Cellulose-bound peptide arrays: Preparation and applications

Biotechnology and Genetic Engineering Reviews

Volumn 24, Issue 1, 2007, Pages 31-106

  Hilpert, Kai ^a   Winkler, Dirk F H ^b   Hancock, Robert E W ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDE ARRAYS;

CELLULOSE; PEPTIDE;

AMINO ACID SEQUENCE; GENOME ANALYSIS; HUMAN; MICROORGANISM; NONHUMAN; PEPTIDE SYNTHESIS; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; REVIEW;

EID: 35649001474     PISSN: 02648725     EISSN: 20465556     Source Type: Journal    
DOI: 10.1080/02648725.2007.10648093     Document Type: Article

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203. Laune, D., Molina, F., Ferrieres, G., Mani, J.-C., Cohen, P., Simon, D., Bernardi, T., Piechaczyk, M., Pau, B., and Granier, C., 1997. Systematic exploration of the antigen binding activity of synthetic peptides isolated from the variable regions of immunoglobulins. The Journal of Biological Chemistry, 272:30937–30944.
204. Laune, D., Molina, F., Mani, J.-C., Del Rio, M., Bouanani, M., Pau, B., and Granier, C., 2000. Dissection of an antibody paratope into peptides discloses the idiotope recognized by the cognate anti-idiotypic antibody. Journal of Immunological Methods, 239:63–73.
205. Laune, D., Molina, F., Ferrieres, G., Villard, S., Bes, C., Rieunier, F., Chardes, T., and Granier, C., 2002. Application of the SPOT method to the identification of peptides and amino acids from the antibody paratope that contribute to antigen binding. Journal of Immunological Methods, 267:53–70.
206. Lazoura, E., Campbell, W., Yamaguchi, Y., Kato, K., Okada, N., and Okada, H., 2002. Rational structure-based design of a novel carboxypeptidase R inhibitor. Chemistry & Biology, 9:1129–1139.
207. Lenze, D., Berg, E., Volkmer-Engert, R., Weiser, A.A., Greiner, A., Knörr-Wittmann, C., Anagnostopoulos, I., Stein, H., and Hummel, M., 2006. Influence of antigen on the development of MALT lymphoma. Blood, 107:1141–1148.
208. Liang, M., Mahler, M., Koch, J., Ji, Y., Li, D., Schmaljohn, C., and Bautz, E.K.F., 2003. Generation of an HFRS patient-derived neutralizing recombinant antibody to Hantaan virus G1 protein and definition of the neutralizing domain. Journal of Medical Virology, 69:99–107.
209. Licha, K., Bhargava, S., Rheinländer, C., Becker, A., Schneider-Mergener, J., and Volkmer-Engert, R., 2000. Highly parallel nano-synthesis of cleavable peptide-dye conjugates on cellulose membranes. Tetrahedron Letters, 41:1711–1715.
210. Liljeqvist, J.-A., Trybala, E., Hoebeke, J., Svennerholm, B., and Bergström, T., 2002. Monoclonal antibodies and human sera directed to the secreted glycoprotein G of herpes simplex virus type 2 recognize type-specific antigenic determinants. Journal of General Virology, 83:157–165.
211. Lin, Q., O´Neill, J.C., and Blackwell, H.E., 2005. Small molecule macroarray construction via Ugi four component reactions. Organic Letters, 7:4455–4458.
212. Lishko, V.K., Podolnikova, N.P., Yakubenko, V.P., Yakovlev, S., Medved, L., Yadav, S.P., and Ugarova, T.P., 2004. Multiple binding sites in fibrinogen for integrin a Mß2 (Mac-1). The Journal of Biological Chemistry, 279:44897–44906.
213. Liu, Z., Song, D., Kramer, A., Martin, A.C.R., Dandekar, T., Schneider-Mergener, J., Bautz, E.K.F., and Dübel, S., 1999. Fine mapping of the antigen-antibody interaction of scFv215, a recombinant antibody inhibiting RNA polymerase II from Drosophila melanogaster. Journal of Molecular Recognition, 12:103–111.
