Sequence Requirements and an Optimization Strategy for Short Antimicrobial Peptides

Chemistry and Biology

Volumn 13, Issue 10, 2006, Pages 1101-1107

  Hilpert, Kai ^a   Elliott, Melissa R ^a   Volkmer Engert, Rudolf ^b   Henklein, Peter ^b   Donini, Oreola ^c   Zhou, Qun ^d   Winkler, Dirk F H ^d   Hancock, Robert E W ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c Inimex Pharmaceuticals Inc   (Canada)

^d Pepmetric Technologies Inc   (Canada)

Author keywords

CHEMBIO; MICROBIO

Indexed keywords

ANTIINFECTIVE AGENT; ANTIMICROBIAL CATIONIC PEPTIDE;

AMINO ACID SEQUENCE; ARTICLE; CHEMICAL PHENOMENA; CHEMISTRY; CIRCULAR DICHROISM; COMPUTER SIMULATION; DRUG DESIGN; DRUG EFFECT; HYDROPHOBICITY; MICROBIOLOGICAL EXAMINATION; MOLECULAR GENETICS; PSEUDOMONAS AERUGINOSA; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SENSITIVITY AND SPECIFICITY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; CIRCULAR DICHROISM; COMPUTER SIMULATION; DRUG DESIGN; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; HYDROPHOBICITY; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PSEUDOMONAS AERUGINOSA; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SENSITIVITY AND SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); BOS TAURUS; CANDIDA ALBICANS; FUNGI; NEGIBACTERIA; POSIBACTERIA; PSEUDOMONAS AERUGINOSA;

EID: 33749680215     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2006.08.014     Document Type: Article

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