Normal regulatory α/β T cells effectively eliminate abnormally activated T cells lacking the interleukin 2 receptor β in vivo

Journal of Experimental Medicine

Volumn 190, Issue 11, 1999, Pages 1561-1571

  Suzuki, Haruhiko ^a   Zhou, Yan Wen ^a   Kato, Masashi ^a   Mak, Tak W ^b   Nakashima, Izumi ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b AMGEN INSTITUTE   (Canada)

Author keywords

Adoptive transfer; Bone marrow transplantation; CD8+ T lymphocytes; Mice, knockout; T lymphocytes

Indexed keywords

INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; CHIMERA; CONTROLLED STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; B-LYMPHOCYTE SUBSETS; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; CD4-CD8 RATIO; CHIMERA; CROSSES, GENETIC; CYTOKINES; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; IMMUNOMAGNETIC SEPARATION; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DEPLETION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, INTERLEUKIN-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0342632839     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.190.11.1561     Document Type: Article

References (42)

1. Smith, K.A. 1988. Interleukin-2: inception, impact, and implications. Science. 240:1169-1176.
2. Waldmann, T.A. 1993. The IL-2/IL-2 receptor system: a target for rational immune intervention, Immunol. Today. 14: 264-270.
3. Minami, Y., T. Kono, T. Miyazaki, and T. Taniguchi. 1993. The IL-2 receptor complex: its structure, function, and target genes. Annu. Rev. Immunol. 11:245-268.
4. Sugamura, K., H. Asao, M. Kondo, N. Tanaka, N. Ishii, M. Nakamura, and T. Takeshita. 1995. The common γ-chain for multiple cytokine receptors. Adv. Immunol. 59:225-277.
5. Theze, J., P.M. Alzari, and J. Bertoglio. 1996. Interleukin 2 and its receptors: recent advances and new immunological functions. Immunol. Today. 17:481-486.
6. Nelson, B.H., and D.M. Willerford. 1998. Biology of the interleukin-2 receptor. Adv. Immunol. 70:1-81.
7. Schorle, H., T. Holtschke, T. Hünig, A. Schimpl, and I. Horak. 1991. Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature. 352:621-624.
8. Willerford, D.M., J. Chen, J.A. Ferry, L. Davidson, A. Ma, and F.W. Alt. 1995. Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment. Immunity. 3:521-530.
9. Suzuki, H., T.M. Kündig, C. Furlonger, A. Wakeham, E. Timms, T. Matsuyama, R. Schmits, J.J. Simard, P.S. Ohashi, H. Griesser, et al. 1995. Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor β. Science. 268:1472-1476.
10. Lenardo, M.J. 1991. Interleukin-2 programs mouse αβ T lymphocytes for apoptosis. Nature. 353:858-861.
11. Kneitz, B., T. Herrmann, S. Yonehara, and A. Schimpl. 1995. Normal clonal expansion but impaired Fas-mediated cell death and anergy induction in interleukin-2-deficient mice. Eur. J. Immunol. 25:2572-2577.
12. Van Parijs, L., A. Biuckians, A. Ibragimov, F.W. Alt, and A.K. Abbas. 1997. Functional responses and apoptosis of CD25 (1L-2R α)-deficient T cells expressing a transgenic antigen receptor. J. Immunol. 158:3738-3745.
13. Suzuki, H., A. Hayakawa, D. Bouchard, I. Nakashima, and T.W. Mak. 1997. Normal thymic selection, superantigen-induced deletion and Fas-mediated apoptosis of T cells in IL-2 receptor β chain-deficient mice. Int. Immunol. 9:1367-1374.
14. Sadlack, B., H. Merz, H. Schorle, A. Schimpl, A.C. Feller, and I. Horak. 1993. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell. 75:253-261.
15. Sadlack, B., R. Kühn, H. Schorle, K. Rajewsky, W. Müller, and I. Horak. 1994. Development and proliferation of lymphocytes in mice deficient for both interleukins-2 and -4. Eur. J. Immunol. 24:281-284.
