CD4+ and CD8+ T cell interactions in IFN-γ and IL-4 responses to viral infections: Requirements for IL-2

Journal of Immunology

Volumn 160, Issue 10, 1998, Pages 5007-5017

  Su, Helen C ^a   Cousens, Leslie P ^a   Fast, Loren D ^a   Slifka, Mark K ^b   Bungiro, Richard D ^a   Ahmed, Rafi ^b   Biron, Christine A ^a  

^a BROWN UNIVERSITY   (United States)

^b EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CELL INTERACTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; IMMUNE RESPONSE; LYMPHOCYTE PROLIFERATION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; VIRUS INFECTION;

ANIMALS; ANTIBODIES, VIRAL; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL COMMUNICATION; FEMALE; FLOW CYTOMETRY; INTERFERON TYPE II; INTERLEUKIN-2; INTERLEUKIN-4; LYMPHOCYTIC CHORIOMENINGITIS; MALE; MICE; MICE, INBRED C57BL;

EID: 0032524968     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (67)

1. + T cells. Annu. Rev. Immunol. 12:635.
2. Biron, C. A., and R. T. Gazzinelli. 1995. Effects of IL-12 on immune responses to microbial infections: a key mediator in regulating disease outcome. Curr. Opin. Immunol. 7:485.
3. Biron, C. A. 1994. Cytokines in the generation of immune responses to, and resolution of, virus infection. Curr. Opin. Immunol. 6:530.
4. + T cell depletion. Reg. Immunol. 5:142.
5. Sarawar, S. R., and P. C. Doherty. 1994. Concurrent production of interleukin-2, interleukin-10, and gamma interferon in the regional lymph nodes of mice with influenza pneumonia. J. Virol. 68:3112.
6. Graziosi, C., G. Pantaleo, K. R. Gantt, J.-P. Fortin, J. F. Demarest, O. J. Cohen, R. P. Sékaly, and A. S. Fauci. 1994. Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals. Science 265:248.
7. Graziosi, C., K. R. Gantt, M. Vaccarezza, J. F. Demarest, M. Daucher, M. S. Saag, G. M. Shaw, T. C. Quinn, O. J. Cohen, C. C. Welbon, G. Pantaleo, and A. S. Fauci. 1996. Kinetics of cytokine expression during primary human immunodeficiency virus type 1 infection. Proc. Natl. Acad. Sci. USA 93:4386.
8. Orange, J. S., and C. A. Biron. 1996. An absolute and restricted requirement for IL-12 in natural killer IFN-γ production and antiviral defense. J. Immunol. 156:1138.
9. Oldstone, M. B. A., P. Blount, P. J. Southern, and P. W. Lampert. 1986. Cytoimmunotherapy for persistent virus infection reveals a unique clearance pattern from the central nervous system. Nature 321:239.
10. + T cells and nonspecific bone marrow-derived cells. J. Virol. 61:3930.
11. + T lymphocytes mediate clearance of virus and regulate the antiviral antibody response. J. Virol. 61:1867.
12. Fung-Leung, W.-P., T. M. Kündig, R. M. Zinkernagel, and T. W. Mak. 1991. Immune response against lymphocytic choriomenigitis virus infection in mice without CD8 expression. J. Exp. Med. 174:1425.
13. Biron, C. A., R. J. Natuk, and R. M. Welsh. 1986. Generation of large granular T lymphocytes in vivo during viral infection. J. Immunol. 136:2280.
14. Biron, C. A., K. F. Pedersen, and R. M. Welsh. 1987. Aberrant T cells in beige mutant mice. J. Immunol. 138:2050.
15. Lau, L. L., B. D. Jamieson, T. Somasundaram, and R. Ahmed. 1994. Cytotoxic T cell memory without antigen. Nature 369:648.
16. Leist, T. P., S. P. Cobbold, H. Waldmann, M. Aguet, and R. M. Zinkernagel. 1987. Functional analysis of T lymphocyte subsets in antiviral host defense. J. Immunol. 138:2278.
17. Gessner, A., D. Moskophidis, and F. Lehmann-Grube. 1989. Enumeration of single IFN-γ-producing cells in mice during viral and bacterial infection. J. Immunol. 142:1293.
18. + T helper cell function in vivo: differential requirement for induction of antiviral cytotoxic T-cell and antibody responses. J. Virol 62:2106.
19. Lynch, F., P. C. Doherty, and R. Ceredig. 1989. Phenotypic and functional analysis of the cellular response in regional lymphoid tissue during an acute virus infection. J. Immunol. 142:3592.
20. + cells in sustaining lymphocyte proliferation during lymphocytic choriomeningitis virus infection. J. Immunol. 146:1955.
21. + cells but markedly decreased helper cell activity in mice lacking CD4. Nature 353:180.