214. Lizcano, J.M., Deak, M., Morrice, N., Kieloch, A., Hastie, C.J., Dong, L., Schutkowski, M., Reimer, U., and Alessi, D.R., 2002. Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK-6). Evidence that NEK-6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo. The Journal of Biological Chemistry, 277:27839–27849.
215. Llanos, R., Chevrier, V., Ronjat, M., Meurer-Grob, P., Martinez, P., Frank, R., Bornens, M., Wade, R.H., Wehland, J., and Job, D., 1999. Tubulin binding sites on g-tubulin:Identification and molecular characterization. Biochemistry, 38:15712–15720.
216. Loog, M., Toomik, R., Sak, K., Muszynska, G., Järv, J., and Ek, P., 2000. Peptide phosphorylation by calcium-dependent protein kinase from maize seedlings. European Journal of Biochemistry, 267:337–343.
217. Lu, Y.-A., and Tam, J.P., 2003. “ X-Cys ligation ”. In Peptide Revolution:Genomics, Proteomics & Therapeutics, Edited by:Chorev, M., and Sawyer, T.K., 159–160. San Diego:American Peptide Society.
218. Mahler, M., Mierau, R., and Blüthner, M., 2000. Fine-specificity of the anti-CENP-A B-cell autoimmune response. Journal of Molecular Medicine, 78:460–467.
219. Mahler, M., Mierau, R., Schlumberger, W., and Blüthner, M., 2001. A population of autoantibodies against a centromere-associated protein A major epitope motif cross-reacts with related cryptic epitopes on other nuclear autoantigens and on the Epstein-Barr nuclear antigen 1. Journal of Molecular Medicine, 79:722–731.
220. Mahler, M., Blüthner, M., and Koch, J., 2002. “ Affinity purification and competition assays using solid-phase oligopeptides ”. In Peptide Arrays on Membrane Support, Edited by:Koch, J., and Mahler, M., 107–122. Berlin Heidelberg:Springer-Verlag.
221. Mahler, M., Kessenbrock, K., Raats, J., Williams, R., Fritzler, M.J., and Blüthner, M., 2003. Characterization of the human autoimmune response to the major C-terminal epitope of the ribosomal P proteins. Journal of Molecular Medicine, 81:194–204.
222. Maier, B., Molinger, M., Cope, A.P., Fugger, L., Schneider-Mergener, J., Sonderstrup, G., Kamradt, T., and Kramer, A., 2000. Multiple cross-reactive self-ligands for Borrelia burgdorferi-specific HLA-DR4-restricted T cells. European Journal of Immunology, 30:448–457.
223. Maier, T., Yu, C., Külleritz, G., and Clemens, S., 2003. Localization and functional characterization of metal-binding sites in phytochelatin synthases. Planta, 218:300–308.
224. Malin, R., Steinbrecher, R., Jannsen, J., Semmler, W., Noll, B., Johannsen, B., Frömmel, C., Höhne, W., and Schneider-Mergener, J., 1995a. Identification of Technetium-99m binding peptides using combinatorial cellulose-bound peptide libraries. Journal of the American Chemical Society, 11 (7):11821–11822.
225. Malin, R., Reineke, U., Landgraf, C., Höhne, W., Semmler, W., Steinbrecher, R., and Schneider-Mergener, J., 1995b. “ Identification of technetium-99m and nickel binding peptides using combinatorial cellulose-bound peptide libraries ”. In Peptides 1994:Proceedings of the 23rd European Peptide Symposium, Edited by:Maia, H.L.S., 477–478. Leiden:ESCOM.
226. Manning, G., Whyte, D.B., Martinez, R., Hunter, T., and Sudarsanam, S., 2002. The protein kinase complement of the human genome. Science, 298:1912–1934.
227. Martens, W., Greiser-Wilke, I., Harder, T.C., Dittmar, K., Frank, R., Örvell, C., Moenning, V., and Liess, B., 1995. Spot synthesis of overlapping peptides on paper membrane supports enables the identification of linear monoclonal antibody binding determinants on morbillivirus phosphoproteins. Veterinary Microbiology, 44:289–298.
228. Mataraza, J.M., Briggs, M.W., Li, Z., Frank, R., and Sacks, D.B., 2003. Identification and characterization of the Cdc42-binding site of IQGAP1. Biochemical and Biophysical Research Communications, 305:315–321.
