, J. Tschopp, and A.K. Abbas. 1998. Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis. Immunity. 8:615-623.
    • (1998) Immunity , vol.8 , pp. 615-623
    • Refaeli, Y.1    Van Parijs, L.2    London, C.A.3    Tschopp, J.4    Abbas, A.K.5
  • 9
    • 0342632839 scopus 로고    scopus 로고
    • Normal regulatory alpha/beta T cells effectively eliminate abnormally activated T cells lacking the interleukin 2 receptor beta in vivo
    • Suzuki, H., Y.W. Zhou, M. Kato, T.W. Mak, and I. Nakashima. 1999. Normal regulatory alpha/beta T cells effectively eliminate abnormally activated T cells lacking the interleukin 2 receptor beta in vivo. J. Exp. Med. 190:1561-1572.
    • (1999) J. Exp. Med. , vol.190 , pp. 1561-1572
    • Suzuki, H.1    Zhou, Y.W.2    Kato, M.3    Mak, T.W.4    Nakashima, I.5
  • 11
    • 0034654319 scopus 로고    scopus 로고
    • Normal lymphoid homeostasis and lack of lethal autoimmunity in mice containing mature T cells with severely impaired IL-2 receptors
    • Malek, T.R., B.O. Porter, E.K. Codias, P. Scibelli, and A. Yu. 2000. Normal lymphoid homeostasis and lack of lethal autoimmunity in mice containing mature T cells with severely impaired IL-2 receptors. J. Immunol. 164:2905-2914.
    • (2000) J. Immunol. , vol.164 , pp. 2905-2914
    • Malek, T.R.1    Porter, B.O.2    Codias, E.K.3    Scibelli, P.4    Yu, A.5
  • 12
    • 0034965185 scopus 로고    scopus 로고
    • Control of T cell hyperactivation in IL-2-deficient mice by CD4(+)CD25(-) and CD4(+)CD25(+) T cells: Evidence for two distinct regulatory mechanisms
    • Wolf, M., A. Schimpl, and T. Hunig. 2001. Control of T cell hyperactivation in IL-2-deficient mice by CD4(+)CD25(-) and CD4(+)CD25(+) T cells: evidence for two distinct regulatory mechanisms. Eur. J. Immunol. 31:1637-1645.
    • (2001) Eur. J. Immunol. , vol.31 , pp. 1637-1645
    • Wolf, M.1    Schimpl, A.2    Hunig, T.3
  • 13
    • 7144259082 scopus 로고    scopus 로고
    • Regulatory CD4 T cells: Expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency
    • Papiernik, M., M.L. de Moraes, C. Pontoux, F. Vasseur, and C. Penit. 1998. Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency. Int. Immunol. 10:371-378.
    • (1998) Int. Immunol. , vol.10 , pp. 371-378
    • Papiernik, M.1    De Moraes, M.L.2    Pontoux, C.3    Vasseur, F.4    Penit, C.5
  • 14
    • 0031821875 scopus 로고    scopus 로고
    • + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
    • + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188:287-296.
    • (1998) J. Exp. Med. , vol.188 , pp. 287-296
    • Thornton, A.M.1    Shevach, E.M.2
  • 15
    • 0028102655 scopus 로고
    • High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice
    • Lafaille, J.J., K. Nagashima, M. Katsuki, and S. Tonegawa. 1994. High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice. Cell. 78:399-408.
    • (1994) Cell , vol.78 , pp. 399-408
    • Lafaille, J.J.1    Nagashima, K.2    Katsuki, M.3    Tonegawa, S.4
  • 16
    • 0032538918 scopus 로고    scopus 로고
    • + T cells expressing endogenous T cell receptor chains protect myelin basic protein-specific transgenic mice from spontaneous autoimmune encephalomyelitis
    • + T cells expressing endogenous T cell receptor chains protect myelin basic protein-specific transgenic mice from spontaneous autoimmune encephalomyelitis. J. Exp. Med. 188:1883-1894.
    • (1998) J. Exp. Med. , vol.188 , pp. 1883-1894
    • Olivares-Villagomez, D.1    Wang, Y.2    Lafaille, J.J.3
  • 17
    • 0032538820 scopus 로고    scopus 로고
    • + T cells prevent spontaneous experimental autoimmune encephalomyelitis in anti-myelin basic protein T cell receptor transgenic mice
    • + T cells prevent spontaneous experimental autoimmune encephalomyelitis in anti-myelin basic protein T cell receptor transgenic mice. J. Exp. Med. 188:1875-1882.
    • (1998) J. Exp. Med. , vol.188 , pp. 1875-1882
    • Van de Keere, F.1    Tonegawa, S.2
  • 19
    • 0025899598 scopus 로고
    • Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting
    • Schorle, H., T. Holtschke, T. Hunig, A. Schimpl, and I. Horak. 1991. Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature. 352:621-624.
