Transcriptional repression of the IL-2 gene in th cells by ZEB

Journal of Immunology

Volumn 160, Issue 9, 1998, Pages 4433-4440

  Yasui, Dag H ^a   Genetta, Tom ^b   Kadesch, Tom ^b   Williams, Thomas M ^c   Swain, Susan L ^d   Tsui, Lisa V ^d   Huber, Brigitte T ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^d TRUDEAU INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 4; TRANSCRIPTION FACTOR; ZINC FINGER PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ELECTROPHORETIC MOBILITY; GENE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HELPER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; CELL LINE; DNA-BINDING PROTEINS; INTERLEUKIN-2; MICE; OLIGONUCLEOTIDES, ANTISENSE; REPRESSOR PROTEINS; TH1 CELLS; TH2 CELLS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSFECTION; ZINC FINGERS;

EID: 0032080450     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Paul, W. E., and R. A. Seder. 1994. Lymphocyte responses and cytokines. Cell 76:241.
2. + T-cell subsets. Immunol. Rev. 123:5.
3. Mosmann, T. R., and R. L. Coffman. 1989. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145.
4. + T cells. Immunol. Rev. 123:209.
5. Romagnani, S. 1995. Biology of human TH1 and TH2 cells. J. Clin. Immunol. 15:121.
6. Sher, A., and R. L. Coffman. 1992. Regulation of immunity to parasites by T cells and T cell-derived cytokines. Annu. Rev. Immunol. 10:385.
7. Jain, J., C. Loh, and A. Rao. 1995. Transcriptional regulation of the IL-2 gene. Curr. Opin. Immunol. 7:333.
8. Fraser, J. D., B. A. Irving, G. R. Crabtree, and A. Weiss. 1991. Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28. Science 251:313.
9. Linsley, P. S., W. Brady, L. Grosmaire, A. Aruffo, N. K. Damle, and J. A. Ledbetter. 1991. Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation. J. Exp. Med. 173:721.
10. Reiser, H., G. J. Freeman, Z. Razi-Wolf, C. D. Gimmi, B. Benacerraf, and L. M. Nadler. 1992. Murine B7 antigen provides an efficient costimulatory signal for activation of murine T lymphocytes via the T-cell receptor/CD3 complex. Proc. Natl. Acad. Sci. USA 89:271.
11. Harding, F. A., J. G. McArthur, J. A. Gross, D. H. Raulet, and J. P. Allison. 1992. CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 356:607.
12. Ghosh, P., T. H. Tan, N. R. Rice, A. Sica, and H. A. Young. 1993. The interleukin 2 CD28-responsive complex contains at least three members of the NF. Proc. Natl. Acad. Sci. USA 90:1696.
13. Rooney, J. W., Y. L. Sun, L. H. Glimcher, and T. Hoey. 1995. Novel NFAT sites that mediate activation of the interleukin-2 promoter in response to T-cell receptor stimulation. Mol. Cell. Biol. 15:6299.
14. Rooney, J. W., M. R. Hodge, P. G. McCaffrey, A. Rao, and L. H. Glimcher. 1994. A common factor regulates both Th1-and Th2-specific cytokine gene expression. EMBO J. 13:625.
15. Lederer, J. A., J. S. Liou, M. D. Todd, L. H. Glimcher, and A. H. Lichtman. 1994. Regulation of cytokine gene expression in T helper cell subsets. J. Immunol. 152:77.
16. Munoz, E., A. Zubiaga, D. Olson, and B. T. Huber. 1989. Control of lymphokine expression in T helper 2 cells. Proc. Natl. Acad. Sci. USA 86:9461.
17. Zubiaga, A. M., E. Munoz, and B. T. Huber. 1991. Superinduction of IL-2 gene transcription in the presence of cycloheximide. J. Immunol. 146:3857.
18. Williams, T. M., D. Moolten, J. Burlein, J. Romano, R. Bhaerman, A. Godillot, M. Mellon, F. J. d. Rauscher, and J. A. Kant. 1991. Identification of a zinc finger protein that inhibits IL-2 gene expression. Science 254:1791.
19. Genetta, T., D. Ruezinsky, and T. Kadesch. 1994. Displacement of an E-box-binding repressor by basic helix-loop-helix proteins: implications for B-cell specificity of the immunoglobulin heavy-chain enhancer. Mol. Cell. Biol. 14:6153.
20. Farrar, J. J., J. Fuller-Farrar, P. L. Simon, M. L. Hilfiker, B. M. Stadler, and W. L. Farrar. 1980. Thymoma production of T cell growth factor (interleukin 2). J. Immunol. 125:2555.
21. Harrison, J. R., K. R. Lynch, and J. J. Sando. 1987. Phorbol esters induce interleukin 2 mRNA in sensitive but not in resistant EL4 cells. J. Biol. Chem. 262:234.
22. Strickland, F. M., J. Cerny, P. Currier, and A. J. Infante. 1989. Restricted idiotypic profile of anti-phosphorylcholine antibodies induced by carrier-specific helper T cell clones. Eur. J. Immunol. 19:971.
23. Kaye, J., S. Porcelli, J. Tite, B. Jones, and C. A. Janeway, Jr. 1983. Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cells. J. Exp. Med. 158:836.
24. Swain, S. L. 1994. Generation and in-vivo persistence of polarized Th1 and Th2 memory cells. Immunity 1:543.
25. Swain, S. L., L. M. Bradley, M. Croft, S. Tonkonogy, G. Atkins, A. D. Weinberg, D. D. Duncan, S. M. Hedrick, R. W. Dutton, and G. Huston. 1991. Helper T cell subsets: phenotype, function and the role of lymphokines in regulating their development. Immunol. Rev. 123:11524.