229. Mayboroda, O., Schlüter, K., and Lokusch, B.M., 1997. Differential colocalization of profilin with microfilaments in PfK2 cells. Cell Motility and the Cytoskeleton, 37:166–177.
230. McCarty, J.S., Rüdiger, S., Schönfeld, H.J., Schneider-Mergener, J., Nakahigashi, K., Yura, T., and Bukau, B., 1996. Regulatory region C of the E.coli heat shock transcription factor, s32, constitutes a DnaK binding site and is conserved among eubacteria. The Journal of Molecular Biology, 256:829–837.
231. Moilanen, A.-M., Karvonen, U., Poukka, H., Jänne, O.A., and Palvimo, J.J., 1998. Activation of androgen receptor function by a novel nuclear protein kinase. Molecular Biology of the Cell, 9:2527–2543.
232. Molina, F., Laune, D., Gougat, C., Pau, B., and Granier, C., 1996. Improved performances of spot multiple peptide synthesis. Peptide Research, 9:151–155.
233. Molina, F., Pau, B., and Granier, C., 1997. The PGK epitope of human thyroglobin:A molecular marker of alternatively spliced thyroglobin molecules?. Letters in Peptide Science, 4:201–205.
234. Montaner, A.D., De Nichilo, A., Elias, F., Rodriguez, J.M., Flo, J.M., Lopez, R.A., Zorzopulos, J., and Frank, R., 2006. Ganglioside GM1-binding peptides as adjuvants of antigens inoculated by the intranasal route. Vaccine, 24:1889–1896.
235. Münch, G., Schicktanz, D., Behme, A., Gerlach, M., Riederer, P., Palm, D., and Schinzel, R., 1999. Amino acid specificity of glycation and protein-AGE crosslinking reactivities determined with a dipeptide SPOT library. Nature Biotechnology, 17:1006–1010.
236. Mukhija, S., Germeroth, L., Schneider-Mergener, J., and Erni, B., 1998. Identification of peptides inhibiting enzyme I of the bacterial phosphotransferase system using combinatorial cellulose-bound peptide libraries. European Journal of Biochemistry, 254:433–438.
237. Mutter, M., and Vuilleumier, S., 1989. A chemical approach to protein design - template assembled synthetic proteins (TASP). Angewandte Chemie International Edition, 28:535–554. Angewandte Chemie101, 551–571
238. Naus, S., Reipschlager, S., Wildeboer, D., Lichtenthaler, S.F., Mitterreiter, S., Guan, Z., Moss, M.L., and Bartsch, J.W., 2006. Identification of candidate substrates for ectodomain shedding by the metalloprotease-disintegrin ADAM8. Biological Chemistry, 387:337–346.
239. Niebuhr, K., Ebel, F., Frank, R., Reinhard, M., Domann, E., Carl, U.D., Walter, U., Gertler, F.B., Wehland, J., and Chakraborty, T., 1997. A novel proline-rich motif present in ActA of Listeria moncytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family. The EMBO Journal, 16:5433–5444.
240. Niggemann, J., Michaelis, K., Frank, R., Zander, N., and Höfle, G., 2002. Natural product-derived building blocks for combinatorial synthesis. Part 1. Fragmentation of natural products from myxobacteria. Journal of the Chemical Society, Perkin Transitions, 1:2490–2503.
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242. Osman, A.A., Günnel, T., Dietl, A., Uhlig, H.H., Amin, M., Fleckenstein, B., and Richter, T., 1998. B cell epitopes of gliadin. Clinical Experimental Immunology, 121:248–254.
243. Otte, L., Wiedemann, U., Kretzschmar, I., Oschkinat, H., Volkmer-Engert, R., and Schneider-Mergener, J., 2002. “ Binding specificity of 42 WW domains ”. In Peptides 2002:Proceedings of the 27th European Peptide Symposium, Edited by:Benedetti, E., and Pedone, C., 994–995. Naples:Edizioni Ziino.
244. Otte, L., Wiedemann, U., Schlegel, B., Pires, J.R., Beyermann, M., Schmieder, P., Krause, G., Volkmer-Engert, R., Schneider-Mergener, J., and Oschkinat, H., 2003. WW domain sequence activity relationships identified using ligand recognition propensities of 42 WW domains. Protein Science, 12:491–500.
