Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity

Nature Genetics

Volumn 39, Issue 3, 2007, Pages 329-337

  Yamanouchi, Jun ^a   Rainbow, Dan ^b   Serra, Pau ^a   Howlett, Sarah ^b   Hunter, Kara ^b   Garner, Valerie E S ^b   Gonzalez Munoz, Andrea ^b   Clark, Jan ^b   Veijola, Riitta ^b   Cubbon, Rose ^c   Chen, Show Ling ^c   Rosa, Raymond ^c   Cumiskey, Anne Marie ^c   Serreze, David V ^d   Gregory, Simon ^e   Rogers, Jane ^e   Lyons, Paul A ^b   Healy, Barry ^b   Smink, Luc J ^b   Todd, John A ^b   Peterson, Laurence B ^c   Wicker, Linda S ^b   Santamaria, Pere ^a   more..

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c MERCK RESEARCH LABORATORIES   (United States)

^d JACKSON LABORATORY   (United States)

^e WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CD4+ CD25+ T LYMPHOCYTE; CHROMOSOME 3; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE PREDISPOSITION; GENE; GENE EXPRESSION; HOMEOSTASIS; LYMPHOCYTE FUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE;

ALLELES; ANIMALS; AUTOIMMUNITY; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DIABETES MELLITUS, TYPE 1; HOMEOSTASIS; INTERLEUKIN-2; MICE; MICE, CONGENIC; MICE, INBRED NOD; T-LYMPHOCYTES, REGULATORY; TRANSCRIPTION, GENETIC;

EID: 33847246293     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng1958     Document Type: Article

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