    • (1991) Nature , vol.352 , pp. 621-624
    • Schorle, H.1    Holtschke, T.2    Hunig, T.3    Schimpl, A.4    Horak, I.5
  • 23
    • 0021839887 scopus 로고
    • Regulation of interleukin 2 (IL2) receptor expression: IL2 as an inducing signal for the expression of its own receptor on a murine T helper cell line
    • Bismuth, G., J.L. Moreau, G. Somme, M. Duphot, A. Dautry-Varsat, R.J. Robb, and J. Theze. 1985. Regulation of interleukin 2 (IL2) receptor expression: IL2 as an inducing signal for the expression of its own receptor on a murine T helper cell line. Eur. J. Immunol. 15:723-727.
    • (1985) Eur. J. Immunol. , vol.15 , pp. 723-727
    • Bismuth, G.1    Moreau, J.L.2    Somme, G.3    Duphot, M.4    Dautry-Varsat, A.5    Robb, R.J.6    Theze, J.7
  • 24
    • 0033523607 scopus 로고    scopus 로고
    • An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation
    • Asseman, C., S. Mauze, M.W. Leach, R.L. Coffman, and F. Powrie. 1999. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 190:995-1004.
    • (1999) J. Exp. Med. , vol.190 , pp. 995-1004
    • Asseman, C.1    Mauze, S.2    Leach, M.W.3    Coffman, R.L.4    Powrie, F.5
  • 25
    • 0035284804 scopus 로고    scopus 로고
    • CD25(+) CD4(+) T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10
    • Annacker, O., R. Pimenta-Araujo, O. Burlen-Defranoux, T.C. Barbosa, A. Cumano, and A. Bandeira. 2001. CD25(+) CD4(+) T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10. J. Immunol. 166:3008-3018.
    • (2001) J. Immunol. , vol.166 , pp. 3008-3018
    • Annacker, O.1    Pimenta-Araujo, R.2    Burlen-Defranoux, O.3    Barbosa, T.C.4    Cumano, A.5    Bandeira, A.6
  • 26
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi, S., N. Sakaguchi, M. Asano, M. Itoh, and M. Toda. 1995. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155:1151-1164.
    • (1995) J. Immunol. , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 27
    • 0034716925 scopus 로고    scopus 로고
    • Regulatory T cells: Key controllers of immunologic self-tolerance
    • Sakaguchi, S. 2000. Regulatory T cells: key controllers of immunologic self-tolerance. Cell. 101:455-458.
    • (2000) Cell , vol.101 , pp. 455-458
    • Sakaguchi, S.1
  • 28
    • 0034084162 scopus 로고    scopus 로고
    • Regulatory T cells in autoimmunity
    • Shevach, E.M. 2000. Regulatory T cells in autoimmunity. Annu. Rev. Immunol. 18:423-449.
    • (2000) Annu. Rev. Immunol. , vol.18 , pp. 423-449
    • Shevach, E.M.1
  • 31
    • 0030931682 scopus 로고    scopus 로고
    • Natural history and therapy of metastatic renal cell carcinoma: The role of interleukin-2
    • Bukowski, R.M. 1997. Natural history and therapy of metastatic renal cell carcinoma: the role of interleukin-2. Cancer. 80:1198-1220.
    • (1997) Cancer , vol.80 , pp. 1198-1220
    • Bukowski, R.M.1
  • 32
    • 7844234373 scopus 로고    scopus 로고
    • Neo-adjuvant chemo-(immuno-)therapy of advanced squamous-cell head and neck carcinoma: A multi-center, phase III, randomized study comparing cisplatin + 5-fluorouracil (5-FU) with cisplatin + 5-FU + recombinant interleukin 2
    • Mantovani, G., V. Gebbia, M. Airoldi, C. Bumma, P. Contu, A. Bianchi, M. Ghiani, D. Dessi, E. Massa, L. Curreli, et al. 1998. Neo-adjuvant chemo-(immuno-)therapy of advanced squamous-cell head and neck carcinoma: a multi-center, phase III, randomized study comparing cisplatin + 5-fluorouracil (5-FU) with cisplatin + 5-FU + recombinant interleukin 2. Cancer Immunol. Immunother. 47:149-156.
    • (1998) Cancer Immunol. Immunother. , vol.47 , pp. 149-156
    • Mantovani, G.1    Gebbia, V.2    Airoldi, M.3    Bumma, C.4    Contu, P.5    Bianchi, A.6    Ghiani, M.7    Dessi, D.8    Massa, E.9    Curreli, L.10
  • 33
    • 0035091720 scopus 로고    scopus 로고
    • Phase II trial of systemic recombinant interleukin-2 in the treatment of refractory nasopharyngeal carcinoma
    • Chi, K.H., J.N. Myers, K.C. Chow, W.K. Chan, Y.W. Tsang, Y. Chao, S.H. Yen, and M.T. Lotze. 2001. Phase II trial of systemic recombinant interleukin-2 in the treatment of refractory nasopharyngeal carcinoma. Oncology. 60:110-115.
    • (2001) Oncology , vol.60 , pp. 110-115
    • Chi, K.H.1    Myers, J.N.2    Chow, K.C.3    Chan, W.K.4    Tsang, Y.W.5    Chao, Y.6    Yen, S.H.7    Lotze, M.T.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.