245. Otte, L., Knaute, T., Schneider-Mergener, J., and Kramer, A., 2006. Molecular basis for the binding polyspecificity of an anti-cholera toxin peptide 3 monoclonal antibody. Journal of Molecular Recognition, 19:49–59.
246. Otvos, L., Jr., Pease, A.M., Bokonyi, K., Giles-Davis, W., Rogers, M.E., Hintz, P.A., Hoffman, R., and Ertl, H.C.J., 2000. In situ stimulation of a T helper cell hybrodoma with a cellulose-bound peptide antigen. Journal of Immunological Methods, 233:95–1051.
247. Panse, S., Dong, L., Burian, A., Carus, R., Schutkowski, M., Reimer, U., and Schneider-Mergener, J., 2004. Profiling of generic anti-phosphopeptide antibodies and kinases with peptide microarrays using radioactive and fluorescence-based assays. Molecular Diversity, 8:291–299.
248. Papgrigoriou, E., Gingras, A.R., Barsukov, I.L., Bate, N., Fillingham, I. J., Patel, B., Frank, R., Ziegler, W. H., Roberts, G.C.K., Critchley, D.R., and Emsley, J., 2004. Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle. The EMBO Journal, 23:2942–2951.
249. Pessi, A., 2002. Editorial:Peptide-based strategies for protease inhibition). Biopolymers (Peptide Science), 66:77–78.
250. Petersen, G., 2002. “ Manual peptide synthesis ”. In Peptide Arrays on Membrane Support, Edited by:Koch, J., and Mahler, M., 41–53. Berlin Heidelberg:Springer-Verlag.
251. Pflegerl, K., Hahn, R., Berger, E., and Jungbauer, A., 2002. Mutational analysis of a blood coagulation factor VIII-binding peptide. Journal of Peptide Research, 59:174–182.
252. Piossek, C., Schneider-Mergener, J., Schirner, M., Vakalopoulou, E., Germeroth, L., and Thierauch, K.-H., 1999a. Vascular endothelial growth factor (VEGF) receptor II-derived peptides inhibit VEGF. The Journal of Biological Chemistry, 274:5612–5619.
253. Piossek, C., Thierauch, K.-H., Schneider-Mergener, J., and Germeroth, L., 1999b. “ Unexpected increase of binding affinity during the transformation of a L- into a D-peptide inhibiting the vascular endothelial growth factor ”. In Peptides 1998:Proceedings of the 25th European Peptide Symposium, Edited by:Bajusz, S., and Hudecz, F., 618–619. Budapest:Akademiai Kiado.
254. Piossek, C., Thierauch, K.-H., Schneider-Mergener, J., Volkmer-Engert, R., Bachmann, M.F., Korff, T., Augustin, H.G., and Germeroth, L., 2003. Potent inhibition of angiogenesis by D, L-peptides derived from vascular endothelial growth factor receptor 2. Thromb Haemost, 90:501–510.
255. Piotukh, K., Gu, W., Kofler, M., Labudde, D., Helm, V., and Freund, C., 2005. Cyclophilin A binds to linear peptide motifs containing a consensus that is present in many human proteins. The Journal of Biological Chemistry, 280:23668–23674.
256. Piquer, S., Valera, L., Lampasona, V., Jardin-Watelet, B., Roche, S., Granier, C., Roquet, F., Christie, M.R., Giordano, T., Malosio, M.-L., Bonifacio, E., and Laune, D., 2006. Monoclonal antibody 76F distinguish IA-2 from IA-2ß and overlaps an autoantibody epitope. Journal of Autoimmunity, 26:215–222.
257. Pires, J.R., Taha-Nejad, F., Toepert, F., Ast, T., Hoffmüller, U., Schneider-Mergener, J., Kühne, R., Macias, M.J., and Oschkinat, H., 2001. Solution structures of the YAP65 WW domain and the variant L30 K in complex with the peptides GTPPPPYTVG, N-(n-octyl)-GPPPY and PLPPY and the application of peptide libraries reveal a minimal binding epitope. The Journal of Molecular Biology, 314:1147–1156.
