IL-2Rβ links IL-2R signaling with Foxp3 expression

European Journal of Immunology

Volumn 37, Issue 7, 2007, Pages 1817-1826

  Soper, David M ^a,b   Kasprowicz, Deborah J ^a   Ziegler, Steven F ^a,b  

^a BENAROYA RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Foxp3; IL 2; Regulatory T cells

Indexed keywords

INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 2 RECEPTOR BETA; TRANSCRIPTION FACTOR FOXP3; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; C57BL 6 MOUSE; CELL COUNT; CONTROLLED STUDY; GENE EXPRESSION; LYMPHOPROLIFERATIVE DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; THYMUS; TRANSGENE; ANIMAL; BIOSYNTHESIS; CELL DIFFERENTIATION; CONFOCAL MICROSCOPY; CYTOLOGY; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; IMMUNOLOGY; METABOLISM; TRANSGENIC MOUSE;

ANIMALS; AUTOIMMUNITY; CELL DIFFERENTIATION; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION; GENE EXPRESSION REGULATION; INTERLEUKIN-2; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; INTERLEUKIN-2 RECEPTOR BETA SUBUNIT; MICE; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, REGULATORY;

EID: 34447572680     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200737101     Document Type: Article

References (43)

1. Godfrey, V. L., Wilkinson, J. E., Rinchik, E. M. and Russell, L. B., Fatal lymphoreticular disease in the scurfy (sf) mouse requires T cells that mature in a sf thymic environment: Potential model for thymic education. Proc. Natl. Acad. Sci. USA 1991. 88: 5528-5532.
2. Godfrey, V. L., Wilkinson, J. E. and Russell, L. B., X-linked lymphoreticular disease in the scurfy (sf) mutant mouse. Am. J. Pathol. 1991. 138: 1379-1387.
3. Powell, B. R., Buist, N. R. and Stenzel, P., An X-linked syndrome of diarrhea, polyendocrinopathy, and fatal infection in infancy. J. Pediatr. 1982. 100: 731-737.
4. Clark, L. B., Appleby, M. W., Brunkow, M. E., Wilkinson, J. E., Ziegler, S. F. and Ramsdell, F., Cellular and molecular characterization of the scurfy mouse mutant. J. Immunol. 1999. 162: 2546-2554.
5. + regulatory T cells. Nat. Immunol. 2003. 4: 330-336.
6. + T regulatory cells. Nat. Immunol. 2003. 4: 337-342.
7. Hori, S., Nomura, T. and Sakaguchi, S., Control of regulatory T cell development by the transcription factor Foxp3. Science 2003. 299: 1057-1061.
8. + T cells. Eur. J. Immunol. 1995. 25: 3053-3059.
9. Sadlack, B., Merz, H., Schorle, H., Schimpl, A., Feller, A. C. and Horak, I., Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 1993. 75: 253-261.
10. Schorle, H., Holtschke, T., Hunig, T., Schimpl, A. and Horak, I., Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature 1991. 352: 621-624.
11. Suzuki, H., Kundig, T. M., Furlonger, C., Wakeham, A., Timms, E., Matsuyama, T., Schmits, R. et al., Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta. Science 1995. 268: 1472-1476.
12. Willerford, D. M., Chen, J., Ferry, J. A., Davidson, L., Ma, A. and Alt, F. W., Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity 1995. 3: 521-530.
13. Nelson, B. H., McIntosh, B. C., Rosencrans, L. L. and Greenberg, P. D., Requirement for an initial signal from the membrane-proximal region of the interleukin 2 receptor gamma(c) chain for Janus kinase activation leading to T cell proliferation. Proc. Natl. Acad. Sci. USA 1997. 94: 1878-1883.
14. Leonard, W. J., Depper, J. M., Crabtree, G. R., Rudikoff, S., Pumphrey, J., Robb, R. J., Kronke, M. et al., Molecular cloning and expression of cDNAs for the human interleukin-2 receptor. Nature 1984. 311: 626-631.
15. Lin, J. X. and Leonard, W. J., Signaling from the IL-2 receptor to the nucleus. Cytokine Growth Factor Rev. 1997. 8: 313-332.
16. Nikaido, T., Shimizu, A., Ishida, N., Sabe, H., Teshigawara, K., Maeda, M., Uchiyama, T. et al., Molecular cloning of cDNA encoding human interleukin-2 receptor. Nature 1984. 311: 631-635.