26. O'Garra, A., and K. Murphy. 1994. Role of cytokines in determining T-lymphocyte function. Curr. Opin. Immunol. 6:458.
27. Kuhlman, P., V. T. Moy, B. A. Lollo, and A. A. Brian. 1995. The accessory function of murine intercellular adhesion molecule-1 in T lymphocyte activation: contributions of adhesion and co-activation. J. Immunol. 146:1773.
28. Jamison, C., P. G. McCaffrey, A. Rao, and R. Sen. 1991. Physiologic activation of T cells via the T cell receptor induces NF-κB. J. Immunol. 147:416.
29. Funahashi, J., R. Sekido, K. Murai, Y. Kamachi, and H. Kondoh. 1993. Delta-crystallin enhancer binding protein delta EF1 is a zinc finger-homeodomain protein implicated in postgastrulation embryogenesis. Development 119:433.
30. McCaffrey, P. G., C. Luo, T. K. Kerppola, J. Jain, T. M. Badalian, A. M. Ho, E. Burgeon, W. S. Lane, J. N. Lambert, T. Curran, G. L. Verdine, A. Rao, and P. G. Hogan. 1993. Isolation of the cyclosporin-sensitive T cell transcription factor NFATp. Science 262:750.
31. Kownin, P., and H. L. Robinson. 1990. Murine retroviral vectors: T-cell line specific expression of a cytomegalovirus immediate early promoter. Biotechnology 8:501.
32. Efrat, S., and R. Kaempfer. 1984. Control of biologically active IL-2 mRNA formation in induced human lymphocytes. Proc. Natl. Acad. Sci. USA 81:2601.
33. Rooney, J. W., T. Hoey, and L. H. Glimcher. 1995. Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene. Immunity 2:473.
34. Kamps, M. P., L. Corcoran, J. H. LeBowitz, and D. Baltimore. 1990. The promoter of the human interleukin-2 gene contains two octamer-binding sites and is partially activated by the expression of Oct-2. Mol. Cell. Biol. 10:5464.
35. Becker, J. C., T. Brabletz, T. Kirchner, C. T. Conrad, E. B. Brocker, and R. A. Reisfeld. 1995. Negative transcriptional regulation in anergic T cells. Proc. Natl. Acad. Sci. USA 92:2375.
36. Lederer, J. A., J. S. Liou, S. Kim, N. Rice, and A. H. Lichtman. 1996. Regulation of NF-κB activation in T helper 1 and T helper 2 cells. J. Immunol. 156:56.
37. Mouzaki, A., D. Rungger, A. Tucci, A. Doucet, and R. H. Zubler. 1993. Occurrence of a silencer of the interleukin-2 gene in naive but not in memory resting T helper lymphocytes. Eur. J. Immunol. 23:1469.
38. 2 and other cyclic AMP-elevating agents modulate IL-2 and IL-2Rα gene expression at multiple levels. J. Immunol. 148:2845.
39. Chen, D., and E. V. Rothenberg. 1994. Interleukin 2 transcription factors as molecular targets of cAMP inhibition: delayed inhibition kinetics and combinatorial transcription roles. J. Exp. Med. 179:931.
40. Tamir, A., and N. Isakov. 1994. Cyclic AMP inhibits phosphatidylinositol-coupled and -uncoupled mitogenic signals in T lymphocytes: evidence that cAMP alters PKC-induced transcription regulation of members of the jun and fos family of genes. J. Immunol. 152:3391.
41. Munoz, E., A. M. Zubiaga, M. Merrow, N. P. Sauter, and B. T. Huber. 1990. Cholera toxin discriminates between T helper 1 and 2 cells in T cell receptor-mediated activation: role of cAMP in T cell proliferation. J. Exp. Med. 172:95.
42. Novak, T. J., and E. V. Rothenberg. 1990. cAMP inhibits induction of interleukin 2 but not of interleukin 4 in T cells. Proc. Natl. Acad. Sci. USA 87:9353.
43. Ho, I., M. R. Hodge, J. W. Rooney, and L. H. Glimcher. 1996. The protooncogene c-maf is responsible for tissue-specific expression of interleukin-4. Cell 85:973.
44. Hodge, M. R., A. M. Ranger, F. Charles de la Brouse, T. Hoey, M. J. Grusby, and L. H. Glimcher. 1996. Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice. Immunity 4:397.
45. Xanthoudakis, S., J. P B. Viola, K. T. Y. Shaw, C. Luo, J. D. Wallace, P. T. Bozza, T. Curran, and A. Rao. 1996. An enhanced immune response in mice lacking the transcription factor NFAT1. Nature 272:892.
46. Genetta, T., and T. Kadesch. 1996. Cloning of a cDNA encoding a mouse transcriptional repressor displaying striking sequence conservation across vertebrates. Gene 169:289.
47. Jenuwein, T., and R. Grosschedl. 1991. Complex pattern of immunoglobulin mu gene expression in normal and transgenic mice: nonoverlapping regulatory sequences govern distinct tissue specificities. Genes Dev. 5:932.
48. Sekido, R., K. Murai, J. Funahashi, Y. Kamachi, A. Fujisawa-Sehara, Y. Nabeshima, and H. Kondoh. 1994. The δ-crystalline enhancer-binding protein delta EF1 is a repressor of E2-box mediated gene activation. Mol. Cell. Biol. 14:5692.
49. Duncan, D. D., M. Adlam, and G. Siu. 1996. Asymmetric redundancy in CD4 silencer function. Immunity 4:301. 50
50. Sekido, R., T. Takagi, M. Okanami, H. Moribe, M. Yamamura, Y. Higashi, and H. Kondoh. 1996. Organization of the gene encoding transcriptional repressor δEF1 and cross-species conservation of its domains. Gene 173:227.