258. Pires, J.R., Hong, X., Brockmann, C., Volkmer-Engert, R., Schneider-Mergener, J., Oschkinat, H., and Erdmann, R., 2003. The ScPex13p SH3 domain exposes two distinct binding sites for Pex5p and Pex14p. The Journal of Molecular Biology, 326:1427–1435.
259. Pitcovsky, T.A., Mucci, J., Alvarez, P., Leguizamon, M.S., Burrone, O., Alzari, P.M., and Campetella, O., 2001. Epitope mapping of trans-sialidase from Trypanosoma cruzi reveals the presence of several cross-reactive determinants. Infection and Immunity, 69:1869–1875.
260. Podolnikova, N.P., Gorkun, O.V., Loreth, R.M., Yee, V.C., Lord, S.T., and Ugarova, T.P., 2005. A cluster of basic amino acid residues in the ?370–381 sequence of fibrinogen comprises a binding site for a platelet integrin ?IIbß3 (glycoprotein IIb/ IIIa). Biochemistry, 44:16920–16930.
261. Pop, O.I., Westermann, M., Volkmer-Engert, R., Schulz, D., Lemke, C., Schreiber, S., Gerlach, R., Wetzker, R., and Müller, J.P., 2003. Sequence-specific binding of prePhoD to soluble TatAd indicates protein-mediated targeting of the Tat export in Bacillus subtilis. The Journal of Biological Chemistry, 278:38428–38436.
262. Portwich, M., Kramer, A., Otte, L., Töpert, F., Volkmer-Engert, R., and Schneider-Mergener, J., 2002. “ Investigation of heterospecific coiled coil interactions by means of synthetic peptide libraries ”. In Peptides 2002:Proceedings of the 27th European Peptide Symposium, Edited by:Benedetti, E., and Pedone, C., 1004–1005. Naples:Edizioni Ziino.
263. Prodinger, W.M., Schwendinger, M.G., Schoch, J., Köchle, M., Larcher, C., and Dierich, M.P., 1998. Characterization of C3dg binding to a recess formed between short consensus repeats 1 and 2 of complement receptor type 2 (CR2; CD21). The Journal of Immunology, 161:4604–4610.
264. Przezdziak, J., Kretzschmar, I., Tremmel, S., and Volkmer-Engert, R., 2005. “ Synthesis of an array comprising 551 variants of the FBP28-WW protein domain ”. In Peptides 2004:Proceedings of the 3rd International and 28th European Peptide Symposium, Edited by:Flegel, M., 393–394. Geneva:Kenes International.
265. Ptushkina, M., von der Haar, T., Vasilescu, S., Frank, R., Birkenhäger, R., and McCarthy, J.E.G., 1998. Cooperative modulation by eIF4G of eIF4E-binding to the mRNA 5´cap in yeast involves a site partially shared by p20. The EMBO Journal, 17 (16):4798–4808.
266. Pulli, T., Lankinen, H., Roivainen, M., and Hyypiä, T., 1998. Antigenic sites of coxsackievirus A9. Virology, 240:202–212.
267. Raffler, N.A., Schneider-Mergener, J., and Famulok, M., 2003. A novel class of small functional peptides that bind and inhibit human ?-thrombin isolated by mRNA display. Chemistry & Biology, 10:69–79.
268. Rampon, C., Prandini, M.-H., Bouillot, S., Pointu, H., Tillet, E., Frank, R., Vernet, M., and Huber, P., 2005. Protocadherin 12 (VE-cadherin 2) is expressed in endothelial, trophoblast, and mesangial cells. Experimental Cell Research, 302:48–60.
269. Rau, H.K., DeJonge, N., and Haehnel, W., 2000. Combinatorial synthesis of four-helix bundle hemoproteins for tuning of cofactor properties. Angewandte Chemie International Edition, 39:250–253.
270. Reineke, U., Sabat, R., Kramer, A., Stigler, R.D., Seifert, M., Michel, T., Volk, H.-D., and Schneider-Mergener, J., 1996. Mapping protein-protein contact sites using cellulose-bound peptide scans. Molecular Diversity, 1:141–148.
