Broad programming by IL-2 receptor signaling for extended growth to multiple cytokines and functional maturation of antigen-activated T cells

Journal of Immunology

Volumn 166, Issue 3, 2001, Pages 1675-1683

  Malek, T R ^a   Yu, A ^a   Scibelli, P ^a   Lichtenheld, M G ^a   Codias, E K ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CD28 ANTIGEN; CYCLIN D3; CYTOKINE; GAMMA INTERFERON; GLYCOPROTEIN GP 39; GRANZYME B; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 4; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; CELL GROWTH; CELL MATURATION; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXIC T LYMPHOCYTE; EFFECTOR CELL; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TRANSGENIC MOUSE;

EID: 0035253708     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.3.1675     Document Type: Article

References (46)

1. c-dependent cytokines and receptors: Regulation of T lymphocyte development and homeostasis
2. Biology of the interleukin-2 receptor
3. IL-15: A pleiotropic cytokine with diverse receptor/signaling pathways whose expression is controlled at multiple levels
4. Cytokine receptor signaling
5. Jaks and STATs: Biological implications
6. Lymphokine regulation of activation-induced apoptosis in T cells of IL-2 and IL-2Rβ knockout mice
7. T cell growth cytokines cause the superinduction of molecules mediating antigen-induced T lymphocyte death
8. In vitro generation of tumor-specific cytotoxic lymphocytes: Secondary allogeneic mixed tumor lymphocyte culture of normal murine spleen cells
9. Selective in vitro growth of T lymphocytes from normal human bone marrows
10. CD28 costimulation mediates T cell expansion via IL-2-independent and IL-2-dependent regulation of cell cycle progression
11. Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F
12. Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin
13. The murine IL 2 receptor. II. Monoclonal anti-IL 2 receptor antibodies as specific inhibitors of T cell function in vitro
14. Monoclonal antibody directed against interleukin 2. I. Inhibition of T lymphocyte mitogenesis and the in vitro differentiation of alloreactive cytolytic T cells
15. + T lymphocytes form interleukin 2-deficient mice by costimulatory B7 molecules
16. Normal lymphoid homeostasis and lack of lethal autoimmunity in mice containing mature T cells with severely impaired IL-2 receptors
17. IL-2-independent activation and proliferation in human T cells induced by CD28
18. Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor β
19. Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment
20. Development and proliferation of lymphocytes in mice deficient for both interleukins-2 and -4
21. Two types of murine helper T cell clones. I. Definition according to profiles of lymphokine activities and secreted proteins
22. Expression and functional properties of mouse B7/BB1 using a fusion protein between mouse CTLA4 and human γ1
23. Expression and function of the interleukin 7 receptor in murine lymphocytes
24. The murine interleukin 2 receptor. Irreversible cross-linking of radiolabeled interleukin 2 to high affinity interleukin 2 receptors reveals a noncovalently associated subunit
25. Generation of primary tumor-specific CTL in vitro to immunogenic and poorly immunogenic mouse tumors
26. Identification and initial characterization of a rat monoclonal antibody reactive with the murine interleukin 2 receptor-ligand complex
27. Determination of lymphocyte division by flow cytometry
28. The murine IL 2 receptor. III. Cellular requirements for the induction of IL-2 receptor expression on T cell subpopulations
29. Nucleotide sequence and expression of a mouse interleukin 2 receptor cDNA
30. The murine interleukin-2 receptor: Biochemical structure and regulation of expression
31. Interleukin 2 upregulates expression of its receptor on a T cell clone
32. Generation of polarized antigen-specific CD8 effector populations: Reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles
33. Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting
34. + T cell survival but not for antigen proliferation
35. Defective lymphoid development in mice lacking expression of the common cytokine receptor γ-chain
36. T cell activation and the cytoskeleton
37. The involvement of interleukin (IL)-15 in regulating the differentiation of granulated metrial gland cells in mouse pregnant uterus
38. Interleukin 4 mediates autocrine growth of helper T cells after antigenic stimulation
39. Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells
40. CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL
41. CD28-Mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon γ production
42. Role of costimulation in the induction of the IL-12/IL-12 receptor pathway and the development of autoimmunity
43. Immune responses in interleukin-2-deficient mice
44. Antiviral immune responses in mice deficient for both interleukin-2 and interleukin-4
45. + T cell interactions in IFN-γ and IL-4 responses to viral infections: Requirements for 1L-2
46. Endogenous 1L-2 contributes to T cell expansion and IFN-γ production during lymphocytic choriomeningitis virus infection