The Tim9p-Tim10p complex binds to the transmembrane domains of the ADP/ATP carrier

EMBO Journal

Volumn 21, Issue 5, 2002, Pages 942-953

  Curran, Sean P ^a   Leuenberger, Danielle ^a   Oppliger, Wolfgang ^a   Koehler, Carla M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Mitochondria; Mitochondrial protein import; Saccharomyces cerevisiae; TIM complex

Indexed keywords

ADENINE NUCLEOTIDE TRANSLOCASE; CARRIER PROTEIN; MEMBRANE PROTEIN;

ARTICLE; COMPLEX FORMATION; DISULFIDE BOND; ESCHERICHIA COLI; MITOCHONDRIAL MEMBRANE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; YEAST;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BINDING SITES; CARRIER PROTEINS; CYSTINE; INTRACELLULAR MEMBRANES; MACROMOLECULAR SUBSTANCES; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIA; MITOCHONDRIAL ADP, ATP TRANSLOCASES; MITOCHONDRIAL PROTEINS; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; ZINC; ZINC FINGERS;

ESCHERICHIA COLI; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0036499987     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/21.5.942     Document Type: Article

References (51)

1. Tim9, a new component of the TIM22.54 translocase in mitochondria
2. Structural analysis of GroE chaperonin complexes using chemical cross-linking
3. Protein translocation into mitochondria: The role of TIM complexes
4. Distribution of binding sequences for the mitochondrial import receptors Tom20, Tom22 and Tom70 in a presequence-carrying preprotein and a non-cleavable preprotein
5. The mitochondrial import receptor Tom70: Identification of a 25 kDa core domain with a specific binding site for preproteins
6. Two intermembrane space TIM complexes interact with different domains of Tim23p during its import into mitochondria
7. Characterization of the preprotein translocase of the outer mitochondrial membrane by blue native electrophoresis
8. Transport of the ADP/ATP carrier of mitochondria from the TOM complex to the TIM22.54 complex
9. Isolation of highly purified mitochondria from S. Cerevisiae
10. 2 are sorted to the intermembrane space of yeast mitochondria by a stop-transfer mechanism
11. Protein import into yeast mitochondria is accelerated by the outer membrane protein MAS70
12. 2+ ion links the cytoplasmic tail of CD4 and the N-terminal region of Lck
13. Chaperone activity with a redox switch
14. A novel X-linked gene, DDP, shows mutations in families with deafness (DFN-1), dystonia, mental deficiency and blindness
15. The Tim54p-Tim22p complex mediates insertion of proteins into the mitochondrial inner membrane
16. Tim18p is a new component of the Tim54p-Tim22p translocon in the mitochondrial inner membrane
17. Import of mitochondrial carriers mediated by essential proteins of the intermembrane space
18. Tim9p, an essential partner subunit of Tim10p for the import of mitochondrial carrier proteins
19. Human deafness dystonia syndrome is a mitochondrial disease
20. How membrane proteins travel across the mitochondrial intermembrane space
21. Tim18p, a novel subunit of the inner membrane complex that mediates protein import into the yeast mitochondrial inner membrane
22. Reversible inactivation of protein-tyrosine phosphatase 1B in A431 cells stimulated with epidermal growth factor
23. Different import pathways through the mitochondrial intermembrane space for inner membrane proteins
24. Functional reconstitution of the import of the yeast ADP/ATP carrier mediated by the TIM10 complex
25. Zinc fingers are sticking together
26. Solution structure and dynamics of the CX3C chemokine domain of fractalkine and its interaction with an N-terminal fragment of CX3CR1
27. Molecular determinants of receptor binding and signaling by the CX3C chemokine fractalkine
28. The essential function of the small Tim proteins in the TIM22 import pathway does not depend on formation of the soluble 70-kilodalton complex
29. Protein import into mitochondria
30. Mitochondrial metabolite transporters
31. The role of the TIM8-13 complex in the import of Tim23 into mitochondria
32. Mitochondrial import: Crossing the aqueous intermembrane space
33. Versatility of the mitochondrial protein import machinery
34. Redox-operated genetic switches: The SoxR and OxyR transcription factors
35. Protein translocation into mitochondria
36. 2 presequence are sorted to the mitochondrial intermembrane space independently of hsp60
37. Protein translocation across mitochondrial membranes: What a long, strange trip it is
38. Functional staging of ADP/ATP carrier translocation across the outer mitochondrial membrane
39. Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa
40. Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active form
41. Analysis of molecular masses and oligomeric states of protein complexes by blue native electrophoresis and isolation of membrane protein complexes by two-dimensional native electrophoresis
42. Common principles of protein translocation across membranes
43. The central matrix loop drives import of uncoupling protein 1 into mitochondria
44. Specific recognition of mitochondrial preproteins by the cytosolic domain of the import receptor MOM72
45. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
46. Carrier protein import into mitochondria mediated by the intermembrane proteins Tim10/Mrs11 and Tim12/Mrs5
47. A new X linked recessive deafness syndrome with blindness, dystonia, fractures and mental deficiency is linked to Xq22
48. A de novo missense mutation in a critical domain of the X-linked DDP gene causes the typical deafness-dystonia-optic atrophy syndrome
49. The ATPase and protease domains of yeast mitochondrial Lon: Roles in proteolysis and respiration-dependent growth
50. p53 protein oxidation in cultured cells in response to pyrrolidine dithiocarbamate: A novel method for relating the amount of p53 oxidation in vivo to the regulation of p53-responsive genes