Homeostasis of peripheral CD4+ T cells: IL-2Rα and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers

Journal of Immunology

Volumn 169, Issue 9, 2002, Pages 4850-4860

  Almeida, Afonso R M ^a   Legrand, Nicolas ^a   Papiernik, Martine ^a   Freitas, António A ^a  

^a INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR;

ANIMAL CELL; ARTICLE; AUTOIMMUNE DISEASE; BONE MARROW CELL; CELL TRANSFER; CHIMERA; CONTROLLED STUDY; HOMEOSTASIS; IMMUNOREGULATION; LYMPHOID CELL; LYMPHOID HYPERPLASIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION;

EID: 0036839102     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.9.4850     Document Type: Article

References (53)

1. Almeida, A. R., J. A. Borghans, and A. A. Freitas. 2001. T cell homeostasis: Thymus regeneration and peripheral T cell restoration in mice with a reduced fraction of competent precursors. J. Exp. Med. 194:591.
2. Leuchars, E., V. J. Wallis, M. J. Doenhoff, A. J. Davies, and J. Kruger. 1978. Studies of hyperthymic mice. I. The influence of multiple thymus grafts on the size of the peripheral T cell pool and immunological performance. Immunology 35:801.
3. Berzins, S. P., R. L. Boyd, and J. F. Miller. 1998. The role of the thymus and recent thymic migrants in the maintenance of the adult peripheral lymphocyte pool. J. Exp. Med. 187:1839.
4. Rocha, B., A. A. Freitas, and A. A. Coutinho. 1983. Population dynamics of T lymphocytes: Renewal rate and expansion in the peripheral lymphoid organs. J. Immunol. 131:2158.
5. Freitas, A. A., B. Rocha, and A. A. Coutinho. 1986. Lymphocyte population kinetics in the mouse. Immunol. Rev. 91:5.
6. Stutman, O. 1986. Postthymic T-cell development. Immunol. Rev. 91:159.
7. Rocha, B., N. Dautigny, and P. Pereira. 1989. Peripheral T lymphocytes: Expansion potential and homeostatic regulation of pool sizes and CD4/CD8 ratios in vivo. Eur. J. Immunol. 19:905.
8. + T cells. Eur. J. Immunol. 26:2640.
9. Freitas, A. A., and B. Rocha. 2000. Lymphocyte population biology: The flight for survival. Annu. Rev. Immunol. 18:83.
10. Willerford, D. M., J. Chen, J. A. Ferry, L. Davidson, A. Ma, and F. W. Alt. 1995. Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment. Immunity 3:521.
11. Van Parijs, L., A. Biuckians, A. Ibragimov, F. W. Alt, D. M. Willerford. and A. K. Abbas. 1997. Functional responses and apoptosis of CD25 (IL-2Rα)-deficient T cells expressing a transgenic antigen receptor. J. Immunol. 158:3738.
12. Leung, D. T., S. Morefield, and D. M. Willerford. 2000. Regulation of lymphoid homeostasis by IL-2 receptor signals in vivo. J. Immunol. 164:3527.
13. Suzuki, H., Y. W. Zhou, M. Kato, T. W. Mak, and I. Nakashima. 1999. Normal regulatory α/β T cells effectively eliminate abnormally activated T cells lacking the interleukin 2 receptor β in vivo. J. Exp. Med. 190:1561.
14. + T cells: Evidence for two distinct regulatory mechanisms. Eur. J. Immunol. 31:1637.
15. + T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10. J. Immunol. 166:3008.
16. Groux, H., and F. Powrie. 1999. Regulatory T cells and inflammatory bowel disease. Immunol. Today 20:442.
17. Malissen, M., A. Gillet, L. Ardouin, G. Bouvier, J. Trucy, P. Ferrier, E. Vivier, and B. Malissen. 1995. Altered T cell development in mice with a targeted mutation of the CD3-ε gene. EMBO J. 14:4641.
18. Mombaerts, P., A. R. Clarke, M. A. Rudnicki, J. Iacomini, S. Itohara, J. J. Lafaille, L. Wang, Y. Ichikawa, R. Jaenisch, and M. L. Hooper. 1992. Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages. Nature 360:225.
19. Kuhn, R., J. Lohler, D. Rennick, K. Rajewsky, and W. Muller. 1993. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75:263.
20. Schorle, H., T. Holtschke, T. Hunig, A. Schimpl, and I. Horak. 1991. Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature 352:621.
21. Lyons, A. B., and C. R. Parish. 1994. Determination of lymphocyte division by flow cytometry. J. Immunol. Methods 171:131.