16. Sadlack, B., J. Löhler, H. Schorle, G. Klebb, H. Haber, E. Sickel, R.J. Noelle, and I. Horak. 1995. Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells. Eur. J. Immunol. 25:3053-3059.
17. Zheng, L., C.L. Trageser, D.M. Willerford, and M.J. Lenardo. 1998. T cell growth cytokines cause the superinduction of molecules mediating antigen-induced T lymphocyte death. J. Immunol. 160:763-769.
18. Krämer, S., A. Schimpl, and T. Hünig. 1995. Immunopathology of interleukin (IL) 2-deficient mice: thymus dependence and suppression by thymus-dependent cells with an intact IL-2 gene. J. Exp. Med. 182:1769-1776.
19. Suda, T., T. Okazaki, Y. Naito, T. Yokota, N. Arai, S. Ozaki, K. Nakao, and S. Nagata. 1995. Expression of the Fas ligand in cells of T cell lineage. J. Immunol. 154:3806-3813.
20. Zheng, L., G. Fisher, R.E. Miller, J. Peschon, D.H. Lynch, and M.J. Lenardo. 1995. Induction of apoptosis in mature T cells by tumour necrosis factor. Nature. 377:348-351.
21. Cohen, P.L., and R.A. Eisenberg. 1991. Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease. Annu. Rev. Immunol. 9:243-269.
22. Pfeffer, K., T. Matsuyama, T.M. Kündig, A. Wakeham, K. Kishihara, A. Shahinian, K. Wiegmann, P.S. Ohashi, M. Kronke, and T.W. Mak. 1993. Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell. 73: 457-467.
23. Kagi, D., B. Ledermann, K. Burki, P. Seiler, B. Odermatt, K.J. Olsen, E.R. Podack, R.M. Zinkernagel, and H. Hengartner. 1994. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature. 369:31-37.
24. Heusel, J.W., R.L. Wesselschmidt, S. Shresta, J.H. Russell, and T.J. Ley. 1994. Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells. Cell. 76:977-987.
25. Rich, R.R., M.N. elMasry, and E.J. Fox. 1986. Human suppressor T cells: induction, differentiation, and regulatory functions. Hum. Immunol. 17:369-387.
26. Tada, T., F.Y. Hu, H. Kishimoto, M. Furutani-Seki, and Y. Asano. 1991. Molecular events in the T cell-mediated suppression of the immune response. Ann. NY Acad. Sci. 636: 20-27.
27. Tada, T., T. Inoue, and Y. Asano. 1992. Suppression of immune responses by cloned T cells and their products, Behring Inst. Mitt. 91:78-86.
28. Noble, A., G.A. Pestano, and H. Cantor. 1998. Suppression of immune responses by CD8 cells. I. Superantigen-activated CD8 cells induce unidirectional Fas-mediated apoptosis of antigen-activated CD4 cells. J. Immunol. 160:559-565.
29. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature. 389:737-742.
30. Kumar, V., and E. Sercarz. 1998. Induction or protection from experimental autoimmune encephalomyelitis depends on the cytokine secretion profile of TCR peptide-specific regulatory CD4 T cells. J. Immunol. 161:6585-6591.
31. (+) T cells prevent spontaneous experimental autoimmune encephalomyelitis in anti-myelin basic protein T cell receptor transgenic mice. J. Exp. Med. 188:1875-1882.
32. (-) thymocytes. J. Exp. Med. 189:279-288.
33. + regulatory T cells via IFN-γ. Scand. J. Immunol. 43:421-430.
34. - regulatory T cells. J. Immunol. 161: 5193-5202.
35. (+) T cells. Proc. Natl. Acad. Sci. USA. 95:4533-4537.
36. Asano, M., M. Toda, N. Sakaguchi, and S. Sakaguchi. 1996. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med. 184:387-396.
37. + T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage ot immunoregulatory cells. J. Immunol. 160: 1212-1218.
38. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin-2 production. J. Exp. Med. 188:287-296.
39. + naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int. Immunol. 10:1969-1980.
40. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J. Immunol. 162: 5317-5326.
41. + T cells: a population of T cells with immune regulatory activities in vitro. Eur. J. Immunol. 28:3435-3447.
42. + T cells expressing Vβ8 TCR: a role of the Qa-1 molecule. Immunity. 2:185-194.