271. Reineke, U., Ehrhard, B., Sabat, R., Volk, H.-D., and Schneider-Mergener, J., 1998a. “ Novel strategies for the mapping of discontinuous epitopes using cellulose-bound peptide and hybritope scans ”. In Peptides 1996:Proceedings of the 24th European Peptide Symposium, Edited by:Ramage, R., and Epton, R., 751–752. Kingswinford:Mayflower Scientific Ltd.
272. Reineke, U., Sabat, R., Volk, H.-D., and Schneider-Mergener, J., 1998b. Mapping of the interleukin-10/interleukin-10 receptor combining site. Protein Science, 7:951–960.
273. Reineke, U., Schneider-Mergener, J., Glaser, R.W., Stigler, R.-D., Seifert, M., Volk, H.-D., and Sabat, R., 1999a. Evidence for conformationally different states of interleukin-10:binding of a neutralizing antibody enhances accessibility of a hidden epitope. Journal of Molecular Recognition, 12:242–248.
274. Reineke, U., Kramer, A., and Schneider-Mergener, J., 1999b. “ Antigen sequence- and library-based mapping of linear and discontinuous protein-protein-interaction sites ”. In Current Topics in Microbiology and Immunology, Edited by:Famuluk, M., Vol. 243, 23–36. Berlin Heidelberg:Springer-Verlag.
275. Reineke, U., Bhargava, S., Schuttkowski, M., Landgraf, C., Germeroth, L., Fischer, G., and Schneider-Mergener, J., 1999c. “ Spatial addressable fluorescence-quenched peptide libraries for the identidication and characterization of protease substrates ”. In Peptides 1998:Proceedings of the 25th European Peptide Symposium, Edited by:Bajusz, S., and Hudecz, F., 562–563. Budapest:Akademiai Kiado.
276. Reineke, U., Volkmer-Engert, R., Welschof, M., Terness, P., and Schneider-Mergener, J., 1999d. “ Synthesis and application of bicystin peptides on continuous cellulose supports ”. In Peptides 1998:Proceedings of the 25th European Peptide Symposium, Edited by:Bajusz, S., and Hudecz, F., 510–511. Budapest:Akademiai Kiado.
277. Reineke, U., Sabat, R., Misselwitz, R., Welfle, H., Volk, H.-D., and Schneider-Mergener, J., 1999e. A synthetic mimic of a discontinuous binding site on interleukin-10. Nature Biotechnology, 17:271–275.
278. Reineke, U., Kurzhals, D., Kohler, A., Blex, C., McCarthy, J., Li, P., Germeroth, L., and Schneider-Mergener, J., 2000. Peptides:Proceedings of the Twenty-Sixth European Peptide Symposium, Edited by:Martinez, J., and Fehrentz, J.-A., 327Paris:EDK.
279. Reineke, U., Ivascu, C., Schlief, M., Landgraf, C., Gericke, S., Zahn, G., Herzel, H., Volkmer-Engert, R., and Schneider-Mergener, J., 2002a. Identification of distinct antibody epitopes and mimotopes from a peptide array of 5520 randomly generated sequences. Journal of Immunological Methods, 267:37–51.
280. Reineke, U., Sabat, R., Hoffmüller, U., Schmidt, M., Kurzhals, D., Wenschuh, H., Volk, H.-D., Germeroth, L., and Schneider-Mergener. 2002b. “ Identification of miniproteins using cellulose-bound duotope scans ”. In Peptides for the New Millenium. Proceedings of the 16th American Peptide Symposium, Edited by:Fields, G., 167–169. New York:Kluwer Academic Publishers.
281. Reuter, M., Schneider-Mergener, J., Kupper, D., Meisel, A., Mackeldanz, P., Krüger, D.H., and Schroeder, C., 1999. Regions of endonuclease EcoRII involved in DNA target recognition identified by membrane-bound peptide repertoires. The Journal of Biological Chemistry, 274:5213–5221.
282. Reuter, M., and Möncke-Buchner, E., 2002. “ Analysis of protein-DNA interactions ”. In Peptide Arrays on Membrane Support, Edited by:Koch, J., and Mahler, M., 97–106. Berlin Heidelberg:Springer-Verlag.
283. Rharbaoui, F., Granier, C., Kellou, M, Mani, J.-C., van Endert, P., Madec, A.-M., Boitard, C., Pau, B., and Bouanani, M., 1998. Peptide specificity of high-titer anti-glutamic acid decarboxylase (GAD) 65 autoantibodies. Immunology Letters, 62:123–130.