22. + cytotoxic T-cell responses during chronic viral infection. J. Virol. 68:8056.
23. Battegay, M., M. F. Bachmann, C. Burhkart, S. Viville, C. Benoist, D. Mathis, H. Hengartner, and R. M. Zinkernagel. 1996. Antiviral immune responses of mice lacking MHC class II or its associated invariant chain. Cell. Immunol. 167:115.
24. Huang, S., W. Dendriks, A. Althage, S. Hemmi, H. Bluethmann, R. Kamijo, J. Vilcek, R. M. Zinkemagel, and M. Aguet. 1993. Immune responses in mice that lack the interferon-γ receptor. Science 259:1742.
25. Müller, U., U. Steinhoff, L. F. L. Reis, S. Hemmi, J. Pavlovic, R. M. Zinkernagel, and M. Aguet. 1994. Functional role of type I and type II interferons in antiviral defense. Science 264:1918.
26. Kündig, T. M., H. Schorle, M. F. Bachmann, H. Hengartner, R. M. Zinkernagel, and I. Horak. 1993. Immune responses in interleukin-2-deficient mice. Science 262:1059.
27. Bachmann, M. F., H. Schorle, R. Kühn, W. Müller, H. Hengartner, R. M. Zinkernagel, and I. Horak. 1995. Antiviral immune responses in mice deficient for both interleukin-2 and interleukin-4. J. Virol. 69:4842.
28. + lymphocytes during virus infection in vivo. J. Immunol. 142:1287.
29. Cousens, L. P., J. S. Orange, and C. A. Biron. 1995. Endogenous IL-2 contributes to T cell expansion and IFN-γ production during lymphocytic choriomeningitis virus infection. J. Immunol. 155:5690.
30. Su, H. C., R. Ishikawa, and C. A. Biron. 1993. Transforming growth factor-β expression and natural killer cell responses during virus infection of normal, nude, and SCID mice. J. Immunol. 151:4878.
31. Su, H. C., J. S. Orange, L. D. Fast, A. T. Chan, S. J. Simpson, C. Terhorst, and C. A. Biron. 1994. IL-2-dependent NK cell responses discovered in virus-infected β2-microglobulin-deficient mice. J. Immunol. 153:5674.
32. O'Garra, A., and K. W. Murphy. 1996. Role of cytokines in determining T cell function (mouse). In Weir's Handbook of Experimental Immunology, 5th Ed. D. M. Weir, ed. Blackwell Science, Cambridge, p. 226.1.
33. Orange, J. S., B. Wang, C. Terhorst, and C. A. Biron. 1995. Requirement for natural killer cell-produced interferon γ in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration. J. Exp. Med. 182:1045.
34. Ahmed, R., A. Salmi, L. D. Butler, J. M. Chiller, and M. B. A. Oldstone. 1984. Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice: role in suppression of cytotoxic T lymphocyte response and viral persistence. J. Exp. Med. 60:521.
35. Slifka, M. K., M. Matloubian, and R. Ahmed. 1995. Bone marrow is a major site of long-term antibody production after acute viral infection. J. Virol. 69:1895.
36. + T cells secreting Th1 or Th2 cytokines. Immunity 2:271.
37. Carter, L. L., and R. W. Dutton. 1996. Type 1 and type 2: a fundamental dichotomy for all T-cell subsets. Curr. Opin. Immunol. 8:336.
38. Croft, M., L. Carter, S. L. Swain, and R. W. Dutton. 1994. Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles. J. Exp. Med. 180:1715.
39. Sypeck, J. P., C. L. Chung, S. E. H. Mayor, J. M. Subramanyam, S. J. Goldman, D. S. Sieburth, S. F. Wolf, and R. G. Schaub. 1993. Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response. J. Exp. Med. 177:1797.
40. Tishon, A., H. Lewicki, G. Rall, M. von Herrath, and M. B. A. Oldstone. 1995. An essential role for type 1 interferon-γ in terminating persistent viral infection. Virology 212:244.
41. Prystowsky, M. B., J. M. Ely, D. I. Beller, L. Eisenberg, J. Goldman, E. Goldwasser, J. Ihle, J. Quintans, H. Remold, S. N. Vogel, and F. W. Fitch. 1982. Alloreactive cloned T cell lines. VI. Multiple lymphokine activities secreted by helper and cytolytic cloned T lymphocytes. J. Immunol. 129:2337.
42. Powers, G. D., A. K. Abbas, and R. A. Miller. 1988. Frequencies of IL-2- and IL-4-secreting T cells in naive and antigen-stimulated lymphocyte populations. J. Immunol. 140:3352.
43. Ehlers, S., and K. A. Smith. 1991. Differentiation of T cell lymphokine gene expression: the in vitro acquisition of T cell memory. J. Exp. Med. 173:25.
