Solution structures of the YAP65 WW domain and the variant L30 K in complex with the peptides GTPPPPYTVG, N-(n-octyl)-GPPPY and PLPPY and the application of peptide libraries reveal a minimal binding epitope

Journal of Molecular Biology

Volumn 314, Issue 5, 2001, Pages 1147-1156

  Pires, José Ricardo ^a   Taha Nejad, Fatemeh ^b   Toepert, Florian ^c   Ast, Thomas ^c   Hoffmüller, Ulrich ^c   Schneider Mergener, Jens ^c   Kühne, Ronald ^a   Macias, Maria J ^b   Oschkinat, Hartmut ^a  

^a LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Ligands; NMR structure; Polyproline motif; WW domain; YAP65

Indexed keywords

ACETYLPROLYLLEUCYLPROLYLPROLYLTYROSINE; ACETYLPROLYLPROLYLPROLYLPROLYLTYROSINE; DYSTROGLYCAN; DYSTROPHIN; EPITOPE; GLYCYLTHREONYLPROLYLPROLYLPROLYLPROLYLTYROSYLTHREONYLVALYLGLYCINE; LEUCINE; LIGAND; LYSINE; M PROTEIN; N (N OCTYL)GLYCYLPROLYLPROLYLPROLYLTYROSINAMIDE; OLIGOPEPTIDE; PEPTIDE LIBRARY; PROLINE; PROTEIN YAP65; TRYPTOPHAN; TYROSINE; UBIQUITIN PROTEIN LIGASE NEDD4; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CRYSTAL STRUCTURE; DISSOCIATION CONSTANT; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR INTERACTION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

EID: 0035861991     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.5199     Document Type: Article

References (30)

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