IL-7 Promotes the Transition of CD4 Effectors to Persistent Memory Cells

Journal of Experimental Medicine

Volumn 198, Issue 12, 2003, Pages 1807-1815

  Li, Ji Chu ^a   Huston, Gail ^a   Swain, Susan L ^a  

^a TRUDEAU INSTITUTE   (United States)

Author keywords

CD4 T cells; Cytokines; Effector cells; Immunity; Survival

Indexed keywords

CD4 ANTIGEN; CYTOKINE ANTIBODY; INTERLEUKIN 7; INTERLEUKIN 7 RECEPTOR;

ADOPTIVE TRANSFER; ANIMAL CELL; ARTICLE; CELL DIVISION; CELL SURVIVAL; CONTROLLED STUDY; EFFECTOR CELL; MEMORY CELL; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; WILD TYPE;

ADOPTIVE TRANSFER; ANIMALS; APOPTOSIS; CD4-POSITIVE T-LYMPHOCYTES; CELL SURVIVAL; IMMUNOLOGIC MEMORY; INTERLEUKIN-7; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, INTERLEUKIN-7;

EID: 0347594000     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20030725     Document Type: Article

References (42)

1. Swain, S.L., H. Hu, and G. Huston. 1999. Class II independent generation of CD4 memory T cells from effectors. Science. 286:1381-1383.
2. Hu, H., G. Huston, D. Duso, N. Lepak, E. Roman, and S.L. Swain. 2001. CD4 T cell effectors can become memory cells with high efficiency and without further division. Nat. Immunol. 2:705-710.
3. Kassiotis, G., S. Garcia, E. Simpson, and B. Stockinger. 2002. Impairment of immunological memory in the absence of MHC despite survival of memory T cells. Nat. Immunol. 3:244-250.
4. Gottlieb, E., S.M. Armour, and C.B. Thompson. 2002. Mitochondrial respiratory control is lost during growth factor deprivation. Proc. Natl. Acad. Sci. USA. 99:12801-12806.
5. Hildeman, D.A., Y. Zhu, T.C. Mitchell, P. Bouillet, A. Strasser, J. Kappler, and P. Marrack. 2002. Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim. Immunity. 16:759-767.
6. Dooms, H., and A.K. Abbas. 2002. Life and death in effector T cells. Nat. Immunol. 3:797-798.
7. Rafaeli, Y., L. Van Parijs, C.A. London, J. Tschopp, and A.K. Abbas. 1998. Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis. Immunity. 8:615-623.
8. Zhang, X., T. Brunner, L. Carter, R.W. Dutton, P. Rogers, L. Bradley, T. Sato, J. Reed, D. Green, and S.L. Swain. 1997. Unequal death in T helper cell (Th)1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosis. J. Exp. Med. 185:1837-1849.
9. Zhang, X., L. Giangreco, H.E. Broome, C.M. Dargan, and S.L. Swain. 1995. Control of CD4 effector fate: TGFβ1 and IL-2 synergize to prevent apoptosis and promote effector expansion. J. Exp. Med. 182:699-709.
10. Chen, W., W. Jin, H. Tian, P. Sicurello, M. Frank, J.M. Orenstein, and S.M. Wahl. 2001. Requirement for transforming growth factor β1 in controlling T cell apoptosis. J. Exp. Med. 194:439-453.
11. Liu, Y., and C.A. Janeway, Jr. 1990. Interferon-γ plays a critical role in induced cell death of effector T cell: a possible third mechanism of self-tolerance. J. Exp. Med. 172:1735-1739.
12. - cells and IFN-γ. J. Exp. Med. 186:71-81.
13. Dalton, D.K., L. Haynes, C. Chu, S.L. Swain, and S. Wittmer. 2000. Interferon-γ eliminates responding CD4 T cells during mycobacterial infection by inducing apoptosis of activated CD4 T Cells. J. Exp. Med. 192:117-212.
14. Rafaeli, Y., L. Van Parijs, S.I. Alexander, and A.K. Abbas. 2002. Interferon-γ is required for activation-induced death of T lymphocytes. J. Exp. Med. 196:999-1005.
15. Hildeman, D.A., T. Mitchell, T.K. Teague, P. Henson, B.J. Day, J. Kappler, and P.C. Marrack. 1999. Reactive oxygen species regulate activation-induced T cell apoptosis. Immunity. 10:735-744.
16. Harbertson, J., E. Biederman, K.E. Bennett, R.M. Kondrack, and L.M. Bradley. 2002. Withdrawal of stimulation may initiate the transition of effector to memory CD4 Cells. J. Immunol. 168:1095-1102.
17. Vella, A., T.K. Teague, J. Ihle, J. Kappler, and P. Marrack. 1997. Interleukin 4 (IL-4) of IL-7 prevents the death of resting T cells: stat 6 is probably not required for the effect of IL-4. J. Exp. Med. 186:325-330.
