Serum Antibodies from Patients with Primary Sjögren's Syndrome and Systemic Lupus Erythematosus Recognize Multiple Epitopes on the La(SS-B) Autoantigen Resembling Viral Protein Sequences

Scandinavian Journal of Immunology

Volumn 43, Issue 1, 1996, Pages 115-121

  Haaheim, L R ^a   Halse, A K ^b,c   Kvakestad, R ^b   Stern, B ^b   Normann, O ^a   Jonsson, R ^b  

^a HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF BERGEN   (Norway)

^c Broegelmann Research Laboratory   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; EPITOPE; NUCLEAR PROTEIN; SYNTHETIC PEPTIDE; VIRUS ANTIGEN; VIRUS PROTEIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HERPES VIRUS; HUMAN; IMMUNE RESPONSE; POLYOMA VIRUS; PRIORITY JOURNAL; SJOEGREN SYNDROME; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADULT; AGED; AMINO ACID SEQUENCE; ANTIGENS, VIRAL; AUTOANTIBODIES; AUTOANTIGENS; CROSS REACTIONS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; FEMALE; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MIDDLE AGED; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; RIBONUCLEOPROTEINS; SJOGREN'S SYNDROME; TRANSCRIPTION FACTORS; VIRAL PROTEINS; VIRUSES;

EID: 0030046179     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.1996.d01-2.x     Document Type: Article

References (32)

1. Tan EM. Autoantibodies to nuclear antigens (ANA): their immunobiology and medicine. Adv Immunol 1982;33:167-240.
2. Talal N. Sjögren's syndrome. In: Schumacher HR, Klippel JH, Robinson DR, eds. Primer on the Rheumatic Diseases. Ninth edn. Atlanta: Arthritis Foundation, 1988:136-8.
3. Alarcon-Segovia D, Asherson RA, Hughes GRV. Systemic lupus erythematosus. In: Schumacher HR, Klippel JH, Robinson DR, eds. Primer on the Rheumatic Diseases. Ninth edn. Atlanta: Arthritis Foundation, 1988:96-107.
4. Chambers JC, Kenan D, Martin BJ, Keene JD. Genomic structure and amino acid sequence domains of the human La autoantigen. J Biol Chem 1988;263:18043-51.
5. St. Clair EW, Kenan D, Burch Jr JA, Keene JD, Pisetsky DS. Anti-La antibody production by MRL-1pr/1pr mice. Analysis of fine specificity. J Immunol 1991;146:1885-92.
6. Reichlin M. Antibodies to RNA proteins in systemic lupus crythematosus: the significance of paired immune responses. In: Talal N, ed. Molecular Autoimmunity. London: Academic Press, 1991:51-63.
7. Habets WJ, den Brok JH, Boerbooms AMTh, van de Putte LBA, van Venrooij WJ. Characterization of the SS-B (La) antigen in adenovirus-infected and uninfected HeLa cells. EMBO J 1983;2:1625-31.
8. Lord PCW, Rothschild CB, DeRose RT, Kilpatrick BA. Human cytomegalovirus RNAs immunoprecipitated by multiple systemic lupus erythematosus antisera. J Gen Virol 1989;70:2383-96.
9. Bachmann M, Falke D, Schröder H-C, Müller WEG. Intracellular distribution of the La antigen in CV-1 cells after herpes simplex virus type 1 infection compared with the localization of U small nuclear ribonucleoprolein particles. J Gen Virol 1989;70:881-91.
10. Kurilla MG, Keene JD. The leader RNA of vesicular stomatitis virus is bound by a cellular protein reactive with anti-La lupus antibodies. Cell 1983;34:837-45.
11. Lerner MR, Andrews NC, Miller G, Steitz JA. Two small RNAs encoded by Epstein-Barr virus and complexed with protein are precipitated by antibodies from patients with systemic lupus erythematosus. Proc Natl Acad Sci USA 1981;78:805-9.
12. Mecrovitch K, Svitkin YV, Lee HS et al. La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate. J Virol 1993:67:3798-807.
13. Sturgess AD, Peterson MG, McNeilage LJ, Whittingham S, Coppel RL. Characteristics and epitope mapping of a cloned human autoantigen La. J Immunol 1988;140:3212-18.
14. Nyman U, Ringertz NR, Pettersson I. Demonstration of an amino terminal La epitope recognized by human anti-La sera. Immunol Lett 1989;22:65-72.
15. McNeilage LJ, Macmillan EM, Whittingham SF. Mapping of epitopes on the La(SS-B) autoantigen of primary Sjögren's syndrome: identification of a cross-reactive epitope. J Immunol 1990;145:3829-35.
16. Rauh AJG, Hornig H, Lührmann R. At least three distinct B cell epitopes reside in the C-terminal half of La protein, as determined by a recombinant DNA approach. Eur J Immunol 1988;18:2049-57.
17. St. Clair EW, Pisetsky DS, Reich CF, Keene JD. Analysis of autoantibody binding to different regions of the human La antigen expressed in recombinant fusion proteins. J Immunol 1988;141:4173-80.
18. 2 terminus of the La/SS-B ribonucleoprotein autoantigen. J Clin Invest 1992;89:1652-6.
19. Fox RI, Pearson G, Vaughan JH. Detection of Epstein-Barr virus-associated antigens and DNA in salivary gland biopsies from patients with Sjögren's syndrome. J Immunol 1986;137:3162-8.
20. Mariette X, Agbalika F, Daniel M-T et al. Detection of human T lymphotropic virus type I tax gene in salivary gland epithelium from two patients with Sjögren's syndrome. Arthritis Rheum 1993;36:1423-8.
21. Talal N, Dauphinée MJ, Dang H, Alexander SS, Hart DJ, Garry RF. Detection of serum antibodies to retroviral proteins in patients with primary Sjögren's syndrome (autoimmune exocrinopathy). Arthritis Rheum 1990;33:774-81.
22. Vitali C, Bombardieri S, Moutsopoulos HM et al. Preliminary criteria for the classification of Sjögren's syndrome. Arthritis Rheum 1993;36:340-7.
23. Tan EM, Cohen AS, Fries JF et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982;25:1271-7.
24. Bairoch A, Boeckmann B. The SWISS-PROT protein sequence data bank: current status. Nucleic Acids Res 1994;22:3578-80.
25. George DG, Barker WC, Mewes H-W, Pfeiffer F, Tsugita A. The PIR-International Protein Sequence Database. Nucleic Acids Res 1994;22:3569-73.
26. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ. Basic local alignment search tool. J Mol Biol 1990;215:403-10.
27. Pearson WR, Lipman DJ. Improved tools for biological sequence comparison. Proc Nail Acad Sci USA 1988;85:2444-8.
28. Sturrock SS, Collins JF. MPsrch program, Version 1.3. Biocomputing Research Unit, University of Edinburgh, Edinburgh, UK, 1993.
29. Rose NR, Bona C. Defining criteria for autoimmune diseases (Witebsky's postulates revisited). Immunol Today 1993;14:426-30.
30. Kohsaka H, Yamamoto K, Fujii H et al. Fine epitope mapping of the human SS-B/La protein. Identification of a distinct autoepitope homologous to a viral gag polyprotein. J Clin Invest 1990;85:1566-74.
31. 1 hybrids, but not in normal mice. Eur J Immunol 1994;24:66-70.
32. Weng YM, McNeilage J, Topfer F, McCluskey J, Gordon T. Identification of a human-specific epitope in a conserved region of the La/SS-B autoantigen. J Clin Invest 1993;92:1104-8.