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Volumn 62, Issue 19, 2006, Pages 4715-4727

Efficient synthesis of small molecule macroarrays: optimization of the macroarray synthesis platform and examination of microwave and conventional heating methods

Author keywords

[No Author keywords available]

Indexed keywords

CHALCONE DERIVATIVE;

EID: 33645959862     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2006.02.083     Document Type: Article
Times cited : (32)

References (54)
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    • For recent reviews of SPOT-synthesis, see:
    • For recent reviews of SPOT-synthesis, see:. Frank R. J. Immunol. Methods 267 (2002) 13-26
    • (2002) J. Immunol. Methods , vol.267 , pp. 13-26
    • Frank, R.1
  • 16
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    • note
    • 2).
  • 19
    • 33646005407 scopus 로고    scopus 로고
    • For selected examples, see:
  • 23
    • 33646000186 scopus 로고    scopus 로고
    • For recent commentaries on MW-assisted combinatorial chemistry, see:
  • 26
    • 33645964841 scopus 로고    scopus 로고
    • For recent reviews on MW-assisted organic chemistry, see:
  • 32
    • 33947091567 scopus 로고
    • Amine functionalization levels were determined by derivatization of support 3 with Fmoc-OSu, cleavage of the N-Fmoc group with piperidine, and quantitation of released fulvene product using UV spectroscopy (at 296 nm) according to standard procedures. See:
    • Amine functionalization levels were determined by derivatization of support 3 with Fmoc-OSu, cleavage of the N-Fmoc group with piperidine, and quantitation of released fulvene product using UV spectroscopy (at 296 nm) according to standard procedures. See:. Carpino L.A., and Han G.Y. J. Org. Chem. 37 (1972) 3404-3409
    • (1972) J. Org. Chem. , vol.37 , pp. 3404-3409
    • Carpino, L.A.1    Han, G.Y.2
  • 34
    • 33645988427 scopus 로고    scopus 로고
    • For further information about this commercial MW reactor system, see:
    • For further information about this commercial MW reactor system, see:. http://www.milestonesci.com/index2.php
  • 35
    • 33645991410 scopus 로고    scopus 로고
    • note
    • Performing this MW-assisted reaction using automated temperature control during the reaction was not possible due to the low solvent volumes used.
  • 36
    • 33645973473 scopus 로고    scopus 로고
    • note
    • Linker loading on support determined by quantifying the amount of free amine (using standard UV Fmoc analysis; see Ref. 22) on the support before and after coupling of the pro-linker unit and its reduction. The difference between these two values was indicative of the amount of linker coupled to the support.
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    • See Ref. 5;
  • 48
    • 33645998649 scopus 로고    scopus 로고
    • For further information about this commercial MW reactor system, see:
    • For further information about this commercial MW reactor system, see:. http://www.cem.com/
  • 49
    • 33646016481 scopus 로고    scopus 로고
    • note
    • Purity and yields determined by integration of HPLC spectra at 254 nm and comparison to a UV calibration curve generated for triarylpyridine 16r. See Supplementary material.
  • 50
    • 20044376318 scopus 로고    scopus 로고
    • For a recent commentary on this process, see:
    • For a recent commentary on this process, see:. Alcázar J. J. Comb. Chem. 7 (2005) 353-355
    • (2005) J. Comb. Chem. , vol.7 , pp. 353-355
    • Alcázar, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.