Cross-reactive binding of cyclic peptides to an anti-TGFα antibody Fab fragment: An X-ray structural and thermodynamic analysis

Journal of Molecular Biology

Volumn 314, Issue 2, 2001, Pages 293-309

  Hahn, Michael ^a   Winkler, Dirk ^a   Welfle, Karin ^b   Misselwitz, Rolf ^b   Welfle, Heinz ^b   Wessner, Helga ^a   Zahn, Grit ^a   Scholz, Christa ^a   Seifert, Martina ^a   Harkins, Rick ^c   Schneider Mergener, Jens ^a   Höhne, Wolfgang ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c BAYER AG   (Germany)

Author keywords

Antibody cross reactivity; Cyclic peptides; Isothermal titration calorimetry; Peptide library; Transforming growth factor

Indexed keywords

CYCLOPEPTIDE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY TAB2; TRANSFORMING GROWTH FACTOR ALPHA; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING KINETICS; BINDING SITE; COMPLEX FORMATION; CROSS REACTION; CYCLIZATION; HYDROGEN BOND; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN STABILITY; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; THERMODYNAMICS; TITRIMETRY; X RAY DIFFRACTION;

EID: 0035940940     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.5135     Document Type: Article

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