17. Rickert, M., Wang, X., Boulanger, M. J., Goriatcheva, N. and Garcia, K. C., The structure of interleukin-2 complexed with its alpha receptor. Science 2005. 308: 1477-1480.
18. Stauber, D. J., Debler, E. W., Horton, P. A., Smith, K. A. and Wilson, I. A., Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor. Proc. Natl. Acad. Sci. USA 2006. 103: 2788-2793.
19. + T cell numbers. J. Immunol. 2002. 169: 4850-4860.
20. + T regulatory cells. J. Immunol. 2006. 176: 3301-3305.
21. Setoguchi, R., Hori, S., Takahashi, T. and Sakaguchi, S., Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J. Exp. Med. 2005. 201: 723-735.
22. + T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10. J. Immunol. 2001. 166: 3008-3018.
23. Gavin, M. A., Clarke, S. R., Negrou, E., Gallegos, A. and Rudensky, A., Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo. Nat. Immunol. 2002. 3: 33-41.
24. Malek, T. R., Porter, B. O., Codias, E. K., Scibelli, P. and Yu, A., Normal lymphoid homeostasis and lack of lethal autoimmunity in mice containing mature T cells with severely impaired IL-2 receptors. J. Immunol. 2000. 164: 2905-2914.
25. Malek, T. R., Yu, A., Vincek, V., Scibelli, P. and Kong, L., CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. Immunity 2002. 17: 167-178.
26. + regulatory T cells. J. Immunol. 2007. 178: 280-290.
27. Antony, P. A., Paulos, C. M., Ahmadzadeh, M., Akpinarli, A., Palmer, D. C., Sato, N., Kaiser, A. et al., Interleukin-2-dependent mechanisms of tolerance and immunity in vivo. J. Immunol. 2006. 176: 5255-5266.
28. Kovanen, P. E. and Leonard, W. J., Cytokines and immunodeficiency diseases: Critical roles of the gamma(c)-dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways. Immunol. Rev. 2004. 202: 67-83.
29. Khattri, R., Kasprowicz, D., Cox, T., Mortrud, M., Appleby, M. W., Brunkow, M. E., Ziegler, S. F. and Ramsdell, F., The amount of scurfin protein determines peripheral T cell number and responsiveness. J. Immunol. 2001. 167: 6312-6320.
30. + CD4 T cells. Ann. N. Y. Acad. Sci. 2007. 1103: 167-178.
31. Kim, H. P., Imbert, J. and Leonard, W. J., Both integrated and differential regulation of components of the IL-2/IL-2 receptor system. Cytokine Growth Factor Rev. 2006. 17: 349-366.
32. Fontenot, J. D., Rasmussen, J. P., Gavin, M. A. and Rudensky, A. Y., A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat. Immunol. 2005. 6: 1142-1151.
33. + regulatory T cells. J. Immunol. 2004. 172: 5287-5296.
34. Cacalano, N. A., Sanden, D. and Johnston, J. A., Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras. Nat. Cell Biol. 2001. 3: 460-465.
35. Cohney, S. J., Sanden, D., Cacalano, N. A., Yoshimura, A., Mui, A., Migone, T. S. and Johnston, J. A., SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation. Mol. Cell. Biol. 1999. 19: 4980-4988.
36. Sitko, J. C., Guevara, C. I. and Cacalano, N. A., Tyrosine-phosphorylated SOCS3 interacts with the Nck and Crk-L adapter proteins and regulates Nck activation. J. Biol. Chem. 2004. 279: 37662-37669.
37. Fujii, H., Ogasawara, K., Otsuka, H., Suzuki, M., Yamamura, K., Yokochi, T., Miyazaki, T. et al., Functional dissection of the cytoplasmic subregions of the IL-2 receptor betac chain in primary lymphocyte populations. EMBO J. 1998. 17: 6551-6557.
38. + regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo. Blood 2006. 108: 1571-1579.
39. + T regulatory cells. J. Immunol. 2006. 177: 5115-5121.
40. Sharfe, N., Dadi, H. K., Shahar, M. and Roifman, C. M., Human immune disorder arising from mutation of the alpha chain of the interleukin-2 receptor. Proc. Natl. Acad. Sci. USA 1997 94: 3168-3171.
41. Nguyen, L. T., Jacobs, J., Mathis, D. and Benoist, C., Where Foxp3-dependent regulatory T cells impinge on the development of inflammatory arthritis. Arthritis Rheum. 2007. 56: 509-520.
42. + regulatory T cells in antitumor immune response. J. Immunol. 2005. 175: 4433-4440.
43. + T cell activation and cell death. Eur. J. Immunol. 2005. 35: 3424-3432.