18. Schluns, K.S., W.C. Kieper, S.C. Jameson, and L. LeFrancois. 2000. Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo. Nat. Immunol. 1:426-432.
19. Tan, J.T., E. Dudl, E. LeRoy, R. Murray, J. Sprent, K.I. Weinberg, and C.D. Surh. 2001. IL-7 is critical for homeostatic proliferation and survival of naive T cells. Proc. Natl. Acad. Sci. USA. 98:8732-8737.
20. Vivien, L., C. Benoist, and D. Mathis. 2001. T lymphocytes need IL-7 but not IL-4 or IL-6 to survive in vivo. Int. Immunol. 13:763-768.
21. Rathmell, J.C., E.A. Farkash, W. Gao, and C.B. Thompson. 2001. IL-7 enhances the survival and maintains the size of naive T cells. J. Immunol. 167:6869-6876.
22. Jelley-Gibbs, D.M., N. Lepak, M. Yen, and S.L. Swain. 2000. Two distinct stages in the transition from naive CD4 T cells to effectors, early antigen dependent and late cytokine driven expansion and differentiation. J. Immunol. 165:5017-5026.
23. + T cells. J. Exp. Med. 194:1711-1719.
24. + cells. J. Exp. Med. 195:1523-1532.
25. + T cells in vivo by IL-15. Immunity. 8:591-599.
26. + memory cells by opposing cytokines. Science. 288:675-678.
27. Lodolce, J.P., D.L. Boone, S. Chai, R.E. Swain, T. Dassopoulos, S. Trettin, and A. Ma. 1998. IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity. 9:669-676.
28. Becker, T.C., E.J. Wherry, D. Boone, K. Murali-Krishna, R. Antia, A. Ma, and R. Ahmed. 2002. Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells. J. Exp. Med. 195:1541-1548.
29. Peschon, J.J., P.J. Morrissey, K.H. Grabstein, F.J. Ramsdell, E. Maraskovsky, B.C. Gliniak, L.S. Park, S.F. Ziegler, D.E. Williams, and C.B. Ware. 1994. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J. Exp. Med. 180:1955-1960.
30. + T cells. J. Exp. Med. 195:1533-1539.
31. Akashi, K., M. Kondo, U. von Freeden-Jeffry, R. Murray, and I.L. Weissman. 1997. Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice. Cell. 89:1033-1041.
32. Maraskovsky, E., L.A. O'Reilly, M. Teepe, L.M. Corcoran, J.J. Peschon, and A. Strasser. 1997. Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice. Cell. 89:1011-1019.
33. von Freeden-Jeffry, U., N. Solvason, M. Howard, and R. Murray. 1997. The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression. Immunity. 7:147-154.
34. Khaled, A.R., W.Q. Li, J. Huang, T.J. Fry, A.S. Khaled, C.L. Mackall, K. Muegge, H.A. Young, and S.K. Durum. 2002. Bax deficiency partially corrects interleukin-7 receptor alpha deficiency. Immunity. 17:561-573.
35. Lantz, O., I. Grandjean, P. Matzinger, and J.P. Di Santo. 2000. Gamma chain required for naïve CD4+ T cell survival but not for antigen proliferation. Nat. Immunol. 1:54-58.
36. Seddon, B., P. Tomlinson, and R. Zamoyska. 2003. Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells. Nat. Immunol. 4:680-686.
37. Kusser, K.L., and T.D. Randall. 2003. Simultaneous detection of EGFP and cells surface markers by fluorescence microscopy in lymphoid tissues. J. Histochem. Cytochem. 51:5-14.
38. Karasuyama, H. 1988. Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using high-copy cDNA expression vectors [in Japanese]. Tanpakushitsu Kakusau Koso. 33:2527-2532.
39. Grabstem, K.H., T.J. Waldschmidt, F.D. Finkelman, B.W. Hess, A.R. Alpert, N.E. Boiai, A.E. Namen, and P.J. Morrissey. 1993. Inhibition of murine B and T lymphopoiesis in vivo by anti-interleukin 7 monoclonal antibody. J. Exp. Med. 178:257-264.
40. Suda, T., S. Nishikawa, N. Ohno, N. Akiyama, M. Takakoshi, H. Yoshida, and S.-I. Nishikawa. 1993. Expression and function of the interleukin 7 receptor in murine lymphocytes. Proc. Natl. Acad. Sci. USA. 90:9125-9129.
41. + T cells. J. Exp. Med. 195:1515-1522.
42. Kondrack, R.M., J. Harbertson, J.T. Tan, M.E. McBreen, C.D. Surh, and L.M. Bradley. 2003. Interleukin 7 regulates the survival and generation of memory CD4 cells. J. Exp. Med. 198:1797-1806.