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note
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2).
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Coffen, D.L.6
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15
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33646439499
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note
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Full experimental details, compound characterization methods, and analytical data for all compounds can be found in Supporting Information.
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17
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0141512514
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MW heating is seeing increasing use in solid-phase combinatorial synthesis: (a) Blackwell, H. E. Org. Biomol Chem. 2003, 1, 1251-1255.
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33646453729
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note
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All MW-assisted reactions were performed in a Milestone MicroSYNTH Labstation multimodal MW reactor using power (wattage) control. Temperature control was not possible due to the low solvent volumes used (i.e., microliter scale). See Supporting Information for full details.
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20
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33646445267
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C. Entela Mineralight Lamp; model UVGL-58
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C. Entela Mineralight Lamp; model UVGL-58.
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21
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16844362313
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Fluorescein, one of the most commonly used fluorophores, has a Stokes shift of 19 nm, For a recent report of fluorescein derivatives, see: Urano, Y.; Kamiya, M.; Kanda, K.; Ueno, T.; Hirose, K.; Nagano, T. J. Am. Chem. Soc. 2005, 127, 4888-4894.
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25
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33646450504
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note
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See Supporting Information for full panel of compounds tested.
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27
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12844265310
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For a recent example of a fluorescent polarity probe used to study proteins, see: Cohen, B. E.; Pralle, A.; Yao, X.; Swaminath, G.; Gandhi, C. S.; Jan, Y. N.; Kobilka, B. K.; Isacoff, E. Y.; Jan, L. Y. Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 965-970. 1649-1652
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Kobilka, B.K.7
Isacoff, E.Y.8
Jan, L.Y.9
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