Evidence for conformationally different states of interleukin-10: Binding of a neutralizing antibody enhances accessibility of a hidden epitope

Journal of Molecular Recognition

Volumn 12, Issue 4, 1999, Pages 242-248

  Reineke, Ulrich ^a,b   Schneider Mergener, Jens ^a   Glaser, Ralf W ^a,c   Stigler, Rolf Dietrich ^a   Seifert, Martina ^a   Volk, Hans Dieter ^a   Sabat, Robert ^a,b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b Jerini Bio Tools GmbH   (Germany)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Antibody; Cryptic epitope; Hidden epitope; Interleukin 10; Peptide scan; Spot synthesis

Indexed keywords

AMINO ACID; ANTIBODY STRUCTURE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; EPITOPE; GENE MAPPING; INTERLEUKIN 10;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIBODIES, MONOCLONAL; ANTIBODY AFFINITY; ANTIGEN-ANTIBODY REACTIONS; BINDING, COMPETITIVE; CRYSTALLOGRAPHY, X-RAY; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; HUMANS; INTERLEUKIN-10; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; RECOMBINANT PROTEINS;

EID: 0033166966     PISSN: 09523499     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1352(199907/08)12:4<242::AID-JMR461>3.0.CO;2-1     Document Type: Article

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