44. Farrar, W. L., H. M. Johnson, and J. J. Farrar. 1981, Regulation of the production of immune interferon and cytotoxic T lymphocytes by interleukin 2. J. Immunol. 126:1120.
45. Torres, B. A., W. L. Farrar, and H. M. Johnson. 1982. Interleukin 2 regulates immune interferon (IFN-γ) production by normal and suppressor cell cultures. J, Immunol. 128:2217.
46. Yamamoto, J. K., W. L. Farrar, and H. M. Johnson. 1982. Interleukin 2 regulation of mitogen induction of immune interferon (IFN-γ) in spleen cells and thymocytes. Cell. Immunol. 66:333.
47. Kasahara, T., J. J. Hooks, S. F. Dougherty, and J. J. Oppenheim. 1983. Interleukin 2-mediated immune interferon (IFN-γ) production by human T cells and T cell subsets. J. Immunol. 130:1784.
48. Reem, G. H., and N.-H. Yeh. 1984. Interleukin 2 regulates expression of its receptor and synthesis of gamma interferon by human T lymphocytes. Science 225:429.
49. Kelso, A., H. R. MacDonald, K. A. Smith, J.-C. Cerottini, and K. T. Brunner. 1984. Interleukin 2 enhancement of lymphokine secretion by T lymphocytes: analysis of established clones and primary limiting dilution microcultures. J. Immunol. 132:2932.
50. Vilcek, J., D. Henriksen-Destefano, D. Siegel, A. Kilon, R. J. Robb, and J. Le. 1985. Regulation of IFN-γ induction in human peripheral blood cells by exogenous and endogenously produced interleukin 2. J. Immunol. 135:1851.
51. Dunn, D. E., K. C. Herold, G. R. Otten, D. W. Lancki, T. Gajewski, S. N. Vogel, and F. W. Fitch. 1987. Interleukin 2 and concanavalin A stimulate interferon-γ production in a murine cytolytic T cell clone by different pathways. J. Immunol. 139:3942.
52. Swain, S. L. 1991. Lymphocytes and the immune response: the central role of interleukin-2. Curr. Opin. Immunol. 3:304.
53. Meuer, S. C. R. E. Hussey, D. A. Cantrell, J. C. Hodgdon, S. F. Schlossman, K. A. Smith, and E. L. Reinhertz. 1984. Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway. Proc. Natl. Acad. Sci. USA 81:1509.
54. Ben-Sasson, S. Z., G. Le Gros, D. H. Conrad, F. D. Finkelman, and W. E. Paul. 1990. IL-4 production by T cells from naive donors: IL-2 is required for IL-4 production. J. Immunol. 145:1127.
55. Le Gros, G., S. Z. Ben-Sasson, R. Seder, F. D. Finkelman, and W. E. Paul. 1990. Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J. Exp. Med. 172:921.
56. + T cells by CD1-expressing cortical thymocytes. J. Exp. Med. 182:2091.
57. Zajac, A. J., D. Muller, K. Pederson, J. A, Frelinger, and D. G. Quinn. 1995. Natural killer cell activity in lymphocytic choriomeningitis virus-infected beta 2 microglobulin-deficient mice. Int. Immunol. 7:1545.
58. + T lymphocytes in virus-infected beta 2-microglobulin-deficient mice. Cell. Immunol. 173:261.
59. + cytotoxic T-cell-mediated pathogenesis during virus infection. Proc. Natl. Acad. Sci. USA 93:14730.
60. + T cells that promptly produce interleukin 4. Proc. Natl. Acad. Sci. USA 92:11931.
61. Junghans, R. P., and C. L. Anderson. 1996. The protection receptor for IgG catabolism is the β2-microglobulin-containing neonatal intestinal transport receptor. Proc. Natl. Acad. Sci. USA 93:5512.
62. Israel, E. J., D. F. Wilsker, K. C. Hayes, D. Schoenfeld, and N. E. Simister. 1996. Increased clearance of IgG in mice that lack beta 2-microglobulin: possible protective role of FcRn. Immunology 89:573.
63. + T lymphocytes because of disruption of the β2-microglobulin gene. J. Virol. 67:332.
64. Epstein, S. L., J. A. Misplon, C. M. Lawson, E. K. Subbarao, M. Connors, and B. R. Murphy. 1993. β2-microglobulin-deficient mice can be protected against influenza A infection by vaccination with vaccinia-influenza recombinants expressing hemagglutinin and neuraminidase. J. Immunol. 150:5484.
65. + T-cell-deficient mice survive inoculation with high doses of vaccinia virus and exhibit altered IgG responses. Proc. Natl. Acad. Sci. USA 89:6070.
66. Kühn, R., K. Rajewsky, and W. Müller. 1991. Generation and analysis of interleukin-4 deficient mice. Science 254:707.
67. Kopf, M., G. Le Gros, M. Bachmann, M. C. Lamers, H. Bluethmann, and G. Köhler. 1993. Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature 362:245.