Efficient internalization of IL-2 depends on the distal portion of the cytoplasmic tail of the IL-2R common γ-chain and a lymphoid cell environment

Journal of Immunology

Volumn 165, Issue 5, 2000, Pages 2556-2562

  Yu, A ^a   Olosz, F ^a   Choi, C Y ^a   Malek, T R ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENISTEIN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; STAT PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; DELETION MUTANT; ENDOCYTOSIS; INTERNALIZATION; LIGAND BINDING; LYMPHOID CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0034283961     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.5.2556     Document Type: Article

References (31)

1. The structure and function of γc-dependent cytokines and receptors: Regulation of T lymphocyte development and homeostasis
2. Heterodimerization of the IL-2 receptor β- and γ-chain cytoplasmic domains is required for signaling
3. Cytoplasmic domains of the interleukin-2 receptor β and γ chains mediate the signal for T-cell proliferation
4. Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits
5. Biology of the interleukin-2 receptor
6. High-affinity interleukin 2 receptor α and β chains are internalized and remain associated inside the cells after interleukin 2 endocytosis
7. Intracellular pathway of interleukin 2 following receptor-mediated endocytosis
8. Only high-affinity receptors for interleukin 2 mediate internalization of ligand
9. Endocytosis of interleukin 2 receptors in human T lymphocytes: Distinct intracellular localization and fate of the receptor α, β, and γ chains
10. Rapid endocytosis of interleukin 2 receptors when clathrin-coated pit endocytosis is inhibited
11. Microtubule depolymerization inhibits clathrin coated-pit internalization in non-adherent cell lines while interleukin 2 endocytosis is not affected
12. Endocytosis and molecular sorting
13. Cloning of the γ chain of the human IL-2 receptor
14. Selection of internalization-deficient cells by interleukin-2-Pseudomonas exotoxin chimeric protein: The cytoplasmic domain of the interleukin-2 receptor β chain does not contribute to internalization of interleukin-2
15. Expression and functional characterization of artifical mutants of interleukin-2 receptor
16. Biochemical identity and characterization of the mouse interleukin-2 receptor β and γc subunits
17. Expression and function of the γc subunit of the IL-2, IL-4. and IL-7 receptors: Distinct interaction of γc in the IL-4 receptor
18. Rapid induction of tumor necrosis factor cytotoxicity in naive splenic T cells by simultaneous CD80 (B7.1) and CD54 (ICAM-1) co-stimulation
19. Distinct tryosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzyme activity
20. Cloning of human Stat5B
21. The protein tryosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction
22. The murine IL-2 receptor. I. Monoclonal antibodies that define distinct functional epitopes on activated T cells and react with activated B cells
23. Identification and initial characterization of a rat monoclonal antibody reactive with the murine interleukin 2 receptor-ligand complex
24. The murine interleukin 2 receptor: Irreversible cross-linking of radiolabeled interleukin 2 to high affinity interleukin 2 receptors reveals a noncovalently associated subunit
25. The endocytic rate constant: A cellular parameter for quantitating receptor-mediated endocytosis
26. Quantitative studies of the rate of insulin internalization in isolated rat hepatocytes
27. Endocytosis of the common cytokine receptor γc chain
28. Functional cleavage of the common cytokine receptor. γ chain (γc) by calpain
29. A membrane-proximal region of the interleukin-2 receptor γc chain sufficient for Jak kinase activation and induction of proliferation in T cells
30. Interaction of the IL-2 receptor with the src-family kinase p56(lck): Identification of novel intermolecular association
31. Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor: Possible link with the c-myc induction pathway