22. Papiernik, M., M. do Carmo Leite-de-Moraes, C. Pontoux, A. M. Joret. B. Rocha. C. Penit, and M. Dy. 1997. T cell deletion induced by chronic infection with mouse mammary tumor virus spares a CD25-positive. IL-10-producing T cell population with infectious capacity. J. Immmnol. 158:4642.
23. Granucci, F., C. Vizzardelli, N. Pavelka, S. Feau, M. Persico, E. Virzi, M. Rescigno, G. Moro, and P. Ricciardi-Castagnoli. 2001. Inducible IL-2 production by dendritic cells revealed by global gene expression analysis. Nat. Immunol. 2:882.
24. + T cell pools. Eur. J. Immunol. 25:2127.
25. Piguet, P. F., C. Irle, E. Kollatte, and P. Vassalli. 1981. Post-thymic T lymphocyte maturation during ontogenesis. J. Exp. Med. 154:581.
26. Miller, R. A., and O. Stutman. 1984. T cell repopulation from functionally restricted splenic progenitors: 10,000-Fold expansion documented by using limiting dilution analyses. J. Immunol. 133:2925.
27. Sakaguchi, S., N. Sakaguchi, M. Asano, M. Itoh, and M. Toda. 1995. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25): Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155:1151.
28. Asano, M., M. Toda, N. Sakaguchi, and S. Sakaguchi. 1996. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med. 184:387.
29. - T cells are important for the balance between protective and pathogenic cell-mediated immunity. J. Exp. Med. 179:589.
30. + T cells. Immunity 1:553.
31. + T cells: A common basis between tumor immunity and autoimmunity. J. Immunol. 163:5211.
32. Saoudi, A., B. Seddon, V. Heath, D. Fowell. and D. Mason. 1996. The physiological role of regulatory T cells in the prevention of autoimmunity: The function of the thymus in the generation of the regulatory T cell subset, Immunol. Rev. 149:195.
33. + T cells. Proc. Natl. Acad. Sci. USA 99:8832.
34. + naturally anergic and suppressive T cells: Induction of autoimmune disease by breaking their anergic/suppressive state. Int. Immunol. 10:1969.
35. + immunoregulatory cells. J. Immunol. 167:1137.
36. + T cells. J. Exp. Med. 183:2669.
37. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389:737.
38. Papiernik, M., M. L. de Moraes, C. Pontoux, F. Vasseur, and C. Penit. 1998. Regulatory CD4 T cells: Expression of IL-2Rα chain, resistance to clonal deletion and IL-2 dependency. Int. Immunol. 10:371.
39. Asseman, C., S. Mauze, M. W. Leach, R. L. Coffman, and F. Powrie. 1999. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 190:995.
40. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188:287.
41. Gorelik, L., and R. A. Flavell. 2000. Abrogation of TGF signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity 12:171.
42. Lucas, P. J., S. J. Kim, S. J. Melby. and R. E. Gress. 2000. Disruption of T cell homeostasis in mice expressing a T cell-specific dominant negative transforming growth factor β II receptor. J. Exp. Med. 191:1187.
43. + regulatory T cells is mediated by cell surface-bound transforming growth factor β. J. Exp. Med. 194:629.
44. + suppressor T cells: More questions than answers. Nat. Rev. Immunol. 2:389.
45. + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 192:303.
46. + regulatory T cells through GITR breaks immunological self-tolerance. Nat. Immunol. 22:22.
47. + immunoregulatory T cells: Gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 16:311.
48. + suppressor T cells in vivo. Nat. Immunol. 3:33.
49. + T cells inhibit both the induction and effector function of autore-active T cells and represent a unique lineage of immunoregulatory cells. J. Immunol. 160:1212.
50. - naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J. Immunol. 162:5317.
51. + immunoregulatory T cells is antigen nonspecific. J. Immunol. 164:183.
52. Shevach, E. M. 2000. Regulatory T cells in autoimmmunity. Annu. Rev. Immunol. 18:423.
53. Saoudi, A., B. Seddon, D. Fowell, and D. Mason. 1996. The thymus contains a high frequency of cells that prevent autoimmune diabetes on transfer into prediabetic recipients. J. Exp. Med. 184:2393.