284. Riemekasten, G., Marell, J., Trebeljahr, G., Klein, R., Hausdorf, G., Häupl, T., Schneider-Mergener, J., Burmester, G.R., and Hiepe, F., 1998. A novel epitope on the C-terminus of SmD1 is recognized by the majority of sera from patients with systemic lupus erythematosus. Journal of Clinical Investigation, 102:754–763.
285. Ringleb, J., Rohleder, M., and Jewgenow, K., 2004. Impact of feline zona pellucida glycoprotein B-derived synthetic peptides on in vitro fertilization of cat oocytes. Reproduction, 127:179–186.
286. Rüdiger, S., Germeroth, L., Schneider-Mergener, J., and Bukau, B., 1997. Substrate specificity of DNAK chaperone determined by screening cellulose-bound peptide libraries. The EMBO Journal, 16:1501–1507.
287. Rüdiger, S., Mayer, M.P., Schneider-Mergener, J., and Bukau, B., 2000. Modulation of substrate specificity of the DnaK chaperone by alteration of a hydrophobic arch. The Journal of Molecular Biology, 304:245–251.
288. Rüdiger, S., Schneider-Mergener, J., and Bukau, B., 2001. Its substrate specificity characterizes the DnaJ co-chaperone as a scanning factor for the DnaK chaperone. The EMBO Journal, 20:1042–1050.
289. Rybka, A., and Frank, H.-G., 2005. “ Microwave assisted peptide synthesis - a tool to replace classical SPPS? ”. In Understanding Biology Using Peptides. Proceedings of the 19th American Peptide Symposium, Edited by:Blondelle, S.E., 148–149. La Costa:American Peptide Society.
290. Rychlewski, L., Kschischo, M., Dong, L., Schutkowski, M., and Reimer, U., 2004. Target specificity analysis of the AbI kinase using peptide microarray data. The Journal of Molecular Biology, 336:307–311.
291. Sachse, K., Helbig, J.H., Lysnyansky, I.L., Grajetzki, C., Müller, W., Jacobs, E., and Yogev, D., 2000. Epitope mapping of immunogenic and adhesive structures in repetitive domains of Mycoplasma bovis variable surface lipoproteins. Infection and Immunity, 68:680–687.
292. Santona, A., Carta, F., Fraghi, P., and Turrini, F., 2002. Mapping antigenic sites of an immunodominant surface lipoprotein of Mycoplasma agalactiae, AvgC, with the use of synthetic peptides. Infection and Immunity, 70:171–176.
293. Santonico, E., Castagnoli, L., and Cesareni, G., 2005. Methods to reveal domain networks. Drug Discovery Today, 10:1111–1117.
294. Scharn, D., Wenschuh, H., Reineke, U., Schneider-Mergener, J., and Germeroth, L., 2000. Spatially addressed synthesis of amino- and amino-oxy-substituted 1,3,5-triazine arrays on polymeric membranes. Journal of Combinatorial Chemistry, 2:361–369.
295. Scharn, D., Germeroth, L., Schneider-Mergener, J., and Wenschuh, H., 2001. Sequential nucelophilic substitution on halogenated triazines, pyrimidines, and purines:A novel approach to cyclic peptidomimetics. Journal of Organic Chemistry, 66:507–513.
296. Schechter, I., and Berger, A., 1967. On the size of the active site in proteases I. Papain. Biochemical and Biophysical Research Communications, 27:157–162.
297. Scheele, U., Alves, J., Frank, R., Düwel, M., Kalthoff, C., and Ungewickell, E., 2003. Molecular and functional characterization of clathrin- and AP-2-binding determinants within a disordered domain of auxilin. The Journal of Biological Chemistry, 278:25357–25368.
298. Schmidt, A., Utepbergenov, D.I., Mueller, S.L., Beyermann, M., Schneider-Mergener, J., Krause, G., and Blasig, I.E., 2004. Occludin binds to the SH3-hinge-GuK unit of zonula occludens protein 1:potential mechanism of tight junction regulation. Cellular and Molecular Life Sciences, 61:1354–1365.
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